発表論文リスト

Omiya H, Yamaguchi S, Watanabe T, Kuniya T, Harada Y, Kawaguchi D, Gotoh Y.
BMP signaling suppresses Gemc1 expression and ependymal differentiation of mouse telencephalic progenitors.
Sci Rep., 11(1):613, 2021.

Eto H, Kishi Y, Yakushiji-Kaminatsu N, Sugishita H, Utsunomiya S, Koseki H, Gotoh Y.
The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon.
Nat. Commun., 11(1):5709, 2020.

Aoyama-Ishiwatari S, Okazaki T, Iemura S, Natsume T, Okada Y, Gotoh Y.
NUDT21 links mitochondrial IPS-1 to RLR-containing stress granules and activates host antiviral defense.
J. Immunol., in press 2020.

Nagahama K, Sakoori K, Watanabe T, Kishi Y, Kawaji K, Koebis M, Nakao K, Gotoh Y, Aiba A, Uesaka N, Kano M.
Setd1a insufficiency in mice attenuates excitatory synaptic function and recapitulates Schizophrenia-related behavioral abnormalities.
Cell Rep., 32(11):108126, 2020.

Nakagawa T, Wada Y, Katada S, Kishi Y.
Epigenetic regulation for acquiring glial identity by neural stem cells during cortical development.
Glia, 68(8):1554-1567, 2020. Review.

Imaizumi Y, Furutachi S, Watanabe T, Miya H, Kawaguchi D, Gotoh Y.
Role of the imprinted allele of the Cdkn1c gene in mouse neocortical development.
Sci Rep., 10(1):1884, 2020.

Tsuboi M, Gotoh Y.
Endfoot regrowth for neural stem cell renewal.
Nat Cell Biol., 22(1):3-5, 2020. Preview.

Sakai H, Fujii Y, Kuwayama N, Kawaji K, Gotoh Y, Kishi Y.
(These authors contributed equally to this work.)
Plag1 regulates neuronal gene expression and neuronal differentiation of neocortical neural progenitorcells.
Genes Cells, 24(10):650-666, 2019.

Tsuboi M, Hirabayashi Y, Gotoh Y.
Diverse gene regulatory mechanisms mediated by Polycomb group proteins during neural development.
Curr. Opin. Neurobiol., 59:164-173, 2019. Review.

Kawaguchi D, Gotoh Y.
Neurexin nanoclusters: A novel structure at presynaptic terminals.
J Cell Biol., 218(8):2442-2443, 2019. Preview.

Hashimoto K, Yamaguchi Y, Kishi Y, Kikko Y, Takasaki K, Maeda Y, Matsumoto Y, Oka M, Miura M, Ohata S, Katada T, Kontani K.
(These authors contributed equally to this work.)
Loss of the small GTPase Arl8b results in abnormal development of the roof plate in mouse embryos.
Genes Cells, 24(6):436-448, 2019.

Tanaka H, Okazaki T, Aoyama S, Yokota M, Koike M, Okada Y, Fujiki Y, Gotoh Y.
Peroxisomes control mitochondrial dynamics and the mitochondrion-dependent pathway of apoptosis.
J. Cell Sci., 132(11), 2019.
Highlighted by a First Person article of J. Cell Sci.

Tsuboi M, Kishi Y, Yokozeki W, Koseki H, Hirabayashi Y, Gotoh Y.
(These authors contributed equally to this work.)
Ubiquitination-Independent Repression of PRC1 Targets during Neuronal Fate Restriction in the Developing Mouse Neocortex.
Dev Cell., 47(6):758-772.e5, 2018.

Kishi Y, Gotoh Y.
Regulation of Chromatin Structure During Neural Development.
Frontiers Neurosci.,12:874, 2018. Review.

Okazaki T, Gotoh Y.
An Unexpected Calm: Mfge8 Controls Stem Cell Quiescence and Maintenance.
Cell Stem Cell,6;23(3):311-312, 2018. Preview.

