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» News
- Publication Lists updated:
K. Sakata, D. Urabe, M. Inoue, "Preparation and palladium-mediated cross-coupling of α-benzoyloxyalkylzinc bromides," Tetrahedron. Lett. 2013, in press.
DOI:10.1016/j.tetlet.2013.05.114
(4 Jun 2013)
- Publication Lists updated:
T. Hoshikawa, M. Inoue, "Photoinduced Direct 4-Pyridination of C(sp3)-H Bonds," Chem. Sci. 2013, in press.
DOI:10.1039/C3SC51080H
(27 May 2013)
- Photos updated.(Sports Festival in Kemigawa)(25 May 2013)
- Publication Lists updated:
Y. Amaoka, M. Nagatomo, M. Inoue, "Metal-Free Fluorination of C(sp3)-H Bonds Using a Catalytic N-Oxyl Radical," Org. Lett. 2013, in press.
DOI:10.1021/ol4006757
(20 Apr 2013)
- Publication Lists updated:
K. Mukai, D. Urabe, S. Kasuya, N. Aoki, M. Inoue, "A Convergent Total Synthesis of 19-Hydroxysarmentogenin," Angew. Chem. Int. Ed. 2013, in press.
DOI:10.1002/anie.201302067
T. Tabuchi, D. Urabe, M. Inoue, "Asymmetric synthesis of a highly functionalized bicyclo[3.2.2]nonene derivative," Beilstein J. Org. Chem. 2013, 9, 655-663.
DOI:10.3762/bjoc.9.74
T. Shiba, Y. Kido, K. Sakamoto, D. K. Inaoka, C. Tsuge, R. Tatsumi, G. Takahashi, E. O. Balogun, T. Nara, T. Aoki, T. Honma, A. Tanaka, M. Inoue, S. Matsuoka, H. Saimoto, A. L. Moore, S. Harada, K. Kita, "Structure of the Trypanosome Cyanide-insensitive Alternative Oxidase, a Promising Drug Target," Proc. Natl. Acad. Sci. U.S.A. 2013, in press.
DOI:10.1073/pnas.1218386110
(11 Apr 2013)
- Publication Lists updated:
K. Murai, S. Katoh, D. Urabe, M. Inoue, "A radical-based approach for the construction of the tetracyclic structure of resiniferatoxin,"
Chem. Sci. 2013, in press.
DOI:10.1039/C3SC50329A
T. Kuranaga, Y. Sesoko, K. Sakata, N. Maeda, A. Hayata, M. Inoue, "Total Synthesis and Complete Structural Assignment of Yaku’amide A,"
J. Am. Chem. Soc. 2013, in press.
DOI:10.1021/ja401457h
(3 Apr 2013)
- Publication Lists (Reviews and Accounts) updated:
H. Itoh, M. Inoue, "Chemical Construction and Structural Permutation of Potent Cytotoxin Polytheonamide B: Discovery of Artificial Peptides with Distinct Functions,"
Acc. Chem. Res. 2013, in press.
DOI:10.1021/ar300315p
(15 Mar 2013)
- Publication Lists updated:
T. Hoshikawa, S. Yoshioka, S. Kamijo, M. Inoue, "Photoinduced Direct Cyanation of C(sp3)-H Bonds"
Synthesis 2013, in press.
DOI:10.1055/s-0032-1318325
Y. Isobe, M. Arita, R. Iwamoto, D. Urabe, H. Todoroki, K. Masuda, M. Inoue and H. Arai,
"Stereochemical assignment and anti-inflammatory properties of the omega-3 lipid mediator resolvin E3,"
J. Biochem. 2013, in press.
DOI:10.1093/jb/mvs151
(4 Mar 2013)
- Publication Lists updated:
D. Urabe, M. Nagatomo, K. Hagiwara, K. Masuda, M. Inoue, "Symmetry-Driven Synthesis of 9-Demethyl-10,15-dideoxyryanodol"
Chem. Sci. 2013, in press.
DOI:10.1039/C3SC00023K
(21 Jan 2013)
- Publication Lists updated:
H. Itoh, M. Inoue, "Structural Permutation of Potent Cytotoxin, Polytheonamide B: Discovery of Cytotoxic Peptide with Altered Activity"
ACS Med. Chem. Lett. 2012, in press.
