発表論文リスト
Omiya H, Yamaguchi S, Watanabe T, Kuniya T, Harada Y, Kawaguchi D, Gotoh Y.
BMP signaling suppresses Gemc1 expression and ependymal differentiation of mouse telencephalic progenitors.
Sci Rep., 11(1):613, 2021.
Eto H, Kishi Y, Yakushiji-Kaminatsu N, Sugishita H, Utsunomiya S, Koseki H, Gotoh Y.
The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon.
Nat. Commun., 11(1):5709, 2020.
Aoyama-Ishiwatari S, Okazaki T, Iemura S, Natsume T, Okada Y, Gotoh Y.
NUDT21 links mitochondrial IPS-1 to RLR-containing stress granules and activates host antiviral defense.
J. Immunol., in press 2020.
Nagahama K, Sakoori K, Watanabe T, Kishi Y, Kawaji K, Koebis M, Nakao K, Gotoh Y, Aiba A, Uesaka N, Kano M.
Setd1a insufficiency in mice attenuates excitatory synaptic function and recapitulates Schizophrenia-related behavioral abnormalities.
Cell Rep., 32(11):108126, 2020.
Nakagawa T, Wada Y, Katada S, Kishi Y.
Epigenetic regulation for acquiring glial identity by neural stem cells during cortical development.
Glia, 68(8):1554-1567, 2020. Review.
Imaizumi Y, Furutachi S, Watanabe T, Miya H, Kawaguchi D, Gotoh Y.
Role of the imprinted allele of the Cdkn1c gene in mouse neocortical development.
Sci Rep., 10(1):1884, 2020.
Tsuboi M, Gotoh Y.
Endfoot regrowth for neural stem cell renewal.
Nat Cell Biol., 22(1):3-5, 2020. Preview.
Sakai H*, Fujii Y*, Kuwayama N, Kawaji K, Gotoh Y, Kishi Y*.
(*These authors contributed equally to this work.)
Plag1 regulates neuronal gene expression and neuronal differentiation of neocortical neural progenitorcells.
Genes Cells, 24(10):650-666, 2019.
Tsuboi M, Hirabayashi Y, Gotoh Y.
Diverse gene regulatory mechanisms mediated by Polycomb group proteins during neural development.
Curr. Opin. Neurobiol., 59:164-173, 2019. Review.
Kawaguchi D, Gotoh Y.
Neurexin nanoclusters: A novel structure at presynaptic terminals.
J Cell Biol., 218(8):2442-2443, 2019. Preview.
Hashimoto K*, Yamaguchi Y*, Kishi Y*, Kikko Y, Takasaki K, Maeda Y, Matsumoto Y, Oka M, Miura M, Ohata S, Katada T, Kontani K.
(*These authors contributed equally to this work.)
Loss of the small GTPase Arl8b results in abnormal development of the roof plate in mouse embryos.
Genes Cells, 24(6):436-448, 2019.
Tanaka H, Okazaki T, Aoyama S, Yokota M, Koike M, Okada Y, Fujiki Y, Gotoh Y.
Peroxisomes control mitochondrial dynamics and the mitochondrion-dependent pathway of apoptosis.
J. Cell Sci., 132(11), 2019.
Highlighted by a First Person article of J. Cell Sci.
Tsuboi M*, Kishi Y*, Yokozeki W, Koseki H, Hirabayashi Y, Gotoh Y.
(*These authors contributed equally to this work.)
Ubiquitination-Independent Repression of PRC1 Targets during Neuronal Fate Restriction in the Developing Mouse Neocortex.
Dev Cell., 47(6):758-772.e5, 2018.
Kishi Y, Gotoh Y.
Regulation of Chromatin Structure During Neural Development.
Frontiers Neurosci.,12:874, 2018. Review.
Okazaki T, Gotoh Y.
An Unexpected Calm: Mfge8 Controls Stem Cell Quiescence and Maintenance.
Cell Stem Cell,6;23(3):311-312, 2018. Preview.
Lanjakornsiripan D*, Pior BJ*, Kawaguchi D*, Furutachi S, Tahara T, Katsuyama Y, Suzuki Y, Fukazawa Y, Gotoh Y.
(*These authors contributed equally to this work.)
Layer-specific morphological and molecular differences in neocortical astrocytes and their dependence on neuronal layers.
Nat Commun., 9(1), 1623, 2018.
Kawai H, Kawaguchi D, Kuebrich BD, Kitamoto T, Yamaguchi M, Gotoh Y, Furutachi S.
Area-Specific Regulation of Quiescent Neural Stem Cells by Notch3 in the Adult Mouse Subependymal Zone.