Lanjakornsiripan D, Pior BJ, Kawaguchi D, Furutachi S, Tahara T, Katsuyama Y, Suzuki Y, Fukazawa Y, Gotoh Y.
(These authors contributed equally to this work.)
Layer-specific morphological and molecular differences in neocortical astrocytes and their dependence on neuronal layers.
Nat Commun., 9(1), 1623, 2018.

Kawai H, Kawaguchi D, Kuebrich BD, Kitamoto T, Yamaguchi M, Gotoh Y, Furutachi S.
Area-Specific Regulation of Quiescent Neural Stem Cells by Notch3 in the Adult Mouse Subependymal Zone.
J Neurosci., 37(49):11867-11880, 2017.

Okazaki T.
ASK family in infection and inflammatory disease.
Advances in Biological Regulation, S2212-4926(17)30144-6, 2017. Review.

Itoh Y, Higuchi M, Oishi K, Kishi Y, Okazaki T, Sakai H, Miyata T, Nakajima K, Gotoh Y.
PDK1-Akt pathway regulates radial neuronal migration and microtubules in the developing mouse neocortex.
Proc. Natl. Acad. Sci. USA., 113(21):E2955-64, 2016.

Nagao M, Ogata T, Sawada Y, Gotoh Y.
Zbtb20 promotes astrocytogenesis during neocortical development.
Nat Commun., 7, 11102, 2016.

Okazaki T, Higuchi M, Takeda K, Iwatsuki-Horimoto K, Kiso M, Miyagishi M, Yanai H, Kato A, Yoneyama M, Fujita T, Taniguchi T, Kawaoka Y, Ichijo H, Gotoh Y.
The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response.
Sci Signal., 8, ra78, 2015. Free access: Summary Abstract Full Text
Featured as a cover in this issue of Sci Signal.
Editorial in Oncotarget

Furutachi S, Miya H, Watanabe T, Kawai H, Yamasaki N, Harada Y, Imayoshi I, Nelson M, Nakayama KI, Hirabayashi Y, Gotoh Y.
Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells.
Nat Neurosci., 18, 657-65, 2015.
Highlighted by a News and Views article of Nat Neurosci.

Oshiro H, Hirabayashi Y, Furuta Y, Okabe S, Gotoh Y.
Up-regulation of HP1γ expression during neuronal maturation promotes axonal and dendritic development in mouse embryonic neocortex.
Genes Cells, 20, 108-20, 2015.

Morimoto-Suzki N, Hirabayashi Y, Tyssowski K, Shinga J, Vidal M, Koseki H, Gotoh Y.
The polycomb component Ring1B regulates the timed termination of subcerebral projection neuron production during mouse neocortical development.
Development, 141, 4343-53, 2014.
Selected by "Faculty of 1000"

Nagao M, Lanjakornsiripan D, Itoh Y, Kishi Y, Ogata T, Gotoh Y.
High mobility group nucleosome-binding family proteins promote astrocyte differentiation of neural precursor cells.
Stem Cells, 32, 2983-97, 2014.

Kuwahara A, Sakai H, Xu Y, Itoh Y, Hirabayashi Y, Gotoh Y.
(These authors contributed equally to this work.)
Tcf3 Represses Wnt-β-Catenin Signaling and Maintains Neural Stem Cell Population during Neocortical Development.
PLoS One, 9(5):e94408, 2014.

Tyssowski K, Kishi Y, Gotoh Y.
Chromatin regulators of neural development.
Neuroscience, 264, 4-16, 2014. Review.

Itoh, Y., Tyssowski, K.* and Gotoh, Y.
(These authors contributed equally to this review.)
Transcriptional coupling of neuronal fate commitment and the onset of migration.
Curr. Opin. Neurobiol., 23, 957-64, 2013. Review.

Kawaguchi, D., Furutachi, S., Kawai, H., Hozumi, K. and Gotoh, Y.
Dll1 maintains quiescence of adult neural stem cells and segregates asymmetrically during mitosis.
Nat. Commun., 4, 1880, 2013.

Okazaki, T., Higuchi, M. and Gotoh, Y.
Mitochondrial localization of the antiviral signaling adaptor IPS-1 is important for its induction of caspase activation.
Genes Cells, 18, 493-501, 2013.

