研究業績

2014

The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane
Tanimura N, Saitoh SI, Ohto U, Akashi-Takamura S, Fujimoto Y, Fukase K, Shimizu T, Miyake K
Int. Immunol. 26, 307-314

Protein arginine methyltransferase 7 has a novel homodimer-like structure formed by tandem repeats
Hasegawa M, Toma-Fukai S, Kim JD, Fukamizu A, Shimizu T.
FEBS letters 588, 1942-1948

Structural basis of pharmacological chaperoning for human β-galactosidase
Suzuki H, Ohto U, Higaki K, Mena-Barragan T, Aguilar-Moncayo M, Mellet CO, Nanba E, M Garcia Fernandez J, Suzuki Y, Shimizu T.
J. Biol. Chem. 289, 14560-14568

Swi5-Sfr1 protein stimulates Rad51-mediated DNA strand exchange reaction through organization of DNA bases in the presynaptic filament.
Fornander LH, Renodon-Cornière A, Kuwabara N, Ito K, Tsutsui Y, Shimizu T, Iwasaki H, Nordén B, Takahashi M.
Nucleic Acid Res. 42, 2358-2365

Structure-Based Design of Novel Human Toll-like Receptor 8 Agonists
Hari Prasad Kokatla, Sil D, Tanji H, Ohto U, Subbalakshmi S. Malladi, Lauren M. Fox, Shimizu T and Sunil A. David
ChemMedChem 9, 719-723

Structure and function of Toll-like receptor 8
Ohto, U., Tanji, H., Shimizu, T.
Microbes and Infection 16, 273-282

Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure-Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds
Yoo E, Salunke D, Sil D, Guo X, Salyer A, Hermanson A, Kumar M, Malladi SS, Balakrishna R, Thompson WH, Tanji H, Ohto U, Shimizu T, David SA.
J. Med. Chem. 57, 7955-7970

構造科学的視点から見た自然免疫に関わるToll様受容体
清水敏之
実験医学 32, 1661-1665

Drug Design – Structure and ligand-based approaches Merz Jr., K.M., Ringe D., Reynolds C.H.
ドラッグデザイン 構造とリガンドに基づくアプローチ 田之倉優、小島正樹 監訳
15章 プリンヌクレオシドホスホリラーゼを標的とした遷移状態類似体設計 
清水敏之
東京化学同人