Fukuyama Team 2001




  2013  2012  2011  2010  2009  2008  2007  2006  2005  2004  2003  2002  2001  2000  1999  -1998

2013

"Total Synthesis of Lyconadins A-C"

Takuya Nishimura, Aditya K. Unni, Satoshi Yokoshima, Tohru Fukuyama
J. Am. Chem. Soc., ASAP, (doi: 10.1021/ja312065m) [PDF] [Supporting Information]


"2-Pyridone Synthesis Using 2-(Phenylsulfinyl)acetamide"

Masaya Fujii, Takuya Nishimura, Takahiro Koshiba, Satoshi Yokoshima, Tohru Fukuyama
Org. Lett., 15, 232 (2013) (doi: 10.1021/ol303320c) [PDF] [Supporting Information]


"Modified McFadyen-Stevens Reaction for a Versatile Synthesis of Aliphatic/Aromatic Aldehydes: Design, Optimization, and Mechanistic Investigations"

Yuri Iwai, Takashi Ozaki, Ryo Takita, Masanobu Uchiyama, Jun Shimokawa, Tohru Fukuyama
Chem. Sci., ASAP (doi: 10.1039/C2SC22045H) [PDF]


2012

"Activity-Dependent Proteolytic Cleavage of Neuroligin-1"
Kunimichi Suzuki, Yukari Hayashi, Soichiro Nakahara, Hiroshi Kumazaki, Johannes Prox
Keisuke Horiuchi, Mingshuo Zeng, Shun Tanimura, Yoshitake Nishiyama, Satoko Osawa
Atsuko Sehara-Fujisawa, Paul Saftig, Satoshi Yokoshima, Tohru Fukuyama, Norio Matsuki
Ryuta Koyama, Taisuke Tomita, Takeshi Iwatsubo
Neuron, 76, 410 (2012) (doi: 10.1016/j.neuron.2012.10.003) [PDF] [Supporting Information]


"Total Synthesis of (–)-Lycoposerramine-S"

Naoaki Shimada, Yuzo Abe, Satoshi Yokoshima, Tohru Fukuyama
Angew. Chem. Int. Ed., 2012 (doi: 10.1002/anie.201206863) [PDF] [Supporting Information]
(This paper was featured on Synfacts)


"Synthetic Studies on Chartelline C: Stereoselective Construction of the Core Skeleton"

Kotaro Iwasaki, Rentaro Kanno, Toshiharu Morimoto, Tohru Yamashita
Satoshi Yokoshima, Tohru Fukuyama
Angew. Chem. Int. Ed., 51, 9160 (2012) (doi: 10.1002/anie.201204726) [PDF] [Supporting Information]


"Total Synthesis of (–)-Lemonomycin"

Atsushi Yoshida, Michinori Akaiwa, Tomohiro Asakawa, Yoshitaka Hamashima
Satoshi Yokoshima, Tohru Fukuyama, Toshiyuki Kan
Chem. Eur. J., 18, 11192 (2012) (doi: 10.1002/chem.201202073q) [PDF] [Supporting Information]


"Total Synthesis of (–)-Isoschizogamine"

Yusuke Miura, Noriyuki Hayashi, Satoshi Yokoshima, Tohru Fukuyama
J. Am. Chem. Soc., 134, 11995 (2012) (doi: 10.1021/ja305856q) [PDF] [Supporting Information]
(This paper was featured on Synfacts)


"Synthetic Studies toward Ecteinascidin 743 (Trabectedin)"

Takahiro Imai, Hiyoku Nakata, Satoshi Yokoshima, Tohru Fukuyama
Synthesis, 44, 2743 (2012) (doi: 10.1055/s-0032-1316579) [PDF] [Supporting Information]


"Convenient Synthesis of -Diazoacetates from -Bromoacetates and N,N'-Ditosylhydrazine: Preparation of Benzyl Diazoacetate"

Eiji Ideue, Tatsuya Toma, Jun Shimokawa, Tohru Fukuyama
Org. Synth., 89, 501 (2012) [PDF]


"Efficient Synthesis of Oxime Using O-TBS-N-Tosylhydroxylamine: Preparation of (2Z)-4-(Benzyloxy)but-2-enal Oxime"

Katsushi Kitahara, Tatsuya Toma, Jun Shimokawa, Tohru Fukuyama
Org. Synth., 89, 480 (2012) [PDF]


"Total Synthesis of Gelsemoxonine"

Jun Shimokawa, Takaaki Harada, Satoshi Yokoshima and Tohru Fukuyama
Pure Appl. Chem., 84, 1643 (2012) (doi: 10.1351/PAC-CON-11-10-25)


"A Practical Preparation of Highly Versatile N-Acylpyrroles from 2,4,4-Trimethoxybutan-1-amine"

Tomoaki Maehara, Rentaro Kanno, Satoshi Yokoshima, and Tohru Fukuyama
Org. Lett., 14, 1946 (2012) (doi: 10.1021/ol3005613) [PDF] [Supporting Information]


"Total Synthesis of (–)-Anisatin"

Akihiro Ogura, Kohei Yamada, Satoshi Yokoshima, and Tohru Fukuyama
Org. Lett., 14, 1632 (2012) (doi: 10.1021/ol300390k) [PDF] [Supporting Information]
(This paper was featured on Synfacts)


" Total Syntheses of All the Amathaspiramides"

Koji Chiyoda, Jun Shimokawa, Tohru Fukuyama
Angew. Chem. Int. Ed., 51, 2505 (2012) (doi: 10.1002/anie.201109221) [PDF] [Supporting Information]
(The paper was selected as a Hot Paper.)