Furutachi, S., Matsumoto, A., Nakayama, K.I. and Gotoh, Y.
p57 controls adult neural stem cell quiescence and modulates the pace of lifelong neurogenesis.
EMBO J., 32, 970-81, 2013.

Itoh, Y., Moriyama, Y., Hasegawa, T., Endo, T.A., Toyoda, T. and Gotoh, Y.
Scratch regulates neuronal migration onset via an epithelial-mesenchymal transition-like mechanism.
Nat. Neurosci., 16, 416-25, 2013.

Fujii, Y., Kishi, Y. and Gotoh, Y.
IMP2 regulates differentiation potentials of mouse neocortical neural precursor cells.
Genes Cells, 18, 79-89, 2013.

Higuchi, M., Kihara, R., Okazaki, T., Aoki, I., Suetsugu, S. and Gotoh, Y.
Akt1 promotes focal adhesion disassembly and cell motility through phosphorylation of FAK in growth factor-stimulated cells.
J. Cell Sci., 126, 745-55, 2013.

Onoguchi, M., Hirabayashi, Y., Koseki, H. and Gotoh, Y.
A noncoding RNA regulates the neurogenin1 gene locus during mouse neocortical development.
Proc.Natl.Acad.Sci.USA, 109, 16939-44. 2012.

Kishi, Y., Fujii, Y., Hirabayashi, Y. and Gotoh, Y.
(These authors contributed equally to this work.)
HMGA regulates the global chromatin state and neurogenic potential in neocortical precursor cells.
Nat. Neurosci., 15, 1127-33, 2012.

Aoki, I., Higuchi, M. and Gotoh, Y.
NEDDylation controls the target specificity of E2F1 and apoptosis induction.
Oncogene, 32, 3954-64, 2012.

Kishi, Y., Kondo, S. and Gotoh, Y.
(These authors contributed equally to this work.)
Transcriptional activation of mouse major satellite regions during neuronal differentiation.
Cell Struct. Funct., 37, 101-10, 2012.

Watatani, K., Hirabayashi, Y., Itoh, Y. and Gotoh, Y.
PDK1 regulates the generation of oligodendrocyte precursor cells at an early stage of mouse telencephalic development.
Genes Cells, 17, 326-335, 2012.

Ip, J.P., Shi, L., Chen, Y., Itoh, Y., Fu, W.Y., Betz, A., Yung, W.H., Gotoh, Y., Fu, A.K. and Ip, N.Y.
(These authors contributed equally to this work.)
a2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2.
Nat. Neurosci., 15, 39-47, 2011.

Hirabayashi, Y. and Gotoh, Y.
Epigenetic control of neural precursor cell fate during development.
Nat. Rev. Neurosci., 11, 377-88, 2010. Review.

Miyata, T., Kawaguchi, D., Kawaguchi, A. and Gotoh Y.
Mechanisms that regulate the number of neurons during mouse neocortical development.
Curr. Opin. Neurobiol., 20, 22-8, 2010. Review.

Kuwahara, A., Hirabayashi, Y., Knoepfler, P.S., Taketo, M.M.,Sakai, J., Kodama, T. and Gotoh, Y.
Wnt signaling and its downstream target N-Myc regulate basal progenitors in the developing neocortex.
Development, 137, 1035-44, 2010.

Hirabayashi, Y., Suzki, N., Tsuboi, M., Endo, T.A., Toyoda, T., Shinga, J., Koseki, H., Vidal, M. and Gotoh, Y.
Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition.
Neuron, 63, 600-613, 2009.

Oishi, K., Watatani, K., Itoh, Y., Okano, H., Guillemot, F., Nakajima, K. and Gotoh, Y.
Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1.
Proc.Natl.Acad.Sci.USA, 106, 13064-9, 2009.

