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  • Publication Lists updated:
    J. Mao, T. Kuranaga, H. Hamamoto, K. Sekimizu, M. Inoue, "Rational Design, Synthesis, and Biological Evaluation of Lactam-Bridged Gramicidin A Analogues: Discovery of a Low-Hemolytic Antibacterial Peptide," ChemMedChem. 2014, in press
    M. Murai, T. Kaji, T. Kuranaga, H. Hamamoto, K. Sekimizu, M. Inoue, "Total Synthesis and Biological Evaluation of the Antibiotic Lysocin E and Its Enantiomeric, Epimeric, and N-Demethylated Analogues," Angew. Chem. Int. Ed. 2014, in press
    DOI:10.1002/anie.201410270
  • Photos updated.(Award 2014) (16 Dec 2014)
  • Publication Lists updated:
    M. Nagatomo, H. Nishiyama, H. Fujino, M. Inoue, "Decarbonylative Radical Coupling of α-Aminoacyl Tellurides: Single-Step Preparation of γ-Amino and α,β-Diamino Acids and Rapid Synthesis of Gabapentin and Manzacidin A," Angew. Chem. In. Ed. 2014, 53, in press
    DOI:10.1002/anie.201410186
    (11 Dec 2014)
  • Publication Lists updated:
    H. Hamamoto, M. Urai, K. Ishii, J. Yasukawa, A. Paudel, M. Murai, T. Kaji, T. Kuranaga, K. Hamase, T. Katsu, J. Su, T. Adachi, R. Uchida, H. Tomoda, M. Yamada, M. Souma, H. Kirihara, M. Inoue, K. Sekimizu, "Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane," Nat. Chem. Bio. 2014, in press
    DOI:10.1038/nchembio.1710 (9 Dec 2014)
  • Taro Asaba (G4) received "Best Poster Presentation Award" at the 4th Junior International Conference on Cutting-Edge Organic Chemistry in Asia (JICCEOCA-4). Title: "Total Synthesis of Crotophorbolone"
  • Taro Asaba (G4) received "The Best Oral Presentation Award" at the 40th Synposium on Progress in Organic Reactions and Syntheses. Title: "Total Synthesis of Crotophorbolone" (6 Dec 2014)
  • Lecturer Daisuke Urabe received The Pharmaceutical Society of Japan Award for Young Scientists '15.(3 Dec 2014)
  • Kengo Masuda (G4) received "The encouragement Award" at the The 56th Symposium of The Chemistry of Natural Products . Title: "Asymmetric Total Synthesis of (+)-Ryanodine"
  • Photos updated.(Boat Tournament) (10 Nov 2014)
  • Publication Lists updated:
    M. Nagatomo, S. Yoshioka, M. Inoue, "Enantioselective Radical Alkynylation of C(sp3)-H Bonds Using Sulfoximine as a Traceless Chiral Auxiliary," Chem. Asian. J. 2014, in press
    DOI:10.1002/asia.201402983
  • Masaki Kochimizu (G3) received "The Best poster Award" at the The 31st Seminar on Synthetic Organic Chemistry. Title: "Total Synthesis of Ryanodol"
  • Photos updated.(The 31st Seminar on Synthetic Organic Chemistry, Autumn Semester Graduation Ceremony
  • New member joins to our laboratory. (2 Oct 2014)
  • Publication Lists updated:
    H. Todoroki, M. Iwatsu, D. Urabe, M. Inoue, "Total Synthesis of (−)-4-Hydroxyzinowol," J. Org. Chem. in press
    DOI:10.1021/jo501666x
  • Photos updated.(Doctor Thesis Presentation, Celebration for Passing Exam)(Sep 9 2014)
  • Publication Lists updated:
    Y. Amaoka, M. Nagatomo, M. Watanabe, K. Tao, S. Kamijo, M. Inoue, "Photochemically Induced Radical Alkenylation of C(sp3)-H Bonds," Chemical Science in press
    DOI:10.1039/C4SC01631A
    T. Yamashita, H. Matoba, T. Kuranaga, M. Inoue, "Total syntheses of nobilamides B and D: application of traceless Staudinger ligation," Tetrahedron in press