2011

"A Practical Synthesis of (–)-Kainic Acid"

Satoshi Takita, Satoshi Yokoshima, Tohru Fukuyama
Synthesis, 3848 (2011) (doi: 10.1055/s-0031-1289570) [PDF] [Supporting Information]


"Total Synthesis of Gelsemoxonine,"

Jun Shimokawa, Takaaki Harada, Satoshi Yokoshima, and Tohru Fukuyama
J. Am. Chem. Soc., 133, 17634-17637 (2011) (doi: 10.1021/ja109516f) [PDF] [Supporting Information]
(This paper was featured on "Chem Station"(Only Japanese Version Available))


"Phenylpiperidine-type -secretase modulators target the transmembrane domain 1 of presenilin 1"

Yu Ohki, Takuya Higo, Kengo Uemura, Naoaki Shimada, Satoko Osawa, Oksana Berezovska, Satoshi Yokoshima, Tohru Fukuyama, Taisuke Tomita and Takeshi Iwatsubo
EMBO Journal, 30, 4815 (2011) (doi: 10.1038/emboj.2011.372) [PDF]


"Total Synthesis of (–)-Histrionicotoxin"

Yohei Adachi, Noriyuki Kamei, Satoshi Yokoshima, and Tohru Fukuyama
Org. Lett., 13, 4446-4449 (2011) (doi: 10.1021/ol2018032) [PDF] [Supporting Information]


"Copper-Mediated Aryl Amination: In Situ Generation of an Active Copper(I) Species"

Takashi Komori, Nobuhiro Satoh, Satoshi Yokoshima, Tohru Fukuyama
Synlett, 1859-1862 (2011) (doi: 10.1055/s-0030-1260954) [PDF]


"Total Synthesis of Tryprostatins A and B,"

Takayuki Yamakawa, Eiji Ideue, Yuzo Iwaki, Ayumu Sato, Hidetoshi Tokuyama, Jun Shimokawa, and Tohru Fukuyama
Tetrahedron, 67, 6547-6560 (2011) (doi: 10.1016/j.tet.2011.05.112) [PDF]


"Total Synthesis of (–)-Salinosporamide A,"

Nobuhiro Satoh, Satoshi Yokoshima, and Tohru Fukuyama
Org. Lett., 13, 3028-3031 (2011) (doi: 10.1021/ol200886j) [PDF] [Supporting Information]


"BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate,"

Nobumasa Takasugi, Tomoki Sasaki, Kunimichi Suzuki, Satoko Osawa, Hayato Isshiki, Yukiko Hori, Naoaki Shimada, Takuya Higo, Satoshi Yokoshima, Tohru Fukuyama, Virginia M.-Y. Lee, John Q. Trojanowski, Taisuke Tomita, and Takeshi Iwatsubo
J. Neurosci., 31, 6850-6857 (2011) (doi: 10.1523/JNEUROSCI.6467-10.2011) [PDF]


"Total Synthesis of (|)-Conophylline and (|)-Conophyllidine,"
Fukuyama Team 2001
Yuki Han-ya, Hidetoshi Tokuyama, and Tohru Fukuyama
Angew. Chem. Int. Ed., 50, 4884-4887 (2011) (doi: 10.1002/anie.201100981) [PDF] [Supporting Information]


"A Practical Synthesis of (|)-Kainic Acid,"

Satoshi Takita, Satoshi Yokoshima, and Tohru Fukuyama
Org. Lett., 13, 2068-2070 (2011) (doi: 10.1021/ol200434a) [PDF] [Supporting Information]


"Concise Total Synthesis of (+)-Lyconadin A,"

Takuya Nishimura, Aditya K. Unni, Satoshi Yokoshima, and Tohru Fukuyama
J. Am. Chem. Soc., 133, 418-419 (2011) (doi: 10.1021/ja109516f) [PDF] [Supporting Information] 1 (Experimental) 2 (Spectrum))


2010

"Total Synthesis of Tryprostatins A and B,"

Takayuki Yamakawa, Eiji Ideue, Jun Shimokawa, Tohru Fukuyama
Angew. Chem. Int. Ed., 49, 9262-9265 (2010) (doi: 10.1002/anie.201004963) [PDF] [Supporting Information]


"Total Synthesis of (|)-Morphine,"

Hifumi Koizumi, Satoshi Yokoshima and Tohru Fukuyama
Chem. Asian. J., 5, 2192-2198 (2010) (doi: 10.1002/asia.201000458) [PDF]


"Synthesis of the optically active key intermediate of FR901483,"

Shigeru Ieda, Toshiyuki Kan, Tohru Fukuyama
Tetrahedron Lett., 51, 4027-4029 (2010) (doi: 10.1016/j.tetlet.2010.05.089) [PDF]


"Total Synthesis of (+)-Manzamine A,"

Tatsuya Toma, Yoichi Kita and Tohru Fukuyama
J. Am. Chem. Soc., 132, 10232-10235 (doi: 10.1021/ja103721s) [PDF] [Supporting Information] 1 (Experimental) 2 (Spectrum))


"Total synthesis of (+)-vinblastine: Control of the stereochemistry at C18,"
Satoshi Yokoshima, Hidetoshi Tokuyama, Tohru Fukuyama
The Chemical Record, 10, 101-118 (2010) (doi: 10.1002/tcr.200900025) [PDF]


"Total Synthesis of (|)-Mersicarpine,"

Rie Nakajima, Tsuyoshi Ogino, Satoshi Yokoshima and Tohru Fukuyama
J. Am. Chem. Soc., 132, 1236-1237 (2010) (doi: 10.1021/ol9022408) [PDF]


2009

"METHOD FOR PRODUCING MORPHINE ,"
Tohru Fukuyama, Satoshi Yokoshima, Hifumi Koizumi
PCT Int. Appl., WO 2009154041 (2009) [Link]


"Development of photoaffinity probes for -secretase equipped with a nitrobenzenesulfonamide-type cleavable linker,"

Satoshi Yokoshima, Yuzo Abe, Naoto Watanabe, Yoichi Kita, Takeshi Iwatsubo, Taisuke Tomita, and Tohru Fukuyama
Bioorg. Med. Chem. Lett., 19, 6869-6871 (2009) (doi: 10.1016/j.bmcl.2009.10.086)


"Total Synthesis of (+)-Haplophytine,"

Hirofumi Ueda, Hitoshi Satoh, Koji Matsumoto, Kenji Sugimoto, Tohru Fukuyama, Hidetoshi Tokuyama
Angew. Chem. Int. Ed., 48, 7600-7603 (2009) (doi: 10.1002/anie.200902192) [PDF] [Supporting Information]


"Total Synthesis of (|)-Huperzine A,"

