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井上 将行

学術論文(査読付)

    2024
  1. A. Watanabe, M. Nagatomo, A. Hirose, Y. Hikone, N. Kishimoto, S. Miura, T. Yasutake, T. Abe, S. Misumi, M. Inoue, "Total Syntheses of Phorbol and 11 Tigliane Diterpenoids and Their Evaluation as HIV Latency-Reversing Agents," J. Am. Chem. Soc. 2024, in press.
    (UTokyo FOCUS内 press releasesにて紹介されました。リンク)

    DOI: 10.1021/jacs.4c01589
  2. H. Asai, K. Hagiwara, M. Inoue, "Enantioselective route to an AE-ring intermediate in the total synthesis of talatisamine," Tetrahedron Lett. 2024, 135, 154903.

    DOI: 10.1016/j.tetlet.2023.154903
  3. 2023
  4. Y. Watanabe, K. Sakata, D. Urabe, K. Hagiwara, M. Inoue, "Formal Total Synthesis of Batrachotoxin Enabled by Radical and Weix Coupling Reactions," J. Org. Chem. 2023, 88, 17479-17484.
    (24/1/4 Selectesd as Most Read Articles)

    DOI: 10.1021/acs.joc.3c02290
  5. T. Watanabe, K. Oga, H. Matoba, M. Nagatomo, M. Inoue, "Total Synthesis of Taxol Enabled by Intermolecular Radical Coupling and Pd-Catalyzed Cyclization," J. Am. Chem. Soc. 2023, 145, 25894. (UTokyo FOCUS内 press releasesにて紹介されました。リンク)
    (23/12/4 Selectesd as Most Read Articles)
    (24/1/9 Featured in "Some Items of Interest to Process R&D Chemists and Engineers," Org. Process Res. Dev. 2024, 28, 1. )
    (Featured in Synfacts)
    (Chem-Stationにて取り上げられました。)

    DOI: 10.1021/jacs.3c10658
  6. Y. Watanabe, H. Morozumi, H. Mutoh, K. Hagiwara, M. Inoue, "Total Synthesis of (−)-Batrachotoxin Enabled by a Pd/Ag-Promoted Suzuki–Miyaura Coupling Reaction," Angew. Chem. Int. Ed. 2023, 62, e202309688.
    (UTokyo FOCUS内 press releasesにて紹介されました。リンク)
    (Selected as Hot Paper)

    DOI: 10.1002/anie.202309688
  7. J. Fu, Y. Nakata, H. Itoh, S. Panthee, H. Hamamoto, K. Sekimizu, M. Inoue, "Molecular Editing Enhances Oxidation Resistance of Menaquinone-Targeting Antibiotics Lysocin E and WAP-8294A2," Chem. Eur. J. 2023, 29, e202301224.
    DOI: 10.1002/chem.202301224
  8. Y. Nakata, J. Fu, H. Itoh, S. Panthee, H. Hamamoto, K. Sekimizu, M. Inoue, "Construction of Five Tryptophan Isomers and Application of the Isomers to Solid-Phase Total Syntheses of Lysocin E Derivatives," Chem. Eur. J. 2023, 29, e202301225.
    DOI: 10.1002/chem.202301225
  9. H. Zhu, M. Kurokawa, M. Chen, Q. Wang, M. Inoue, T. Takao, "Characteristic Fragmentation of Polyunsaturated Fatty Acids with Allylic Vicinal Diols in Positive-Ion LC/ESI-MS/MS," J. Lipid Res. 2023, 64, 100384. DOI: 10.1016/j.jlr.2023.100384
  10. Y.-W. Xue, K. Miura, H. Itoh, M. Inoue, "C-Terminal Modification of Polytheonamide B Uncouples Its Dual Functions in MCF-7 Cancer Cells," Chem. Commun. 2023, 59, 3914-3917.

    DOI: 10.1039/D2CC05915K
  11. Y. Imamura, K. Takaoka, Y. Komori, M. Nagatomo, M. Inoue, "Total Synthesis of Taxol Enabled by Inter- and Intramolecular Radical Coupling Reactions," Angew. Chem. Int. Ed. 2023, 62, e202219114.
    (UTokyo FOCUS内 press releasesにて紹介されました。リンク)
    (Selected as Hot Paper)
    (Chem-Stationにて取り上げられました。)
    (Featured in Synfacts)

    DOI: 10.1002/anie.202219114
  12. T. Shimakawa, S. Nakamura, H. Asai, K. Hagiwara, M. Inoue, "Total Synthesis of Puberuline C," J. Am. Chem. Soc. 2023, 145, 600-609.
    (UTokyo FOCUS内 press releasesにて紹介されました。リンク)
    (ChemistryViewsにて取り上げられました。)
    (Selected as Most Read Articles)
    (Chem-Stationにて取り上げられました。)
    (Featured in Synfacts)
    (Organic Chemistry Highlightsで紹介されました。リンク)

    DOI: 10.1021/jacs.2c11259
  13. 2022
  14. N. Nakajima, E. Yoshida, T. Toma, Y. Nishiyama, M. Inoue, T. Fukuyama, S. Yokoshima, "Formal Synthesis of Ecteinascidin 743 via an Intramolecular Cascade Heck Reaction to Construct the Diazabicyclo[3.3.1]nonane Framework," Org. Lett. 2022, 22, 8228-8232.
    DOI: 10.1021/acs.orglett.2c03357
  15. Y.-W. Xue, H. Itoh, S. Dan, M. Inoue, "Gramicidin A Accumulates in Mitochondria, Reduces ATP Levels, Induces Mitophagy, and Inhibits Cancer Cell Growth," Chem. Sci. 2022, 13, 7482-7491.

    DOI: 10.1039/D2SC02024F
  16. T. Nagai, Y. Wang, K. Hagiwara, M. Inoue, "Asymmetric synthesis of evoninic acid," Tetrahedron Lett. 2022, 97, 153747.

    DOI: 10.1016/j.tetlet.2022.153747
  17. Y. Hikone, T. Kato, M. Nagatomo, M. Inoue, "Total Synthesis of Resiniferatoxin Enabled by Photocatalytic Decarboxylative Radical Cyclization," Org. Lett. 2022, 24, 929–933.
    (Selected as Most Read Articles)

    DOI: 10.1021/acs.orglett.1c04286
  18. D. Kuwana, Y. Komori, M. Nagatomo, M. Inoue, "Photoinduced Decarboxylative Radical Coupling Reaction of Multiply Oxygenated Structures by Catalysis of Pt-Doped TiO2," J. Org. Chem. 2022, 87, 730-736.

    DOI: 10.1021/acs.joc.1c02736
  19. 2021
  20. Y. Wang, T. Nagai, I. Watanabe, K. Hagiwara, M. Inoue, "Total Synthesis of Euonymine and Euonyminol Octaacetate," J. Am. Chem. Soc. 2021, 143, 21037–21047.
    (UTokyo FOCUS内 press releasesにて紹介されました。リンク)
    (Selected as Most Read Articles)

    DOI: 10.1021/jacs.1c11038
  21. H. Hamamoto, S. Panthee, A. Paudel, K. Ishii, J. Yasukawa, J. Su, A. Miyashita, H. Itoh, K. Tokumoto, M. Inoue, K. Sekimizu, "Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus," Nat. Commun. 2021, 12, 6364.
    DOI: 10.1038/s41467-021-26702-0
  22. A. Hirose, A. Watanabe, K. Ogino, M. Nagatomo, M. Inoue, "Unified Total Syntheses of Rhamnofolane, Tigliane, and Daphnane Diterpenoids," J. Am. Chem. Soc. 2021, 143, 12387-12396.
    (Featured in Synfacts)
    (Organic Chemistry Highlightsで紹介されました。リンク)

    DOI: 10.1021/jacs.1c06450
  23. A. Takeuchi, H. Itoh, M. Inoue, "18O/16O-Encoding Strategy for Microscale Stereochemical Determination of Peptidic Natural Products," Chem. Asian J. 2021, 16, 2447-2452.

    DOI: 10.1002/asia.202100674
  24. K. Kamiya, H. Itoh, M. Inoue, "Generation and Biological Evaluation of Degraded Derivatives of the Three E/Z-Isomers of Yaku'amide B," J. Nat. Prod. 2021, 84, 1854–1859.

    DOI: 10.1021/acs.jnatprod.1c00339
  25. H. Mutoh, S. Nakamura, K. Hagiwara, M. Inoue, "Construction of Pentacyclic Limonoid Skeletons via Radical Cascade Reactions," J. Org. Chem. 2021, 86, 6869–6878.

    DOI: 10.1021/acs.joc.1c00212
  26. K. Kamiya, K. Miura, H. Itoh, M. Inoue, "Divergent Solid‐Phase Synthesis and Biological Evaluation of Yaku’amide B and Its Seven E/Z Isomers," Chem. Eur. J. 2021, 27, 1088-1093.
    (Selected as Hot Paper)

    DOI: 10.1002/chem.202003858
  27. 2020
  28. S. Shimizu, K. Hagiwara, H. Itoh, M. Inoue, "Unified Total Synthesis of Five Bufadienolides," Org. Lett. 2020, 22, 8652-8657.
    (Selected as Most Read Articles of the month)

    DOI: 10.1021/acs.orglett.0c03251
  29. Y. Iwahashi, Y. Toyama, S. Imai, H. Itoh, M. Osawa, M. Inoue, I. Shimada, "Conformational equilibrium shift underlies altered K+ channel gating as revealed by NMR," Nat. Commun. 2020, 11, 5168.
    DOI: 10.1038/s41467-020-19005-3
  30. M. Nagatomo, K. Zhang, H. Fujino, M. Inoue, "Et3B/Et2AlCl/O2‐Mediated Radical Coupling Reaction between α‐Alkoxyacyl Tellurides and 2‐Hydroxybenzaldehyde Derivatives," Chem. Asian. J. 2020, 15, 3820-3824.

    DOI: 10.1002/asia.202001090
  31. Y. Takada, H. Itoh, A. Paudel, S. Panthee, H. Hamamoto, K. Sekimizu, M. Inoue, "Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library," Nat. Commun. 2020, 11, 4935.
    (UTokyo FOCUS内 Press Releasesにて紹介されました。 日本語, English)
    (Selected as Nature Communications Editors' Highlights, link)

    DOI: 10.1038/s41467-020-18711-2
  32. T. Teratani, Y. Mikami, N. Nakamoto, T. Suzuki, Y. Harada, K. Okabayashi, Y. Hagihara, N. Taniki, K. Kohno, S. Shibata, K. Miyamoto, H. Ishigame, P.-S. Chu, T. Sujino, W. Suda, M. Hattori, M. Matsui, T. Okada, H. Okano, M. Inoue, T. Yada, Y. Kitagawa, A. Yoshimura, M. Tanida, M. Tsuda, Y. Iwasaki, T. Kanai, "The Liver-Brain-Gut Neural Arc Maintains the Treg Cell Niche in the Gut," Nature 2020, 585, 591-596.
    DOI: 10.1038/s41586-020-2425-3
  33. T. Fukuda, M. Nagatomo, M. Inoue, "Total Synthesis of Diospyrodin and Its Three Diastereomers," Org. Lett. 2020, 22, 6468–6472.

    DOI: 10.1021/acs.orglett.0c02280
  34. K. Minagawa, D. Kamakura, K. Hagiwara, M. Inoue, "Construction of the ABCE-ring structure of talatisamine via decarboxylative radical cyclization," Tetrahedron 2020, 76, 131385.
    (Selected as Editor’s Choice Collection, link)

    DOI: 10.1016/j.tet.2020.131385
  35. H. Fujino, T. Fukuda, M. Nagatomo, M. Inoue, "Convergent Total Synthesis of Hikizimycin Enabled by Intermolecular Radical Addition to Aldehyde," J. Am. Chem. Soc. 2020, 142, 13227–13234.
    (UTokyo FOCUS内 articlesにて紹介されました。 リンク)
    (Organic Chemistry Highlightsで紹介されました。リンク)


    DOI: 10.1021/jacs.0c06354
  36. J. Mao, H. Itoh, K. Sakurai, M. Inoue, "Phospholipid-Dependent Functions of a Macrocyclic Analogue of the Ion-Channel-Forming Antibiotic Gramicidin A," Chem. Pharm. Bull. 2020, 68, 173-178.

    DOI: 10.1248/cpb.c19-00967
  37. H. Itoh, K. Miura, K. Kamiya, T. Yamashita, M. Inoue, "Solid‐Phase Total Synthesis of Yaku’amide B Enabled by Traceless Staudinger Ligation," Angew. Chem. Int. Ed. 2020, 59, 4564-4571.
    (UTokyo FOCUS内 articlesにて紹介されました。 リンク)

    DOI: 10.1002/anie.201916517
  38. D. Kamakura, H. Todoroki, D. Urabe, K. Hagiwara, M. Inoue, "Total Synthesis of Talatisamine," Angew. Chem. Int. Ed. 2020, 59, 479-486.
    (Featured in Synfacts)
    (UTokyo FOCUS内 articlesにて紹介されました。 リンク)
    (Synthesis Workshop Videosにて紹介されました。 link)
    (Selected as Top Downloaded Article link)


    DOI: 10.1002/anie.201912737
  39. 2019
  40. Y.-W. Xue, A. Hayata, H. Itoh, M. Inoue, "Biological Effects of a Simplified Synthetic Analogue of Ion‐Channel‐Forming Polytheonamide B on Plasma Membrane and Lysosomes," Chem. Eur. J. 2019, 25, 15198-15204.
    (Selected as Hot Paper)

    DOI: 10.1002/chem.201903974
  41. E. O. Balogun, D. K. Inaoka, T. Shiba, C. Tsuge, B. May, T. Sato, Y. Kido, T. Nara, T. Aoki, T. Honma, A. Tanaka, M. Inoue, S. Matsuoka, P. A. M. Michels, Y.-I. Watanabe, A. L. Moore, S. Harada, K. Kita, "Discovery of Trypanocidal Coumarins with Dual Inhibition of Both the Glycerol Kinase and Alternative Oxidase of Trypanosoma brucei brucei," FASEB J. 2019, 33, 13002-13013.
    DOI: 10.1096/fj.201901342R
  42. D. Kuwana, M. Nagatomo, M. Inoue, "Total Synthesis of 5-epi-Eudesm-4(15)-ene-1β,6β-diol via Decarbonylative Radical Coupling Reaction," Org. Lett. 2019, 21, 7619-7623.