    DOI:10.1016/j.tet.2014.05.091
  • Photos updated.(BBQ)(23 Jun 2014)
  • Photos updated.(Group Photo)(14 Jun 2014)
  • Publication Lists updated:
    K. Hagiwara, M. Iwatsu, D. Urabe, M. Inoue, "N-(2,3,4,5,6-Pentafluorophenyl)maleimide as a Powerful Dienophile in Dearomatizing Diels-Alder Reactions," Heterocycles in press
    DOI:10.3987/COM-14-S(K)23(3 Jun 2014)
  • Publication Lists updated:
    K. Hagiwara, D. Urabe, M. Inoue, "Studies in symmetry-driven synthesis of ryanodol: application of nucleophilic alkynylation for regio- and stereoselective desymmetrization," Tetrahedron Lett. in press
    DOI:10.1016/j.tetlet.2014.05.075
  • Photos updated.(Practice for Sports Festival, Sports Festival in Kemigawa)(1 Jun 2014)
  • Publication Lists updated:
    M. Inoue, "Chemical construction and structural permutation of neurotoxic natural product, antillatoxin: importance of the three-dimensional structure of the bulky side chain," Proc. Jpn. Acad., Ser. B 2014, 90, 56-66.
    DOI:10.2183/pjab.90.56
  • Photos updated.(7th Astellas Lecture)(7 May 2014)
  • Publication Lists updated:
    T. Kubota, M. Arita, Y. Isobe, R. Iwamoto, T. Goto, T. Yoshioka, D. Urabe, M. Inoue, H. Arai, "Eicosapentaenoic Acid Is Converted via ω-3 Epoxygenation to the Anti-inflammatory Metabolite 12-Hydroxy-17,18-epoxyeicosatetraenoic acid," FASEB J. 2014, 28, 586-593.
    DOI:10.1096/fj.13-236224(21 Apr 2014)
  • Student Presentation Award at the 134 th Annual Meeting of the Pharmaceutical Society of Japan.(14 Apr 2014)
    Yuuki Amaoka (G5) "Development of Photochemically Induced C(sp3)-H Alkenylation"
    Taro Asaba (G3) "A Study toward Total Synthesis of Crotophorbolone"
    Takuya Kaji (G2) "Synthetic Studies on Batrachotoxin"
    Komei Sakata (G2) "Synthetic Studies on Batrachotoxin"
    Koichi Hagiwara (G1) "Synthetic Study of Puberuline C"
    Atsushi Hayata (G1) "Synthesis and functional control of polytheonamide mimic"
  • Publication Lists updated:
    M. Nagatomo, M. Koshimizu, K. Masuda, T. Tabuchi, D. Urabe, M. Inoue "Total Synthesis of Ryanodol," J. Am. Chem. Soc., in press
    DOI:10.1021/ja502770n
  • Photos updated.(Welcome Party)(1 Apr 2014)
  • 2014/2015 has started with new members.(1 Apr 2014)
  • Photos updated(The 134th Annual Meeting of the Pharmaceutical Society of Japan, Commencement, Farewell Prty, Master Thesis Presentation, Celebration for Mukaiyama award, 55th Symposium of The Chemistry of Natural Products)(31 Mar 2014)
  • Publication Lists updated:
    H. Itoh, S. Matsutaka, T. Kuranaga, M. Inoue, "Control of the cytotoxicity of dansylated polytheonamide mimic, an artificial peptide ion channel, by modification of the N-terminal structure," Tetrahedron Lett. 2014, 55, 728-731.
    DOI:10.1016/j.tetlet.2013.12.007
    H. Itoh, M. Inoue, "Antibody-mediated functional control of a dansylated polytheonamide mimic," Chem. Commun. 2014, 50, 939-941.
    DOI:10.1039/C3CC48348G
    (4 Jan 2014)
  • Publication Lists (Book Chapters) updated:
    M. Inoue, D. Urabe, "Symmetry-Driven Total Synthesis of Merrilactone A and Resolvin E2," Strategy and Tactics in Organic Synthesis 2013, 9, 149-175.
