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2015
  • Photos updated:The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015) (22 Dec 2015)
  • Masaki Koshimizu (G4) received "Student Poster Competition Award" at The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015). Title: "Unified total synthesis of ryanoids" (20 Dec 2015)
  • Photos updated:Volleyball Tournament 2nd-round, Cambridge-UTokyo Joint Symposium, Doctor Thesis Presentation (17 Dec 2015)
  • Satoshi Hashimoto (G3) received "The Best Poster Presentation Award" at The 40th Synposium on Progress in Organic Reactions and Syntheses. Title: "Synthetic study on resiniferatoxin" (15 Dec 2015)
  • Publication Lists updated:
    K. Masuda, M. Koshimizu, M. Nagatomo, M. Inoue, "Asymmetric Total Synthesis of (+)-Ryanodol and (+)-Ryanodine," Chem. Eur. J. in press
    DOI:10.1002/chem.201503641
    M. Nagatomo, K. Hagiwara, K. Masuda, M. Koshimizu, T. Kawamata, Y. Matsui, D. Urabe, M. Inoue, " Symmetry-Driven Strategy for the Assembly of the Core Tetracycle of (+)-Ryanodine: Synthetic Utility of a Cobalt-Catalyzed Olefin Oxidation and α-Alkoxy Bridgehead Radical Reaction," Chem. Eur. J. in press
    DOI:10.1002/chem.201503640
    (1 Dec 2015)
  • Publication Lists updated:
  • J. Okude, T. Ueda,Y. Kofuku, M. Sato,N. Nobuyama, K. Kondo, Y. Shiraishi, T. Mizumura, K. Onishi, M. Natsume, M. Maeda, H. Tsujishita, T. Kuranaga, M. Inoue, I. Shimada, "Identification of a Conformational Equilibrium That Determines the Efficacy and Functional Selectivity of the μ-Opioid Receptor," Angew. Chem. Int. Ed. in press
    DOI:10.1002/anie.201508794
    (17 Nov 2015)
  • Photos updated:ICCEOCA-10/JICCEOCA-5, LMU-UTokyo Symposium (10 Nov 2015)
  • Komei Sakata (G4) received "Outstanding Oral Presentation Award" at the 5th Junior International Conference on Cutting-Edge Organic Chemistry in Asia (JICCEOCA-5). Title: "Synthetic Study of Batrachotoxin"
    (6 Nov 2015)
  • Publication Lists updated:
    T. Asaba, Y. Katoh, D. Urabe, M. Inoue, "Total Synthesis of Crotophorbolone," Angew. Chem. Int. Ed. in press
    DOI:10.1002/anie.201509160
  • Hiroyuki Mutoh (G2) received "The encouragement Award" at the The 57th Symposium of The Chemistry of Natural Products . Title: "Structual Revision and Total Synthesis of Yaku'amide A"
    (24 Oct 2015)
  • Photos updated:Volleyball Tournament 1st-round (8 Oct 2015)
  • Photos updated:BBQ, 57th Symposium of The Chemistry of Natural Products (6 Oct 2015)
  • Publication Lists updated:
    T. Goto, D. Urabe, Y. Isobe, M. Arita, M. Inoue, "Total Synthesis of Four Stereoisomers of (5Z,8Z,10E,14Z)-12-Hydroxy-17,18-epoxy-5,8,10,14-eicosatetraenoic Acid and Their Anti-Inflammatory Activities," Tetrahedron 2015, in press
    DOI:10.1016/j.tet.2015.08.047
    (12 Sep 2015)
  • Publication Lists updated:
    T. Goto, D. Urabe, K. Masuda, Y. Isobe, M. Arita, M. Inoue, "Total Synthesis of Four Stereoisomers of (4Z,7Z,10Z,12E,16Z,18E)-14,20-Dihydroxy-4,7,10,12,16,18-docosahexaenoic Acid and Their Anti-inflammatory Activities," J. Org. Chem. 2015, in press
    DOI:10.1021/acs.joc.5b01461
  • Publication Lists updated:
    T. Kuranaga, H. Mutoh, Y. Sesoko, T. Goto, S. Matsunaga, M. Inoue, "Elucidation and Total Synthesis of the Correct Structures of Tridecapeptides Yaku’amides A and B. Synthesis-Driven Stereochemical Reassignment of Four Amino Acid Residues," J. Am. Chem. Soc. 2015, in press
    DOI:10.1021/jacs.5b05550
    (8 Jul 2015)
  • Photos updated:Practice for Sports Festival, Year-End Party (19 Jun 2015)
  • Photos updated:Sports Festival in Kemigawa (14 Jun 2015)
  • Photos updated:Group Photo 2015, RCS Organic Chemistry Symposia in Tokyo, 8th Astellas Lecture (5 Jun 2015)
  • The movie Prof. Inoue lectured in Lectureship Award MBLA 10th Anniversary Special Lectures performed at Nihon University on March 29 was exhibited. (5 Jun 2015)
  • RSC Organic Chemistry Symposia will be held at Takeda Hall, 5th Fl., Takeda Bldg., Asano Campus, the University of Tokyo on June 6, 2015. For detail here
  • Astellas Lecture will be held at Lecture Hall, 2nd Fl., Faculty of Medicine Bldg. 1, Hongo Campus, the University of Tokyo on May 25, 2015.