    DOI: 10.1021/acs.orglett.9b02895
  43. H. Itoh, K. Tokumoto, T. Kaji, A. Paudel, S. Panthee, H. Hamamoto, K. Sekimizu, M. Inoue, "Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E," Nat. Commun. 2019, 10, 2992.
    (UTokyo FOCUS内 press releasesにて紹介されました。 リンク, 英語版リンク)
    (Selected as Nature Communications Editor's Highlights, link)
    (Associated link: NIKKEI BUSINESS DAILY (July 18, 2019), link)
    (Associated link: NIKKEI (October 13, 2019), link1, link2, link3)

    DOI: 10.1038/s41467-019-10754-4
  44. Y. Imamura, S. Yoshioka, M. Nagatomo, M. Inoue, "Total Synthesis of 1‐Hydroxytaxinine," Angew. Chem. Int. Ed. 2019, 58, 12159-12163.
    (Selected as Hot Paper)
    (UTokyo FOCUS内 articlesにて紹介されました。 リンク)
    (Chem-Stationで紹介されました。リンク)
    (Organic Chemistry Highlightsで紹介されました。リンク)

    DOI: 10.1002/anie.201906872
  45. D. Kuwana, B. Ovadia, D. Kamimura, M. Nagatomo, M. Inoue, "Installation of O‐Heterocycles to N‐Heteroarenes via an Et3B/O2‐mediated Radical Reaction of α-Alkoxy and α-Alkoxyacyl Tellurides," Asian J. Org. Chem. 2019, 8, 1088-1091.
    DOI: 10.1002/ajoc.201900170
  46. T. Shiba, D. K. Inaoka, G. Takahashi, C. Tsuge, Y. Kido, L. Young, S. Ueda, E. O. Balogun, T. Nara, T. Honma, A. Tanaka, M. Inoue, H. Saimoto, S. Harada, A. L. Moore, K. Kita, "Insights into the Ubiquinol/dioxygen Binding and Proton Relay Pathways of the Alternative Oxidase," Biochim. Biophys. Acta, Bioenerg. 2019, 1860, 375-382.
    DOI: 10.1016/j.bbabio.2019.03.008
  47. M. Nagatomo, Y. Fujimoto, K. Masuda, M. Inoue, "Construction of a 6/5/9-membered tricyclic structure of cladiellins via radical-polar crossover reaction," J. Antibiot. 2019, 72, 486-489.
    DOI: 10.1038/s41429-019-0150-7
  48. 2018
  49. H. Matoba, T. Watanabe, M. Nagatomo, M. Inoue, "Convergent Synthesis of Taxol Skeleton via Decarbonylative Radical Coupling Reaction," Org. Lett. 2018, 20, 7554-7557.
    (Selected as Most Read Articles of the month)

    DOI: 10.1021/acs.orglett.8b03302
  50. T. Kawamata, A. Yamaguchi, M. Nagatomo, M. Inoue, "Convergent Total Synthesis of Asimicin via Decarbonylative Radical Dimerization," Chem. Eur. J. 2018, 24, 18907-18912.
    DOI: 10.1002/chem.201805317
  51. D. Urabe, Y. Nakagawa, K. Mukai, K. Fukushima, N. Aoki, H. Itoh, M. Nagatomo, M. Inoue, "Total synthesis and biological evaluation of 19-hydroxysarmentogenin-3-O-a-L-rhamnoside, trewianin, and their aglycons," J. Org. Chem. 2018, 83, 13888-13910.

    DOI: 10.1021/acs.joc.8b02219
  52. K. Kitamura, H. Itoh, K. Sakurai, S. Dan, M. Inoue, "Target Identification of Yaku’amide B and Its Two Distinct Activities against Mitochondrial FoF1-ATP Synthase," J. Am. Chem. Soc. 2018, 140, 12189-12199.
    (Selected as Spotlights on Recent JACS Publications)

    DOI: 10.1021/jacs.8b07339
  53. A. Hayata, H. Itoh, M. Inoue, "Solid-Phase Total Synthesis and Dual Mechanism of Action of the Channel-Forming 48-mer Peptide Polytheonamide B," J. Am. Chem. Soc. 2018, 140, 10602-10611.

    DOI: 10.1021/jacs.8b06755
  54. M. Koshimizu, M. Nagatomo, M. Inoue, "Construction of a pentacyclic ring system of isoryanodane diterpenoids by SmI2-mediated transannular cyclization," Tetrahedron 2018, 74, 3384-3390.

    DOI: 10.1016/j.tet.2018.03.061
  55. Y. Kofuku, T. Yokomizo, S. Imai, Y. Shiraishi, M. Natsume, H. Itoh, M. Inoue, K. Nakata, S. Igarashi, H. Yamaguchi, T. Mizukoshi, E. Suzuki, T. Ueda, I. Shimada, "Deuteration and selective labeling of alanine methyl groups of β2-adrenergic receptor expressed in a baculovirus-insect cell expression system," J. Biomol. NMR 2018, 71, 185-192.
    DOI: 10.1007/s10858-018-0174-5
  56. K. Sakata, Y. Wang, D. Urabe, M. Inoue, "Synthesis of the Tetracyclic Structure of Batrachotoxin Enabled by Bridgehead Radical Coupling and Pd/Ni-Promoted Ullmann Reaction," Org. Lett. 2018, 20, 130-133.


    DOI: 10.1021/acs.orglett.7b03482
  57. T. Mochimaru, K. Fukunaga, J. Miyata, M. Matsusaka, K. Masaki, H. Kabata, S. Ueda, Y. Suzuki, T. Goto, D. Urabe, M. Inoue, Y. Isobe, M. Arita, T. Betsu, "12-OH-17,18-Epoxyeicosatetraenoic acid alleviates eosinophilic airway inflammation in murine lungs," Allergy 2018, 73, 369-378.
    DOI: 10.1111/all.13297
  58. K. Minagawa, D. Urabe, M. Inoue, "A three-component coupling approach to the ACE-ring substructure of C19-diterpene alkaloids," J. Antibiotics 2018, 71, 326-332.
    DOI: 10.1038/ja.2017.69
  59. H. Itoh, K. Tokumoto, T. Kaji, A. Paudel, S. Panthee, H. Hamamoto, K. Sekimizu, M. Inoue, "Total Synthesis and Biological Mode of Action of WAP-8294A2: A Menaquinone-Targeting Antibiotic," J. Org. Chem. 2018, 83, 6924-6935.
    (Selected as ACS editors' choice)
    (The Journal of Organic Chemistry Outstanding Publication of the Year Lectureship Award)
    (Selected as the three most read papers in JOC in 2018)

    DOI:10.1021/acs.joc.7b02318
  60. 2017
  61. S. Hashimoto, S. Katoh, T. Kato, D. Urabe, M. Inoue, "Total Synthesis of Resiniferatoxin Enabled by Radical-Mediated Three-Component Coupling and 7-endo Cyclization," J. Am. Chem. Soc. 2017, 139, 16420-16429.

    DOI: 10.1021/jacs.7b10177
  62. H. Fujino, M. Nagatomo, A. Paudel, S. Panthee, H. Hamamoto, K. Sekimizu, M. Inoue, "Unified Total Synthesis of Polyoxin J, L, and Their Fluorinated Analogues on the Basis of Decarbonylative Radical Coupling Reactions," Angew. Chem. Int. Ed. 2017, 56, 11865-11869.

    DOI:10.1002/anie.201706671
  63. H. Umihara, S. Yokoshima, M. Inoue, T. Fukuyama, "Total Synthesis of (-)-Morphine," Chem. Eur. J. 2017, 23, 6993-6995.

    DOI:10.1002/chem.201701438
  64. K. Masuda, M. Tanigawa, M. Nagatomo, D. Urabe, M. Inoue, "Construction of carbocycles initiated by Cu-catalyzed radical reaction of Cl2C(CN)2," Tetrahedron 2017, 73, 3596-3605.

    DOI:10.1016/j.tet.2017.03.063
  65. H. Fujisawa, T. Ishiyama, D. Urabe, M. Inoue, "Construction of the septahydroxylated ABC-ring system of dihydro-β-agarofurans: Application of 6-exo-dig radical cyclization," Chem. Commun. 2017, 53, 4073-4076.

    DOI:10.1039/C7CC00507E
  66. T. Kawamata, M. Nagatomo, M. Inoue, "Total Synthesis of Zaragozic Acid C: Implementation of Photochemical C(sp3)-H Acylation," J. Am. Chem. Soc. 2017, 139, 1814-1817.
    (Highlighted in Synfacts 2017, 13, 0337. and selected as its Cover Picture)

    DOI:10.1021/jacs.6b13263
  67. D. K. Inaoka, M. Iida, S. Hashimoto, T. Tabuchi,T. Kuranaga, E. O. Balogun, T. Honma, A. Tanaka, S. Harada, T. Nara, K. Kita, M. Inoue, "Design and Synthesis of Potent Substrate-based Inhibitors of the Trypanosoma cruzi Dihydroorotate Dehydrogenase," Bioorg. Med. Chem. 2017, 25, 1465-1470.

    DOI:10.1016/j.bmc.2017.01.009
  68. K. Masuda, M. Nagatomo, M. Inoue, "Direct assembly of multiply oxygenated carbon chains by decarbonylative radical-radical coupling reactions," Nature Chem. 2017, 9, 207-212.
    (Highlighted in Synfacts 2017, 13, 0534.)
    (Associated Link: News and Views - "Organic chemistry: A radical step forward")


    DOI:10.1038/nchem.2639
  69. 2016
  70. D. K. Inaoka, M. Iida, T. Tabuchi, T. Honma, N. Lee, S. Hashimoto, S. Matsuoka, T. Kuranaga, K. Sato, T. Shiba, K. Sakamoto, E. O. Balogun, S. Suzuki, T. Nara, J. R. Rocha, C. A. Montanari, A. Tanaka, M. Inoue, K. Kita, S. Harada, "The Open Form Inducer Approach for Structure-Based Drug Design," PLoS ONE 2016, 11, e0167078.
    DOI:10.1371/journal.pone.0167078
  71. T. Kaji, M. Murai, H. Itoh, J. Yasukawa, H. Hamamoto, K. Sekimizu, M. Inoue, "Total Synthesis and Functional Evaluation of Fourteen Derivatives of Lysocin E: Importance of Cationic, Hydrophobic, and Aromatic Moieties for Antibacterial Activity," Chem. Eur. J. 2016, 22, 16912-16919.

    DOI:10.1002/chem.201604022
  72. S. Matsumura, Y. Matsui, M. Nagatomo, M. Inoue, "Stereoselective construction of anti- and syn-1,2-diol structures via decarbonylative radical coupling of α-alkoxyacyl tellurides," Tetrahedron 2016, 72, 4859-4866.

    DOI:10.1016/j.tet.2016.06.056
  73. T. Tabuchi, D. Urabe, M. Inoue, "Construction of the Fused Pentacycle of Talatisamine via a Combination of Radical and Cationic Cyclizations," J. Org. Chem. 2016, 81, 10204-10213.

    DOI:10.1021/acs.joc.6b01011
  74. D. Kamimura, M. Nagatomo, D. Urabe, M. Inoue, "Expanding the scope of Et3B/O2-mediated coupling reactions of O,Te-acetal," Tetrahedron 2016, 72, 7839-7848.

    DOI:10.1016/j.tet.2016.04.023
  75. H. Mutoh, Y. Sesoko, T. Kuranaga, H. Itoh, M. Inoue, "Total Synthesis and Functional Evaluation of Fourteen Stereoisomers of Yaku’amide B. Importance of Stereochemistry for Hydrophobicity and Cytotoxicity," Org. Biomol. Chem. 2016, 14, 4199-4204.
    (Selected as Hot Article)
    (Selected as 2016's Most Popular Article)


    DOI: 10.1039/C6OB00640J
  76. K. Masuda, M. Nagatomo, M. Inoue, "Chemical Conversion of Ryanodol to Ryanodine," Chem. Pharm. Bull. 2016, 64, 874-879.

    DOI: 10.1248/cpb.c16-00214
  77. K. Hagiwara, T. Tabuchi, D. Urabe, M. Inoue, "Expeditious synthesis of the fused hexacycle of puberuline C via radical-based cyclization/translocation/cyclization process," Chem. Sci. 2016, 7, 4372-4378.

    DOI: 10.1039/C6SC00671J
  78. F. Zhao, X. Li, L. Jin, F. Zhang, M. Inoue, B. Yu, Z. Cao, "Development of a Rapid Throughput Assay for Identification of hNav1.7 Antagonist Using Unique Efficacious Sodium Channel Agonist, Antillatoxin," Mar. Drugs. 2016, 14, 36-47.
    DOI: 10.3390/md14020036
  79. A. Hayata, H. Itoh, S. Matsutaka, M. Inoue, "Dual Chemical Modification of a Polytheonamide Mimic: Rational Design and Synthesis of Ion-Channel-Forming 48-mer Peptides with Potent Cytotoxicity," Chem. Eur. J. 2016, 22, 3370-3377.
    (Selected as Very Important Paper)

    DOI: 10.1002/chem.201504632
  80. M. Koshimizu, M. Nagatomo, M. Inoue, "Unified Total Synthesis of 3-epi-Ryanodol, Cinnzeylanol, Cinncassiols A and B, and Structural Revision of Natural Ryanodol and Cinnacasol," Angew. Chem. Int. Ed. 2016, 55, 2493-2497.

    DOI: 10.1002/anie.201511116
  81. K. Masuda, M. Koshimizu, M. Nagatomo, M. Inoue, "Asymmetric Total Synthesis of (+)-Ryanodol and (+)-Ryanodine," Chem. Eur. J. 2016, 22, 230-236.

    DOI: 10.1002/chem.201503641
  82. M. Nagatomo, K. Hagiwara, K. Masuda, M. Koshimizu, T. Kawamata, Y. Matsui, D. Urabe, M. Inoue, " Symmetry-Driven Strategy for the Assembly of the Core Tetracycle of (+)-Ryanodine: Synthetic Utility of a Cobalt-Catalyzed Olefin Oxidation and α-Alkoxy Bridgehead Radical Reaction," Chem. Eur. J. 2016, 22, 222-229.

    DOI: 10.1002/chem.201503640
  83. 2015
  84. J. Okude, T. Ueda,Y. Kofuku, M. Sato,N. Nobuyama, K. Kondo, Y. Shiraishi, T. Mizumura, K. Onishi, M. Natsume, M. Maeda, H. Tsujishita, T. Kuranaga, M. Inoue, I. Shimada, "Identification of a Conformational Equilibrium That Determines the Efficacy and Functional Selectivity of the μ-Opioid Receptor," Angew. Chem. Int. Ed. 2015, 54, 15771-15776.

    DOI: 10.1002/anie.201508794
  85. T. Asaba, Y. Katoh, D. Urabe, M. Inoue, "Total Synthesis of Crotophorbolone," Angew. Chem. Int. Ed. 2015, 54, 14457-14461.
    (Highlighted in Synfacts 2016, 12, 0002. )

    DOI: 10.1002/anie.201509160
  86. T. Goto, D. Urabe, Y. Isobe, M. Arita, M. Inoue, "Total Synthesis of Four Stereoisomers of (5Z,8Z,10E,14Z)-12-Hydroxy-17,18-epoxy-5,8,10,14-eicosatetraenoic Acid and Their Anti-Inflammatory Activities," Tetrahedron 2015, 71, 8320-8332.

    DOI: 10.1016/j.tet.2015.08.047
  87. T. Goto, D. Urabe, K. Masuda, Y. Isobe, M. Arita, M. Inoue, "Total Synthesis of Four Stereoisomers of (4Z,7Z,10Z,12E,16Z,18E)-14,20-Dihydroxy-4,7,10,12,16,18-docosahexaenoic Acid and Their Anti-inflammatory Activities," J. Org. Chem. 2015, 80, 7713-7726.

    DOI: 10.1021/acs.joc.5b01461
  88. T. Kuranaga, H. Mutoh, Y. Sesoko, T. Goto, S. Matsunaga, M. Inoue, "Elucidation and Total Synthesis of the Correct Structures of Tridecapeptides Yaku’amides A and B. Synthesis-Driven Stereochemical Reassignment of Four Amino Acid Residues," J. Am. Chem. Soc. 2015, 137, 9443-9451.