Takahiro Koshiba, Satoshi Yokoshima and Tohru Fukuyama
Org. Lett., 11, 5354-5356 (2009) (doi: 10.1021/ol9022408) [PDF]


"Synthesis of Lysergic Acid Methyl Ester via the Double Cyclization Strategy,"

Toshiki Kurokawa, Minetaka Isomura, Hidetoshi Tokuyama and Tohru Fukuyama
Synlett, 775-778 (2009) (doi: 10.1055/s-0028-1087948) [PDF]


"Stereocontrolled Total Synthesis of (})-FR901483,"

Shigeru Ieda, Yusuke Asoh, Teppei Fujimoto, Haruka Kitaoka, Toshiyuki Kan, and Tohru Fukuyama
Heterocycles, 79, 721-738 (2009) (doi: 10.3987/COM-08-S(D)38) [PDF]


"Synthetic Studies toward (+)-Lysergic Acid: Construction of the Tetracyclic Ergoline Skeleton,"

Tohru Inoue, Satoshi Yokoshima, and Tohru Fukuyama
Heterocycles, 79, 373-378 (2009) (doi: 10.3987/COM-08-S(D)42) [PDF]


"A Practical Synthesis of (−)-Oseltamivir,"

Nobuhiro Satoh, Takahiro Akiba, Satoshi Yokoshima and Tohru Fukuyama
Tetrahedron, 64, 3239-3245 (2009) (doi: 10.1016/j.tet.2008.09.103) [PDF]


"Total Synthesis of (±)-Morphine,"

Kenji Uchida, Satoshi Yokoshima, Toshiyuki Kan, and Tohru Fukuyama
Heterocycles, 77, 1219-1234 (2009) (doi: 10.3987/COM-08-S(F)103) [PDF]


"Palladium-catalyzed Coupling of N-Heteroaryl Sulfides with Organozinc Reagents,"

Takahiro Koshiba, Tohru Miyazaki, Hidetoshi Tokuyama, and Tohru Fukuyama
Heterocycles, 77, 233-239 (2009) ([abstract] [PDF])


2008

"Total Synthesis of (−)-Serotobenine,"

Yasuaki Koizumi, Hideki Kobayashi, Toshiyuki Wakimoto, Takumi Furuta, Tohru Fukuyama and Toshiyuki Kan
J. Am. Chem. Soc., 130,16854-16855 (2008) (doi: 10.1021/ja807676v [PDF] [Supporting Information] 1 (Experimental) 2 (Spectrum))


"Mild Debenzylation of Aryl Benzyl Ether with BCl3 in the Presence of Pentamethylbenzene as a Non-Lewis-Basic Cation Scavenger,"

Kentaro Okano, Kei-ichiro Okuyama, Tohru Fukuyama, and Hidetoshi Tokuyama
Synlett, 13, 1977-1980 (2008) (doi: 10.1055/s-2008-1077980 [PDF])


"Synthetic Studies on (+)-Manzamine A: Stereoselective Synthesis of the Tetracyclic Core Framework,"

Yoichi Kita, Tatsuya Toma, Toshiyuki Kan, and Tohru Fukuyama
Org. Lett., 10, 3251-3253 (2008) (doi: 10.1021/ol801111r [PDF] [Supporting Information] 1 (Experimental) 2 (Spectrum))


"(1-Nosyl-5-nitroindol-3-yl)methyl Ester: A Novel Protective Group for Carboxylic Acids,"

Takuya Nishimura, Kouhei Yamada, Tohru Takebe, Satoshi Yokoshima, and Tohru Fukuyama
Org. Lett., 10, 2601-2604 (2008) (doi: 10.1021/ol8008655 [PDF] [Supporting Information])


"Synthesis of Eudistomin C and E: Improved Preparation of the Indole Unit,"

Hiroaki Yamagishi, Koji Matsumoto, Kotaro Iwasaki, Tohru Miyazaki, Satoshi Yokoshima, Hidetoshi Tokuyama, and Tohru Fukuyama
Org. Lett., 10, 2369-2372 (2008) (doi: 10.1021/ol800527p [PDF] [Supporting Information])


"A Simple Chiral Template for the Synthesis of Fuctionalized -Arylglycine Derivatives,"

Hiyoku Nakata, Takahiro Imai, Satoshi Yokoshima, and Tohru Fukuyama
Heterocycles, 76, 747-757 (2008) ([abstract] [PDF])


"O-TBS-N-tosylhydroxylamine: A Reagent for Facile Conversion of Alcohols to Oximes,"

Katsushi Kitahara, Tatsuya Toma, Jun Shimokawa, and Tohru Fukuyama
Org. Lett., 10, 2259-2261 (2008) (doi: 10.1021/ol800677p [PDF] [Supporting Information])


"Total Synthesis of (|)-Kainic Acid via Intramolecular Michael Addition: A Second-Generation Route,"

Hiroshi Sakaguchi, Hidetoshi Tokuyama, and Tohru Fukuyama
Org. Lett., 10, 1711-1714 (2008) (doi: 10.1021/ol800328q [PDF] [Supporting Information])


"Oseltamivir Enhances Hippocampal Network Synchronization"
Atsushi Usami, Takuya Sasaki, Nobuhiro Satoh, Takahiro Akiba, Satoshi Yokoshima, Tohru Fukuyama, Kenzo Yamatsugu, Motomu Kanai, Masakatsu Shibasaki, Norio Matsuki and Yuji Ikegaya
J. Pharmacol. Sci., 106, 659-662 (2008) (doi: 10.1254/jphs.SC0070467 [PDF])


"Isoquinuclidine derivative and method for producing 1-cyclohexene-1-carboxylic acid derivative by using the same,"
Tohru Fukuyama, Satoshi Yokoshima, Nobuhiro Satoh
PCT Int. Appl., WO 2008013269 (2008) [Link]


"Synthetic Studies on Altemicidin: Stereocontrolled Construction of the Core Framework,"

Toshiyuki Kan, Yuichiro Kawamoto, Tomohiro Asakawa, Takumi Furuta and Tohru Fukuyama
Org. Lett., 10, 169-171 (2008) (doi: 10.1021/ol701940f [PDF] [Supporting Information] 1 (spectrum) 2 (experimental))


