当研究室では以下のテーマで研究が進行中です。
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1.発生・成長・老化における細胞死シグナルの調節と生体機能
a) 全身性創傷応答が組織幹細胞系を制御する分子メカニズムと生理機能
b) 組織再生の全身性制御機構
c) カスパーゼと細胞死によるサイトカイン放出機構
d) 老化による神経細胞死誘導機構
e) 上皮組織の品質管理機構
f) 哺乳類神経管閉鎖期における細胞死の役割

2.細胞死による組織の細胞数(定足数)とサイズの制御機構

3.機能的な神経回路の形成と維持機構

4.哺乳類の発生における代謝変化の意義

5. 哺乳類の冬眠を可能とする分子機構

6.社会環境応答の神経メカニズム〜社会性昆虫モデル


総説:
Yamaguchi, Y., and Miura, M.: Programmed Cell Death in Neurodevelopment. Dev. Cell 32, 478-490, 2015, doi: 10.1016/j.devcel.2015.01.019.
Igaki, T., and Miura, M.: The Drosophila TNF ortholog Eiger: Emerging physiological roles and evolution of the TNF system. Seminar Immunol. 26, 267-274, 2014, doi: 10.1016/j.smim.2014.05.003.
Sakuma, C., Anzo, M., Miura, M., and Chihara, T.: Development of olfactory projection neuron dendrites that contribute to wiring specificity of the Drosophila olfactory circuit.
Genes & Genetic Systems. 89, 17-26, 2014
Kashio, S., Obata, F., and Miura, M.: Interplay of cell proliferation and cell death in Drosophila tissue regeneration.
Dev. Growth Diff. 56, 368-375, 2014
Lee W-J., and Miura, M.: Mechanisms of Systemic Wound Response in Drosophila.
Cur. Topics Dev Biol. 108, 153-183, 2014
Yamaguchi, Y., and Miura, M.: How to form and close the brain: insight into the mechanism of cranial neural tube closure in mammals.
Cell Mol Life Sci. 70, 3171-3186, 2013
Miura, M.: Apoptotic and nonapoptotic caspase functions in animal development.
Cold Spring Harb. Perspect. Biol. 4, doi: 10.1101/cshperspect.a008664, 2012
Miura, M.: Active participation of cell death in development and organismal homeostasis.
Dev. Growth. Diff. 53, 125-136, 2011
Koto, A., and Miura, M.: Who lives and who dies: role of apoptosis in quashing developmental errors.
Comm. Integ. Biol. 4, 495-497, 2011
Sekine, S., Miura, M., and Chihara, T.: Organelles in developing neurons: essential regulators of neuronal morphogenesis and function.
Int. J. Dev. Biol. 53. 19-27. 2009
Kuranaga, E., and Miura, M.: Nonapoptotic functions of caspases: caspases as regulatory molecules for immunity and cell-fate determination.
Trends Cell Biol. 17, 135-144, 2007




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