    DOI: 10.1021/jacs.5b05550
  89. D. K. Inaoka, T. Shiba, D. Sato, E. O. Balogun,T. Sasaki, M. Nagahama, M. Oda, S. Matsuoka, J. Ohmori, T. Honma, M. Inoue, K. Kita, S. Harada, "Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria," Int. J. Mol. Sci. 2015, 16, 15287-15308.

    DOI: 10.3390/ijms160715287
  90. R. Yoshino, N. Yasuo, D. K. Inaoka, Y. Hagiwara, K. Ohno, M. Orita, M. Inoue, T. Shiba, S. Harada, T. Honma, E. O. Balogun, J. Rodrigues da Rocha, C. A. Montanari, K. Kita, M. Sekijima, "Pharmacophore Modeling for Anti-Chagas Drug Design Using the Fragment Molecular Orbital Method," PLoS ONE 2015, 10, e0125829.
    DOI: 10.1371/journal.pone.0125829
  91. T. Yamashita, T. Kuranaga, M. Inoue, "Solid-Phase Total Synthesis of Bogorol A: Stereocontrolled Construction of Thermodynamically Unfavored (E)-2-Amino-2-butenamide," Org. Lett. 2015, 17, 2170-2173.

    DOI: 10.1021/acs.orglett.5b00769
  92. K. Mukai, S. Kasuya, Y. Nakagawa, D. Urabe, M. Inoue, "A Convergent Total Synthesis of Ouabagenin," Chem. Sci. 2015, 6, 3383-3387.

    DOI: 10.1039/C5SC00212E
  93. M. Nagatomo, D. Kamimura, Y. Matsui, K. Masuda, M. Inoue, "Et3B-Mediated Two- and Three-Component Coupling Reactions via Radical Decarbonylation of α-Alkoxyacyl Tellurides: Single-Step Construction of Densely Oxygenated Carboskeletons," Chem. Sci. 2015, 6, 2765-2769.

    DOI: 10.1039/C5SC00457H
  94. S. Yamashita, K. Takeuchi, T. Koyama, M. Inoue, Y. Hayashi, M. Hirama, "Practical Route to the Left Wing of CTX1B and Total Syntheses of CTX1B and 54-deoxyCTX1B," Chem. Eur. J. 2015, 21, 2621-2628.

    DOI: 10.1002/chem.201405629
  95. S. Yoshioka, M. Nagatomo, M. Inoue, "Application of Two Direct C(sp3)-H Functionalizations for Total Synthesis of (+)-Lactacystin," Org. Lett. 2015, 17, 90-93.

    DOI: 10.1021/ol503291s
  96. J. Mao, T. Kuranaga, H. Hamamoto, K. Sekimizu, M. Inoue, "Rational Design, Synthesis, and Biological Evaluation of Lactam-Bridged Gramicidin A Analogues: Discovery of a Low-Hemolytic Antibacterial Peptide," ChemMedChem. 2015, 10, 540-545.

    DOI: 10.1002/cmdc.201402473
  97. M. Murai, T. Kaji, T. Kuranaga, H. Hamamoto, K. Sekimizu, M. Inoue, "Total Synthesis and Biological Evaluation of the Antibiotic Lysocin E and Its Enantiomeric, Epimeric, and N-Demethylated Analogues," Angew. Chem. Int. Ed. 2015, 54, 1556-1560.

    DOI: 10.1002/anie.201410270
  98. M. Nagatomo, H. Nishiyama, H. Fujino, M. Inoue, "Decarbonylative Radical Coupling of α-Aminoacyl Tellurides: Single-Step Preparation of γ-Amino and α,β-Diamino Acids and Rapid Synthesis of Gabapentin and Manzacidin A," Angew. Chem. Int. Ed. 2015, 54, 1537-1541.
    (Selected as Hot Paper)

    DOI: 10.1002/anie.201410186
  99. H. Hamamoto, M. Urai, K. Ishii, J. Yasukawa, A. Paudel, M. Murai, T. Kaji, T. Kuranaga, K. Hamase, T. Katsu, J. Su, T. Adachi, R. Uchida, H. Tomoda, M. Yamada, M. Souma, H. Kirihara, M. Inoue, K. Sekimizu, "Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane," Nat. Chem. Biol. 2015, 11, 127-133.

    DOI: 10.1038/nchembio.1710
  100. M. Nagatomo, S. Yoshioka, M. Inoue, "Enantioselective Radical Alkynylation of C(sp3)-H Bonds Using Sulfoximine as a Traceless Chiral Auxiliary," Chem. Asian. J. 2015, 10, 120-123.

    DOI: 10.1002/asia.201402983
  101. K. Hagiwara, M. Iwatsu, D. Urabe, M. Inoue, "N-(2,3,4,5,6-Pentafluorophenyl)maleimide as a Powerful Dienophile in Dearomatizing Diels-Alder Reactions," Heterocycles 2015, 90, 659-672.

    DOI: 10.3987/COM-14-S(K)23
  102. 2014
  103. Y. Yokokura, Y. Isobe, S. Matsueda, R. Iwamoto, T. Goto, T. Yoshioka, D. Urabe, M. Inoue, H. Arai, M. Arita, "Identification of 14,20-dihydroxy-docosahexaenoic acid as a novel anti-inflammatory metabolite," J. Biochem. 2014, 156, 315-321.
    DOI: 10.1093/jb/mvu044
  104. E. O. Balogun, D. K. Inaoka, T. Shiba, Y. Kido, C. Tsuge, T. Nara, T. Aoki, T. Honma, A. Tanaka, M. Inoue, S. Matsuoka, P. A. M. Michels, K. Kita, S. Harada, "Molecular Basis for the Reverse Reaction of African Human Trypanosomes Glycerol Kinase," Mol. Microbiol. 2014, 94, 1315-1329.
    DOI: 10.1111/mmi.12831
  105. H. Todoroki, M. Iwatsu, D. Urabe, M. Inoue, "Total Synthesis of (-)-4-Hydroxyzinowol," J. Org. Chem. 2014, 79, 8835-8849.

    DOI: 10.1021/jo501666x
  106. Y. Amaoka, M. Nagatomo, M. Watanabe, K. Tao, S. Kamijo, M. Inoue, "Photochemically Induced Radical Alkenylation of C(sp3)-H Bonds," Chem. Sci. 2014, 5, 4339-4345.

    DOI: 10.1039/C4SC01631A
  107. T. Yamashita, H. Matoba, T. Kuranaga, M. Inoue, "Total syntheses of nobilamides B and D: application of traceless Staudinger ligation," Tetrahedron 2014, 70, 7746-7752.

    DOI: 10.1016/j.tet.2014.05.091
  108. K. Hagiwara, D. Urabe, M. Inoue, "Studies in symmetry-driven synthesis of ryanodol: application of nucleophilic alkynylation for regio- and stereoselective desymmetrization," Tetrahedron Lett. 2014, 55, 3817.

    DOI: 10.1016/j.tetlet.2014.05.075
  109. M. Nagatomo, M. Koshimizu, K. Masuda, T. Tabuchi, D. Urabe, M. Inoue, "Total Synthesis of Ryanodol," J. Am. Chem. Soc. 2014, 136, 5916-5919.

    DOI: 10.1021/ja502770n
  110. T. Kubota, M. Arita, Y. Isobe, R. Iwamoto, T. Goto, T. Yoshioka, D. Urabe, M. Inoue, H. Arai, "Eicosapentaenoic Acid Is Converted via ω-3 Epoxygenation to the Anti-inflammatory Metabolite 12-Hydroxy-17,18-epoxyeicosatetraenoic acid," FASEB J. 2014, 28, 586-593.
    DOI: 10.1096/fj.13-236224
  111. H. Itoh, S. Matsutaka, T. Kuranaga, M. Inoue, "Control of the cytotoxicity of dansylated polytheonamide mimic, an artificial peptide ion channel, by modification of the N-terminal structure," Tetrahedron Lett. 2014, 55, 728-731.

    DOI: 10.1016/j.tetlet.2013.12.007
  112. H. Itoh, M. Inoue, "Antibody-mediated functional control of a dansylated polytheonamide mimic," Chem. Commun. 2014, 50, 939-941.

    DOI: 10.1039/C3CC48348G
  113. 2013
  114. D. Kamimura, D. Urabe, M. Nagatomo, M. Inoue, "Et3B‐Mediated Radical-Polar Crossover Reaction for Single-Step Coupling of O,Te-Acetal, α,β-Unsaturated Ketones, and Aldehydes/Ketones," Org. Lett. 2013, 15, 5122-5125.

    DOI: 10.1021/ol402563v
  115. T. Ishiyama, D. Urabe, H. Fujisawa, M. Inoue, "Concise Synthesis of the Multiply Oxygenated ABC-Ring System of the Dihydro-β-agarofurans," Org. Lett. 2013, 15, 4488-4491.

    DOI: 10.1021/ol402038b
  116. K. Okura, M. Inoue, "The Orientation of the Terminal tBu Group of Antillatoxin is Important for Potent Toxicity: Design, Synthesis and Biological Evaluation of Conformationally Restricted Analogues of Antillatoxin," Asian J. Org. Chem. 2013, 2, 650-653.

    DOI: 10.1002/ajoc.201300111
  117. K. Okura, S. Matsuoka, M. Inoue, "The bulky side chain of antillatoxin is important for potent toxicity: rational design of photoresponsive cytotoxins based on SAR studies," Chem. Commun. 2013, 49, 8024-8026.

    DOI: 10.1039/C3CC44066D
  118. K. Sakata, D. Urabe, M. Inoue, "Preparation and palladium-mediated cross-coupling of α-benzoyloxyalkylzinc bromides," Tetrahedron Lett. 2013, 54, 4189-4192.

    DOI: 10.1016/j.tetlet.2013.05.114
  119. T. Hoshikawa, M. Inoue, "Photoinduced Direct 4-Pyridination of C(sp3)-H Bonds," Chem. Sci. 2013, 4, 3118-3123.

    DOI: 10.1039/C3SC51080H
  120. Y. Amaoka, M. Nagatomo, M. Inoue, "Metal-Free Fluorination of C(sp3)-H Bonds Using a Catalytic N-Oxyl Radical," Org. Lett. 2013, 15, 2160-2163.

    DOI: 10.1021/ol4006757
  121. K. Mukai, D. Urabe, S. Kasuya, N. Aoki, M. Inoue, "A Convergent Total Synthesis of 19-Hydroxysarmentogenin," Angew. Chem. Int. Ed. 2013, 52, 5300-5304.

    DOI: 10.1002/anie.201302067
  122. T. Kuranaga, Y. Sesoko, K. Sakata, N. Maeda, A. Hayata, M. Inoue, "Total Synthesis and Complete Structural Assignment of Yaku’amide A," J. Am. Chem. Soc. 2013, 135, 5467-5474.

    DOI: 10.1021/ja401457h
  123. K. Murai, S. Katoh, D. Urabe, M. Inoue, "A radical-based approach for the construction of the tetracyclic structure of resiniferatoxin," Chem. Sci. 2013, 4, 2364-2368.

    DOI: 10.1039/C3SC50329A
  124. T. Tabuchi, D. Urabe, M. Inoue, "Asymmetric synthesis of a highly functionalized bicyclo[3.2.2]nonene derivative," Beilstein J. Org. Chem. 2013, 9, 655-663.

    DOI: 10.3762/bjoc.9.74
  125. E. O. Balogun, D. K. Inaoka, T. Shiba, Y. Kido, T. Nara, T. Aoki, T. Honma, A. Tanaka, M. Inoue, S. Matsuoka, P. AM. Michels, S. Harada, K. Kita, "Biochemical characterization of highly active Trypanosoma brucei gambiense glycerol kinase, a promising drug target," J. Biochem. 2013, 154, 77-84.
    DOI: 10.1093/jb/mvt037
  126. T. Shiba, Y. Kido, K. Sakamoto, D. K. Inaoka, C. Tsuge, R. Tatsumi, G. Takahashi, E. O. Balogun, T. Nara, T. Aoki, T. Honma, A. Tanaka, M. Inoue, S. Matsuoka, H. Saimoto, A. L. Moore, S. Harada, K. Kita, "Structure of the Trypanosome Cyanide-insensitive Alternative Oxidase, a Promising Drug Target," Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 4580-4585.
    DOI: 10.1073/pnas.1218386110
  127. T. Hoshikawa, S. Yoshioka, S. Kamijo, M. Inoue, "Photoinduced Direct Cyanation of C(sp3)-H Bonds," Synthesis 2013, 45, 874-887.

    DOI: 10.1055/s-0032-1318325
  128. D. Urabe, M. Nagatomo, K. Hagiwara, K. Masuda, M. Inoue, "Symmetry-Driven Synthesis of 9-Demethyl-10,15-dideoxyryanodol," Chem. Sci. 2013, 4, 1615-1619.

    DOI: 10.1039/C3SC00023K
  129. Y. Isobe, M. Arita, R. Iwamoto, D. Urabe, H. Todoroki, K. Masuda, M. Inoueand H. Arai, "Stereochemical assignment and anti-inflammatory properties of the omega-3 lipid mediator resolvin E3," J. Biochem. 2013, 153, 355-360.
    DOI: 10.1093/jb/mvs151
  130. H. Itoh, M. Inoue, "Structural Permutation of Potent Cytotoxin, Polytheonamide B: Discovery of Cytotoxic Peptide with Altered Activity," ACS Med. Chem. Lett. 2013, 4, 52-56.

    DOI: 10.1021/ml300264c
  131. T. Hoshikawa, S. Kamijo, M. Inoue, "Photochemically Induced Radical Alkynylation of C(sp3)-H Bonds," Org. Biomol. Chem. 2013, 11, 164-169.

    DOI: 10.1039/C2OB26785C
  132. 2012
  133. Y. Amaoka, S. Kamijo, T. Hoshikawa, M. Inoue, "Radical Amination of C(sp3)-H Bonds Using N-Hydroxyphthalimide and Dialkyl Azodicarboxylate," J. Org. Chem. 2012, 77, 9959-9969.

    DOI: 10.1021/jo301840e
  134. H. Itoh, S. Matsuoka, M. Kreir, M. Inoue, "Design, Synthesis and Functional Analysis of Dansylated Polytheonamide Mimic: An Artificial Peptide Ion Channel," J. Am. Chem. Soc. 2012, 134, 14011-14018.

    DOI: 10.1021/ja303831a
  135. M. Iwatsu, D. Urabe, H. Todoroki, K. Masuda, M. Inoue, "Selective Introduction of Four Contiguous Stereocenters on the B-Ring of 4-Hydroxyzinowol," Heterocycles 2012, 86, 181-188.

    DOI: 10.3987/COM-12-S(N)76
  136. D. Urabe, H. Yamaguchi, A. Someya, M. Inoue, "Intermolecular Radical Reaction of O,Se-Acetals Generated via Seleno-Pummerer Rearrangement," Org. Lett. 2012, 14, 3842-3845.

    DOI: 10.1021/ol301482f
  137. S. Kamijo, S. Matsumura, M. Inoue, "Microwave-assisted atom transfer radical addition of polychlorinated compounds to olefins without addition of metal catalysts," Tetrahedron Lett. 2012, 53, 4368-4371.