    (4 Jan 2014)
  • Photos updated.( Doctor Thesis Presentation)(13 Dec 2013)
  • Lecturer Daisuke Urabe received Thieme Chemistry Journal Award 2014.
    (3 Dec 2013)
  • Hidenori Todoroki (G4) received "The Best Oral Presentation Award" at the 3rd ACP Junior Symposium. Title: "Synthetic Study of 4-Hydroxyzinowol" (30 Nov 2013)
  • Photos updated.(Boat Tournament)(19 Nov 2013)
  • Professor Masayuki Inoue received Mukaiyama Award Year 2014.
    (2 Oct 2013)
  • Publication Lists updated:
    D. Kamimura, D. Urabe, M. Nagatomo, M. Inoue, "Et3B‐Mediated Radical-Polar Crossover Reaction for Single-Step Coupling of O,Te-Acetal, α,β-Unsaturated Ketones, and Aldehydes/Ketones," Org. Lett. 2013, in press.
    DOI:10.1021/ol402563v
    (27 Sep 2013)
  • Publication Lists updated:
    T. Ishiyama, D. Urabe, H. Fujisawa, M. Inoue, "Concise Synthesis of the Multiply Oxygenated ABC-Ring System of the Dihydro-β-agarofurans," Org. Lett. 2013, in press.
    DOI:10.1021/ol402038b
    (31 Aug 2013)
  • Photos updated.(BBQ, Celebration for Passing Exam)(31 Aug 2013)
  • Publication Lists updated:
    K. Okura, M. Inoue, "The Orientation of the Terminal tBu Group of Antillatoxin is Important for Potent Toxicity: Design, Synthesis and Biological Evaluation of Conformationally Restricted Analogues of Antillatoxin," Asian J. Org. Chem. 2013, in press.
    DOI:10.1002/ajoc.201300111
    K. Okura, S. Matsuoka, M. Inoue, "The bulky side chain of antillatoxin is important for potent toxicity: rational design of photoresponsive cytotoxins based on SAR studies," Chem. Commun. 2013, in press.
    DOI:10.1039/C3CC44066D
    (1 Aug 2013)
  • Photos updated.(Group Photo)(29 Jun 2013)
  • Publication Lists updated:
    K. Sakata, D. Urabe, M. Inoue, "Preparation and palladium-mediated cross-coupling of α-benzoyloxyalkylzinc bromides," Tetrahedron. Lett. 2013, in press.
    DOI:10.1016/j.tetlet.2013.05.114
    (4 Jun 2013)
  • Publication Lists updated:
    T. Hoshikawa, M. Inoue, "Photoinduced Direct 4-Pyridination of C(sp3)-H Bonds," Chem. Sci. 2013, in press.
    DOI:10.1039/C3SC51080H
    (27 May 2013)
  • Photos updated.(Sports Festival in Kemigawa)(25 May 2013)
  • Publication Lists updated:
    Y. Amaoka, M. Nagatomo, M. Inoue, "Metal-Free Fluorination of C(sp3)-H Bonds Using a Catalytic N-Oxyl Radical," Org. Lett. 2013, in press.
    DOI:10.1021/ol4006757
    (20 Apr 2013)
  • Publication Lists updated:
    K. Mukai, D. Urabe, S. Kasuya, N. Aoki, M. Inoue, "A Convergent Total Synthesis of 19-Hydroxysarmentogenin," Angew. Chem. Int. Ed. 2013, in press.
    DOI:10.1002/anie.201302067
    T. Tabuchi, D. Urabe, M. Inoue, "Asymmetric synthesis of a highly functionalized bicyclo[3.2.2]nonene derivative," Beilstein J. Org. Chem. 2013, 9, 655-663.
    DOI:10.3762/bjoc.9.74
    T. Shiba, Y. Kido, K. Sakamoto, D. K. Inaoka, C. Tsuge, R. Tatsumi, G. Takahashi, E. O. Balogun, T. Nara, T. Aoki, T. Honma, A. Tanaka, M. Inoue, S. Matsuoka, H. Saimoto, A. L. Moore, S. Harada, K. Kita, "Structure of the Trypanosome Cyanide-insensitive Alternative Oxidase, a Promising Drug Target," Proc. Natl. Acad. Sci. U.S.A. 2013, in press.