J Neurosci., 37(49):11867-11880, 2017.
Okazaki T.
ASK family in infection and inflammatory disease.
Advances in Biological Regulation, S2212-4926(17)30144-6, 2017. Review.
Itoh Y, Higuchi M, Oishi K, Kishi Y, Okazaki T, Sakai H, Miyata T, Nakajima K, Gotoh Y.
PDK1-Akt pathway regulates radial neuronal migration and microtubules in the developing mouse neocortex.
Proc. Natl. Acad. Sci. USA., 113(21):E2955-64, 2016.
Nagao M, Ogata T, Sawada Y, Gotoh Y.
Zbtb20 promotes astrocytogenesis during neocortical development.
Nat Commun., 7, 11102, 2016.
Okazaki T, Higuchi M, Takeda K, Iwatsuki-Horimoto K, Kiso M, Miyagishi M, Yanai H, Kato A, Yoneyama M, Fujita T, Taniguchi T, Kawaoka Y, Ichijo H, Gotoh Y.
The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response.
Sci Signal., 8, ra78, 2015.
Free access:
Summary
Abstract
Full Text
Featured as a cover in this issue of Sci Signal.
Editorial in Oncotarget
Furutachi S, Miya H, Watanabe T, Kawai H, Yamasaki N, Harada Y, Imayoshi I, Nelson M, Nakayama KI, Hirabayashi Y, Gotoh Y.
Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells.
Nat Neurosci., 18, 657-65, 2015.
Highlighted by a News and Views article of Nat Neurosci.
Oshiro H, Hirabayashi Y, Furuta Y, Okabe S, Gotoh Y.
Up-regulation of HP1γ expression during neuronal maturation promotes axonal and dendritic development in mouse embryonic neocortex.
Genes Cells, 20, 108-20, 2015.
Morimoto-Suzki N, Hirabayashi Y, Tyssowski K, Shinga J, Vidal M, Koseki H, Gotoh Y.
The polycomb component Ring1B regulates the timed termination of subcerebral projection neuron production during mouse neocortical development.
Development, 141, 4343-53, 2014.
Selected by "Faculty of 1000"
Nagao M, Lanjakornsiripan D, Itoh Y, Kishi Y, Ogata T, Gotoh Y.
High mobility group nucleosome-binding family proteins promote astrocyte differentiation of neural precursor cells.
Stem Cells, 32, 2983-97, 2014.
Kuwahara A*, Sakai H*, Xu Y*, Itoh Y, Hirabayashi Y, Gotoh Y.
(*These authors contributed equally to this work.)
Tcf3 Represses Wnt-β-Catenin Signaling and Maintains Neural Stem Cell Population during Neocortical Development.
PLoS One, 9(5):e94408, 2014.
Tyssowski K, Kishi Y, Gotoh Y.
Chromatin regulators of neural development.
Neuroscience, 264, 4-16, 2014. Review.
Itoh, Y.*, Tyssowski, K.* and Gotoh, Y.
(*These authors contributed equally to this review.)
Transcriptional coupling of neuronal fate commitment and the onset of migration.
Curr. Opin. Neurobiol., 23, 957-64, 2013. Review.
Kawaguchi, D., Furutachi, S., Kawai, H., Hozumi, K. and Gotoh, Y.
Dll1 maintains quiescence of adult neural stem cells and segregates asymmetrically during mitosis.
Nat. Commun., 4, 1880, 2013.
Okazaki, T., Higuchi, M. and Gotoh, Y.
Mitochondrial localization of the antiviral signaling adaptor IPS-1 is important for its induction of caspase activation.
Genes Cells, 18, 493-501, 2013.
Furutachi, S., Matsumoto, A., Nakayama, K.I. and Gotoh, Y.
p57 controls adult neural stem cell quiescence and modulates the pace of lifelong neurogenesis.
EMBO J., 32, 970-81, 2013.
Itoh, Y., Moriyama, Y., Hasegawa, T., Endo, T.A., Toyoda, T. and Gotoh, Y.
Scratch regulates neuronal migration onset via an epithelial-mesenchymal transition-like mechanism.
Nat. Neurosci., 16, 416-25, 2013.
Fujii, Y., Kishi, Y. and Gotoh, Y.
IMP2 regulates differentiation potentials of mouse neocortical neural precursor cells.
Genes Cells, 18, 79-89, 2013.
Higuchi, M., Kihara, R., Okazaki, T., Aoki, I., Suetsugu, S. and Gotoh, Y.