    DOI: 10.1016/j.tetlet.2012.06.027
  138. S. Kamijo, S. Yokosaka, M. Inoue, "Carbocyanation of trisubstituted olefins via Cu-catalyzed atom transfer radical addition," Tetrahedron Lett. 2012, 53, 4324-4327.

    DOI: 10.1016/j.tetlet.2012.06.004
  139. N. Shinohara, H. Itoh, S. Matsuoka, M. Inoue, "Selective Modification of the N-Terminal Structure of Polytheonamide B Significantly Changes its Cytotoxicity and Activity as an Ion Channel," ChemMedChem 2012, 7, 1770-1773.

    DOI: 10.1002/cmdc.201200142
  140. T. Nara, M. Hashimoto, H. Hirawake, C.-W. Liao, Y. Fukai, S. Suzuki, A. Tsubouchi, J. Morales, S. Takamiya, T. Fujimura, H. Taka, R. Mineki, C.-K. Fan, D. K. Inaoka, M. Inoue, A. Tanaka, S. Harada, K. Kita, T. Aoki, "Molecular Interaction of the First 3 Enzymes of the De Novo Pyrimidine Biosynthetic Pathway of Trypanosoma Cruzi," Biochem. Biophys. Res. Commun. 2012, 418, 140-143.
    DOI: 10.1016/j.bbrc.2011.12.148
  141. M. Hashimoto, J. Morales, Y. Fukai, S. Suzuki, S. Takamiya, A. Tsubouchi, S. Inoue, M. Inoue, K. Kita, S. Harada, A. Tanaka, T. Aoki, T. Nara, "Critical Importance of the De Novo Pyrimidine Biosynthesis Pathway for Trypanosoma Cruzi Growth in the Mammalian Host Cell Cytoplasm," Biochem. Biophys. Res. Commun. 2012, 417, 1002-1006.
    DOI: 10.1016/j.bbrc.2011.12.073
  142. S. Kamijo, S. Yokosaka, M. Inoue, "Attachment of Carbonyl Functionalities onto Olefins via Copper-Promoted Radical Reaction of Dichloromethylcyanides," Tetrahedron 2012, 68, 5290-5296.

    DOI: 10.1016/j.tet.2012.01.089
  143. D. Urabe, H. Todoroki, K. Masuda, M. Inoue, "Total syntheses of four possible stereoisomers of resolvin E3," Tetrahedron 2012, 68, 3210-3219.

    DOI: 10.1016/j.tet.2012.02.045
  144. S. Matsuoka, M. Murai, T. Yamazaki, M. Inoue, "Short polyglutamine peptide forms a high-affinity binding site for thioflavin-T at the N-terminus," Org. Biomol. Chem. 2012, 10, 5787-5790.

    DOI: 10.1039/C2OB07157F
  145. Y. Isobe, M. Arita, S. Matsueda, R. Iwamoto, T. Fujihara, H. Nakanishi, R. Taguchi, K. Masuda, K. Sasaki, D. Urabe, M. Inoue, H. Arai, "Identification and structure determination of novel anti-inflammatory mediator resolvin E3, 17,18-dihydroxyeicosapentaenoic acid," J. Biol. Chem. 2012, 287, 10525-10534.
    DOI: 10.1074/jbc.M112.340612
  146. S. Matsuoka, J. Mao, and M. Inoue, "Effects of the phosphatidylglycerol head group on the binding of short dermcidin-derived peptides to the phospholipid membrane surface," Tetrahedron Lett. 2012, 53, 1078-1081.

    DOI: 10.1016/j.tetlet.2011.12.071
  147. 2011
  148. S. Kamijo, T. Hoshikawa, and M. Inoue, "Photochemically Induced Radical Transformation of C(sp3)-H Bonds to C(sp3)-CN Bonds," Org. Lett. 2011, 13, 5928-5931.

    DOI: 10.1021/ol202659e
  149. D. Urabe, H. Yamaguchi, M. Inoue, "Application of α-Alkoxy Bridgehead Radical for Coupling of Oxygenated Carbocycles," Org. Lett. 2011, 13, 4778-4781.

    DOI: 10.1021/ol201758a
  150. R. Goto, K. Okura, H. Sakazaki, T. Sugawara, S. Matsuoka, M. Inoue, "Synthesis and biological evaluation of triazole analogues of antillatoxin," Tetrahedron 2011, 67, 6659-6672.

    DOI: 10.1016/j.tet.2011.05.012
  151. S. Kamijo, Y. Amaoka, M. Inoue, "Direct oxidative installation of nitrooxy group at benzylic positions and its transformation into various functionalities," Tetrahedron Lett. 2011, 52, 4654-4657.

    DOI: 10.1016/j.tetlet.2011.06.118
  152. M. Ui, Y. Tanaka, T. Tsumuraya, I. Fujii, M. Inoue, M. Hirama, K. Tsumoto, "Structural and Energetic Hot-spots for the Interaction between a Ladder-like Polycyclic Ether and the Anti-ciguatoxin Antibody 10C9Fab," Mol. BioSyst. 2011, 7, 793-798.

    DOI: 10.1039/C0MB00162G
  153. K. Yamaoka, M. Inoue, M. Hirama, "A Study on Mechanisms of Toxic Actions of Ciguatoxins: Existence of Functional Relationship between CTX3C and Charged Residues of Voltage Sensors in Nav1.4 Sodium Channel," Forensic Toxicol. 2011, 29, 125-131.
    DOI: 10.1007/s11419-011-0113-6
  154. S. Kamijo, T. Hoshikawa, M. Inoue, "Photoinduced carbamoylation of ethereal C-H bonds using pentafluorophenyl isocyanate," Tetrahedron Lett. 2011, 52, 2885-2888.

    DOI: 10.1016/j.tetlet.2011.03.128
  155. S. Matsuoka, N. Shinohara, T. Takahashi, M. Iida, M. Inoue, "Functional Analysis of Synthetic Substructures of Polytheonamide B: A Transmembrane Channel-Forming Peptide," Angew. Chem. Int. Ed. 2011, 50, 4879-4883.

    DOI: 10.1002/anie.201101533
  156. S. Yamashita, Y. Ishihara, H. Morita, J. Uchiyama, K. Takeuchi, M. Inoue, M. Hirama, "Stereoselective 6-exo Radical Cyclization Using cis-Vinyl Sulfoxide: Practical Total Synthesis of CTX3C," J. Nat. Prod. 2011, 74, 357-364.

    DOI: 10.1021/np100729d
  157. K. Sasaki, D. Urabe, H. Arai, M. Arita, M. Inoue, "Total Synthesis and Bioactivities of Two Proposed Structures of Maresin," Chem. Asian J. 2011, 6, 534-543.

    DOI: 10.1002/asia.201000494
  158. 2010
  159. S. Kamijo, Y. Amaoka, M. Inoue, "Unified Oxidation Protocol for the Synthesis of Carbonyl Compounds Using a Manganese Catalyst," Synthesis 2010, 2475-2489.

    DOI: 10.1055/s-0029-1218809
  160. S. Kamijo, S. Matsumura, M. Inoue, "CCl3CN: A Crucial Promoter of mCPBA-Mediated Direct Ether Oxidation," Org. Lett. 2010, 12, 4195-4197.

    DOI: 10.1021/ol1018079
  161. S. Matsuoka, Y. Mizoguchi, H. Itoh, K. Okura, N. Shinohara, M. Inoue, "The effect of sulfur stereochemistry of L-β,β-dimethylmethionine S-oxide on the physicochemical properties of truncated polytheonamides," Tetrahedron Lett. 2010, 51, 4644-4647.

    DOI: 10.1016/j.tetlet.2010.06.126
  162. M. Iwatsu, D. Urabe, M. Inoue, "Asymmetric Syntheses of Highly Functionalized Bicyclo[2.2.2]octene Derivatives," Heterocycles 2010, 82, 491-504.

    DOI: 10.3987/COM-10-S(E)22
  163. Y. Ishihara, N. Lee, N. Oshiro, S. Matsuoka, S. Yamashita, M. Inoue, M. Hirama, "The first F-ring modified ciguatoxin analogue showing significant toxicity," Chem. Commun. 2010, 46, 2968-2970.

    DOI: 10.1039/B924375E
  164. E. O. Balogun, D. K. Inaoka, Y. Kido, T. Shiba, T. Nara, T. Aoki, T. Honma, A. Tanaka, M. Inoue, S. Matsuoka, P. A. M. Michels, S. Harada, K. Kita, "Overproduction, Purification, Crystallization and Preliminary X-ray Diffraction Analysis of Trypanosoma Brucei Gambiense Glycerol Kinase," Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun. 2010, F66, 304-308.
    DOI: 10.1107/S1744309110000369
  165. Y. Kido, T. Shiba, D. K. Inaoka, K. Sakamoto, T. Nara, T. Aoki, T. Honma, A. Tanaka, M. Inoue, S. Matsuoka, A. Moore, S. Harada, K. Kita, "Crystallization and preliminary crystallographic analysis of cyanide-insensitive alternative oxidase from Trypanosoma brucei brucei," Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun. 2010, F66, 275-278.
    DOI: 10.1107/S1744309109054062
  166. S. Kamijo, T. Hoshikawa, M. Inoue, "Regio- and Stereoselective Acylation of Saturated Carbocycles via Norrish-Yang Photocyclization," Tetrahedron Lett. 2010, 51, 872-874.

    DOI: 10.1016/j.tetlet.2009.12.027
  167. M. Inoue, N. Shinohara, S. Tanabe, T. Takahashi, K. Okura, H. Itoh, Y. Mizoguchi, M. Iida, N. Lee, S. Matsuoka, "Total synthesis of the large non-ribosomal peptide polytheonamide B," Nature Chem. 2010, 2, 280-285.

    DOI: 10.1038/nchem.554
  168. K. Okura, S. Matsuoka, R. Goto, M. Inoue, "The Twisted Side Chain of Antillatoxin is Important for Potent Toxicity: Total Synthesis and Biological Evaluation of Antillatoxin and Analogues," Angew. Chem. Int. Ed. 2010, 49, 329-332.

    DOI: 10.1002/anie.200905892
  169. S. Kamijo, Y. Amaoka, M. Inoue, "Manganese-Catalyzed Direct Oxidation of Methyl Ethers to Ketones," Chem. Asian J. 2010, 5, 486-489.

    DOI: 10.1002/asia.200900420
  170. 2009
  171. K. Matoba, T. Nara, T. Aoki, T. Honma, A. Tanaka, M. Inoue, S. Matsuoka, D. K. Inaoka, K. Kita, S. Harada, "Crystallization and Preliminary X-ray Analysis of Aspartate Transcarbamoylase from the Parasitic Protist Trypanosoma Cruzi," Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun. 2009, F65, 933.
    DOI: 10.1107/S1744309109031959
  172. S. Kasuya, S. Kamijo, M. Inoue, "Direct Construction of 1,3-Diaxial Diol Derivatives by C-H Hydroxylation," Org. Lett. 2009, 11, 3630-3632.

    DOI: 10.1021/ol901367m
  173. S. Ogawa, D. Urabe, Y. Yokokura, H. Arai, M. Arita, M. Inoue, "Total Synthesis and Bioactivity of Resolvin E2," Org. Lett. 2009, 11, 3602-2605.

    DOI: 10.1021/ol901350g
  174. M. Inoue, N. Lee, T. Tsumuraya, I. Fujii, M. Hirama, "Use of Monoclonal Antibodies as an Effective Strategy for Treatment of Ciguatera Poisoning," Toxicon 2009, 53, 802-805.
    DOI: 10.1016/j.toxicon.2009.02.017
  175. K. Yamaoka, M. Inoue, K. Miyazaki, M. Hirama, C. Kondo, E. Kinoshita, H. Miyoshi, I. Seyama, "Synthetic Ciguatoxins Selectively Activate Nav1.8-Derived Chimeric Sodium Channels Expressed in HEK293 Cells," J. Biol. Chem. 2009, 284, 7597-7605.
    DOI: 10.1074/jbc.M806481200
  176. K. Hagiwara, M. Himuro, M. Hirama, M. Inoue, "A Concise Route to C2-symmetric Tricyclic Skeleton of Ryanodine," Tetrahedron Lett. 2009, 50, 1035-1037.

    DOI: 10.1016/j.tetlet.2008.12.054
  177. N. Lee, M. Inoue, M. Hirama, "Design and Synthesis of a Conformationally Restricted Analogue of the EFGH-Ring System of Ciguatoxin," Heterocycles 2009, 79, 325-330.

    DOI: 10.3987/COM-08-S(D)7
  178. 2008
  179. M. Inoue, N. Lee, K. Miyazaki, T. Usuki, S. Matsuoka, M. Hirama "Critical Importance of the Nine-Membered F Ring of Ciguatoxin for Potent Bioactivity: Total Synthesis and Biological Evaluation of F-Ring-Modified Analogues," Angew. Chem. Int. Ed. 2008, 47, 8611-8614.
    (Selected as Very Important Paper)

    DOI: 10.1002/anie.200803921
  180. M. Ui, Y. Tanaka, T. Tsumuraya, I. Fujii, M. Inoue, M. Hirama, K. Tsumoto, "How Protein Recognizes Ladder-like Polycyclic Ethers: Interactions between Ciguatoxin (CTX3C) Fragments and Its specific antibody 10C9," J. Biol. Chem. 2008, 283, 19440-19447.
    DOI: 10.1074/jbc.M801282200
  181. K. Nabatame, M. Hirama, M. Inoue, "A Simple Desymmetrization Approach to the Framework of Spiroxins," Heterocycles 2008, 76, 1011-1016.

    DOI: 10.3987/COM-08-S(N)70
  182. K. Tsumoto, A. Yokota, Y. Tanaka, M. Ui, T. Tsumuraya, I. Fujii, I. Kumagai, Y. Nagumo, H. Oguri, M. Inoue, M. Hirama, "Critical contribution of aromatic rings to specific recognition of polyether rings.: The case of ciguatoxin CTX3C-ABC and its specific antibody 1C49," J. Biol. Chem. 2008, 283, 12259-12266
    DOI: 10.1074/jbc.M710553200
  183. M. Inoue, I. Ohashi, T. Kawaguchi, M. Hirama, "Total Synthesis of the C-1027 Chromophore Core: Extremely Facile Enediyne Formation through SmI2-Mediated 1,2-Elimination," Angew. Chem. Int. Ed. 2008, 47, 1777-1779.

    DOI: 10.1002/anie.200704842
  184. K. Iso, M. Inoue, N. Kato, M. Hirama, "Synthesis of the Bicyclo[7.3.0]dodecadiyne Core of the Maduropeptin Chromophore," Chem. Asian J. 2008, 3, 447-453.

    DOI: 10.1002/asia.200700310
  185. 2007
  186. K. Komano, S. Shimamura, M. Inoue, M. Hirama, "Total Synthesis of the Maduropeptin Chromophore Aglycon," J. Am. Chem. Soc. 2007, 129, 14184-14186.

    DOI: 10.1021/ja076671f
  187. M. Inoue, N. Lee, S. Kasuya, T. Sato, M. Hirama, M. Moriyama, Y. Fukuyama, "Total Synthesis and Bioactivity of an Unnatural Enantiomer of Merrilactone A: Development of an Enantioselective Desymmetrization Strategy," J. Org. Chem. 2007, 72, 3065-3075.