    DOI:10.1073/pnas.1218386110
    (11 Apr 2013)
  • Publication Lists updated:
    K. Murai, S. Katoh, D. Urabe, M. Inoue, "A radical-based approach for the construction of the tetracyclic structure of resiniferatoxin," Chem. Sci. 2013, in press.
    DOI:10.1039/C3SC50329A
    T. Kuranaga, Y. Sesoko, K. Sakata, N. Maeda, A. Hayata, M. Inoue, "Total Synthesis and Complete Structural Assignment of Yaku’amide A," J. Am. Chem. Soc. 2013, in press.
    DOI:10.1021/ja401457h
    (3 Apr 2013)
  • Publication Lists (Reviews and Accounts) updated:
    H. Itoh, M. Inoue, "Chemical Construction and Structural Permutation of Potent Cytotoxin Polytheonamide B: Discovery of Artificial Peptides with Distinct Functions," Acc. Chem. Res. 2013, in press.
    DOI:10.1021/ar300315p
    (15 Mar 2013)
  • Publication Lists updated:
    T. Hoshikawa, S. Yoshioka, S. Kamijo, M. Inoue, "Photoinduced Direct Cyanation of C(sp3)-H Bonds" Synthesis 2013, in press.
    DOI:10.1055/s-0032-1318325
    Y. Isobe, M. Arita, R. Iwamoto, D. Urabe, H. Todoroki, K. Masuda, M. Inoue and H. Arai, "Stereochemical assignment and anti-inflammatory properties of the omega-3 lipid mediator resolvin E3," J. Biochem. 2013, in press.
    DOI:10.1093/jb/mvs151
    (4 Mar 2013)
  • Publication Lists updated:
    D. Urabe, M. Nagatomo, K. Hagiwara, K. Masuda, M. Inoue, "Symmetry-Driven Synthesis of 9-Demethyl-10,15-dideoxyryanodol" Chem. Sci. 2013, in press.
    DOI:10.1039/C3SC00023K (21 Jan 2013)
  • Publication Lists updated:
    H. Itoh, M. Inoue, "Structural Permutation of Potent Cytotoxin, Polytheonamide B: Discovery of Cytotoxic Peptide with Altered Activity" ACS Med. Chem. Lett. 2012, in press.
    DOI:10.1021/ml300264c
    Y. Amaoka, S. Kamijo, T. Hoshikawa, M. Inoue, "Radical Amination of C(sp3)-H Bonds Using N-Hydroxyphthalimide and Dialkyl Azodicarboxylate" J. Org. Chem. 2012, in press.
    DOI:10.1021/jo301840e
  • "Featured Articles" is updated. (5 Nov 2012)
  • Publication Lists updated:
    T. Hoshikawa, S. Kamijo, M. Inoue, "Photochemically Induced Radical Alkynylation of C(sp3)-H Bonds" Org. Biomol. Chem. 2012, in press.
    DOI:10.1039/C2OB26785C (23 Oct 2012)
  • Our paper (N. Shinohara, H. Itoh, S. Matsuoka, M. Inoue "Selective Modification of the N-Terminal Structure of Polytheonamide B Significantly Changes its Cytotoxicity and Activity as an Ion Channel" ChemMedChem 2012, 7, 1770-1773.) has been placed on the back cover of ChemMedChem.
    DOI:10.1002/cmdc.201290052(2012/10/14)
  • Photos updated.(Lab Trip) (1 Sep 2012)
  • Publication Lists updated:
    H. Itoh, S. Matsuoka, M. Kreir, M. Inoue, "Design, Synthesis and Functional Analysis of Dansylated Polytheonamide Mimic: An Artificial Peptide Ion Channel" J. Am. Chem. Soc. 2012, 14011-14018.