Akt1 promotes focal adhesion disassembly and cell motility through phosphorylation of FAK in growth factor-stimulated cells.
J. Cell Sci., 126, 745-55, 2013.
Onoguchi, M., Hirabayashi, Y., Koseki, H. and Gotoh, Y.
A noncoding RNA regulates the neurogenin1 gene locus during mouse neocortical development.
Proc.Natl.Acad.Sci.USA, 109, 16939-44. 2012.
Kishi, Y.*, Fujii, Y.*, Hirabayashi, Y. and Gotoh, Y.
(*These authors contributed equally to this work.)
HMGA regulates the global chromatin state and neurogenic potential in neocortical precursor cells.
Nat. Neurosci., 15, 1127-33, 2012.
Aoki, I., Higuchi, M. and Gotoh, Y.
NEDDylation controls the target specificity of E2F1 and apoptosis induction.
Oncogene, 32, 3954-64, 2012.
Kishi, Y.*, Kondo, S.* and Gotoh, Y.
(*These authors contributed equally to this work.)
Transcriptional activation of mouse major satellite regions during neuronal differentiation.
Cell Struct. Funct., 37, 101-10, 2012.
Watatani, K., Hirabayashi, Y., Itoh, Y. and Gotoh, Y.
PDK1 regulates the generation of oligodendrocyte precursor cells at an early stage of mouse telencephalic development.
Genes Cells, 17, 326-335, 2012.
Ip, J.P.*, Shi, L.*, Chen, Y., Itoh, Y., Fu, W.Y., Betz, A., Yung, W.H., Gotoh, Y., Fu, A.K. and Ip, N.Y.
(*These authors contributed equally to this work.)
a2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2.
Nat. Neurosci., 15, 39-47, 2011.
Hirabayashi, Y. and Gotoh, Y.
Epigenetic control of neural precursor cell fate during development.
Nat. Rev. Neurosci., 11, 377-88, 2010. Review.
Miyata, T., Kawaguchi, D., Kawaguchi, A. and Gotoh Y.
Mechanisms that regulate the number of neurons during mouse neocortical development.
Curr. Opin. Neurobiol., 20, 22-8, 2010. Review.
Kuwahara, A., Hirabayashi, Y., Knoepfler, P.S., Taketo, M.M.,Sakai, J., Kodama, T. and Gotoh, Y.
Wnt signaling and its downstream target N-Myc regulate basal progenitors in the developing neocortex.
Development, 137, 1035-44, 2010.
Hirabayashi, Y., Suzki, N., Tsuboi, M., Endo, T.A., Toyoda, T., Shinga, J., Koseki, H., Vidal, M. and Gotoh, Y.
Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition.
Neuron, 63, 600-613, 2009.
Oishi, K., Watatani, K., Itoh, Y., Okano, H., Guillemot, F., Nakajima, K. and Gotoh, Y.
Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1.
Proc.Natl.Acad.Sci.USA, 106, 13064-9, 2009.
Kawaguchi, D., Yoshimatsu, T., Hozumi, K. and Gotoh, Y.
Selection of differentiating cells by different levels of Delta-like 1 among neural precursor cells in the developing mouse telencephalon.
Development 135, 3849-3858. (2008)
Higuchi, M., Onishi, K.,
Kikuchi, C. and Gotoh, Y.
Scaffolding function of PAK in the PDK1-Akt
pathway.
Nat. Cell Biol. 10, 1356-1364. (2008)
Mori, Y.,
Higuchi, M., Hirabayashi, Y., Fukuda, M. and Gotoh, Y.
JNK phosphorylates
synaptotagmin-4 and enhances Ca2+-evoked release.
EMBO J. 27, 76-87.
(2008)
Adachi, K., Mirzadeh, Z., Sakaguchi, M., Yamashita, T.,
Nikolcheva, T., Gotoh, Y., Peltz, G., Gong, L., Kawase, T., Alvarez-Buylla, A.,
Okano, H. and Sawamoto, K.
Beta-catenin signaling promotes proliferation of
progenitor cells in the adult mouse subventricular zone.
Stem Cells.
25, 2827-36. (2007)
Ura, S., Nishina, H., Gotoh, Y. and Katada,
T.
Activation of the c-Jun N-terminal kinase pathway by MST1 is essential and
sufficient for the induction of chromatin condensation during
apoptosis.
Mol Cell Biol. 27, 5514-22. (2007)
Onishi, K.,
Higuchi, M., Asakura, T., Masuyama, N. and Gotoh, Y.
The PI3K-Akt pathway
promotes microtubule stabilization in migrating fibroblasts.