2007

"Synthetic Studies on Haplophytine: Protective Group Controlled Rearrangement,"

Koji Matsumoto, Hidetoshi Tokuyama, and Tohru Fukuyama
Synlett, 3137-3140 (2007) (doi: 10.1055/s-2007-990911 [PDF])


"Total Synthesis of (+)-Yatakemycin,"
Kentaro Okano, Hidetoshi Tokuyama, and Tohru Fukuyama
Chem. Asian J., 3, 296-309. (2007) (doi: 10.1002/asia.200700282 [PDF] [abstract])


"A Versatile Synthesis of -Amino Acid Derivatives via the Ugi Four-Component Condensation with a Novel Convertible Isonitrile,"

Kentaro Rikimaru, Arata Yanagisawa, Toshiyuki Kan, and Tohru Fukuyama
Heterocycles, 73, 403-417 (2007) [Abstract] [pdf]


"Synthesis of (+)-Vinblastine and Its Analogues,"

Tohru Miyazaki, Satoshi Yokoshima, Siro Simizu, Hiroyuki Osada, Hidetoshi Tokuyama, and Tohru Fukuyama
Org. Lett., 9, 4737-4740 (2007) (doi: 10.1021/ol702040y [PDF] [Supporting Information])


"Design and synthesis of thiazoline-thiazole hybrid macrocycles possessing strong binding affinity to Pb2+ and Cd2+,"

Fu She Han, Hidetoshi Tokuyama and Tohru Fukuyama
Chem. Commun., 3444-3446 (2007) (doi: 10.1039/b707904d [PDF] [Supporting Information])


"Novel Structual Motifs Consisting of Chiral Thiazolines: Synthesis, Molecular Recognition, and Anticancer Activity"
Fu She Han, Hiroyuki Osajima, Mui Cheung, Hidetoshi Tokuyama and Tohru Fukuyama
Chem. Eur. J., 13, 3026-3038. (2007) (doi: 10.1002/chem.200601446 [PDF])


"N,N'-Ditosylhydrazine: A Convenient Reagent for Facile Synthesis of Diazoacetates,"

Tatsuya Toma, Jun Shimokawa, and Tohru Fukuyama
Org. Lett., 9, 3195-3197 (2007) (doi: 10.1021/ol701432k [PDF] [Supporting Information])


"A Practical Synthesis of (-)-Oseltamivir,"

Nobuhiro Satoh, Takahiro Akiba, Satoshi Yokoshima and Tohru Fukuyama
Angew. Chem. Int. Ed., 46, 5734-5736 (2007) (doi: 10.1002/anie.200701754 [PDF] [Supporting Information])


"Divergent Synthesis of Multifunctional Molecular Probes Enabled Elucidation of the Enzyme Specificity of Dipeptidic -Secretase Inhibitors on Presenilin-Type Aspartic Proteases,"
Haruhiko Fuwa, Yasuko Takahashi, Yu Konno, Naoto Watanabe, Hiroyuki Miyashita, Makoto Sasaki, Hideaki Natsugari, Toshiyuki Kan, Tohru Fukuyama, Taisuke Tomita and Takeshi Iwatsubo
ACS Chemical Biology, 2, 408-418 (2007) (doi: 10.1021/cb700073y [PDF] [Supporting Information])
Most-accessed articles: 15th

"A Novel Indole Synthesis via Conjugate Addition of Pyrrolidine to o-Nitrophenylacetylenes,"

Hidetoshi Tokuyama, Takaki Makido, Yuki Han-ya, and Tohru Fukuyama
Heterocycles, 72, 191-197 (2007) [Abstract] [pdf]


"Total Syntheses of FR900482,"
Hidetoshi Tokuyama, Masashi Suzuki, and Tohru Fukuyama
J. Synth. Org. Chem. Jpn., 65, 470-480 (2007)


"Convenient Synthesis of Photoaffinity Probes and Evaluation of Their Labeling Abilities"

Toshiyuki Kan, Yoichi Kita, Yuichi Morohashi, Yusuke Tominari, Shinnosuke Hosoda,
Taisuke Tomita, Hideaki Natsugari, Takeshi Iwatsubo, and Tohru Fukuyama
Org. Lett., 9, 2055-2058 (2007) (doi: 10.1021/ol070376i [PDF] [Supporting Information])


"Stereocontrolled Total Synthesis of (-)-Kainic Acid,"

Hiroshi Sakaguchi, Hidetoshi Tokuyama, and Tohru Fukuyama
Org. Lett., 9, 1635-1638 (2007) (doi: 10.1021/ol0631197 [PDF] [Supporting Information])


2006


"Synthesis of chiral cyclic oligothiazolines: a novel structural motif for a macrocyclic molecule,"

Fu She Han, Hiroyuki Osajima, Mui Cheung, Hidetoshi Tokuyama and Tohru Fukuyama
Chem. Commun., 1757-1759 (2006) (doi: 10.1039/b601628f)

"Total Synthesis of (±)-Morphine,"

Kenji Uchida, Satoshi Yokoshima, Toshiyuki Kan, and Tohru Fukuyama
Org. Lett., 8, 5311-5313 (2006)
(doi: 10.1021/ol062112m [PDF] [Supporting Information])


Most-Accessed Articles: October-December, 2006 : Ranked as 1st!
Most-Accessed Articles: Full year, 2006 : Ranked as 13th!

"Total Synthesis of (+)-Yatakemycin,"

Kentaro Okano, Hidetoshi Tokuyama, and Tohru Fukuyama
J. Am. Chem. Soc., 128, 7136-7137 (2006) (doi: 10.1021/ja0619455 [PDF] [Supporting Information])


Most-Accessed Articles: April-June, 2006 : Ranked as 6th communication paper!
Most-Accessed Articles: Full year, 2006 : Ranked as 19th!