    DOI:10.1021/ja303831a (27 Aug 2012)
  • Publication Lists updated:
    M. Iwatsu, D. Urabe, H. Todoroki, K. Masuda, M. Inoue, "Selective Introduction of Four Contiguous Stereocenters on the B-Ring of 4-Hydroxyzinowol" Heterocycles 2012, in press.
    DOI:10.3987/COM-12-S(N)76 (25 Aug 2012)
  • Photos updated.(Sports Festival in Kemigawa) (25 Aug 2012)
  • Publication Lists updated:
    D. Urabe, H. Yamaguchi, A. Someya, M. Inoue, "Intermolecular Radical Reaction of O,Se-Acetals Generated via Seleno-Pummerer Rearrangement" Org. Lett. 2012, in press.
    DOI:10.1021/ol301482f
    (20 Jul 2012)
  • Publication Lists updated:
    S. Kamijo, S. Matsumura, M. Inoue, "Microwave-assisted atom transfer radical addition of polychlorinated compounds to olefins without addition of metal catalysts" Tetrahedron Lett. 2012, in press.
    DOI:10.1016/j.tetlet.2012.06.027
    S. Kamijo, S. Yokosaka, M. Inoue, "Carbocyanation of trisubstituted olefins via Cu-catalyzed atom transfer radical addition" Tetrahedron Lett. 2012, in press.
    DOI:10.1016/j.tetlet.2012.06.004
    (26 Jun 2012)
  • Hiroki Yamaguchi (former member, G2) received Student Presentation Award at the 132 th Annual Meeting of the Pharmaceutical Society of Japan. Title: "Application of α-Alkoxy Bridgehead Radical for Coupling of Oxygenated Carbocycles" (28 Apr 2012)
  • Publication Lists updated:
    N. Shinohara, H. Itoh, S. Matsuoka, M. Inoue, "Selective Modification of the N-Terminal Structure of Polytheonamide B Significantly Changes its Cytotoxicity and Activity as an Ion Channel" ChemMedChem 2012, in press.
    DOI:10.1002/cmdc.201200142 (19 Apr 2012)
  • Group Members updated.
    (6 Apr 2012)
  • Dr. Nagatomo has been promoted to assistant professor.
    (1 Apr 2012)
  • Dr. Kamijo has moved to Faculty of Science, Yamaguchi University.
    (31 Mar 2012)
  • Publication Lists updated:
    S. Matsuoka, M. Murai, T. Yamazaki, M. Inoue, "Short polyglutamine peptide forms a high-affinity binding site for thioflavin-T at the N-terminus" Org. Biomol. Chem. 2012, in press.
    DOI:10.1039/C2OB07157F
    D. Urabe, H. Todoroki, K. Masuda, M. Inoue, "Total syntheses of four possible stereoisomers of resolvin E3" Tetrahedron 2012, 3210-3219.
    DOI:10.1016/j.tet.2012.02.045 (21 Mar 2012)
  • Publication Lists updated:
    S. Kamijo, S. Yokosaka, M. Inoue, "Attachment of Carbonyl Functionalities onto Olefins via Copper-Promoted Radical Reaction of Dichloromethylcyanides" Tetrahedron 2012, in press.
    DOI:10.1016/j.tet.2012.01.089
    M. Inoue, "Total synthesis and functional analysis of non-ribosomal peptides," Chem. Rec. 2011, 11, 284-294.
    DOI:10.1002/tcr.201100014 (16 Feb 2012)
  • Publication Lists updated:
    S. Matsuoka, J. Mao, and M. Inoue, "Effects of the phosphatidylglycerol head group on the binding of short dermcidin-derived peptides to the phospholipid membrane surface" Tetrahedron Lett. 2012, 1078-1081.
    DOI:10.1016/j.tetlet.2011.12.071
    (1 Feb 2012)
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Contact Information
Masayuki Inoue
Graduate School of Pharmaceutical Sciences,
The University of Tokyo
7-3-1 Hongo, Bunkyo-ku
Tokyo 113-0033, Japan
Phone (+81)-3-5841-1354
Fax (+81)-3-5841-0568
E-mail inouemol.f.u-tokyo.ac.jp
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