    DOI: 10.1021/jo0700474
  188. M. Inoue, M. Iwatsu, S. Yamashita, M. Hirama, "A Concise Route to Two Distinct E-Ring Structures of Ciguatoxins," Heterocycles 2007, 72, 327-338.

    DOI: 10.3987/COM-06-S(K)16
  189. K. Yoshikawa, M. Inoue, M. Hirama, "Synthesis of the LMN-Ring Fragment of the Caribbean Ciguatoxin C-CTX-1," Tetrahedron Lett. 2007, 48, 2177-2180.

    DOI: 10.1016/j.tetlet.2007.01.103
  190. M. Inoue, F. Saito, M. Iwatsu, Y. Ishihara, M. Hirama, "Convergent Synthesis of the ABCDE-Ring Fragment of the Caribbean Ciguatoxin C-CTX-1," Tetrahedron Lett. 2007, 48, 2171-2175.

    DOI: 10.1016/j.tetlet.2007.01.102
  191. 2006
  192. M. Inoue, S. Yamashita, Y. Ishihara, M. Hirama, "Two Convergent Routes to the Left Wing Fragment of Ciguatoxin CTX3C Using O,S-Acetals As Key Intermediates," Org. Lett. 2006, 8, 5805-5808.

    DOI: 10.1021/ol062350h
  193. M. Inoue, Y. Ishihara, S. Yamashita, M. Hirama, "Convergent Assembly of Polycyclic Ethers via Acyl Radical Addition to Unactivated Enol Ether," Org. Lett. 2006, 8, 5801-5804.

    DOI: 10.1021/ol062349i
  194. V. Ghiaroni, H. Fuwa, M. Inoue, M. Sasaki, M. Hirama, T. Yasumoto, G. P. Rossini, G. Scalera,P. Pietra A. Bigiani, "Effect of Ciguatoxin 3C on Voltage-Gated Na+ and K+ Currents in Mouse Taste Cells," Chem. Senses 2006, 31, 673-680.
    DOI: 10.1093/chemse/bjl008
  195. T. Tsumuraya, I. Fujii, M. Inoue, A. Tatami, K. Miyazaki, M. Hirama, "Production of monoclonal antibodies for sandwich immunoassay detection of ciguatoxin 51-hydroxyCTX3C," Toxicon 2006, 48, 287-294.
    DOI: 10.1016/j.toxicon.2006.05.014
  196. M. Inoue, K. Miyazaki, Y. Ishihara, A. Tatami, Y. Ohnuma, Y. Kawada, K. Komano, S. Yamashita, N. Lee, M. Hirama, "Total Synthesis of Ciguatoxin and 51-HydroxyCTX3C," J. Am. Chem. Soc. 2006, 128, 9352-9354.

    DOI: 10.1021/ja063041p
  197. M. Inoue, T. Takahashi, H. Furuyama, M. Hirama, "Structural Factors Governing Stereoselective Heck Reaction for the Construction of the Oxindole Portion of TMC-95A," Synlett 2006, 3037-3040.

    DOI: 10.1055/s-2006-951522
  198. M. Inoue, T. Sato, M. Hirama, "Asymmetric Total Synthesis of (-)-Merrilactone A: Use of a Bulky Protective Group as Long-Range Stereocontrolling Element," Angew. Chem. Int. Ed. 2006, 45, 4843-4848.

    DOI: 10.1002/anie.200601358
  199. M. Inoue, T. Usuki, N. Lee, M. Hirama, T. Tanaka, F. Hosoi, S. Ohie, T. Otani, "Antitumor Enediyne Chromoprotein C-1027: Mechanistic Investigation of the Chromophore-Mediated Self-Decomposition Pathway," J. Am. Chem. Soc. 2006, 128, 7896-7903.

    DOI: 10.1021/ja060724w
  200. 2005
  201. T. Usuki, M. Inoue, K. Akiyama, M. Hirama, "ESR Studies on the DNA Cleavage Induced by Enediyne C-1027 Chromophore," Bioorg. & Med. Chem. 2005, 13, 5218-5224.

    DOI: 10.1016/j.bmc.2005.05.049
  202. 2004
  203. S. Sakamoto, H. Sakazaki, K. Hagiwara, K. Kamada, K. Ishii, T. Noda, M. Inoue, M. Hirama, "A Formal Total Synthesis of (+)-Pinnatoxin A," Angew. Chem. Int. Ed. 2004, 43, 6505-6510.

    DOI: 10.1002/anie.200461802
  204. M. Inoue, T. Sasaki, S. Hatano, M. Hirama, "Synthesis of the C-1027 Chromophore Framework through Atropselective Macrolactonization," Angew. Chem. Int. Ed. 2004, 43, 6500-6505.

    DOI: 10.1002/anie.200461428
  205. M. Inoue, S. Hatano, M. Kodama, T. Sasaki, T. Kikuchi, M. Hirama, "Synthesis of the Bicyclo[7.3.0]dodecatrienediyne Core of the C-1027 Chromophore," Org. Lett. 2004, 6, 3833-3836.

    DOI: 10.1021/ol048494i
  206. M. Inoue, T. Kikuchi, M. Hirama, "Synthesis of the Fully Functionalized Nine-membered Diyne Core of the C-1027 Chromophore," Tetrahedron Lett. 2004, 45, 6439-6442.

    DOI: 10.1016/j.tetlet.2004.06.136
  207. T. Usuki, T. Mita, M. J. Lear, P. Das, F. Yoshimura, M. Inoue, M. Hirama, K. Akiyama, S. Tero-Kubota, "Spin-Trapping of 13C-Labeled p-Benzynes, Generated via the Masamune-Bergman Cyclization of Bicyclic Nine-Membered Enediynes," Angew. Chem. Int. Ed. 2004, 43, 5249-5253.

    DOI: 10.1002/anie.200454133
  208. M. Inoue, K. Miyazaki, H. Uehara, M. Maruyama, M. Hirama, "First and Second Generation Total Synthesis of Ciguatoxin CTX3C," Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 12013-12018.
    DOI: 10.1073/pnas.0401684101
  209. K. Yamaoka, M. Inoue, H. Miyahara, K. Miyazaki, M. Hirama, "A Quantitative and Comparative Study of the Effects of a Synthetic Ciguatoxin CTX3C on the Kinetic Properties of Voltage-dependent Sodium Channels," Br. J. Pharmacol. 2004, 142, 879-889.
    DOI: 10.1038/sj.bjp.0705852
  210. M. Inoue, S. Yamashita, A. Tatami, K. Miyazaki, M. Hirama, "A New Stereoselective Synthesis of Ciguatoxin Right Wing Fragments," J. Org. Chem. 2004, 69, 2797-2804.

    DOI: 10.1021/jo049877x
  211. M. Inoue, S. Yamashita, M. Hirama, "A New Synthesis of Key Intermediates for the Assembly of Polycyclic Ethers: Yb(OTf)3-promoted Formation of O,S-Acetals from -Fluorosulfides and Alcohols," Tetrahedron Lett. 2004, 45, 2053-2056.

    DOI: 10.1016/j.tetlet.2004.01.077
  212. T. Usuki, M. Inoue, M. Hirama, T. Tanaka, "Rational Design of a Supra C-1027: Kinetically Stabilized Analogue of the Antitumor Enediyne Chromoprotein ," J. Am. Chem. Soc. 2004, 126, 3022-3023.

    DOI: 10.1021/ja039635z
  213. M. Inoue, H. Zhai, H. Sakazaki, H. Furuyama, Y. Fukuyama, M. Hirama, "TMC-95A, a Reversible Proteasome Inhibitor, Induces Neurite Outgrowth in PC12 Cells," Bioorg. Med. Chem. Lett. 2004, 14, 663-665.

    DOI: 10.1016/j.bmcl.2003.11.043
  214. 2003
  215. M. Inoue, T. Sato, M. Hirama, "Total Synthesis of Merrilactone A," J. Am. Chem. Soc. 2003, 125, 10772-10773.

    DOI: 10.1021/ja036587+
  216. M. Inoue, J. Wang, G.-X. Wang, Y. Ogasawara, M. Hirama, "Divergent Synthesis of the Tetracyclic Ethers of 6-X-7-6 Ring System," Tetrahedron 2003, 59, 5645-5659.

    DOI: 10.1016/S0040-4020(03)00913-X
  217. A. Tatami, M. Inoue, H. Uehara, M. Hirama, "A Concise Route to the Right Wing of Ciguatoxin," Tetrahedron Lett. 2003, 44, 5229-5233.

    DOI: 10.1016/S0040-4039(03)01214-0
  218. M. Inoue, H. Sakazaki, H. Furuyama, M. Hirama, "Total Synthesis of TMC-95A," Angew. Chem. Int. Ed. 2003, 42, 2654-2657.

    DOI: 10.1002/anie.200351130
  219. M. Inoue, M. Hirama, M. Satake, K. Sugiyama, T. Yasumoto, "Inhibition of Brevetoxin Binding to the Voltage-gated Sodium Channel by Gambierol and Gambieric Acid-A," Toxicon 2003, 41, 469-474.
    DOI: 10.1016/S0041-0101(02)00369-0
  220. M. Inoue, K. Nabatame, M. Hirama, "A Novel Route to 1,8-Dihydroxynaphthalene-derived Natural Products. Synthesis of (±)-CJ-12,372," Heterocycles 2003, 59, 87-92.

    DOI: 10.3987/COM-02-S32
  221. 2002
  222. M. Inoue, H. Uehara, M. Maruyama, M. Hirama, "Practical Total Synthesis of Ciguatoxin CTX3C by Improved Protective Group Strategy," Org. Lett. 2002, 4, 4551-4554.

    DOI: 10.1021/ol027105m
  223. M. Inoue, G. X. Wang, J. Wang, M. Hirama, "Novel Assembly of Cyclic Ethers by Coupling -Chlorosulfides and Alcohols," Org. Lett. 2002, 4, 3439-3442.

    DOI: 10.1021/ol026529d
  224. T. Usuki, M. Inoue, K. Akiyama, M. Hirama, "Spin-trapping Study of DNA Cleavage Induced by Enediyne C-1027 Chromophore," Chem. Lett. 2002, 1148.
    DOI: 10.1246/cl.2002.1148
  225. S. Nozaki, Y. Tomioka, T. Hishinuma, M. Inoue, Y. Nagumo, L. R. .Tsuruta, K. Hayashi, T. Matsumoto, Y. Kato, S. Ishiwata, K. Itoh, T. Suzuki, M. Hirama, M. Mizuzaki, "Design, Production, and Characterization of Recombinant Neocarzinostatin Apoprotein in Escherichia coli," J. Biochem. 2002, 131, 729-738.
  226. H. Uehara, T. Oishi, M. Inoue, M. Shoji, Y. Nagumo, M., Kosaka, J.-.Y. Le Brazidec, M. Hirama, "Convergent Synthesis of the HIJKLM Ring Fragment of Ciguatoxin CTX3C," Tetrahedron Symposia-in-Print 2002, 58, 6493-6512.

    DOI: 10.1016/S0040-4020(02)00660-9
  227. M. Maruyama, M. Inoue, T. Oishi, H. Oguri, Y. Ogasawara, Y. Shindo, M. Hirama, "Convergent Synthesis of the ABCDE Ring System of Ciguatoxin CTX3C," Tetrahedron Symposia-in-Print 2002, 58, 1835-1851.

    DOI: 10.1016/S0040-4020(02)00041-8
  228. 2001
  229. M. Hirama, T. Oishi, H. Uehara, M. Inoue, M. Maruyama, H. Oguri, M. Satake, "Total Synthesis of Ciguatoxin CTX3C," Science 2001, 294, 1904-1907.
    DOI: 10.1126/science.1065757
  230. M. Inoue, H. Furuyama, H. Sakazaki, M. Hirama, "Stereocontrolled Synthesis of the Nothern Part of Potent Proteasome Inhibitor TMC-95A," Org. Lett. 2001, 3, 2863-2865.

    DOI: 10.1021/ol016303v
  231. H. Imai, H. Uehara, M. Inoue, H. Oguri, T. Oishi, M. Hirama, "Convergent Synthesis of the EFGH Ring Fragment of Ciguatoxin CTX3C," Tetrahedron Lett. 2001, 42, 6219-6222.

    DOI: 10.1016/S0040-4039(01)01219-9
  232. T. Sasaki, M. Inoue, M. Hirama, "Synthetic Stidies toward C-1027 Chromophore: Construction of a Highly Unsaturated Macrocycle," Tetrahedron Lett. 2001, 42, 5299-5303.

    DOI: 10.1016/S0040-4039(01)00959-5
  233. M. Inoue, M. D. Carson, A. J. Frontier, S. J. Danishefsky, "Total Synthesis and Determination of the Absolute Configuration of Frondosin B," J. Am. Chem. Soc. 2001, 123, 1878-1889.

    DOI: 10.1021/ja0021060
  234. 2000
  235. M. Inoue, A. J. Frontier, S. J. Danishefsky, "The Total Synthesis of Frondosin B," Angew. Chem. Int. Ed. 2000, 39, 761-764.
    DOI: 10.1002/(SICI)1521-3773(20000218)39:4<761::AID-ANIE761>3.0.CO;2-I
  236. T. P. P. Petus, M. Inoue, X.-T. Chen, S. J. Danishefsky, "A Fully Synthetic Route to the Neurotrophic Illicinones: Synthesis of Tricycloillicinone and Bicycloillicinone Aldehyde," J. Am. Chem. Soc. 2000, 122, 6160-6168.

    DOI: 10.1021/ja000521m
  237. S. Pauillac, M. Sasaki, M. Inoue, J. Naar, P. Branaa, M. Chinain, K. Tachibana, A.-M. Legrand, "Characterization of Mice Antisera Elicited with a Ciguatoxin Tetracyclic Synthetic Ring Fragment (JKLM) Conjugated to Carrier Proteins," Toxicon 2000, 38, 669-685.
    DOI: 10.1016/S0041-0101(99)00183-X
  238. 1999
  239. M. Inoue, M. Sasaki, K. Tachibana, "A Convergent Synthesis of Decacyclic Ciguatoxin Model Containing the F-M Ring Framework," J. Org. Chem. 1999, 64, 9416-9429.

    DOI: 10.1021/jo990989b
  240. M. Sasaki, M. Inoue, K. Takamatsu, K. Tachibana, "Stereocontrolled Synthesis of the JKLM Ring Fragment of Ciguatoxin," J. Org. Chem. 1999, 64, 9399-9415.

    DOI: 10.1021/jo990988j
  241. M. Inoue, M. Sasaki, K. Tachibana, "A Convergent Synthesis of the trans-Fused Hexahydrooxonine Ring System and Reproduction of Conformational Behavior Shown by Ring F of Ciguatoxin," Tetrahedron 1999, 55, 10949-10970.

    DOI: 10.1016/S0040-4020(99)00620-1
  242. 1998
  243. M. Sasaki, H. Fuwa, M. Inoue, K. Tachibana, "New Strategy for Convergent Synthesis of trans-Fused Polyether Frameworks Based on Palladium-Catalyzed Suzuki Cross-Coupling Reaction," Tetrahedron Lett. 1998, 39, 9027-9030.