    For detail (in Japanese) here
    (23 May 2015)
  • Publication Lists updated:
    T. Yamashita, T. Kuranaga, M. Inoue, "Solid-Phase Total Synthesis of Bogorol A: Stereocontrolled Construction of Thermodynamically Unfavored (E)-2-Amino-2-butenamide," Org. Lett. in press
    DOI:10.1021/acs.orglett.5b00769
    (14 Apr 2015)
  • Tomoya Ymashita (G5) received Student Presentation Award at the 135th Annual Meeting of the Pharmaceutical Society of Japan. Title: "Total Synthesis of Bogorol A"
    (10 Apr 2015)
  • Photos updated:The 135th Annual Meeting, Welcome Party (6 Apr 2015)
  • 2015/2016 has started with new members.
    (1 Apr 2015)
  • Publication Lists updated:
    K. Mukai, S. Kasuya, Y. Nakagawa, D. Urabe, M. Inoue, "A Convergent Total Synthesis of Ouabagenin," Chem. Sci. 2015, in press
    DOI:10.1039/C5SC00212E
    (31 Mar 2015)
  • Publication Lists updated:
    D. Urabe, T. Asaba, M. Inoue, "Convergent Strategies in Total Syntheses of Complex Terpenoids," Chem. Rev. 2015, in press
    DOI:10.1021/cr500716f
    (19 Mar 2015)
  • Photos updated:Soccer, Farewell Party, Commencement
  • Birthday, Master Thesis Presentation) (6 Mar 2015)
  • Publication Lists updated:
    M. Nagatomo, D. Kamimura, Y. Matsui, K. Masuda, M. Inoue, "Et3B-Mediated Two- and Three-Component Coupling Reactions via Radical Decarbonylation of α-Alkoxyacyl Tellurides: Single-Step Construction of Densely Oxygenated Carboskeletons," Chem. Sci. in press
    DOI:10.1039/C5SC00457H
    (6 Mar 2015)
  • Our paper (J. Mao, T. Kuranaga, H. Hamamoto, K. Sekimizu, M. Inoue "Rational Design, Synthesis, and Biological Evaluation of Lactam-Bridged Gramicidin A Analogues: Discovery of a Low-Hemolytic Antibacterial Peptide" ChemMedChem 2015, 10, 540-545.) has been placed on the back cover of ChemMedChem.
    DOI:10.1002/cmdc.201402473 (27 Feb 2015)
  • Prof. Inoue has been named as a Fellow of the Royal Society of Chemistry. (28 Jan 2015)
  • Our paper(H. Todoroki, M. Iwatsu, D. Urabe, M. Inoue, "Total Synthesis of (−)-4-Hydroxyzinowol," J. Org. Chem. 2014, 79, 8835-8849.) has been highlighted in Synfacts.
    Synfacts 2015, 0009.