"Novel g-secretase inhibitors discovered by library screening of in-house
synthetic natural product intermediates
,"

Yasuko Takahashi, Haruhiko Fuwa, Akane Kaneko, Makoto Sasaki, Satoshi Yokoshima,
Hifumi Koizumi, Tohru Takebe, Toshiyuki Kan, Takeshi Iwatsubo,
Taisuke Tomita, Hideaki Natsugari, and Tohru Fukuyama
Bioorg. Med. Chem. Lett., 16, 3813-3816 (2006) (doi: 10.1016/j.bmcl.2006.04.025)

"Synthesis of biotinylated photoaffinity probes based on arylsulfonamide
-secretase inhibitors,"

Haruhiko Fuwa, Kenichi Hiromoto, Yasuko Takahashi, Satoshi Yokoshima,
Toshiyuki Kan, Tohru Fukuyama, Takeshi Iwatsubo, Taisuke Tomita and Hideaki
Natsugari
Bioorg. Med. Chem. Lett., 16, 4184-4189 (2006) (doi: 10.1016/j.bmcl.2006.05.091)

"C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic
-Secretase-specific Inhibitor DAPT
(N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-Butyl Ester)
,"
Yuichi Morohashi, Toshiyuki Kan, Yusuke Tominari, Haruhiko Fuwa, Yumiko
Okamura, Naoto Watanabe, Chihiro Sato, Hideaki Natsugari, Tohru Fukuyama,
Takeshi Iwatsubo, and Taisuke Tomita
J. Biol. Chem., 281, 14670-14676 (2006) (doi: 10.1074/jbc.M513012200 )

"A Novel Synthesis of Bicyclo[3.3.0]octane Ring System via a Desymmetric C-H Insertion Reaction,"
Kan, Toshiyuki; Inoue, Tohru; Kawamoto, Yuichiro; Yonehara, Mitsuhiro; Fukuyama, Tohru


Synlett, 1583-1585 (2006) (doi: 10.1055/s-2006-941603)

2005

"Stereocontrolled Total Synthesis of (-)-Eudistomin C,"

Tohru Yamashita, Nobutaka Kawai, Hidetoshi Tokuyama, and Tohru Fukuyama
J. Am. Chem. Soc, 127, 15038-15039 (2005) (doi: 10.1021/ja055832h [PDF] [Supporting Information])

"Synthesis of Tetrahydro-β-carbolines via Radical Cyclization of 2-Alkenylthioanilides,"

Manami Iwadate, Tohru Yamashita, Hidetoshi Tokuyama, and Tohru Fukuyama
Heterocycles, 66, 241-249 (2005) (doi: 10.3987/COM-05-S(K)11[PDF])

"Stereocontrolled Total Synthesis of (-)-Kainic Acid. Regio- and Stereoselective Lithiation of Pyrrolidine Ring with the (+)-Sparteine Surrogate,"

Yasuhiro Morita, Hidetoshi Tokuyama, and Tohru Fukuyama
Org. Lett., 7, 4337-4340 (2005) (doi: 10.1021/ol051408+ [PDF] [Supporting Information])

"Synthetic Studies on (-)-Lemonomycin: Stereocontrolled Construction of the 3,8-Diazabicyclo[3.2.1] Skeleton,"

Kentaro Rikimaru, Kazuki Mori, Toshiyuki Kan, and Tohru Fukuyama
Chem. Commun., 394-396 (2005) (doi: 10.1039/b415030a)

"Synthesis of 2,3-Dialkylindoles from 2-Alkenylphenylisocyanides and Imines by Silyltelluride- and Tin Hydride-Mediated Sequential Radical Reactions,"

Masashi Kotani, Shigeru Yamago, Ayumu Satoh, Hidetoshi Tokuyama, and Tohru Fukuyama
Synlett, 1893-1896 (2005) (doi: 10.1055/s-2005-871931)

2004

"Synthetic Studies on (+)-Naphthyridinomycin: Stereoselective Synthesis of the Tetracyclic Core Framework,"
Kazuki Mori, Kentaro Rikimaru, Toshiyuki Kan and Tohru Fukuyama
Org. Lett., 6, 3095-3097 (2004)

"Palladium-Mediated Synthesis of Aldehydes and Ketones from Thiol Esters,"
Tohru Fukuyama and Hidetoshi Tokuyama
Aldrichimica Acta,
37, 87 (2004)

"Total Synthesis of (-)-Strychnine,"
Yosuke Kaburagi, Hidetoshi Tokuyama, and Tohru Fukuyama
J. Am. Chem. Soc.,
126, 10246-10247 (2004)

"Stereocontrolled Total Synthesis of Potent Immunosuppressant FR901483,"
Toshiyuki Kan, Teppei Fujimoto, Yusuke Asoh, Shigeru Ieda, Haruka Kitaoka and
Tohru Fukuyama
Org. Lett., 6, 2729-2731 (2004)

"Total Synthesis of (-)-Ephedradine A (Orantine): An Efficient Construction of Optically Active Dihydrobenzofuran-ring via C-H Insertion Reaction,"
Wataru Kurosawa, Hideki Kobayashi, Toshiyuki Kan and Tohru Fukuyama
Tetrahedron, 60, 9615-9628 (2003)

"Stereocontrolled Total Synthesis of (+)-Vincristine,"
Takeshi Kuboyama, Satoshi Yokoshima, Hidetoshi Tokuyama, and Tohru Fukuyama
Proc. Natl. Acad. Sci. USA, 101, 11966-11970 (2004)

"Enantioselective Total Synthesis of FR900482,"
Masashi Suzuki, Mika Kambe, Hidetoshi Tokuyama, and Tohru Fukuyama
J. Org. Chem., 69, 2831-2843 (2004)

"4-(t-Butyldimethylsilyloxy)benzylidene Acetal: A Novel Benzylidene-type Protecting Group for 1,2-Diols,"
Yosuke Kaburagi, Hiroyuki Osajima, Kousei Shimada, Hidetoshi Tokuyama, and Tohru Fukuyama
Tetrahedron Lett., 45, 3817-3821 (2004)

"Stereoselective Nucleophilic Addition Reaction with a New Chiral Template and Its Application to Synthesis of Optically Active -Aryglycine Derivatives,"
Shigemitsu Tohma, K. Rikimaru, A. Endo, T. Kan, T. Fukuyama
Synthesis, 909-917 (2004)