Genes
Cells. 12, 535-46. (2007)
Hayakawa-Yano, Y., Nishida, K., Fukami, S.,
Gotoh, Y., Hirano, T., Nakagawa, T., Shimazaki, T. and Okano, H.
Epidermal
growth factor signaling mediated by grb2 associated binder1 is required for the
spatiotemporally regulated proliferation of olig2-expressing progenitors in the
embryonic spinal cord.
Stem Cells. 25, 1410-22. (2007)
Itoh,
Y., Masuyama, N., Nakayama, K., Nakayama, KI. and Gotoh Y.
The
cyclin-dependent kinase inhibitors p57 and p27 regulate neuronal migration in
the developing mouse neocortex.
J Biol Chem. 282, 390-6.
(2007)
Yoshizaki, H., Mochizuki, N., Gotoh, Y. and Matsuda,
M.
Akt-PDK1 complex mediates epidermal growth factor-induced membrane
protrusion through Ral activation.
Mol Biol Cell. 18, 119-28.
(2007)
Yoshimatsu, T., Kawaguchi, D., Oishi, K., Takeda, K., Akira, S.,
Masuyama N. and Gotoh Y.
Non-cell-autonomous action of STAT3 in maintenance
of neural precursor cells in the mouse neocortex.
Development. 133,
2553-63. (2006)
Sunayama, J.,Tsuruta, F., Masuyama, N. and Gotoh,
Y.
JNK antagonizes Akt-mediated survival signals by phosphorylating
14-3-3.
J. Cell. Biol. 170, 295-304. (2005)
Takada, T., Suzuki,
H., Gotoh, Y. and Sugiyama, Y.
Regulation of the cell surface expression of
human BCRP/ABCG2 by the phosphorylation state of Akt in polarized
cells.
Drug Metab Dispos. 33, 905-9. (2005)
Hirabayashi, Y. and
Gotoh, Y.
Stage-dependent fate determination of neural precursor cells in
mouse forebrain.
Neurosci. Res. 51, 331-336. (2005) Review.
Mori, Y.,
Higuchi, M., Masuyama, N. and Gotoh Y.
Adenosine A2A receptor facilitates
calcium-dependent protein secretion through the activation of protein kinase A
and phosphatidylinositol-3 kinase in PC12 cells.
Cell. Struct.
Funct. 29, 101-110. (2004)
Oishi, K., Kamakura S., Isazawa Y.,
Yoshimatsu T., Kuida K., Nakafuku M., Masuyama, N. and Gotoh, Y.
Notch
promotes survival of neural precursor cells via mechanisms distinct from those
regulating neurogenesis.
Dev. Biol. 276, 172-184.
(2004)
Kamakura, S., Oishi, K., Yoshimatsu, T., Nakafuku, M., Masuyama,
N. and Gotoh, Y.
Hes binding to STAT3 mediates crosstalk between Notch and
JAK-STAT signaling.
Nat. Cell Biol. 6, 547-554. (2004)
Tsuruta,
F., Sunayama, J., Mori, Y., Shimizu, S., Tsujimoto, Y., Yoshioka, K., Masuyama,
N. and Gotoh, Y.
JNK promotes Bax translocation to mitochondria through
phosphorylation of 14-3-3 proteins.
EMBO J. 23, 1889-1899.
(2004)
Hirabayashi, Y., Itoh, Y., Tabata, H., Nakajima, K., Akiyama, T.,
Masuyama, N. and Gotoh, Y.
The Wnt-beta-catenin pathway directs neuronal
differentiation of cortical neural precursor cells.
Development 131,
2791-2801. (2004)
Miyagi, S., Saito, T., Mizutani, K., Masuyama, N.,
Gotoh, Y., Iwama, A., Nakauchi, H., Masui, S., Niwa, H., Nishimoto, M.,
Muramatsu, M. and Okuda, A.
The sox-2 regulatory regions display their
activities in two distinct multipotent stem cells.
Mol. Cell. Biol.
24, 4207-4220. (2004)
Higuchi, M., Onishi, K., Masuyama, N. and
Gotoh, Y.
The phosphatidylinositol-3 kinase (PI3K)-Akt pathway suppresses
neurite branch formation in NGF-treated PC12 cells.
Genes Cells 8,
657. (2003)
Fujishiro, M., Gotoh, Y., Katagiri, H., Sakoda, H., Ogihara, T.,
Anai, M., Onishi, Y., Ono, H., Abe, M., Shojima, N., Fukushima, Y., Kikuchi, M.,
Oka, Y. and Asano, T.