Kawaguchi, D., Yoshimatsu, T., Hozumi, K. and Gotoh, Y.
Selection of differentiating cells by different levels of Delta-like 1 among neural precursor cells in the developing mouse telencephalon.
Development 135, 3849-3858. (2008)

Higuchi, M., Onishi, K., Kikuchi, C. and Gotoh, Y.
Scaffolding function of PAK in the PDK1-Akt pathway.
Nat. Cell Biol. 10, 1356-1364. (2008)

Mori, Y., Higuchi, M., Hirabayashi, Y., Fukuda, M. and Gotoh, Y.
JNK phosphorylates synaptotagmin-4 and enhances Ca2+-evoked release.
EMBO J. 27, 76-87. (2008)

Adachi, K., Mirzadeh, Z., Sakaguchi, M., Yamashita, T., Nikolcheva, T., Gotoh, Y., Peltz, G., Gong, L., Kawase, T., Alvarez-Buylla, A., Okano, H. and Sawamoto, K.
Beta-catenin signaling promotes proliferation of progenitor cells in the adult mouse subventricular zone.
Stem Cells. 25, 2827-36. (2007)

Ura, S., Nishina, H., Gotoh, Y. and Katada, T.
Activation of the c-Jun N-terminal kinase pathway by MST1 is essential and sufficient for the induction of chromatin condensation during apoptosis.
Mol Cell Biol. 27, 5514-22. (2007)

Onishi, K., Higuchi, M., Asakura, T., Masuyama, N. and Gotoh, Y.
The PI3K-Akt pathway promotes microtubule stabilization in migrating fibroblasts.
Genes Cells. 12, 535-46. (2007)

Hayakawa-Yano, Y., Nishida, K., Fukami, S., Gotoh, Y., Hirano, T., Nakagawa, T., Shimazaki, T. and Okano, H.
Epidermal growth factor signaling mediated by grb2 associated binder1 is required for the spatiotemporally regulated proliferation of olig2-expressing progenitors in the embryonic spinal cord.
Stem Cells. 25, 1410-22. (2007)

Itoh, Y., Masuyama, N., Nakayama, K., Nakayama, KI. and Gotoh Y.
The cyclin-dependent kinase inhibitors p57 and p27 regulate neuronal migration in the developing mouse neocortex.
J Biol Chem. 282, 390-6. (2007)

Yoshizaki, H., Mochizuki, N., Gotoh, Y. and Matsuda, M.
Akt-PDK1 complex mediates epidermal growth factor-induced membrane protrusion through Ral activation.
Mol Biol Cell. 18, 119-28. (2007)

Yoshimatsu, T., Kawaguchi, D., Oishi, K., Takeda, K., Akira, S., Masuyama N. and Gotoh Y.
Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex.
Development. 133, 2553-63. (2006)

Sunayama, J.,Tsuruta, F., Masuyama, N. and Gotoh, Y.
JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3.
J. Cell. Biol. 170, 295-304. (2005)

Takada, T., Suzuki, H., Gotoh, Y. and Sugiyama, Y.
Regulation of the cell surface expression of human BCRP/ABCG2 by the phosphorylation state of Akt in polarized cells.
Drug Metab Dispos. 33, 905-9. (2005)

Hirabayashi, Y. and Gotoh, Y.
Stage-dependent fate determination of neural precursor cells in mouse forebrain.
Neurosci. Res. 51, 331-336. (2005) Review.

Mori, Y., Higuchi, M., Masuyama, N. and Gotoh Y.
Adenosine A2A receptor facilitates calcium-dependent protein secretion through the activation of protein kinase A and phosphatidylinositol-3 kinase in PC12 cells.
Cell. Struct. Funct.　29, 101-110. (2004)

Oishi, K., Kamakura S., Isazawa Y., Yoshimatsu T., Kuida K., Nakafuku M., Masuyama, N. and Gotoh, Y.
Notch promotes survival of neural precursor cells via mechanisms distinct from those regulating neurogenesis.
Dev. Biol. 276, 172-184. (2004)

Kamakura, S., Oishi, K., Yoshimatsu, T., Nakafuku, M., Masuyama, N. and Gotoh, Y.
Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signaling.
Nat. Cell Biol. 6, 547-554. (2004)