DOI:10.1021/ml300264c
Y. Amaoka, S. Kamijo, T. Hoshikawa, M. Inoue, "Radical Amination of C(sp3)-H Bonds Using N-Hydroxyphthalimide and Dialkyl Azodicarboxylate"
J. Org. Chem. 2012, in press.
DOI:10.1021/jo301840e
- "Featured Articles" is updated.
(5 Nov 2012)
- Publication Lists updated:
T. Hoshikawa, S. Kamijo, M. Inoue, "Photochemically Induced Radical Alkynylation of C(sp3)-H Bonds"
Org. Biomol. Chem. 2012, in press.
DOI:10.1039/C2OB26785C (23 Oct 2012)
- Our paper (N. Shinohara, H. Itoh, S. Matsuoka, M. Inoue "Selective Modification of the N-Terminal Structure of Polytheonamide B Significantly Changes its Cytotoxicity and Activity as an Ion Channel" ChemMedChem 2012, 7, 1770-1773.) has been placed on the back cover of ChemMedChem.
DOI:10.1002/cmdc.201290052（2012/10/14）
- Photos updated.(Lab Trip) (1 Sep 2012)
- Publication Lists updated:
H. Itoh, S. Matsuoka, M. Kreir, M. Inoue, "Design, Synthesis and Functional Analysis of Dansylated Polytheonamide Mimic: An Artificial Peptide Ion Channel"
J. Am. Chem. Soc. 2012, 14011-14018.
DOI:10.1021/ja303831a (27 Aug 2012)
- Publication Lists updated:
M. Iwatsu, D. Urabe, H. Todoroki, K. Masuda, M. Inoue, "Selective Introduction of Four Contiguous Stereocenters on the B-Ring of 4-Hydroxyzinowol"
Heterocycles 2012, in press.
DOI:10.3987/COM-12-S(N)76 (25 Aug 2012)
- Photos updated.(Sports Festival in Kemigawa) (25 Aug 2012)
- Publication Lists updated:
D. Urabe, H. Yamaguchi, A. Someya, M. Inoue, "Intermolecular Radical Reaction of O,Se-Acetals Generated via Seleno-Pummerer Rearrangement"
Org. Lett. 2012, in press.
DOI:10.1021/ol301482f
(20 Jul 2012)
- Publication Lists updated:
S. Kamijo, S. Matsumura, M. Inoue, "Microwave-assisted atom transfer radical addition of polychlorinated compounds to olefins without addition of metal catalysts"
Tetrahedron Lett. 2012, in press.
DOI:10.1016/j.tetlet.2012.06.027
S. Kamijo, S. Yokosaka, M. Inoue, "Carbocyanation of trisubstituted olefins via Cu-catalyzed atom transfer radical addition"
Tetrahedron Lett. 2012, in press.
DOI:10.1016/j.tetlet.2012.06.004
(26 Jun 2012)
- Hiroki Yamaguchi (former member, G2) received Student Presentation Award at the 132 th Annual Meeting of the Pharmaceutical Society of Japan. Title: "Application of α-Alkoxy Bridgehead Radical for Coupling of Oxygenated Carbocycles" (28 Apr 2012)
- Publication Lists updated:
N. Shinohara, H. Itoh, S. Matsuoka, M. Inoue, "Selective Modification of the N-Terminal Structure of Polytheonamide B Significantly Changes its Cytotoxicity and Activity as an Ion Channel"
ChemMedChem 2012, in press.
DOI:10.1002/cmdc.201200142
(19 Apr 2012)
- Group Members updated.
(6 Apr 2012)
- Dr. Nagatomo has been promoted to assistant professor.
(1 Apr 2012)
- Dr. Kamijo has moved to Faculty of Science, Yamaguchi University.
(31 Mar 2012)
- Publication Lists updated:
S. Matsuoka, M. Murai, T. Yamazaki, M. Inoue, "Short polyglutamine peptide forms a high-affinity binding site for thioflavin-T at the N-terminus"
Org. Biomol. Chem. 2012, in press.
DOI:10.1039/C2OB07157F
D. Urabe, H. Todoroki, K. Masuda, M. Inoue, "Total syntheses of four possible stereoisomers of resolvin E3"
Tetrahedron 2012, 3210-3219.