Three Mitogen-Activated Protein kinases inhibit Insulin
signaling by different mechanisms in 3T3-L1 adipocytes.
Mol. Endocrinology
17, 487-497. (2003)
Sakoda, H., Gotoh, Y., Katagiri, H., Kurokawa,
M., Ono, H., Onishi, Y., Anai, M., Ogihara, T., Fujishiro, M., Fukushima, Y.,
Abe, M., Shojima, N., Kikuchi, M., Oka, Y., Hirai, H. and Asano, T.
Differing
roles of Akt and SGK in glucose metabolism, DNA synthesis and oncogenic
activity.
J. Biol. Chem. 278, 25802-25807. (2003)
Katome, T.,
Obata, T., Matsushima, R., Masuyama, N., Cantley, L.C., Gotoh, Y., Kishi, K.,
Shiota, H. and Ebina, Y.
Use of RNA-interference-mediated gene silencing and
adenoviral overexpression to elucidate the roles of AKT/PKB-isoforms in insulin
actions.
J. Biol. Chem. 278, 28312-28323. (2003)
Ogawara, Y.,
Kishishita, S., Obata, T., Suzuki, T., Tanaka, K., Masuyama, N. and Gotoh,
Y.
Akt enhances Mdm2-mediated ubiquitination and degradation of p53.
J.
Biol. Chem. 277, 21843-21850. (2002)
Tsuruta, F., Masuyama, N. and
Gotoh, Y.
The PI3K-Akt pathway suppresses Bax translocation to
mitochondria.
J. Biol. Chem. 277, 14040-14047.
(2002)
Shinohara, M., Terada, Y., Iwamatsu, A., Shinohara, A., Mochizuki,
N., Higuchi, M., Gotoh, Y., Ihara, S., Nagata, S., Itoh, H., Fukui, Y. and
Jessberger, R.
SWAP-70 is a guanine nucleotide exchange factor that mediates
signaling of membrane ruffling.
Nature 416, 759-763.
(2002)
Higuchi, M., Masuyama, N., Suzuki, A. and Gotoh, Y.
Akt
mediates Rac/Cdc42-Regulated Cell Motility in Growth Factor-Stimulated Cells and
in Invasive PTEN-Knockout Cells.
Curr. Biol. 11, 1958-1962.
(2001)
Morishima, Y., Gotoh, Y., Barrett, T., Takano, H., Davis, R.J.,
Shirasaki, Y. and Greenberg, M.E.
β-Amyloid Induces Neuronal Apoptosis Via
JNK Pathway Activation and the Subsequent Induction of Fas Ligand.
J.
Neurosci. 21,7551-7560.(2001)
Masuyama, N., Oishi, K., Mori, Y.,
Ueno, T., Takahama, Y. and Gotoh, Y.
Akt Inhibits the Orphan Nuclear Receptor
Nur77 and T cell Apoptosis.
J. Biol. Chem. 276, 32799-32805.
(2001)
Ura, S., Masuyama, N., Graves, J. and Gotoh, Y.
Caspase
Cleavage of MST1 Promotes Nuclear Translocation and Chromatin
Condensation.
Proc.Natl.Acad.Sci.USA 98,
10148-10153.(2001)
Graves, J.D., Draves, K.E., Gotoh, Y., Krebs, E.G. and
Clark, E.A.
Both phosphorylation and caspase-mediated cleavage contribute to
regulation of the Ste-20-like Protein Kinase Mst1 during CD95/Fas-induced
apoptosis.
J. Biol. Chem. 276, 14909-14915. (2001)
Fujishiro,
M., Gotoh, Y., Katagiri, H., Sakoda, H., Ogihara, T., Anai, M., Onishi, Y., Ono,
H., Funaki, M., Inukai, K., Fukushima, Y., Kikuchi, M., Oka, Y. and Asano,
T.
MKK6/3 and p38 MAPK Pathway Activation is not Necessary for
Insulin-Induced Glucose Uptake, but Regulates Glucose Transporter
Expression.
J. Biol. Chem. 276, 19800-19806. (2001)
Ura, S.,
Masuyama, N., Graves, J. and Gotoh, Y.
MST1-JNK promotes apoptosis via
caspase-dependent and -independent pathways.
Genes Cells 6,
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Kawasaki, H., Fujii, H., Gotoh, Y., Morooka, T.,
Shimohama, S., Nishida, E. and Hirano, T.
Requirement for mitogen-activated
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J. Biol. Chem. 274,
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Gotoh, Y. and Cooper, J.A.