    DOI: 10.1016/S0040-4039(98)02025-5
  244. M. Sasaki, M. Inoue, T. Noguchi, A. Takeichi, K. Tachibana, "Convergent and Stereoselective Method for Synthesis of O-Linked Oxepane Ring System by Intramolecular Radical Cyclization," Tetrahedron Lett. 1998, 39, 2783-2786.

    DOI: 10.1016/S0040-4039(98)00338-4
  245. M. Inoue, M. Sasaki, K. Tachibana, "Synthetic Studies on Ciguatoxin: A Convergent Strategy for Construction of the F-M Ring Framework," Angew. Chem. Int. Ed. 1998, 37, 965-969.
    DOI: 10.1002/(SlCl)1521-3773(19980420)37:7<965::AID-ANIE965>3.0.CO;2-P
  246. 1997
  247. M. Inoue, M. Sasaki, K. Tachibana, "Construction of Fused Oxonene Ring and Reproduction of Conformational Behavior Shown by Ring F of Ciguatoxin," Tetrahedron Lett. 1997, 38, 1611-1614.

    DOI: 10.1016/S0040-4039(97)00125-1
  248. 1994
  249. M. Sasaki, M. Inoue, K. Tachibana, "Synthetic Studies toward Ciguatoxin. Stereocontrolled Construction of the KLM Ring Fragment," J. Org. Chem. 1994, 59, 715-717.
    DOI: 10.1021/jo00083a008

総説

  1. 彦根悠人、長友優典、井上将行 "複雑分子構築の単純化: レジニフェラトキシンの3つの全合成経路の確立" 有機合成化学協会誌 2023, 81, 1136-1149.

    DOI: 10.5059/yukigoseikyokaishi.81.1136
  2. H. Itoh, M. Inoue, "Development of a High-Throughput Strategy for Functional Enhancement and Alteration of Antibacterial Natural Products," J. Synth. Org. Chem., Jpn. 2021, 79, 996-1004.

    DOI: 10.5059/yukigoseikyokaishi.79.996
  3. H. Fujino, M. Nagatomo, M. Inoue, "Total Syntheses of Hikosamine and Hikizimycin," J. Org. Chem. 2021, 86, 16220–16230.
    (Selected as the cover picture link)

    DOI: 10.1021/acs.joc.1c01773
  4. T. Shimakawa, K. Hagiwara, M. Inoue, "Total Synthesis of Talatisamine: Exploration of Convergent Synthetic Strategies," Bull. Chem. Soc. Jpn. 2021, 94, 973-983.

    DOI: 10.1246/bcsj.20200400
  5. M. Nagatomo, M. Inoue, "Convergent Assembly of Highly Oxygenated Natural Products Enabled by Intermolecular Radical Reactions," Acc. Chem. Res. 2021, 54, 595-604.

    DOI: 10.1021/acs.accounts.0c00792
  6. H. Itoh, M. Inoue, "Full solid-phase total synthesis of macrocyclic natural peptides using four-dimensionally orthogonal protective groups," Org. Biomol. Chem. 2019, 17, 6519-6527.

    DOI: 10.1039/C9OB01130G
  7. 占部大介、井上将行 "生物活性カルデノリド類の収束的全合成" 有機合成化学協会誌 2019, 77, 452-461.
    DOI: 10.5059/yukigoseikyokaishi.77.452
  8. H. Itoh, M. Inoue, "Comprehensive Structure–Activity Relationship Studies of Macrocyclic Natural Products Enabled by Their Total Syntheses," Chem. Rev. 2019, 119, 10002-10031.

    DOI: 10.1021/acs.chemrev.9b00063
  9. M. Inoue, "Evolution of Radical-Based Convergent Strategies for Total Syntheses of Densely Oxygenated Natural Products," Acc. Chem. Res. 2017, 50, 460-464.

    DOI: 10.1021/acs.accounts.6b00475
  10. T. Asaba, D. Urabe, M. Inoue, "Asymmetric Total Synthesis of Crotophorbolone: Construction of the 5/7/6-Fused Ring System via an α-Alkoxy Bridgehead Radical Reaction," Bull. Chem. Soc. Jpn. 2016, 89, 1137-1144.

    DOI: 10.1246/bcsj.20160208
  11. D. Urabe, H. Todoroki, M. Inoue, "Asymmetric Total Synthesis of (-)-4-Hydroxyzinowol, a Highly Oxygenated Dihydro-β-Agarofuran," J. Synth. Org. Chem., Jpn 2015, 73, 1081-1091.
    DOI: 10.5059/yukigoseikyokaishi.73.1081
  12. D. Urabe, T. Asaba, M. Inoue, "Convergent Strategies in Total Syntheses of Complex Terpenoids," Chem. Rev. 2015, 115, 9207-9231.

    DOI: 10.1021/cr500716f
  13. M. Inoue, "Chemical Construction and Structural Permutation of Neurotoxic Natural Product, Antillatoxin: Importance of the Three-Dimensional Structure of the Bulky Side Chain," Proc. Jpn. Acad., Ser. B 2014, 90, 56-66.
    DOI: 10.2183/pjab.90.56
  14. T. Kuranaga, Y. Sesoko, M. Inoue, "Cu-mediated enamide formation in the total synthesis of complex peptide natural products," Nat. Prod. Rep. 2014, 31, 514-532.

    DOI: 10.1039/C3NP70103D
  15. H. Itoh, M. Inoue, "Chemical Construction and Structural Permutation of Potent Cytotoxin Polytheonamide B: Discovery of Artificial Peptides with Distinct Functions," Acc. Chem. Res. 2013, 46, 1567-1578.

    DOI: 10.1021/ar300315p
  16. M. Inoue, "Total synthesis and functional analysis of non-ribosomal peptides," Chem. Rec. 2011, 11, 284-294.

    DOI: 10.1002/tcr.201100014
  17. M. Inoue, S. Matsuoka, "Convergent Total Synthesis of the Complex Non-Ribosomal Peptide Polytheonamide B," Isr. J. Chem. 2011, 51, 346-358.
    DOI: 10.1002/ijch.201100002
  18. S. Matsuoka, M. Inoue, "Application of REDOR NMR in Natural Product Chemistry," Chem. Commun. 2009, 5664-5675.
    DOI: 10.1039/B910230B
  19. D. Urabe, M. Inoue, "Total Syntheses of Sesquiterpenes from Illicium Species," Tetrahedron 2009, 65, 6271-6289.

    DOI: 10.1016/j.tet.2009.06.010
  20. 井上将行、佐藤隆章、平間正博 "メリラクトンAの全合成:遠隔不斉誘導と不斉非対称化" 有機合成化学協会誌 2007, 65, 419-429.
    DOI: 10.5059/yukigoseikyokaishi.65.419
  21. M. Inoue, "Exploring the Chemistry and Biology of Antitumor Enediyne Chromoprotein C-1027," Bull. Chem. Soc. Jpn. 2006, 79, 501-510.
    DOI: 10.1246/bcsj.79.501
  22. M. Inoue, "Convergent Strategies for Syntheses of trans-Fused Polycyclic Ethers," Chem. Rev. 2005, 105, 4379-4405.

    DOI: 10.1021/cr0406108
  23. M. Inoue, M. Hirama, "Evolution of a Practical Total Synthesis of Ciguatoxin CTX3C," Acc. Chem. Res. 2004, 37, 961-968.

    DOI: 10.1021/ar0301577
  24. M. Inoue, "Convergent Syntheses of Polycyclic Ethers. Illustrations of the Utility of Acetal-linked Intermediates," Org. Biomol. Chem. 2004, 2, 1811-1817.

    DOI: 10.1039/B407187E
  25. M. Inoue, M. Hirama, "Total Synthesis of Ciguatoxin CTX3C, a Causative Toxin of Ciguatera Seafood Poisoning," Synlett 2004, 577-595.

    DOI: 10.1055/s-2004-817767
  26. 佐々木 誠、 井上 将行"ポリエーテル系天然物の化学合成:新しい中員環エーテルの構築法とエーテル環連結法の開発," 有機合成化学協会誌 2001, 59, 193-205.
    DOI: 10.5059/yukigoseikyokaishi.59.193

著書

  1. H. Fujino, M. Inoue, "Fragmentation Reactions," Reference Module in Chemistry, Molecular Sciences and Chemical Engineering 2023
    DOI: 10.1016/B978-0-323-96025-0.00010-7
  2. 井上将行 "巨大複雑天然物の全合成経路を構築するー合成終盤でのデッドエンドを回避した二つの方策," ドラマチック有機合成化学 感動の瞬間 100, 編集  有機合成化学協会, 東京化学同人, pp 106-107 (2023).
  3. Submitted by H. Huang, Z. Xu, G.-J. Deng, Checked by H. Morozumi, K. Hagiwara, M. Inoue, "Synthesis of 2-Phenyl-4,6-bis(trifluoromethyl)pyridine via NH4I/Na2S2O4-Mediated Cyclization of Ketoxime Acetates," Org. Synth. 2023, 100, 248-270.
    DOI: 10.15227/orgsyn.100.0248
  4. Submitted by Y. Xue, A. Parsad, G. Dong, Checked by J. Han, M. Nagatomo, M. Inoue, "α-Arylation of Cyclopentanones by Palladium/Enamine Cooperative Catalysis," Org. Synth. 2023, 100, 99-112.
    DOI: 10.15227/orgsyn.100.0099
  5. 井上将行 "全合成戦略と天然物機能のアップグレード," 有機化学イノベーション(現代化学増刊47), 監修  山本尚, 東京化学同人, pp 209-223 (2023).
  6. Submitted by D. P. Graeff, N. J. Sims, Q. R. Savage, R. K. Jackson, III, A. C. Jackson, D. M. Lawson, M. R. Wixom, J. L. Wood, Checked by Y. Shiga, H. Fujino, M. Inoue, "Preparation of N-Boc-3-methylpyrrole via Anionic Rearrangement," Org. Synth. 2023, 100, 61-83.
    DOI: 10.15227/orgsyn.100.0061
  7. Submitted by M. Varghese, H. E. Caputo, R. Xiao, A. Balijepalli, A. Hamoud, M. W. Grinstaff, Checked by K. Oga, M. Nagatomo, M. Inoue, "Stereoselective [2+2] Cycloadditions: Synthesis of a Tri-O-Bn-D-Glucal-derived β-Lactam," Org. Synth. 2021, 98, 491-508.
    DOI: 10.15227/orgsyn.098.0491
  8. Submitted by J. S. Kingsbury, V. L. Rendina, J. S. Burman, B. A. Smolarski, Checked by J. Taguchi, H. Fujino, M. Inoue, "Catalytic Diazoalkane-Carbonyl Homologation: Synthesis of 2,2-Diphenylcycloheptanone and Other Quaternary or Tertiary Arylalkanones and Spirocycles by Ring Expansion," Org. Synth. 2021, 98, 343-362.
    DOI: 10.15227/orgsyn.098.0343
  9. Submitted by A. K. Bodnar, A. Turlik, D. Huang, W. Butcher, J. K. Lew, T. R. Newhouse, Checked by A. Takeuchi, H. Itoh, M. Inoue, "Preparation of Hindered Aniline CyanH and Application in the Allyl-Ni-Catalyzed α,β-Dehydrogenation of Carbonyls," Org. Synth. 2021, 98, 263-288.
    DOI: 10.15227/orgsyn.098.0263
  10. Submitted by M. Krzeszewski, M. Tasior, M. Grzybowski, D. T. Gryko, Checked by S. Nakamura, K. Hagiwara, M. Inoue, "Synthesis of Tetraaryl-, Pentaaryl-, and Hexaaryl-1,4-dihydropyrrolo[3,2-b]pyrroles," Org. Synth. 2021, 98, 242-262.
    DOI: 10.15227/orgsyn.098.0242
  11. Submitted by N. Zhu, W.-M. Wan, H. Bao, Checked by Y. Watanabe, K. Hagiwara, M. Inoue, "Reductive Deuteration of Ketones with Magnesium and D2O for the Synthesis of α-Deutero-o-methyl-benzhydrol," Org. Synth. 2021, 98, 51-67.
    DOI: 10.15227/orgsyn.098.0051
  12. Submitted by Y. Chen, Q. Chen, L. Tan, L. Chen, X. Wang, Checked by Y. Komori, M. Nagatomo, M. Inoue, "Preparation of 1H-Indazole-3-carbonitrile," Org. Synth. 2020, 97, 314-326.
    DOI: 10.15227/orgsyn.097.0314
  13. Submitted by J. R. Lizza, P. Wipf, Checked by K. Miura, H. Itoh, M. Inoue, "Synthesis of 4-Nitrophenyl (2,2,6,6-Tetramethylpiperidin-1-yl) Carbonate (NPTC) for N-Protection of L-Phenylalanine Ethyl Ester," Org. Synth. 2020, 97, 96-124.
    DOI: 10.15227/orgsyn.097.0096
  14. Submitted by J. Klepp, W. Dillon, Y. Lin, P. Feng, B. W. Greatrex, Checked by Y. Imamura, M. Nagatomo, M. Inoue, "Preparation of (-)-Levoglucosenone from Cellulose Using Sulfuric Acid in Polyethylene Glycol," Org. Synth. 2020, 97, 38-53.
    DOI: 10.15227/orgsyn.097.0038
  15. Submitted by S. M. Engle, T. R. Kirkner, C. B. Kelly, Checked by S. Shimizu, K. Hagiwara, M. Inoue, "Preparation of 2,4,5,6-Tetra(9H-carbazol-9-yl)isophthalonitrile," Org. Synth. 2019, 96, 455-473.
    DOI: 10.15227/orgsyn.096.0455
  16. Submitted by B. J. Simmons, M. Ramirez, N. K. Garg, Checked by T. Shimakawa, K. Hagiwara, M. Inoue, "Facile Reduction of Amides Using Nickel Catalysis: Reduction of 12-Aminododecanolactam," Org. Synth. 2019, 96, 436-454.
    DOI: 10.15227/orgsyn.096.0436
  17. Submitted by Y. Kawashima, T. Furukawa, N. Chatani, M. Tobisu, Checked by T. Fukuda, M. Nagatomo, M. Inoue, “Nickel-Catalyzed Cross-Coupling of 2-Methoxynaphthalene with Methyl 4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzoate,” Org. Synth. 2019, 96, 36-52.
    DOI: 10.15227/orgsyn.096.0036
  18. 長友優典, 井上将行, “リアノダンジテルペンの統一的全合成,”  天然有機化合物の全合成 独創的なものづくりの反応と戦略(CSJカレントレビュー 27) (日本化学会 編), 化学同人, pp 103-109 (2018).
  19. 井上将行, 占部大介, “全合成の現在と未来:戦略面から見た全合成と人工分子創製の重要性,”  天然有機化合物の全合成 独創的なものづくりの反応と戦略(CSJカレントレビュー 27) (日本化学会 編), 化学同人, pp 20-23 (2018).
  20. 井上将行, “失敗をオリジナリティーにつなげる戦略,”  東大エグゼクティブ・マネジメント デザインする思考力 (東大EMP 横山禎徳 編), 東京大学出版, pp 205-242 (2014).
  21. M. Inoue, D. Urabe, "Symmetry-Driven Total Synthesis of Merrilactone A and Resolvin E2," Strategy and Tactics in Organic Synthesis 2013, 9, pp 149-175.
  22. 井上将行, ブラウン有機化学, 東京化学同人, (2014).
  23. 上條真,  井上将行, "Wacker酸化," トップドラッグから学ぶ創薬化学, 東京化学同人, pp 168-168 (2012).
  24. 占部大介, 井上将行, "オレフィンメタセシス," トップドラッグから学ぶ創薬化学, 東京化学同人, pp 128-129 (2012).
  25. 石山備凡, 井上将行, "Michael反応," トップドラッグから学ぶ創薬化学, 東京化学同人, pp 121-121 (2012).
  26. 井上将行, “革新的戦略による天然物全合成,” 化学のブレークスルー, 化学同人, pp 30-34 (2011).
  27. 井上将行, 佐藤隆章, “[2+2]光付加環化反応,” 天然物合成で活躍した反応: 実験のコツとポイント, 化学同人, pp 62-63 (2011).
  28. 井上将行 "対称性を利用したメリラクトンAの全合成―遠隔不斉誘導と不斉非対称化―," 創薬科学の魅力-東京大学大学院薬学系研究科からの発信, 廣川書店, pp 105-117 (2010).
  29. 井上将行,佐藤隆章,平間正博 "対称性を利用したメリラクトンAの全合成―遠隔不斉誘導と不斉非対称化―," 天然物全合成の最新動向, 監修 北泰行, シーエムシー出版, pp 3-17 (2009).
  30. 井上将行, "革新的戦略による天然物全合成," 別冊化学『化学のブレークスルー【有機化学編】』, 化学同人, pp 22-27 (2009).
  31. 平間正博, 井上将行, "シガトキシン," 大学院講義 有機化学 改訂第2版, 編集代表 野依良治, 東京化学同人, II巻 6·8, (2015).
  32. M. Inoue, S. Yamashita, "Product Class: 5-, 6- and Larger Ring Oxacycloalkanes," Science of Synthesis, ed. by C. J. Forsyth, Thieme, Chapter 37.5.
  33. S. J. Danishefsky, M. Inoue, D. Trauner, "Synthesis of Immunomodulatory Marine Natural Products," The Role of Natural Products in Drug Discovery, eds. by J. Mulzer, R. Bohlmann, Springer-Verlag, 2000, pp. 1-24.