    DOI:10.1055/s-0034-1379678 (5 Jan 2015)
2014
  • Publication Lists updated:
    S. Yoshioka, M. Nagatomo, M. Inoue, "Application of Two Direct C(sp3)-H Functionalizations for Total Synthesis of (+)-Lactacystin," Org. Lett. in press
    DOI:10.1021/ol503291s (24 Dec 2014)
  • Publication Lists updated:
    J. Mao, T. Kuranaga, H. Hamamoto, K. Sekimizu, M. Inoue, "Rational Design, Synthesis, and Biological Evaluation of Lactam-Bridged Gramicidin A Analogues: Discovery of a Low-Hemolytic Antibacterial Peptide," ChemMedChem. 2014, in press
    M. Murai, T. Kaji, T. Kuranaga, H. Hamamoto, K. Sekimizu, M. Inoue, "Total Synthesis and Biological Evaluation of the Antibiotic Lysocin E and Its Enantiomeric, Epimeric, and N-Demethylated Analogues," Angew. Chem. Int. Ed. 2014, in press
    DOI:10.1002/anie.201410270
    (16 Dec 2014)
  • Photos updated:Award 2014) (16 Dec 2014)
  • Publication Lists updated:
    M. Nagatomo, H. Nishiyama, H. Fujino, M. Inoue, "Decarbonylative Radical Coupling of α-Aminoacyl Tellurides: Single-Step Preparation of γ-Amino and α,β-Diamino Acids and Rapid Synthesis of Gabapentin and Manzacidin A," Angew. Chem. In. Ed. 2014, 53, in press
    DOI:10.1002/anie.201410186
    (11 Dec 2014)
  • Publication Lists updated:
    H. Hamamoto, M. Urai, K. Ishii, J. Yasukawa, A. Paudel, M. Murai, T. Kaji, T. Kuranaga, K. Hamase, T. Katsu, J. Su, T. Adachi, R. Uchida, H. Tomoda, M. Yamada, M. Souma, H. Kirihara, M. Inoue, K. Sekimizu, "Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane," Nat. Chem. Bio. 2014, in press
    DOI:10.1038/nchembio.1710 (9 Dec 2014)
  • Taro Asaba (G4) received "Best Poster Presentation Award" at the 4th Junior International Conference on Cutting-Edge Organic Chemistry in Asia (JICCEOCA-4). Title: "Total Synthesis of Crotophorbolone"
  • Taro Asaba (G4) received "The Best Oral Presentation Award" at the 40th Synposium on Progress in Organic Reactions and Syntheses. Title: "Total Synthesis of Crotophorbolone" (6 Dec 2014)
  • Lecturer Daisuke Urabe received The Pharmaceutical Society of Japan Award for Young Scientists '15.(3 Dec 2014)
  • Kengo Masuda (G4) received "The encouragement Award" at the The 56th Symposium of The Chemistry of Natural Products . Title: "Asymmetric Total Synthesis of (+)-Ryanodine"
    (10 Nov 2014)
  • Photos updated:Boat Tournament) (10 Nov 2014)
  • Publication Lists updated:
    M. Nagatomo, S. Yoshioka, M. Inoue, "Enantioselective Radical Alkynylation of C(sp3)-H Bonds Using Sulfoximine as a Traceless Chiral Auxiliary," Chem. Asian. J. 2014, in press
    DOI:10.1002/asia.201402983
  • Masaki Kochimizu (G3) received "The Best poster Award" at the The 31st Seminar on Synthetic Organic Chemistry. Title: "Total Synthesis of Ryanodol"
  • New member joins to our laboratory. (2 Oct 2014)
  • Photos updated:The 31st Seminar on Synthetic Organic Chemistry, Autumn Semester Graduation Ceremony (2 Oct 2014)
  • Publication Lists updated:
    H. Todoroki, M. Iwatsu, D. Urabe, M. Inoue, "Total Synthesis of (−)-4-Hydroxyzinowol," J. Org. Chem. in press
    DOI:10.1021/jo501666x
    (Sep 9 2014)
  • Photos updated:Doctor Thesis Presentation, Celebration for Passing Exam (Sep 9 2014)
  • Publication Lists updated:
    Y. Amaoka, M. Nagatomo, M. Watanabe, K. Tao, S. Kamijo, M. Inoue, "Photochemically Induced Radical Alkenylation of C(sp3)-H Bonds," Chem. Sci. in press
    DOI:10.1039/C4SC01631A