DOI:10.1016/j.tet.2012.02.045
(21 Mar 2012)
- Publication Lists updated:
S. Kamijo, S. Yokosaka, M. Inoue, "Attachment of Carbonyl Functionalities onto Olefins via Copper-Promoted Radical Reaction of Dichloromethylcyanides"
Tetrahedron 2012, in press.
DOI:10.1016/j.tet.2012.01.089
M. Inoue, "Total synthesis and functional analysis of non-ribosomal peptides,"
Chem. Rec. 2011, 11, 284-294.
DOI:10.1002/tcr.201100014
(16 Feb 2012)
- Publication Lists updated:
S. Matsuoka, J. Mao, and M. Inoue, "Effects of the phosphatidylglycerol head group on the binding of short dermcidin-derived peptides to the phospholipid membrane surface"
Tetrahedron Lett. 2012, 1078-1081.
DOI:10.1016/j.tetlet.2011.12.071
(1 Feb 2012)
- Our paper (D. Urabe, H. Yamaguchi, M. Inoue "Application of α-Alkoxy Bridgehead Radical for Coupling of Oxygenated Carbocycles" Org. Lett. 2011, 13, 4778-4781.) has been highlighted in Synfacts.
Synfacts 2011, 1347. DOI:10.1055/s-0031-1289352
(9 Dec 2011)
- Dr. Shin Kamijo received Incentive Award in Synthetic Organic Chemistry, Japan. Research subject: "Development of Novel Synthetic Reactions via Selective Bond Cleavage as a Key Process." The award ceremony and award lecture will be held after the annual meeting '12 of The Society of Synthetic Organic Chemistry, Japan (17 Feb 2012).
(7 Dec 2011)
- Publication Lists updated:
S. Kamijo, T. Hoshikawa, and M. Inoue, "Photochemically Induced Radical Transformation of C(sp3)-H Bonds to C(sp3)-CN Bonds"
Org. Lett. 2011, 5928-5931.
DOI:10.1021/ol202659e
(18 Oct 2011)
- Group Members updated. Dr. Matsuoka has moved to Graduate School of Science, Osaka University.
(18 Oct 2011)
- Publication Lists updated:
D. Urabe, H. Yamaguchi, M. Inoue, Org. Lett. 2011, in press.
DOI:10.1021/ol201758a
S. Kamijo, Y. Amaoka, M. Inoue, Tetrahedron Lett. 2011, 52, 4654-4657.
DOI:10.1016/j.tetlet.2011.06.118
(28 Aug 2011)
- Publication Lists updated:
R. Goto, K. Okura, H. Sakazaki, T. Sugawara, S. Matsuoka, M. Inoue, Tetrahedron 2011, in press. DOI:10.1016/j.tet.2011.05.012
(8 Jun 2011)
- Research Interests updated.
(1 May 2011)
- Publication Lists updated:
M. Inoue, S. Matsuoka, Isr. J. Chem. 2011, 51, 346-358. DOI:10.1002/ijch.201100002
S. Kamijo, T. Hoshikawa, M. Inoue, Tetrahedron Lett. 2011, in press. DOI:10.1016/j.tetlet.2011.03.128
S. Matsuoka, N. Shinohara, T. Takahashi, M. Iida, M. Inoue, Angew. Chem. Int. Ed. 2011, in press. DOI:10.1002/anie.201101533
(26 Apr 2011)
- 2011/2012 has started with new members.(21 Apr 2011)
- Photos updated. (Pacifichem 2010/Doctor Thesis Presentation/5th IPS/Soccor Tournament (2nd)/Soccor Tournament (1st)/Volleyball Tournament (2nd)/Volleyball Tournament (1st)) (10 Feb 2011)
- Photos updated. (Boat Tournament of the Department) (9 Feb 2011)
- Group Members updated. (8 Feb 2011)
- Photos updated. (Celebration for Passing Entrance Exam/Farewell Party for Sascha) (3 Feb 2011)
- "Access Guide and Map" is available here. We added DOIs to a page of publication lists. (29 Jan 2011)
- Group Members updated. (7 Jan 2011)
- Masanori Nagatomo (G4) received Student Poster Award at 2010 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010). Title: "Synthetic Study of Ryanodine" (22 Dec 2010)
- Dr. Shigeru Matsuoka received The Pharmaceutical Society of Japan Award for Young Scientists '11. Research subject: "Solid-State NMR-Based Structural Analyses of Complexes Between Natural Products and Their Target Sites." The award ceremony and award lecture will be held during the 131st annual meeting of the Pharmaceutical Society of Japan. PSJ Website (29 Nov 2010)
- Publication Lists updated: K. Sasaki, D. Urabe, H. Arai, M. Arita, M. Inoue, Chem. Asian J. 2010, in press. (22 Nov 2010)
Now available online.(29 Nov 2010)
- Photos updated. (Lab Trip) (9 Sep 2010)
- "Total synthesis of the large non-ribosomal peptide polytheonamide B" Nature Chem. 2010, 2, 280-285. has been highlighted in the following articles and website:
C. J. Forsyth, "Marine natural products: Totally tubular peptide synthesis," Nature Chem. 2010, 2, 252-254.
C. Ducho, "Convergence Leads to Success: Total Synthesis of the Complex Nonribosomal Peptide Polytheonamide B," Angew. Chem. Int. Ed. 2010, 49, 5034-5036.
"Must Read" article in Faculty of 1000 Biology (2010/9/1)
- Photos updated.(45th Tennenbutsukagakudanwakai/Basketball Tournament of the Department (2nd round)) (26 Aug 2010)
- Publication Lists updated: S. Kamijo, S. Matsumura, M. Inoue, Org. Lett. in press. Available online. (25 Aug 2010)
- Publication Lists updated: S. Matsuoka, Y. Mizoguchi, H. Itoh, K. Okura, N. Shinohara, M. Inoue, Tetrahedron Lett. 2010, 51, 4644-4647. Available online. (24 Aug 2010)
- Publication Lists updated: M. Iwatsu, D. Urabe, M. Inoue, Heterocycles in press. (17 Jun 2010)
- Publication Lists updated: S. Kamijo, Y. Amaoka, M. Inoue, Synthesis in press. Available online. (9 Jun 2010)
- Photos updated.(Group Photo) (8 Jun 2010)
- Photos updated.(Sports Festival in Kemigawa) (4th Jun 2010)
- Photos updated.(Farewell Party/Welcome Party) (17th May 2010)
- Group Members updated/Publication Lists updated:
T. Yu, M. Singh, S. Matsuoka, Gary J. Patti, G. S. Potter, J. Schaefer, J. Am. Chem. Soc. in press. Available online.
Y. Ishihara, N. Lee, N. Oshiro, S. Matsuoka, S. Yamashita, M. Inoue, M. Hirama, Chem. Commun. 2010, 46, 2968-2970. Available online.
E. O. Balogun, D. K. Inaoka, Y. Kido, T. Shiba, T. Nara, T. Aoki, T. Honma, A. Tanaka, M. Inoue, S. Matsuoka, P. A. M. Michels, S. Harada, K. Kita, Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun. 2010, F66, 304-308. Available online.
Y. Kido, T. Shiba, D. K. Inaoka, K. Sakamoto, T. Nara, T. Aoki, T. Honma, A. Tanaka, M. Inoue, S. Matsuoka, A. Moore, S. Harada, K. Kita, Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun. 2010, F66, 275-278. Available online. (16th Apr 2010)
- 2010/2011 has started with new members.(1st Apr 2010)
- Photos updated.(Welcome, 4th year undergraduates!/Party after Master Thesis Presentation/Research Presentation by B4) (26th Mar 2010)
- Publication Lists updated: M. Inoue, N. Shinohara, S. Tanabe, T. Takahashi, K. Okura, H. Itoh, Y. Mizoguchi, M. Iida, N. Lee, S. Matsuoka, Nature Chem. AOP. Available online.(22th Feb 2010)
 Archives (2008-2009)
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Contact Information
Masayuki InoueGraduate School of Pharmaceutical Sciences, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-0033, Japan Phone (+81)-3-5841-1354 Fax (+81)-3-5841-0568 E-mail inoue  mol.f.u-tokyo.ac.jp
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