Tsuruta, F., Sunayama, J., Mori, Y., Shimizu, S., Tsujimoto, Y., Yoshioka, K., Masuyama, N. and Gotoh, Y.
JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins.
EMBO J. 23, 1889-1899. (2004)

Hirabayashi, Y., Itoh, Y., Tabata, H., Nakajima, K., Akiyama, T., Masuyama, N. and Gotoh, Y.
The Wnt-beta-catenin pathway directs neuronal differentiation of cortical neural precursor cells.
Development 131, 2791-2801. (2004)

Miyagi, S., Saito, T., Mizutani, K., Masuyama, N., Gotoh, Y., Iwama, A., Nakauchi, H., Masui, S., Niwa, H., Nishimoto, M., Muramatsu, M. and Okuda, A.
The sox-2 regulatory regions display their activities in two distinct multipotent stem cells.
Mol. Cell. Biol. 24, 4207-4220. (2004)

Higuchi, M., Onishi, K., Masuyama, N. and Gotoh, Y.
The phosphatidylinositol-3 kinase (PI3K)-Akt pathway suppresses neurite branch formation in NGF-treated PC12 cells.
Genes Cells 8, 657. (2003)

Fujishiro, M., Gotoh, Y., Katagiri, H., Sakoda, H., Ogihara, T., Anai, M., Onishi, Y., Ono, H., Abe, M., Shojima, N., Fukushima, Y., Kikuchi, M., Oka, Y. and Asano, T.
Three Mitogen-Activated Protein kinases inhibit Insulin signaling by different mechanisms in 3T3-L1 adipocytes.
Mol. Endocrinology 17, 487-497. (2003)

Sakoda, H., Gotoh, Y., Katagiri, H., Kurokawa, M., Ono, H., Onishi, Y., Anai, M., Ogihara, T., Fujishiro, M., Fukushima, Y., Abe, M., Shojima, N., Kikuchi, M., Oka, Y., Hirai, H. and Asano, T.
Differing roles of Akt and SGK in glucose metabolism, DNA synthesis and oncogenic activity.
J. Biol. Chem. 278, 25802-25807. (2003)

Katome, T., Obata, T., Matsushima, R., Masuyama, N., Cantley, L.C., Gotoh, Y., Kishi, K., Shiota, H. and Ebina, Y.
Use of RNA-interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/PKB-isoforms in insulin actions.
J. Biol. Chem. 278, 28312-28323. (2003)

Ogawara, Y., Kishishita, S., Obata, T., Suzuki, T., Tanaka, K., Masuyama, N. and Gotoh, Y.
Akt enhances Mdm2-mediated ubiquitination and degradation of p53.
J. Biol. Chem. 277, 21843-21850. (2002)

Tsuruta, F., Masuyama, N. and Gotoh, Y.
The PI3K-Akt pathway suppresses Bax translocation to mitochondria.
J. Biol. Chem. 277, 14040-14047. (2002)

Shinohara, M., Terada, Y., Iwamatsu, A., Shinohara, A., Mochizuki, N., Higuchi, M., Gotoh, Y., Ihara, S., Nagata, S., Itoh, H., Fukui, Y. and Jessberger, R.
SWAP-70 is a guanine nucleotide exchange factor that mediates signaling of membrane ruffling.
Nature 416, 759-763. (2002)

Higuchi, M., Masuyama, N., Suzuki, A. and Gotoh, Y.
Akt mediates Rac/Cdc42-Regulated Cell Motility in Growth Factor-Stimulated Cells and in Invasive PTEN-Knockout Cells.
Curr. Biol. 11, 1958-1962. (2001)

Morishima, Y., Gotoh, Y., Barrett, T., Takano, H., Davis, R.J., Shirasaki, Y. and Greenberg, M.E.
β-Amyloid Induces Neuronal Apoptosis Via JNK Pathway Activation and the Subsequent Induction of Fas Ligand.
J. Neurosci. 21,7551-7560.(2001)

Masuyama, N., Oishi, K., Mori, Y., Ueno, T., Takahama, Y. and Gotoh, Y.
Akt Inhibits the Orphan Nuclear Receptor Nur77 and T cell Apoptosis.
J. Biol. Chem. 276, 32799-32805. (2001)