依頼解説記事

  1. 長友優典, 今村祐亮, 井上将行, "抗がん剤タキソールの全合成――ラジカル反応を活用した新しい合成戦略とその展開," 化学 2023, 78 (7), 33-37.
    Link
  2. 井上将行, 徳本皓太郎, 加治拓哉, 伊藤寛晃, "ライソシンEを基盤としたOBOCライブラリー構築と評価による新規抗菌類縁体の探索," MEDCHEM NEWS 2020, 30 (2), 84-88.
    DOI: 10.14894/medchem.30.2_84
  3. M. Inoue, D. Trauner, "In Honor of Professor Samuel J. Danishefsky," J. Antibiot. 2019, 72, 324.
    DOI: 10.1038/s41429-019-0182-z
  4. 井上将行, "新・化学を創ってゆく人びと:井上将行教授に聞く," 化学 2018, 73 (10), 12-18.
  5. 井上将行, 長友優典, 占部大介, "ラジカル反応を基盤とした高酸化度天然物の収束的合成戦略," ファルマシア 2017, 53, 860-864.
  6. 長友優典, 井上将行, "リアノジン類の統一的全合成-多様性を志向した共通中間体の設計戦略," 化学 2016, 71 (4), 47-48.
    (Associated Link: Link1)
  7. 伊藤寛晃, 井上将行, "脂質を見分ける天然物," 化学 2015, 70 (8), 64-65.
  8. M. Inoue, "A Special Issue on Total Synthesis," Chem. Rec. 2014, 14, 579.
  9. T. Hoshikawa, M. Nagatomo, M. Inoue, “Pentafluorophenyl Isocyanate,” e-EROS 2013, RN01621.
    DOI: 10.1002/047084289X.rn01621
  10. S. Kamijo, M. Inoue, "4,4',4"-tri-tert-butyl-2,2':6',2"-terpyridine," e-EROS 2012, RN01474.
    DOI: 10.1002/047084289X.rn01474
  11. M. Inoue, "Author Profile," Angew. Chem. Int. Ed. 2011, 50, 9016.
    DOI: 10.1002/anie.201103732
  12. 井上将行, 占部大介, "ラジカル反応を基軸とする複雑天然物の合成," 化学工業 2011, 62, 594-596.
  13. 井上将行, 松岡茂, "イオンチャネルを形成する巨大ペプチド系天然物の全合成," ペプチドニュースレター 2010, 78, 1-3.
  14. 井上将行, "巨大天然物の全合成と機能," 化学と工業 2009, 62, 138-141.
  15. 井上将行, 平間正博, "高反応性エンジイン系抗腫瘍性物質の機能と合成," ファルマシア 2008, 44, 130-134.
  16. M. Inoue, "Nature Journal Club," Nature 2008, 452, 257.
    DOI: 10.1038/452257a
  17. M. Inoue, "Zippier synthesis in water," Nature 2007, 449, 667-669.
    DOI: 10.1038/449667a
  18. 井上将行, 鈴木国夫, "第一回Merck Banyu Lectureship Award (MBLA)の受賞にあたって," 有機合成化学協会誌 2006, 64, 263-268.
    DOI: 10.5059/yukigoseikyokaishi.64.263
  19. 井上将行, "抗生物質をアップグレードする," 化学 2005, 60(9), 68-69.
  20. 井上将行, "20年後の有機合成はどこへ行くのか," 創立60周年記念ポスト事業 『有機合成化学と精密化学工業の将来一若手研究者は語る一』 第4回有機合成化学協会東北北海道支部, 東北地区からの報告 有機合成化学協会誌 2004, 62, 836-837.
    DOI: 10.5059/yukigoseikyokaishi.62.833
  21. 井上将行, "留学のすすめ," 化学 2002, 57(9), 22-23.
  22. 井上将行, "生理活性発現機構解明を目的とした天然物の全合成研究," 化学 2002, 57(2), 31-32.

伊藤 寛晃

原著論文

    2023
  1. J. Fu, Y. Nakata, H. Itoh, S. Panthee, H. Hamamoto, K. Sekimizu, M. Inoue, "Molecular Editing Enhances Oxidation Resistance of Menaquinone-Targeting Antibiotics Lysocin E and WAP-8294A2," Chem. Eur. J. 2023, 29, e202301224.
    DOI: 10.1002/chem.202301224
  2. Y. Nakata, J. Fu, H. Itoh, S. Panthee, H. Hamamoto, K. Sekimizu, M. Inoue, "Construction of Five Tryptophan Isomers and Application of the Isomers to Solid-Phase Total Syntheses of Lysocin E Derivatives," Chem. Eur. J. 2023, 29, e202301225.
    DOI: 10.1002/chem.202301225
  3. Y.-W. Xue, K. Miura, H. Itoh, M. Inoue, "C-Terminal Modification of Polytheonamide B Uncouples Its Dual Functions in MCF-7 Cancer Cells," Chem. Commun. 2023, 59, 3914-3917.

    DOI: 10.1039/D2CC05915K
  4. 2022
  5. Y.-W. Xue, H. Itoh, S. Dan, M. Inoue, "Gramicidin A Accumulates in Mitochondria, Reduces ATP Levels, Induces Mitophagy, and Inhibits Cancer Cell Growth," Chem. Sci. 2022, 13, 7482-7491.

    DOI: 10.1039/D2SC02024F
  6. 2021
  7. H. Hamamoto, S. Panthee, A. Paudel, K. Ishii, J. Yasukawa, J. Su, A. Miyashita, H. Itoh, K. Tokumoto, M. Inoue, K. Sekimizu, "Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus," Nat. Commun. 2021, 12, 6364.
    DOI: 10.1038/s41467-021-26702-0
  8. A. Takeuchi, H. Itoh, M. Inoue, "18O/16O-Encoding Strategy for Microscale Stereochemical Determination of Peptidic Natural Products," Chem. Asian J. 2021, 16, 2447-2452.

    DOI: 10.1002/asia.202100674
  9. K. Kamiya, H. Itoh, M. Inoue, "Generation and Biological Evaluation of Degraded Derivatives of the Three E/Z-Isomers of Yaku'amide B," J. Nat. Prod. 2021, 84, 1854–1859.

    DOI: 10.1021/acs.jnatprod.1c00339
  10. K. Kamiya, K. Miura, H. Itoh, M. Inoue, "Divergent Solid‐Phase Synthesis and Biological Evaluation of Yaku’amide B and Its Seven E/Z Isomers," Chem. Eur. J. 2021, 27, 1088-1093.
    (Selected as Hot Paper)

    DOI: 10.1002/chem.202003858
  11. 2020
  12. S. Shimizu, K. Hagiwara, H. Itoh, M. Inoue, "Unified Total Synthesis of Five Bufadienolides," Org. Lett. 2020, 22, 8652-8657.
    (Selected as Most Read Articles of the month)

    DOI: 10.1021/acs.orglett.0c03251
  13. Y. Iwahashi, Y. Toyama, S. Imai, H. Itoh, M. Osawa, M. Inoue, I. Shimada, "Conformational equilibrium shift underlies altered K+ channel gating as revealed by NMR," Nat. Commun. 2020, 11, 5168.
    DOI: 10.1038/s41467-020-19005-3
  14. Y. Takada, H. Itoh, A. Paudel, S. Panthee, H. Hamamoto, K. Sekimizu, M. Inoue, "Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library," Nat. Commun. 2020, 11, 4935.
    (UTokyo FOCUS内 Press Releasesにて紹介されました。 日本語, English)
    (Selected as Nature Communications Editors' Highlights, link)

    DOI: 10.1038/s41467-020-18711-2
  15. J. Mao, H. Itoh, K. Sakurai, M. Inoue, "Phospholipid-Dependent Functions of a Macrocyclic Analogue of the Ion-Channel-Forming Antibiotic Gramicidin A," Chem. Pharm. Bull. 2020, 68, 173-178.

    DOI: 10.1248/cpb.c19-00967
  16. H. Itoh, K. Miura, K. Kamiya, T. Yamashita, M. Inoue, "Solid‐Phase Total Synthesis of Yaku’amide B Enabled by Traceless Staudinger Ligation," Angew. Chem. Int. Ed. 2020, 59, 4564-4571.
    (UTokyo FOCUS内 articlesにて紹介されました。 リンク)

    DOI: 10.1002/anie.201916517
  17. 2019
  18. Y.-W. Xue, A. Hayata, H. Itoh, M. Inoue, "Biological Effects of a Simplified Synthetic Analogue of Ion‐Channel‐Forming Polytheonamide B on Plasma Membrane and Lysosomes," Chem. Eur. J. 2019, 25, 15198-15204.
    (Selected as Hot Paper)

    DOI: 10.1002/chem.201903974
  19. H. Itoh, K. Tokumoto, T. Kaji, A. Paudel, S. Panthee, H. Hamamoto, K. Sekimizu, M. Inoue, "Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E," Nat. Commun. 2019, 10, 2992.
    (UTokyo FOCUS内 press releasesにて紹介されました。 リンク, 英語版リンク)
    (Selected as Nature Communications Editor's Highlights. link)
    (Associated link: NIKKEI BUSINESS DAILY (July 18, 2019), link)
    (Associated link: NIKKEI (October 13, 2019), link1, link2, link3)

    DOI: 10.1038/s41467-019-10754-4
  20. 2018
  21. D. Urabe, Y. Nakagawa, K. Mukai, K. Fukushima, N. Aoki, H. Itoh, M. Nagatomo, M. Inoue, "Total synthesis and biological evaluation of 19-hydroxysarmentogenin-3-O-a-L-rhamnoside, trewianin, and their aglycons," J. Org. Chem. 2018, 83, 13888-13910.

    DOI: 10.1021/acs.joc.8b02219
  22. K. Kitamura, H. Itoh, K. Sakurai, S. Dan, M. Inoue, "Target Identification of Yaku’amide B and Its Two Distinct Activities against Mitochondrial FoF1-ATP Synthase," J. Am. Chem. Soc. 2018, 140, 12189-12199.
    (Selected as Spotlights on Recent JACS Publications)

    DOI: 10.1021/jacs.8b07339
  23. A. Hayata, H. Itoh, M. Inoue, "Solid-Phase Total Synthesis and Dual Mechanism of Action of the Channel-Forming 48-mer Peptide Polytheonamide B," J. Am. Chem. Soc. 2018, 140, 10602-10611.

    DOI: 10.1021/jacs.8b06755
  24. Y. Kofuku, T. Yokomizo, S. Imai, Y. Shiraishi, M. Natsume, H. Itoh, M. Inoue, K. Nakata, S. Igarashi, H. Yamaguchi, T. Mizukoshi, E. Suzuki, T. Ueda, I. Shimada, "Deuteration and selective labeling of alanine methyl groups of β2-adrenergic receptor expressed in a baculovirus-insect cell expression system," J. Biomol. NMR 2018, 71, 185-192.
    DOI: 10.1007/s10858-018-0174-5
  25. H. Itoh, K. Tokumoto, T. Kaji, A. Paudel, S. Panthee, H. Hamamoto, K. Sekimizu, M. Inoue, "Total Synthesis and Biological Mode of Action of WAP-8294A2: A Menaquinone-Targeting Antibiotic," J. Org. Chem. 2018, 83, 6924-6935.
    (Selected as ACS editors' choice)
    (The Journal of Organic Chemistry Outstanding Publication of the Year Lectureship Award)
    (Selected as the three most read papers in JOC in 2018)

    DOI:10.1021/acs.joc.7b02318
  26. 2016
  27. T. Kaji, M. Murai, H. Itoh, J. Yasukawa, H. Hamamoto, K. Sekimizu, M. Inoue, "Total Synthesis and Functional Evaluation of Fourteen Derivatives of Lysocin E: Importance of Cationic, Hydrophobic, and Aromatic Moieties for Antibacterial Activity," Chem. Eur. J. 2016, 22, 16912-16919.

    DOI:10.1002/chem.201604022
  28. H. Mutoh, Y. Sesoko, T. Kuranaga, H. Itoh, M. Inoue, "Total Synthesis and Functional Evaluation of Fourteen Stereoisomers of Yaku’amide B. Importance of Stereochemistry for Hydrophobicity and Cytotoxicity," Org. Biomol. Chem. 2016, 14, 4199-4204.
    (Selected as Hot Article)
    (Selected as 2016's Most Popular Article)


    DOI: 10.1039/C6OB00640J
  29. A. Hayata, H. Itoh, S. Matsutaka, M. Inoue, "Dual Chemical Modification of a Polytheonamide Mimic: Rational Design and Synthesis of Ion-Channel-Forming 48-mer Peptides with Potent Cytotoxicity," Chem. Eur. J. 2016, 22, 3370-3377.
    (Selected as Very Important Paper)

    DOI: 10.1002/chem.201504632
  30. 2014
  31. H. Itoh, S. Matsutaka, T. Kuranaga, M. Inoue, "Control of the cytotoxicity of dansylated polytheonamide mimic, an artificial peptide ion channel, by modification of the N-terminal structure," Tetrahedron Lett. 2014, 55, 728-731.

