Metabolic regulation of development and growth

Energy metabolism underlies all of the biological activities. Recent studies have shown that several biological events such as cancer growth, infection, or development accompany changes of energy metabolism at cellular and organismal levels. These observations suggest importance of controlling energy metabolism to meet the demands of each biological event, but it remains unclear yet how the control of energy metabolism is coupled with cell death, development, and growth. We have revealed how energy metabolism is reorganized during early mouse development by exhaustive metabolomics analysis and gene expression analysis. We are now investigating the regulative mechanisms of metabolic reorganization around mid-gestation stages.

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