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Research Interests

Our bodies have hundreds of cell types that each have distinct jobs, but they all contain the same genetic information. Our lab asks how the distinct fates of cells during development and homeostasis are determined by both cell-intrinsic programs and by environmental inputs.
Our first research goal is to understand the molecular basis of brain development with an emphasis on the regulation of neural stem/progenitor cell fate. Our second goal is to understand the intracellular signal transduction pathways that regulate cell proliferation, survival/death and migration, and the involvement of these pathways in tumorigenesis.

More ⇒ Research Projects   

Selected Recent Publications

Nagao M, Ogata T, Sawada Y, Gotoh Y.
Zbtb20 promotes astrocytogenesis during neocortical development.
Nat. Commun., 7, 11102, 2016
Itoh Y, Higuchi M, Oishi K, Kishi Y, Okazaki T, Sakai H, Miyata T, Nakajima K, Gotoh Y.
PDK1-Akt pathway regulates radial neuronal migration and microtubules in the developing mouse neocortex.
Proc. Natl. Acad. Sci. U.S.A., 113(21):E2955-64, 2016
Furutachi S, Miya H, Watanabe T, Kawai H, Yamasaki N, Harada Y, Imayoshi I, Nelson M, Nakayama KI, Hirabayashi Y, Gotoh Y.
Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells.
Nat. Neurosci. 18, 657-65, 2015
Highlighted by a News and Views article of Nat Neurosci.
Okazaki T, Higuchi M, Takeda K, Iwatsuki-Horimoto K, Kiso M, Miyagishi M, Yanai H, Kato A, Yoneyama M, Fujita T, Taniguchi T, Kawaoka Y, Ichijo H, Gotoh Y.
The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response.
Sci. Signal., 8, ra78, 2015
Morimoto-Suzki N, Hirabayashi Y, Tyssowski K, Shinga J, Vidal M, Koseki H, Gotoh Y.
The polycomb component Ring1B regulates the timed termination of subcerebral projection neuron production during mouse neocortical development.
Development 141, 4343-53, 2014
Selected by "Faculty of 1000"
Kawaguchi, D., Furutachi, S., Kawai, H., Hozumi, K. and Gotoh, Y.
Dll1 maintains quiescence of adult neural stem cells and segregates asymmetrically during mitosis.
Nat. Commun. 4, 1880, 2013.
Furutachi, S., Matsumoto, A., Nakayama, K.I. and Gotoh, Y.
p57 controls adult neural stem cell quiescence and modulates the pace of lifelong neurogenesis.
EMBO J. 32, 970-981, 2013.
Itoh, Y., Moriyama, Y., Hasegawa, T., Endo, T.A., Toyoda, T. and Gotoh, Y.
Scratch regulates neuronal migration onset via an epithelial-mesenchymal transition-like mechanims.
Nat. Neurosci. 16, 416-425, 2013.
Kishi, Y., Fujii, Y., Hirabayashi, Y. and Gotoh, Y.
HMGA proteins regulate global chromatin state and the neurogenic potential in neocortical precursor cells.
Nat. Neurosci. 15, 1127-1133, 2012.
Onoguchi, M., Hirabayashi, Y., Koseki, H. and Gotoh, Y.
A noncoding RNA regulates the neurogenin1 gene locus during mouse neocortical development.
Proc. Natl. Acad. Sci. U.S.A. 109, 16939-16944, 2012.
Kuwahara, A., Hirabayashi, Y., Knoepfler, P.S., Taketo, M.M., Sakai, J., Kodama, T. and Gotoh, Y.
Wnt signaling and its downstream target N-myc regulate basal progenitors in the developing neocortex.
Development 137, 1035-1044, 2010.
Hirabayashi, Y., Suzki, N., Tsuboi, M., Endo, T.A., Toyoda, T., Shinga, J., Koseki, H., Vidal, M. and Gotoh, Y.
Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition.
Neuron 63, 600-613, 2009.
Oishi, K., Watatani, K., Itoh, Y., Okano, H., Guillemot, F., Nakajima, K. and Gotoh, Y.
Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1.
Proc. Natl. Acad. Sci. U.S.A. 106, 13064-13069, 2009.
Higuchi, M., Onishi, K., Yoneyama, C. and Gotoh, Y.
Scaffolding function of PAK in the PDK1-Akt pathway.
Nat. Cell Biol. 10, 1356-1364, 2008.
Kawaguchi, D., Yoshimatsu, T., Hozumi, K. and Gotoh, Y.
Selection of differentiating cells by different levels of delta-like 1 among neural precursor cells in the developing mouse telencephalon.
Development 135, 3849-3858, 2008.
Mori, Y., Higuchi, M., Hirabayashi, Y., Fukuda, M. and Gotoh, Y.
JNK phosphorylates Syt 4 and enhances Ca2+-evoked release.
EMBO J. 27, 76-87, 2008.
More ⇒ Published Papers   

Graduate School of Pharmaceutical Sciences, The University of Tokyo
Institute of Molecular and Cellular Biosciences, The University of Tokyo
Department of Chemistry and Biotechnology, School of Engineering,
The University of Tokyo
Department of Integrated Biosciences, The Graduate School of Frontier Sciences,
The University of Tokyo
JST-CREST Basic Reaserch Programs "Elucidation of the Principles of Formation and Function of the Brain Neural Network and Creation of Control Technologies"
JST-CREST Basic Reaserch Programs "Innovation for Ideal Medical Treatment Based on the Understanding of Maintenance, Change and Breakdown Mechanisms of Homeostasis among Interacting Organ Systems"