    DOI: 10.1016/j.tetlet.2013.12.007
  32. H. Itoh, M. Inoue, "Antibody-mediated functional control of a dansylated polytheonamide mimic," Chem. Commun. 2014, 50, 939-941.

    DOI: 10.1039/C3CC48348G
  33. 2013
  34. H. Itoh, M. Inoue, "Structural Permutation of Potent Cytotoxin, Polytheonamide B: Discovery of Cytotoxic Peptide with Altered Activity," ACS Med. Chem. Lett. 2013, 4, 52-56.

    DOI: 10.1021/ml300264c
  35. 2012
  36. H. Itoh, S. Matsuoka, M. Kreir, M. Inoue, "Design, Synthesis and Functional Analysis of Dansylated Polytheonamide Mimic: An Artificial Peptide Ion Channel," J. Am. Chem. Soc. 2012, 134, 14011-14018.

    DOI: 10.1021/ja303831a
  37. N. Shinohara, H. Itoh, S. Matsuoka, M. Inoue, "Selective Modification of the N-Terminal Structure of Polytheonamide B Significantly Changes its Cytotoxicity and Activity as an Ion Channel," ChemMedChem 2012, 7, 1770-1773.

    DOI: 10.1002/cmdc.201200142
  38. 2010
  39. S. Matsuoka, Y. Mizoguchi, H. Itoh, K. Okura, N. Shinohara, M. Inoue, "The effect of sulfur stereochemistry of L-β,β-dimethylmethionine S-oxide on the physicochemical properties of truncated polytheonamides," Tetrahedron Lett. 2010, 51, 4644-4647.

    DOI: 10.1016/j.tetlet.2010.06.126
  40. M. Inoue, N. Shinohara, S. Tanabe, T. Takahashi, K. Okura, H. Itoh, Y. Mizoguchi, M. Iida, N. Lee, S. Matsuoka, "Total synthesis of the large non-ribosomal peptide polytheonamide B," Nature Chem. 2010, 2, 280-285.

    DOI: 10.1038/nchem.554

総説

  1. H. Itoh, "Total Synthesis and Functional Analysis of Complex Peptidic Natural Products and Their Artificial Analogues," YAKUGAKU ZASSHI 2022, 142, 561-571.
    DOI: 10.1248/yakushi.22-00042
  2. H. Itoh, M. Inoue, "Development of a High-Throughput Strategy for Functional Enhancement and Alteration of Antibacterial Natural Products," J. Synth. Org. Chem., Jpn. 2021, 79, 996-1004.

    DOI: 10.5059/yukigoseikyokaishi.79.996
  3. H. Itoh, M. Inoue, "Full solid-phase total synthesis of macrocyclic natural peptides using four-dimensionally orthogonal protective groups," Org. Biomol. Chem. 2019, 17, 6519-6527.

    DOI: 10.1039/C9OB01130G
  4. H. Itoh, M. Inoue, "Comprehensive Structure–Activity Relationship Studies of Macrocyclic Natural Products Enabled by Their Total Syntheses," Chem. Rev. 2019, 119, 10002-10031.

    DOI: 10.1021/acs.chemrev.9b00063
  5. H. Itoh, M. Inoue, "Chemical Construction and Structural Permutation of Potent Cytotoxin Polytheonamide B: Discovery of Artificial Peptides with Distinct Functions," Acc. Chem. Res. 2013, 46, 1567-1578.

    DOI: 10.1021/ar300315p

著書

  1. H. Itoh, “Discovery of Natural Product Analogues with Altered Activities by a High-Throughput Strategy,”  New Tide of Natural Product Chemistry, Springer, Singapore, pp 333-354 (2023).
    DOI: 10.1007/978-981-99-1714-3_16
  2. Submitted by A. K. Bodnar, A. Turlik, D. Huang, W. Butcher, J. K. Lew, and T. R. Newhouse, Checked by A. Takeuchi, H. Itoh, M. Inoue, "Preparation of Hindered Aniline CyanH and Application in the Allyl-Ni-Catalyzed α,β-Dehydrogenation of Carbonyls," Org. Synth. 2021, 98, 263-288.
    DOI: 10.15227/orgsyn.098.0263
  3. Submitted by J. R. Lizza, P. Wipf, Checked by K. Miura, H. Itoh, M. Inoue, "Synthesis of 4-Nitrophenyl (2,2,6,6-Tetramethylpiperidin-1-yl) Carbonate (NPTC) for N-Protection of L-Phenylalanine Ethyl Ester," Org. Synth. 2020, 97, 96-124.
    DOI: 10.15227/orgsyn.097.0096

依頼解説記事

  1. 伊藤寛晃, "ペプチド系複雑天然物の全合成を基盤とした機能解明・新機能分子創出," 薬事日報 2021, 12432, 19. link
  2. 井上将行, 徳本皓太郎, 加治拓哉, 伊藤寛晃, "ライソシンEを基盤としたOBOCライブラリー構築と評価による新規抗菌類縁体の探索," MEDCHEM NEWS 2020, 30 (2), 84-88.
    DOI: 10.14894/medchem.30.2_84
  3. 伊藤寛晃, 井上将行, "脂質を見分ける天然物," 化学 2015, 70(8), 64-65.

萩原 浩一

原著論文

    2024
  1. H. Asai, K. Hagiwara, M. Inoue, "Enantioselective route to an AE-ring intermediate in the total synthesis of talatisamine," Tetrahedron Lett. 2024, 135, 154903.

    DOI: 10.1016/j.tetlet.2023.154903
  2. 2023
  3. Y. Watanabe, K. Sakata, D. Urabe, K. Hagiwara, M. Inoue, "Formal Total Synthesis of Batrachotoxin Enabled by Radical and Weix Coupling Reactions," J. Org. Chem. 2023, 88, 17479-17484.
    (24/1/4 Selectesd as Most Read Articles)

    DOI: 10.1021/acs.joc.3c02290
  4. Y. Watanabe, H. Morozumi, H. Mutoh, K. Hagiwara, M. Inoue, "Total Synthesis of (−)-Batrachotoxin Enabled by a Pd/Ag-Promoted Suzuki–Miyaura Coupling Reaction," Angew. Chem. Int. Ed. 2023, 62, e202309688.
    (UTokyo FOCUS内 press releasesにて紹介されました。リンク)
    (Selected as Hot Paper)

    DOI: 10.1002/anie.202309688
  5. T. Shimakawa, S. Nakamura, H. Asai, K. Hagiwara, M. Inoue, "Total Synthesis of Puberuline C," J. Am. Chem. Soc. 2023, 145, 600-609.
    (UTokyo FOCUS内 press releasesにて紹介されました。リンク)
    (ChemistryViewsにて取り上げられました。)
    (Selected as Most Read Articles)
    (Chem-Stationにて取り上げられました。)
    (Featured in Synfacts)
    (Organic Chemistry Highlightsで紹介されました。リンク)

    DOI: 10.1021/jacs.2c11259
  6. 2022
  7. T. Nagai, Y. Wang, K. Hagiwara, M. Inoue, "Asymmetric synthesis of evoninic acid," Tetrahedron Lett. 2022, 97, 153747.

    DOI: 10.1016/j.tetlet.2022.153747
  8. 2021
  9. Y. Wang, T. Nagai, I. Watanabe, K. Hagiwara, M. Inoue, "Total Synthesis of Euonymine and Euonyminol Octaacetate," J. Am. Chem. Soc. 2021, 143, 21037–21047.
    (UTokyo FOCUS内 press releasesにて紹介されました。リンク)
    (Selected as Most Read Articles)

    DOI: 10.1021/jacs.1c11038
  10. H. Mutoh, S. Nakamura, K. Hagiwara, M. Inoue, "Construction of Pentacyclic Limonoid Skeletons via Radical Cascade Reactions," J. Org. Chem. 2021, 86, 6869–6878.

    DOI: 10.1021/acs.joc.1c00212
  11. 2020
  12. S. Shimizu, K. Hagiwara, H. Itoh, M. Inoue, "Unified Total Synthesis of Five Bufadienolides," Org. Lett. 2020, 22, 8652-8657.
    (Selected as Most Read Articles of the month)

    DOI: 10.1021/acs.orglett.0c03251
  13. K. Minagawa, D. Kamakura, K. Hagiwara, M. Inoue, "Construction of the ABCE-ring structure of talatisamine via decarboxylative radical cyclization," Tetrahedron 2020, 76, 131385.
    (Selected as Editor’s Choice Collection, link)

    DOI: 10.1016/j.tet.2020.131385
  14. D. Kamakura, H. Todoroki, D. Urabe, K. Hagiwara, M. Inoue, "Total Synthesis of Talatisamine," Angew. Chem. Int. Ed. 2020, 59, 479-486.
    (Featured in Synfacts)
    (UTokyo FOCUS内 articlesにて紹介されました。 リンク)
    (Synthesis Workshop Videosにて紹介されました。link)
    (Selected as Top Downloaded Article link)


    DOI: 10.1002/anie.201912737
  15. 2016
  16. K. Hagiwara, T. Tabuchi, D. Urabe, M. Inoue, "Expeditious synthesis of the fused hexacycle of puberuline C via radical-based cyclization/translocation/cyclization process," Chem. Sci. 2016, 7, 4372-4378.

    DOI: 10.1039/C6SC00671J
  17. 2015
  18. K. Hagiwara, M. Iwatsu, D. Urabe, M. Inoue, "N-(2,3,4,5,6-Pentafluorophenyl)maleimide as a Powerful Dienophile in Dearomatizing Diels-Alder Reactions," Heterocycles 2015, 90, 659-672.

    DOI: 10.3987/COM-14-S(K)23

総説

  1. T. Shimakawa, K. Hagiwara, M. Inoue, "Total Synthesis of Talatisamine: Exploration of Convergent Synthetic Strategies," Bull. Chem. Soc. Jpn. 2021, 94, 973-983.

    DOI: 10.1246/bcsj.20200400

著書

  1. Submitted by H. Huang, Z. Xu, G.-J. Deng, Checked by H. Morozumi, K. Hagiwara, M. Inoue, "Synthesis of 2-Phenyl-4,6-bis(trifluoromethyl)pyridine via NH4I/Na2S2O4-Mediated Cyclization of Ketoxime Acetates," Org. Synth. 2023, 100, 248-270.
    DOI: 10.15227/orgsyn.100.0248
  2. Submitted by M. Krzeszewski, M. Tasior, M. Grzybowski, D. T. Gryko, Checked by S. Nakamura, K. Hagiwara, M. Inoue, "Synthesis of Tetraaryl-, Pentaaryl-, and Hexaaryl-1,4-dihydropyrrolo[3,2-b]pyrroles," Org. Synth. 2021, 98, 242-262.
    DOI: 10.15227/orgsyn.098.0242
  3. Submitted by N. Zhu, W.-M. Wan, H. Bao, Checked by Y. Watanabe, K. Hagiwara, M. Inoue, "Reductive Deuteration of Ketones with Magnesium and D2O for the Synthesis of α-Deutero-o-methyl-benzhydrol," Org. Synth. 2021, 98, 51-67.
    DOI: 10.15227/orgsyn.098.0051
  4. Submitted by S. M. Engle, T. R. Kirkner, C. B. Kelly, Checked by S. Shimizu, K. Hagiwara, M. Inoue, "Preparation of 2,4,5,6-Tetra(9H-carbazol-9-yl)isophthalonitrile," Org. Synth. 2019, 96, 455-473.
    DOI: 10.15227/orgsyn.096.0455
  5. Submitted by B. J. Simmons, M. Ramirez, N. K. Garg, Checked by T. Shimakawa, K. Hagiwara, M. Inoue, "Facile Reduction of Amides Using Nickel Catalysis: Reduction of 12-Aminododecanolactam," Org. Synth. 2019, 96, 436-454.
    DOI: 10.15227/orgsyn.096.0436

藤野 遥

原著論文

    2020
  1. M. Nagatomo, K. Zhang, H. Fujino, M. Inoue, "Et3B/Et2AlCl/O2‐Mediated Radical Coupling Reaction between α‐Alkoxyacyl Tellurides and 2‐Hydroxybenzaldehyde Derivatives," Chem. Asian. J. 2020, 15, 3820-3824.

    DOI: 10.1002/asia.202001090
  2. H. Fujino, T. Fukuda, M. Nagatomo, M. Inoue, "Convergent Total Synthesis of Hikizimycin Enabled by Intermolecular Radical Addition to Aldehyde," J. Am. Chem. Soc. 2020, 142, 13227–13234.
    (UTokyo FOCUS内 articlesにて紹介されました。 リンク)
    (Organic Chemistry Highlightsで紹介されました。リンク)


    DOI: 10.1021/jacs.0c06354
  3. 2019
  4. M. Yang, F. Yin, H. Fujino, S. A. Snyder, “The Total Synthesis of Chalctrin,” J. Am. Chem. Soc. 2019, 141, 4515-4520.
    DOI: 10.1021/jacs.8b12612
  5. 2017
  6. H. Fujino, M. Nagatomo, A. Paudel, S. Panthee, H. Hamamoto, K. Sekimizu, M. Inoue, "Unified Total Synthesis of Polyoxin J, L, and Their Fluorinated Analogues Based on Decarbonylative Radical Coupling Reactions," Angew. Chem. Int. Ed. 2017, 56, 11865-11869.

    DOI:10.1002/anie.201706671
  7. 2015
  8. M. Nagatomo, H. Nishiyama, H. Fujino, M. Inoue, "Decarbonylative Radical Coupling of α-Aminoacyl Tellurides: Single-Step Preparation of γ-Amino and α,β-Diamino Acids and Rapid Synthesis of Gabapentin and Manzacidin A," Angew. Chem. Int. Ed. 2015, 54, 1537-1541.
    (Selected as Hot Paper)

    DOI: 10.1002/anie.201410186

総説

  1. H. Fujino, M. Nagatomo, M. Inoue, "Total Syntheses of Hikosamine and Hikizimycin," J. Org. Chem. 2021, 86, 16220–16230.
    (Selected as the cover picture link)

    DOI: 10.1021/acs.joc.1c01773

著書

  1. H. Fujino, M. Inoue, "Fragmentation Reactions," Reference Module in Chemistry, Molecular Sciences and Chemical Engineering 2023
    DOI: 10.1016/B978-0-323-96025-0.00010-7
  2. Submitted by D. P. Graeff, N. J. Sims, Q. R. Savage, R. K. Jackson, III, A. C. Jackson, D. M. Lawson, M. R. Wixom, J. L. Wood, Checked by Y. Shiga, H. Fujino, M. Inoue, "Preparation of N-Boc-3-methylpyrrole via Anionic Rearrangement," Org. Synth. 2023, 100, 61-83.
    DOI: 10.15227/orgsyn.100.0061
  3. Submitted by J. S. Kingsbury, V. L. Rendina, J. S. Burman, B. A. Smolarski, Checked by J. Taguchi, H. Fujino, M. Inoue, "Catalytic Diazoalkane-Carbonyl Homologation: Synthesis of 2,2-Diphenylcycloheptanone and Other Quaternary or Tertiary Arylalkanones and Spirocycles by Ring Expansion," Org. Synth. 2021, 98, 343-362.
    DOI: 10.15227/orgsyn.098.0343