Reactive oxygen species
and dimerization-induced activation of ASK1 in TNFα signal
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J. Biol. Chem. 273, 17477-17482.(1998)
Shibuya,
H., Iwata, H., Masuyama, N., Gotoh, Y., Yamaguchi, K., Irie, K., Matsumoto, K.,
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Role of TAK1 and TAB1 in BMP signaling in early
Xenopus development.
EMBO J. 17, 1019-1028.(1998)
Graves, J.D.,
Gotoh, Y., Draves, K.E., Ambrose, D., Han, D., Wright, M., Chernoff, J., Clark,
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Caspase-mediated activation and induction of apoptosis
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EMBO J. 17, 2224-2234.
(1998)
Fukuda, M., Gotoh, I., Adachi, M., Gotoh, Y. and Nishida, E.
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EMBO J. 16,
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Datta, S.R., Dudek, H., Tao, X., Masters, S., Fu, H.,
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Akt phosphorylation of BAD couples survival
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Cell 91, 231-241.
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Kawasaki, H., Morooka, T., Shimohama, S., Kimura, J., Hirano, T.,
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Activation and involvement of p38 MAP kinase in
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J. Biol.
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Advances in
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Takenaka, K., Gotoh, Y. and Nishida,
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MAP kinase is required for the spindle assembly checkpoint, but
dispensable for the normal M phase entry and exit, in Xenopus egg cell cycle
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Fukuda, M.,
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Shimohama, S., Kimura, J., Gotoh, Y., and Nishida, E.
Ras-dependent and
Ras-independent activation pathways for the stress-activated-protein kinase
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Eur. J. Biochem. 241, 315-321.(1996)
Toda, T., Dhut,
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Fission yeast pmk1+ gene encodes a novel MAPK homologue which regulates
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Gotoh, Y. and Nishida, E.
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Biochemistry 35,
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TAB1: An activator of TAK1 MAPKKK in TGF-βsignal
transduction.
Science 272, 1179-1182. (1996)
Gotoh, Y. and
Nishida, E.
The MAP kinase cascade: Its role in Xenopus oocytes, eggs and
embryos.
Progress in Cell Cycle Research, 1, 287-297. (Meijer, L.,
Guidet, S. and Tung, H.Y.L., eds.) Plenum Press, New York, USA.
(1995)
Kato, S., Endo, H., Masuhiro, Y., Kitamoto, T., Uchiyama, S.,
Sasaki, H., Masushige, S., Gotoh, Y., Nishida, E., Kawashima, H., Metzger, D.
and Chambon, P.
Activation of the Estrogen Receptor through phosphorylation
by mitogen-activated protein kinase.
Science 270, 1491-1494.
(1995)
Moriguchi, T., Gotoh, Y. and Nishida, E.
Activation of two
isoforms of mitogen-activated protein kinase kinase in response to epidermal
growth factor and nerve growth factor.
Eur. J. Biochem. 234, 32-38.
(1995)
Gotoh, Y., Masuyama, N., Dell, K., Shirakabe, K. and Nishida,
E.
Initiation of Xenopus oocyte maturation by activation of the
mitogen-activated protein kinase cascade.
J. Biol. Chem. 270,
25898-25904. (1995)
Gotoh, Y. and Nishida, E.
Activation mechanism and
function of the MAP kinase cascade.
Molecular Reproduction and Development
42, 486-492. (1995)
Fukuda, M., Gotoh, Y., Tachibana, T., Dell, K.,
Hattori, S., Yoneda, Y. and Nishida, E.
Induction of neurite outgrowth by MAP
kinase in PC12 cells.
Oncogene 11, 239-244. (1995)
Shiina, N.,
Gotoh, Y. and Nishida, E.
Microtubule-severing activity in M
phase.
Trends Cell Biol. 5, 283-286. (1995)
Moriguchi, T.,
Kawasaki, H., Matsuda, S., Gotoh, Y. and Nishida, E.
Evidence for multiple
activators for stress-activated protein kinases / c-Jun amino-terminal kinases.
Existence of novel activators.
J. Biol. Chem. 270, 12969-12972.
(1995)
Matsuda, S., Kawasaki, H., Moriguchi, T., Gotoh, Y. and Nishida,
E.
Activation of protein kinase cascades by osmotic shock.
J. Biol.
Chem. 270, 12781-12786. (1995)
Gotoh, Y., Masuyama, N., Suzuki, A.,
Ueno, N. and Nishida, E.
Involvement of the MAP kinase cascade in Xenopus
mesoderm induction.
EMBO J. 14, 2491-2498. (1995)
Fukuda, M.,
Gotoh, Y., Kosako, H., Hattori, S. and Nishida, E.
