研究業績

2012

Structural analyses of human Toll-like receptor 4 polymorphisms D299G and T399I (2012)
Ohto U., Yamakawa N., Akashi-Takamura S., Miyake K. and Shimizu T.
J.Biol.Chem. 287, 40611-40617

Coagulation Factor X Activates Innate Immunity to Human Species C Adenovirus. (2012)
Doronin K, Flatt JW, Di Paolo NC, Khare R, Kalyuzhniy O, Acchione M, Sumida JP, Ohto U, Shimizu T, Akashi-Takamura S, Miyake K, Macdonald JW, Bammler TK, Beyer RP, Farin FM, Stewart PL, Shayakhmetov DM.
Science 338, 795-798

Crystallization and X-ray diffraction analysis of the ternary complex of the C-terminal domain of human REV1 in complex with REV7 bound to a REV3 fragment involved in translesion DNA synthesis (2012)
Kikuchi S, Hara K, Shimizu T, Sato M, Hashimoto H.
Acta Crystallogr F68, 962-964

Structural Basis of Recruitment of DNA Polymerase ζ by Interaction between REV1 and REV7 Proteins (2012)
Kikuchi S, Hara K, Shimizu T, Sato M, Hashimoto H.
J Biol Chem. 287, 33847-33852

Structural basis for the inhibition of xyloglucan-specific endo-β-1,4-glucanase (XEG) by XEG-protein inhibitor (2012)
Yoshizawa, Y., Shimizu, T., Hirano, H., Sato, M., Hashimoto, H.
J.Biol.Chem. 287, 18710-18716

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2 (2012)
Ohto, U., Fukase, K., Miyake, K., and Shimizu, T
Proc. Natl. Acad. Sci., USA 109, 7421-7426

Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation. (2012)
Eguchi, K., Manabe, I., Oishi-Tanaka, Y., Ohsugi, M., Kono, N., Ogata, F., Yagi, N., Ohto, U., Kimoto, M., Miyake, K., Tobe, K., Arai, H., Kadowaki, T., & Nagai, R.
Cell Metab. 15, 1-16.

Mechanistic insights into the activation of rad51-mediated strand exchange from the structure of a recombination activator, the swi5-sfr1 complex. (2012)
Kuwabara N, Murayama Y, Hashimoto H, Kokabu Y, Ikeguchi M, Sato M, Mayanagi K, Tsutsui Y, Iwasaki H, Shimizu T. 
Structure 20, 440-449.

Peroxisome Proliferator-activatedreceptors (PPARs) have multiple binding points that accommodate ligands invarious conformations: Phenypropanoic acid-type PPAR ligands bind to PPAR indifferent conformations, depending on the subtype (2012)
Kuwabara N, Oyama T, Tomioka D, Ohashi M, Yanagisawa J, Shimizu T, Miyachi H 
J. Med. Chem. 55, 893-902

Crystal Structure of Human β-Galactosidase: The Structural Basis of GM1 Gangliosidosis and Morquio B Diseases (2012)
Ohto U, Usui K, , Ochi T, ,Yuki K, Satow Y and Shimizu T 
J. Biol. Chem. 287, 1801-1812

Expression, purification, crystallisation and preliminary X-ray crystallographic analysis of human β-Galactosidase (2012)
Usui K, Ohto U, Ochi T, Shimizu T, and Satow Y
Acta Crystallogr. F68, 73-77


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東京大学
東京大学大学院 薬学系研究科・薬学部
PF-UA タンパク質結晶構造解析ユーザーグループ