Regulation of cell number and size of tissue via programmed cell death

A developing animal is exposed to both intrinsic and extrinsic stresses. Even in these stressful environmental conditions, animal development is achieved with the surprisingly robust patterns. We thought that stress response in developing animal is a key for the regulation of robustness of development. One important stress response will be caspase activation. Caspase activation is not only observed in apoptosis but also in non apoptotic condition. Non apoptotic caspase function includes cell proliferation, migration and differentiation. We are studying the roles of caspases that play crucial roles for developmental robustness. Cell number of the tissue is tightly regulated and this regulation is crucial for homeostatic maintenance of the body. Regulatory mechanisms of the tissue quorum are thought to be based on the communication between dying cells and proliferating cells in whole body. We are investigating the basic mechanisms of the tissue quorum control not only in the tissue but also in whole body.

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