Analysis of the Ras
p21/mitogen-activated protein kinase signaling in vitro and in Xenopus
oocytes.
J. Biol. Chem. 269, 33097-33101. (1994)
Kosako, H.,
Gotoh, Y. and Nishida, E.
Mitogen-activated protein kinase kinase is required
for the Mos-induced metaphase arrest.
J. Biol. Chem. 269, 28354-28358.
(1994)
Kosako, H., Gotoh, Y. and Nishida, E.
Regulation and function
of the MAP kinase cascade in Xenopus oocytes.
J. Cell Sci. 18
(supple.), 115-119. (1994)
Matsuda, S., Gotoh, Y. and Nishida,
E.
Signaling pathways mediated by the mitogen-activated protein (MAP) kinase
kinase/MAP kinase cascade.
J. Leukoc. Biol. 56, 548-553.
(1994)
Shiina, N., Gotoh, Y., Kubomura, J., Iwamatsu, A. & Nishida,
E.
Microtubule severing by elongation factor-1α.
Science 266,
282-285. (1994)
Irie, K., Gotoh, Y., Yasher, B.M., Errede, B., Nishida,
E. and Matsumoto, K.
Stimulatory effects of yeast and mammalian 14-3-3
proteins on the Raf protein kinase.
Science 265, 1716-1719.
(1994)
Gotoh, Y., Matsuda, S., Takenaka, K., Hattori, S., Iwamatsu, A.,
Ishikawa, M., Kosako, H. & Nishida, E.
Characterization of recombinant
Xenopus MAP kinase kinases mutated at potential phosphorylation
sites.
Oncogene 9, 1891-1898. (1994)
Kosako, H., Gotoh, Y.
& Nishida, E.
Requirement for the MAP kinase kinase/MAP kinase cascade in
Xenopus oocyte maturation.
EMBO J. 13, 2131-2138. (1994)
Ueki,
K., Matsuda, S., Tobe, K., Gotoh, Y., Tamemoto, H., Yachi, M., Akanuma, Y.,
Yazaki, Y., Nishida, E. and Kadowaki, T.
Feedback regulation of
mitogen-activated protein kinase kinase kinase activity of c-Raf-1 by insulin
and phorbol ester stimulation.
J. Biol. Chem. 269, 15756-15761.
(1994)
Bito, H., Mori, M., Sakanaka, C., Takano, T., Honda, Z., Gotoh,
Y., Nishida, E. & Shimizu, T.
Functional coupling of SSTR4, a major
hippocampal samatostatin receptor, to adenylate cyclase inhibition, arachidonate
release, and activation of the mitogen-activated protein kinase
cascade.
J. Biol. Chem. 269, 12722-12730. (1994)
Mizoguchi, T.,
Gotoh, Y., Nishida, E., Yamaguchi-Shinozaki, K., Hayashida, N., Iwasaki, T.,
Kamada, H. & Shinozaki, K.
Characterization of two cDNAs that encode MAP
kinase homologues in Arabidopsis thaliana and analysis of the possible role of
auxin in activating such kinase activities in cultured cells.
Plant J.
5, 111-122. (1994)
Honda, Z., Takano, T., Gotoh, Y., Nishida, E., Ito, K.
& Shimizu, T.
Transfected Platelet-activating factor activates
mitogen-activated protein kinase and MAP kinase kinase in chinese hamster ovary
cells.
J. Biol. Chem. 269, 2307-2315. (1994)
Gotoh, Y.,
Nishida, E., Shimanuki, M., Toda, T., Imai, Y. & Yamamoto,
M.
Schizosaccharomyces pombe Spk1 is a tyrosine-phosphorylated protein
functionally related to Xenopus mitogen-activated protein kinase.
Mol.
Cell. Biol. 13, 6427-6431. (1993)
Nishida, E. & Gotoh, Y.
The
MAP kinase cascade is essential for diverse signal tansduction
pathways.
Trends Biochem. Sci. 18, 128-131. (1993)
Lee, K.S.,
Irie, K., Gotoh, Y., Watanabe, Y., Araki, H., Nishida, E., Matsumoto, K. &
Levin, D.E.
A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates
signalling by protein kinase C.
Mol. Cell. Biol. 13, 3067-3075.
(1993)
Kosako, H., Nishida, E. & Gotoh, Y.
cDNA cloning of MAP
kinase kinase reveals kinase cascade pathways in yeasts to
vertebrates.
EMBO J. 12, 787-794. (1993)
Matsuda, S., Gotoh, Y.
& Nishida, E.
Phosphorylation of Xenopus MAP kinase kinase by MAP kinase
kinase kinase and MAP kinase.