"New Odorless Protocols for the Synthesis of Aldehydes and Ketones from Thiol Esters,"
Tohru Miyazaki, Yuki Han-ya, Hidetoshi Tokuyama, Tohru Fukuyama
Synlett, 477-480 (2004)

"Highly Efficient Synthesis of Medium-Sized Lactams Via Intramolecular Staudinger -Aza-Wittig Reaction of omega-Azide Pentaphenyl Ester: Synthesis and Biological Evaluation of LY411575 Analogues,"
Haruhiko Fuwa, Yumiko Okamura, Yuichi Morohashi, Taisuke Tomita, Takeshi Iwatsubo, Toshiyuki Kan, Tohru Fukuyama and Hideaki Natsugari
Tetrahedron Lett., 45, 2323-2326 (2004)

"Parallel Synthesis of DAPT Derivatives and Their -Secretase-Inhibitory Activity,"
Toshiyuki Kan,
YusukeTominari, Kentaro Rikimaru, Yuichi Morohashi, Hideaki Natsugari, Taisuke Tomita, Takeshi Iwatsubo and Tohru Fukuyama
Bioorg. Med. Chem. Lett., 14, 1983-1985 (2004)

"Ns Strategies: A Highly Versatile Synthetic Method for Amines,"
Toshiyuki Kan, Tohru Fukuyama
Chem. Commun., 353-359 (2004)

"A Versatile Synthesis of -Amino Acid Derivatives Via the Ugi Four-Component Condensation with a Novel Convertible Isonitrile,"
Kentaro Rikimaru, Arata Yanagisawa, Toshiyuki Kan, Tohru Fukuyama
Synlett, 41-44 (2004)

2003

"Synthesis of Secondary Arylamines through Copper-Mediated Intermolecular Aryl Amination,"
Kentaro Okano, Hidetoshi Tokuyama, Tohru Fukuyama
Org. Lett., 5, 4987-4990 (2003)

"Solid-Phase Synthesis of Photoaffinity Probes: Highly Efficient Incorporation of Biotin-tag and Cross-linking group,"
Toshiyuki Kan, Yusuke Tominari, Yuichi Morohashi, Hideaki Natsugari, Taisuke Tomita, Takeshi Iwatsubo, Tohru Fukuyama
Chem. Commun., 2244-2245 (2003)

"Stereocontrolled Total Synthesis of (–)-Aspidophytine,"
Shinjiro Sumi, Koji Matsumoto, Hidetoshi Tokuyama, and Tohru Fukuyama
Tetrahedron, 59, 8571-8587 (2003)

"Stereocontrolled Total Synthesis of (–)-Ephedradine A (Orantine),"
Wataru Kurosawa, Toshiyuki Kan, and Tohru Fukuyama
J. Am. Chem. Soc., 125, 8112-8113 (2003)

"A Novel Palladium-Catalyzed Coupling of Thiol Esters with 1-Alkynes,"
Hidetoshi Tokuyama, Tohru Miyazaki, Satoshi Yokoshima, and Tohru Fukuyama
Synlett, 1512-1514 (2003)

"A New Synthetic Route to Phomoidride B and Its Derivatives,"
Yuki Hayashi, Tetsuji Itoh, and Tohru Fukuyama
Org. Lett., 5, 2235-2238 (2003)

"An Efficient Synthesis of Optically Active trans-2-Aryl-2,3-dihydrobenzofuran-3-carboxylic Acid Esters via C-H Insertion Reaction,"
Wataru Kurosawa, Toshiyuki Kan, and Tohru Fukuyama
Synlett, 1028-1030 (2003)

"Sulindac Sulfide Is a Noncompetitive -Secretase Inhibitor That Preferentially Reduces Ab 42 Generation,"
Yasuko Takahashi, Ikuo Hayashi, YusukeTominari, Kentaro Rikimaru, Yuichi Morohashi, Toshiyuki Kan, Hideaki Natsugari, Tohru Fukuyama, Taisuke Tomita, and Takeshi Iwatsubo
J. Biol. Chem., 278, 18664-18670 (2003)

"Total Synthesis of Duocarmycins,"
Ken Yamada, Toshiki Kurokawa, Hidetoshi Tokuyama, and Tohru Fukuyama
J. Am. Chem. Soc., 125, 6630-6631 (2003)

"Enantioselective Total Synthesis of Aspidophytine,"
Shinjiro Sumi, Koji Matsumoto, Hidetoshi Tokuyama, and Tohru Fukuyama
Org. Lett., 5, 1891-1893 (2003)

"Total Synthesis of Leustroducsin B,"
Kousei Shimada, Yosuke Kaburagi, and Tohru Fukuyama
J. Am. Chem. Soc., 125, 4048-4049 (2003)

"Stereoselective Formation of a b-Lactam Fused Oxathiazepin: A Synthetic Approach to Eudistomins,"
Tohru Yamashita, Hidetoshi Tokuyama, and Tohru Fukuyama
Synlett,
738-741 (2003)

"Transformation of Primary Amines to N-Monoalkylhydroxylamines: N-Hydroxy-(S)-phenylethylamine Oxalate,"
Hidetoshi Tokuyama, Takeshi Kuboyama, and Tohru Fukuyama
Org. Synth., 80, 207-218 (2003)

"Stereocontrolled Total Synthesis of (+)-Vinblastine,"
Satoshi Yokoshima, Toshihiro Ueda, Satoshi Kobayashi, Ayato Sato, Takeshi Kuboyama, Hidetoshi Tokuyama, and Tohru Fukuyama
Pure Appl. Chem., 75, 29-38 (2003)


2002

"Preparation of Secondary Amines from Primary Amines via 2-Nitrobenzenesulfonamides: N-(4-Methoxybenzyl)-3-phenylpropylamine,"
Wataru Kurosawa, Toshiyuki Kan, Tohru Fukuyama
Org. Synth., 79, 186-195 (2002)

"Facile Construction of N-Hydroxybenzazocine: Enantioselective Total Synthesis of (+)-FR900482,"
Masashi Suzuki, Mika Kambe, Hidetoshi Tokuyama, and Tohru Fukuyama
Angew. Chem. Int. Ed., 41, 4686-4688 (2002)

