4, Metabolic regulation of tissue regeneration and aging

Organismal health is maintained by regulation of systemic homeostasis, or tissue interactions. Regulatory mechanisms for tissue repair and regeneration within damaged tissue have been extensively studied. However, the systemic regulation of tissue repair remains poorly understood. To elucidate tissue nonautonomous control of repair process, we develop a system in Drosophila larvae for spatiotemporal tissue injury. Using this technique, we demonstrate that methionine metabolism in the fat body, a counterpart of mammalian liver and adipose tissue, supports the wing regeneration.
Methionine metabolism is also involved in organismal aging. Interestingly, we found that S-adenosyl-methionine (SAM) increases age-dependently, and enhancement of SAM catabolism extends the lifespan in Drosophila. These studies indicate the significance of methionine metabolism for organismal homeostasis like tissue regeneration and aging.
Instead of the importance of metabolism on organismal health, there are still many remaining questions. Our research goals are elucidating the organismal recovery systems from a viewpoint of metabolism and tissue interactions.

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Kashio, S., Obata, F., Zhang, L., Katsuyama, T., Chihara, T., and Miura, M.: Tissue non-autonomous effects of fat body methionine metabolism on imaginal disc repair in Drosophila. Proc. Natl. Acad. Sci. USA., 113, 1835-1840, 2016. doi: 10.1073/pnas.1523681113
Obata, F., and Miura, M.: Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan. Nat. Commun., 6, 8332, 2015, doi:10.1038/ncomms9332

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