J. Biol. Chem. 268, 3277-3281.
(1993)
Shiina, N., Gotoh, Y. & Nishida, E.
A novel homo-oligomeric
protein responsible for an MPF-dependent microtubule-severing
activity.
EMBO J. 11, 4723-4731. (1992)
Shiina, N., Moriguchi,
T., Ohta, K., Gotoh, Y. & Nishida, E.
Regulation of a major
microtubule-associated protein by MPF and MAP kinase.
EMBO J. 11,
3977-3984. (1992)
Hattori, S., Fukuda, M., Yamashita, T., Nakamura, S.,
Gotoh, Y. & Nishida, E.
Activation of MAP kinase and its activator by ras
in intact cells and in a cell-free system.
J. Biol. Chem. 267,
20346-20351. (1992)
Shirakabe, K., Gotoh, Y. & Nishida, E.
A MAP
kinase activating factor in mammalian mitogen-stimulated cells is homologous to
Xenopus M phase MAP kinase activator.
J. Biol. Chem. 267,
16685-16690. (1992)
Kosako, H., Gotoh, Y., Matsuda, S., Ishikawa, M.
& Nishida, E.
Xenopus MAP kinase activator is a serine/threonine/tyrosine
kinase activated by threonine phosphorylation.
EMBO J. 11, 2903-2908.
(1992)
Nishida, E. & Gotoh, Y.
MAP kinase and cytoskeleton in
mitogenic signal transduction.
Int. Rev. Cytol. 138, 211-238.
(1992)
Matsuda, S., Kosako, H., Takenaka, K., Moriyama, K., Sakai, H.,
Akiyama, T., Gotoh, Y. & Nishida, E.
Xenopus MAP kinase activator :
identification and function as a key intermediate in the phosphorylation
cascade.
EMBO J. 11, 973-982. (1992)
Hoshi, M., Ohta, K.,
Gotoh, Y., Mori, A., Murofushi, H., Sakai, H. & Nishida,
E.
Mitogen-activated-protein-kinase-catalyzed phosphorylation of
microtubule-associated proteins, microtubule-associated protein 2 and
microtubule-associated protein 4, induces an alteration in their
function.
Eur. J. Biochem. 203, 43-52. (1992)
Gotoh, Y.,
Moriyama, K., Matsuda, S., Okumura, E., Kishimoto, T., Kawakami, H., Suzuki, K.,
Yahara, I., Sakai, H. & Nishida, E.
Xenopus M phase MAP kinase :
isolation of its cDNA and activation by MPF.
EMBO J. 10, 2661-2668.
(1991)
Shinohara-Gotoh, Y., Nishida, E., Hoshi, M. & Sakai,
H.
Activation of microtubule-associated protein kinase by microtubule
disruption in quiescent rat 3Y1 cells.
Exp. Cell Res. 193, 161-166.
(1991)
Gotoh, Y., Nishida, E., Matsuda, S., Shiina, N., Kosako, H.,
Shiokawa, K., Akiyama, T., Ohta, K. & Sakai, H.
In vitro effects on
microtubule dynamics of purified Xenopus M phase-activated MAP
kinase.
Nature 349, 251-254. (1991)
Gotoh, Y., Nishida, E.
& Sakai, H.
Okadaic acid activates MAP kinase in quiescent fibroblastic
cells.
Eur. J. Biochem. 193, 671-674. (1990)
Gotoh, Y.,
Nishida, E., Yamashita, T., Hoshi, M., Kawakami, M. & Sakai, H.
MAP
kinase activated by nerve growth factor and epidermal growth factor in PC12
cells. Identity with the mitogen-activated MAP kinase of fibroblastic cells.
Eur. J. Biochem. 193, 661-669. (1990)
Shinohara, Y., Nishida,
E. & Sakai, H.
Initiation of DNA synthesis by microtubule disruption in
rat 3Y1 cells.
Eur. J. Biochem. 183, 275-280. (1989)
Shinohara, Y., Nishida-E. and Sakai, E.
Colchicine acts as a
progression factor to initiate DNA synthesis in quiescent Balb/c 3T3
cells.
FEBS lett. 236, 19-22. (1988)
Hoshi, M., Akiyama, T.,
Shinohara, Y., Miyata, Y., Ogawara, H., Nishida, E. and Sakai,
H.
Protein-kinase-C-catalyzed phosphorylation of the microtubule-binding
domain of microtubule-associated protein 2 inhibits its ability to induce
tubulin polymerization.
Eur. J. Biochem. 174, 225-230. (1988)