"Highly Versatile Synthesis of Polyamines by the Ns-strategy on a Novel Trityl Chloride Resin,"
Toshiyuki Kan, Hideki Kobayashi, and Tohru Fukuyama
Synlett, 1338-1340 (2002)

"Synthetic Approach to Tetrodotoxin,"
Tetsuji Itoh, Manabu Watanabe, Tohru Fukuyama
Synlett, 1323-1325 (2002)

"Efficient Macrocyclization by Means of 2-Nitrobenzenesulfonamide and Total Synthesis of Lipogrammistin-A,"
Toshiyuki Kan, Akiko Fujiwara, Hideki Kobayashi, and Tohru Fukuyama
Tetrahedron, 58, 6267-6276 (2002)

"Reduction of Ethanethiol Esters to Aldehydes,"
Hidetoshi Tokuyama, Satoshi Yokoshima, Shao-Cheng Lin, Leping Li, and Tohru Fukuyama
Synthesis, 1121-1123 (2002)

"Total Synthesis of Ecteinascidin 743,"
Atsushi Endo, Arata Yanagisawa, Masanao Abe, Shigemitsu Tohma, Toshiyuki Kan, and Tohru Fukuyama
J. Am. Chem. Soc., 124, 6552-6554 (2002)

"Efficient Synthesis of Medium-Sized Cyclic Amines by Means of 2-Nitrobenzenesulfonamide,"
Toshiyuki Kan, Hideki Kobayashi, and Tohru Fukuyama
Synlett, 697-699 (2002)

"Stereocontrolled Total Synthesis of (+)-Vinblastine,"
Satoshi Yokoshima, Toshihiro Ueda, Satoshi Kobayashi, Ayato Sato, Takeshi Kuboyama, Hidetoshi Tokuyama, and Tohru Fukuyama
J. Am. Chem. Soc., 124, 2137-2139 (2002)

"A Novel Conversion of a -Aminonitrile to Amide,"
Satoshi Yokoshima, Tetsuji Kubo, Hidetoshi Tokuyama, and Tohru Fukuyama
Chem. Lett., 122-124 (2002)

"A Mild Copper-Mediated Intramolecular Amination of Aryl Halides,"
Ken Yamada, Testuji Kubo, Hidetoshi Tokuyama, and Tohru Fukuyama
Synlett, 231-234 (2002)

"Synthesis of 2,3-Disubstituted Indoles by Radical Cyclization of 2-Alkenylphenylisocyanide,"
Hidetoshi Tokuyama and Tohru Fukuyama
Chem. Rec., 2, 37-45 (2002)

"One-Pot ClaisenRearrangement with n-Butyl Vinyl Ether,"
Hidetoshi Tokuyama, Takaaki, Makido, Toshihiro Ueda, and Tohru Fukuyama
Syn. Commun., 32, 869-873 (2002)

"Synthesis of 2,3-Disubstituted Indoles by Radical Cyclization with Hypophosphorous Acid and Its Application to Total Synthesis of (})-Catharanthine,"
Matthew T. Reding, Yosuke Kaburagi, Hidetoshi Tokuyama, and Tohru Fukuyama
Heterocycles, 56, 313-330 (2002)


2001

"Highly Versatile Synthesis of Nitrogen-Containing Compounds by Means of Nitrobenzenesulfonamides,"
Toshiyuki Kan, Tohru Fukuyama
J. Syn. Org. Chem., Jpn., 59, 779-789 (2001)

"Synthesis of Optically Active Arylglycines: Stereoselective Mannich Reaction of Phenols with a New Chiral Template,"
Shigemitsu Tohma, Atsushi Endo, Toshiyuki Kan, Tohru Fukuyama
Synlett, 1179-1181 (2001)

"A Novel Protocol for Construction of Indolylmethyl Group at Aldehydes or Ketones,"
Hidetoshi Tokuyama, Manabu Watanabe, Yuki Hayashi, Toshiki Kurokawa, Ge Peng, Tohru Fukuyama
Synlett, 1403-1406 (2001)

"Intramolecular 1,3-Dipolar Cycloaddition Strategy for Enantioselective Synthesis of FR-900482 Analogues,"
Mika Kambe, Eri Arai, Masashi Suzuki, Hidetoshi Tokuyama, and Tohru Fukuyama
Org. Lett., 3, 2575-2578 (2001)

"A Practical Route to Quinolines from Anilines,"
Hidetoshi Tokuyama, Masashi Sato, Toshihiro Ueda, and Tohru Fukuyama
Heterocycles, 54, 105-108 (2001)


2000

"Enantioselective Total Synthesis of (+)-Gelsemine: Determination of Its Absolute Configuration,"
Satoshi Yokoshima, Hidetoshi Tokuyama, and Tohru Fukuyama
Angew. Chem., Int. Ed., 39, 4073-4075 (2000)

"Total Synthesis of Lipogrammistin-A,"
Akiko Fujiwara, Toshiyuki Kan, and Tohru Fukuyama
Synlett, 1667-1669 (2000)

"Total Synthesis of Polyamine Toxin HO-416b and Agel-489 Using a 2-Nitrobenzenesulfonamide Strategy,"
Yuko Hidai, Toshiyuki Kan, and Tohru Fukuyama
Chem. Pharm. Bull., 48, 1570 (2000)

"Total Synthesis of (-)-CP-263,114 (Phomoidride B),"
Nobuaki Waizumi, Tetsuji Itoh, and Tohru Fukuyama
J. Am. Chem. Soc., 122, 7825-7826 (2000)

"A Novel Transformation of Primary Amines to N-Monoalkylhydroxylamines,"
Hidetoshi Tokuyama, Takeshi Kuboyama, Akiko Amano, Tohru Yamashita,and Tohru Fukuyama
Synthesis, 1299-1304 (2000)

"An Efficient Total Synthesis of (-)-Vindoline,"
Satoshi Kobayashi, Toshihiro Ueda, Tohru Fukuyama
Synlett, 883-886 (2000)

"Synthesis of 2,3-Disubstituted Indoles by Palladium-Mediated Coupling of 2-Iodoindoles,"
Hidetoshi Tokuyama, Yosuke Kaburagi, Xiaoqi Chen, and Tohru Fukuyama,
Synthesis, 429-434 (2000)