    T. Yamashita, H. Matoba, T. Kuranaga, M. Inoue, "Total syntheses of nobilamides B and D: application of traceless Staudinger ligation," Tetrahedron in press
    DOI:10.1016/j.tet.2014.05.091
  • Photos updated:BBQ (23 Jun 2014)
  • Photos updated:Group Photo (14 Jun 2014)
  • Publication Lists updated:
    K. Hagiwara, M. Iwatsu, D. Urabe, M. Inoue, "N-(2,3,4,5,6-Pentafluorophenyl)maleimide as a Powerful Dienophile in Dearomatizing Diels-Alder Reactions," Heterocycles in press
    DOI:10.3987/COM-14-S(K)23 (3 Jun 2014)
  • Publication Lists updated:
    K. Hagiwara, D. Urabe, M. Inoue, "Studies in symmetry-driven synthesis of ryanodol: application of nucleophilic alkynylation for regio- and stereoselective desymmetrization," Tetrahedron Lett. in press
    DOI:10.1016/j.tetlet.2014.05.075
    (1 Jun 2014)
  • Photos updated:Practice for Sports Festival, Sports Festival in Kemigawa (1 Jun 2014)
  • Photos updated:7th Astellas Lecture (7 May 2014)
  • Publication Lists updated:
    M. Inoue, "Chemical construction and structural permutation of neurotoxic natural product, antillatoxin: importance of the three-dimensional structure of the bulky side chain," Proc. Jpn. Acad., Ser. B 2014, 90, 56-66.
    DOI:10.2183/pjab.90.56
  • Publication Lists updated:
    T. Kubota, M. Arita, Y. Isobe, R. Iwamoto, T. Goto, T. Yoshioka, D. Urabe, M. Inoue, H. Arai, "Eicosapentaenoic Acid Is Converted via ω-3 Epoxygenation to the Anti-inflammatory Metabolite 12-Hydroxy-17,18-epoxyeicosatetraenoic acid," FASEB J. 2014, 28, 586-593.
    DOI:10.1096/fj.13-236224 (21 Apr 2014)
  • Student Presentation Award at the 134 th Annual Meeting of the Pharmaceutical Society of Japan.(14 Apr 2014)
    Yuuki Amaoka (G5) "Development of Photochemically Induced C(sp3)-H Alkenylation"
    Taro Asaba (G3) "A Study toward Total Synthesis of Crotophorbolone"
    Takuya Kaji (G2) "Synthetic Studies on Batrachotoxin"
    Komei Sakata (G2) "Synthetic Studies on Batrachotoxin"
    Koichi Hagiwara (G1) "Synthetic Study of Puberuline C"
    Atsushi Hayata (G1) "Synthesis and functional control of polytheonamide mimic"
  • Publication Lists updated:
    M. Nagatomo, M. Koshimizu, K. Masuda, T. Tabuchi, D. Urabe, M. Inoue "Total Synthesis of Ryanodol," J. Am. Chem. Soc., in press
    DOI:10.1021/ja502770n
    (1 Apr 2014)
  • Photos updated:Welcome Party (1 Apr 2014)
  • 2014/2015 has started with new members. (1 Apr 2014)
  • Photos updated(The 134th Annual Meeting of the Pharmaceutical Society of Japan, Commencement, Farewell Prty, Master Thesis Presentation, Celebration for Mukaiyama award, 55th Symposium of The Chemistry of Natural Products (31 Mar 2014)
  • Publication Lists updated:
    H. Itoh, S. Matsutaka, T. Kuranaga, M. Inoue, "Control of the cytotoxicity of dansylated polytheonamide mimic, an artificial peptide ion channel, by modification of the N-terminal structure," Tetrahedron Lett. 2014, 55, 728-731.
    DOI:10.1016/j.tetlet.2013.12.007
    H. Itoh, M. Inoue, "Antibody-mediated functional control of a dansylated polytheonamide mimic," Chem. Commun. 2014, 50, 939-941.
    DOI:10.1039/C3CC48348G
    (4 Jan 2014)
  • Publication Lists (Book Chapters) updated:
    M. Inoue, D. Urabe, "Symmetry-Driven Total Synthesis of Merrilactone A and Resolvin E2," Strategy and Tactics in Organic Synthesis 2013, 9, 149-175.
    (4 Jan 2014)
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