Welcome to Masayuki Miura Laboratory!

Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo

Last update: 2017,5,25


Faculty stuffs:
MIURA, Masayuki. Professor, Molecular Genetics of Cell Death
YAMAGUCHI, Yoshifumi. Associate Professor, Molecular Genetics of Development
KATSUYAMA, Tomonori. Project Assistant Professor, Molecular Genetics of Development

Research Subjects:
We aim to reveal how cell society is constructed and maintained during development, growth, and aging process with a particular focus on understanding the regulatory mechanisms and functions of cell death. From the perspective of cell sociology, we are also studying the unique biological phenomena such as neural development, metabolic regulation of development, hibernation and social insect behavior by using various model animals.

Regulation and function of cell death signaling in development, growth, and aging

(1) Cell death in adult tissue homeostasis
(2) Cell death in aged nervous system
(3) Regulation of mammalian neural development via cell death signaling
(4) Dynamics of cell death signaling
(5) Regulation of cell number and size of tissue via programmed cell death

(6) Formation and maintenance of neural circuit

(7) Metabolic regulation of development and growth

(8) Molecular mechanisms of hibernation
(9) Neural mechanisms of social behavior

Review article
Yamaguchi, Y., and Miura, M.: Programmed Cell Death in Neurodevelopment. Dev. Cell 32, 478-490, 2015, doi: 10.1016/j.devcel.2015.01.019.
Igaki, T., and Miura, M.: The Drosophila TNF ortholog Eiger: Emerging physiological roles and evolution of the TNF system. Seminar Immunol. 26, 267-274, 2014, doi: 10.1016/j.smim.2014.05.003.
Sakuma, C., Anzo, M., Miura, M., and Chihara, T.: Development of olfactory projection neuron dendrites that contribute to wiring specificity of the Drosophila olfactory circuit.
Genes & Genetic Systems. 89, 17-26, 2014
Kashio, S., Obata, F., and Miura, M.: Interplay of cell proliferation and cell death in Drosophila tissue regeneration.
Dev. Growth Diff. 56, 368-375, 2014
Lee W-J., and Miura, M.: Mechanisms of Systemic Wound Response in Drosophila.
Cur. Topics Dev Biol. 108, 153-183, 2014
Yamaguchi, Y., and Miura, M.: How to form and close the brain: insight into the mechanism of cranial neural tube closure in mammals.
Cell Mol Life Sci. 70, 3171-3186, 2013
Miura, M.: Apoptotic and nonapoptotic caspase functions in animal development.
Cold Spring Harb. Perspect. Biol. 4, doi: 10.1101/cshperspect.a008664, 2012
Miura, M.: Active participation of cell death in development and organismal homeostasis.
Dev. Growth. Diff. 53, 125-136, 2011
Koto, A., and Miura, M.: Who lives and who dies: role of apoptosis in quashing developmental errors.
Comm. Integ. Biol. 4, 495-497, 2011
Sekine, S., Miura, M., and Chihara, T.: Organelles in developing neurons: essential regulators of neuronal morphogenesis and function.
Int. J. Dev. Biol. 53. 19-27. 2009
Kuranaga, E., and Miura, M.: Nonapoptotic functions of caspases: caspases as regulatory molecules for immunity and cell-fate determination.
Trends Cell Biol. 17, 135-144, 2007

Publication List

Lab member@2017

The University of Tokyo

Graduate School of Pharmaceutical Sciences

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