1999

"Stereocontrolled Total Synthesis of (})-Catharanthine via Radical-Mediated Indole Formation,"
Matthew T. Reding and Tohru Fukuyama,
Org. Lett., 1, 973-976 (1999)

"N-Carboalkoxy-2-Nirobenzenesulfonamides: A Practical Preparation of N-Boc-, N-Alloc-, and N-Cbz-Protected Primary Amines,"
Tohru Fukuyama, Mui Cheung, Toshiyuki Kan,
Synlett, 1301-1303 (1999)

"Stereocontrolled Total Synthesis of (+)-K252a,"
Yoshihisa Kobayashi, Teppei Fujimoto, and Tohru Fukuyama,
J. Am. Chem. Soc., 121, 6501-6502 (1999)

"Synthetic Study on Ecteinascidin 743 Starting from D-Glucose,"
Atsushi Endo, Toshiyuki Kan, and Tohru Fukuyama,
Synlett, 1103-1105 (1999)

"Total Synthesis of Polyamine Toxin HO-416b Utilizing the 2-Nitrobenzenesulfonamide Protecting Group,"
Yuko Hidai, Toshiyuki Kan, and Tohru Fukuyama,
Tetrahedron Lett., 40, 4711-4714 (1999)

"Radical Cyclization of 2-Alkenylthioanilides: A Novel Synthesis of 2,3-Disubstituted Indoles,"
Hidetoshi Tokuyama, Tohru Yamashita, Matthew T. Reding, Yosuke Kaburagi, and Tohru Fukuyama,
J. Am. Chem. Soc., 121, 3791-3792 (1999)

"Efficient TotalSyntheses of (})-Vincadifformine and (–)-Tabersonine,"
Satoshi Kobayashi, Ge Peng, and Tohru Fukuyama,
Tetrahedron Lett., 40, 1519-1522 (1999)


-1998

"Synthetic Studies on CP-225,917 and CP-263,114,"
Nobuaki Waizumi, Tetsuji Itoh, and Tohru Fukuyama,
Tetrahedron Lett., 39, 6015-6018 (1998)

"A Novel Ketone Synthesis by a Palladium-Catalyzed Reaction of Thiol Esters and Organozinc Reagents,"
Hidetoshi Tokuyama, Satoshi Yokoshima, Tohru Yamashita, and Tohru Fukuyama,
Tetrahedron Lett., 39, 3189-3192 (1998)

"2-(2-Aminophenyl)-acetaldehyde Dimethyl Acetal: A Novel Reagent for the Protection of Carboxylic Acids,"
Eri Arai, Hidetoshi Tokuyama, M. S. Linsell, and Tohru Fukuyama,
Tetrahedron Lett., 39, 71-74 (1998)

"2,4-Dinitrobenzenesulfonamides: A Simple and Practical Method for the Preparation of Secondary Amines and Diamines,"
T. Fukuyama, M. Cheung, C. -K. Jow, Y. Hidai, and T. Kan,
Tetrahedron Lett., 38, 5831-5834 (1997)

"Stereocontrolled Total Synthesis of (})-Gelsemine,"
T. Fukuyama and G. Liu,
Pure Appl. Chem., 69, 501-505 (1997)

"Stereocontrolled Total Synthesis of (})-Gelsemine,"
T. Fukuyama and G. Liu,
J. Am. Chem. Soc., 118, 7426-7428 (1996)

"2- and 4- Nitrobenzenesulfonamides: Exceptionally Versatile Means for Preparation of Secondary Amines and Protection of Amines,"
T. Fukuyama, C. -K. Jow, and M. Cheung,
Tetrahedron Lett., 36, 6373-6374 (1995)

"Total Synthesis of (+)-Leinamycin,"
T. Fukuyama and Y. Kanda,
J. Synth. Org. Chem., Jpn., 52, 888-899 (1994)

"Use of 1,1,1,3,3,3-Hexamethyldisilazane and N,O-Bis(trimethylsilyl)acetaamide in Aromatic Claisen Rearrangement: An Efficient Method for Preventing Abnormal Claisen Rearrangement,"
T. Fukuyama, T. Li, and G. Peng,
Tetrahedron Lett., 35, 2145-2148 (1994)

"A Novel Tin-Mediated Indole Synthesis,"
T. Fukuyama, X. Chen, and G. Peng,
J. Am. Chem. Soc., 116, 3127-3128 (1994)

"Stereocontrolled Synthesis of (-)-Hapalindole G,"
T. Fukuyama and X. Chen,
J. Am. Chem. Soc., 116, 3125-3126 (1994)

"Total Synthesis of (+)-Leinamycin,"
Y. Kanda and T. Fukuyama,
J. Am. Chem. Soc., 115, 8451-8452 (1993)

"Total Synthesis of (-)-Tantazole B,"
T. Fukuyama and L. Xu,
J. Am. Chem. Soc., 115, 8449-8450 (1993)

"Total Synthesis of Mitomycins," in "Studies in Natural Products Chemistry,"
T. Fukuyama and L. Yang, Ed. by Atta-ur-Rahman, Elsevier, Amsterdam, 1993, pp 433-472.

"Synthesis of Naphthyridinomycin," in "Advanves in Heterocyclic Natural ProductsSynthesis,
T. Fukuyama, Ed. by W. H. Person, JAI Press, 1992, pp 189-249.

"Synthetic Studies on Leinamycin. A Synthesis of 1-Oxo-1,3-dithiolan-3-one Moiety,"
Y. Kanda, H. Saito, and T. Fukuyama,
Tetrahedron Lett., 33, 5701-5704 (1992)

"Total Synthesisof (})-FR-900482,"
T. Fukuyama, L. Xu, and S. Goto,
J. Am. Chem. Soc., 114, 383-385 (1992)

"Total Synthesisof (})-Renieramycin A,"
T. Fukuyama, S. D. Linton, and M. M. Tun,
Tetrahedron Lett., 31, 5989-5992 (1990)

"Total Synthesisof (})-Saframycin A,"
T. Fukuyama, L. -H. Yang, K. L. Ajeck, and R. A. Sachleben,
J. Am. Chem. Soc., 112, 3712-3714 (1990)