研究業績

2018

Small-molecule inhibition of TLR8 through stabilization of its resting state
Shuting Zhang, Zhenyi Hu, Hiromi Tanji, Shuangshuang Jiang, Nabanita Das, Jing Li, Kentaro Sakaniwa, Jin Jin, Yanyan Bian, Umeharu Ohto, Toshiyuki Shimizu & Hang Yin
Nature Chem. Biol.14,58-64

Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation.
Ohto U, Ishida H, Shibata T, Sato R, Miyake K, Shimizu T.
Immunity 48, 649-658

Mechanisms controlling nucleic acid-sensing Toll-like receptors
Miyake K, Shibata T, Ohto U, Shimizu T, Saitoh SI, Fukui R, Murakami Y
Int. Immunol. 30, 43-51

Structural basis for species-specific activation of mouse Toll-like receptor 9.
Ishida H, Ohto U, Shibata T, Miyake K, Shimizu T.
FEBS Lett 592, 2636-2646

Small-molecule TLR8 antagonists based on structure-based rational design
Hu, Z., Tanji, H., Jiang, S. Zhang, S., Koo, K., Chan, J., Sakaniwa, K., Ohto U, Candia, A., Shimizu T & Yin H
Cell Chem. Biol. 25, 1286-1291

GEF mechanism revealed by the structure of SmgGDS-558 and farnesylated RhoA complex and its implication for chaperone mechanism
Shimizu, H., Toma-Fukai, S., Kontani, K., Katada, T. and Shimizu, T.
Proc. Natl. Acad. Sci., USA 115, 9563-9568

Structural analysis of HTL and D14 proteins reveals the basis for ligand selectivity in Striga.
Xu Y, Miyakawa T, Nosaki S, Nakamura A, Lyu Y, Nakamura H, Ohto U, Ishida H, Shimizu T, Asami T, Tanokura M.
Nature comm. 9, 3947

Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Zhang Z, Ohto U, Shibata T, Taoka M, Yamauchi Y, Sato R, Shukla NM, David SA, Isobe T, Miyake K, Shimizu T.
Cell reports 25, 3371-3381.e5

Toll様受容体TLR8の低分子阻害剤は不活性型の二量体構造を安定化する
丹治裕美、清水敏之
臨床免疫・アレルギー科 70, 187-192

TLRの構造とリガンド認識機構
大戸梅治
医学のあゆみ 265, 1061-1066


Japanese / English
東京大学
東京大学大学院 薬学系研究科・薬学部
PF-UA タンパク質結晶構造解析ユーザーグループ