Ura, S., Masuyama, N., Graves, J. and Gotoh, Y.
Caspase Cleavage of MST1 Promotes Nuclear Translocation and Chromatin Condensation.
Proc.Natl.Acad.Sci.USA 98, 10148-10153.(2001)

Graves, J.D., Draves, K.E., Gotoh, Y., Krebs, E.G. and Clark, E.A.
Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste-20-like Protein Kinase Mst1 during CD95/Fas-induced apoptosis.
J. Biol. Chem. 276, 14909-14915. (2001)

Fujishiro, M., Gotoh, Y., Katagiri, H., Sakoda, H., Ogihara, T., Anai, M., Onishi, Y., Ono, H., Funaki, M., Inukai, K., Fukushima, Y., Kikuchi, M., Oka, Y. and Asano, T.
MKK6/3 and p38 MAPK Pathway Activation is not Necessary for Insulin-Induced Glucose Uptake, but Regulates Glucose Transporter Expression.
J. Biol. Chem. 276, 19800-19806. (2001)

Ura, S., Masuyama, N., Graves, J. and Gotoh, Y.
MST1-JNK promotes apoptosis via caspase-dependent and -independent pathways.
Genes Cells 6, 519-530. (2001)

Kawasaki, H., Fujii, H., Gotoh, Y., Morooka, T., Shimohama, S., Nishida, E. and Hirano, T.
Requirement for mitogen-activated protein kinase in cerebellar long term depression.
J. Biol. Chem. 274, 13498-13502. (1999)

Gotoh, Y. and Cooper, J.A.
Reactive oxygen species and dimerization-induced activation of ASK1 in TNFα signal transduction.
J. Biol. Chem. 273, 17477-17482.(1998)

Shibuya, H., Iwata, H., Masuyama, N., Gotoh, Y., Yamaguchi, K., Irie, K., Matsumoto, K., Nishida, E. and Ueno, N.
Role of TAK1 and TAB1 in BMP signaling in early Xenopus development.
EMBO J. 17, 1019-1028.(1998)

Graves, J.D., Gotoh, Y., Draves, K.E., Ambrose, D., Han, D., Wright, M., Chernoff, J., Clark, E.A. and Krebs, E.G.
Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1.
EMBO J. 17, 2224-2234. (1998)

Fukuda, M., Gotoh, I., Adachi, M., Gotoh, Y. and Nishida, E.
A novel regulatory mechanism in the mitogen-activated protein (MAP) kinase cascade. Role of nuclear export signal of MAP kinase kinase.
J. Biol. Chem. 272, 32642-32648. (1997)

Moriguchi, T., Toyoshima, F., Masuyama, N., Hanafusa, H., Gotoh, Y. and Nishida, E.
A novel SAPK/JNK kinase, MKK7, stimulated by TNF and cellular stresses.
EMBO J. 16, 7045-7053.(1997)

Datta, S.R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y. and Greenberg, M.E.
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
Cell 91, 231-241. (1997)

Kawasaki, H., Morooka, T., Shimohama, S., Kimura, J., Hirano, T., Gotoh, Y. and Nishida, E.
Activation and involvement of p38 MAP kinase in glutamate-induced apoptosis in rat cerebellar granule cells.
J. Biol. Chem. 272, 18518-18521.(1997)

Moriguchi, T., Gotoh, Y. and Nishida, E.
Roles of the MAPK cascades in vertebrates.
Advances in Pharmacology 36, 121-137. (1997)

Takenaka, K., Gotoh, Y. and Nishida, E.
MAP kinase is required for the spindle assembly checkpoint, but dispensable for the normal M phase entry and exit, in Xenopus egg cell cycle extracts.
J. Cell Biol. 136, 1091-1097. (1997)

Fukuda, M., Gotoh, Y. and Nishida, E.
Interaction of MAP kinase with MAP kinase kinase : Its possible role in the control of nucleocytoplasmic transport of MAP kinase.
EMBO J. 16, 1901-1908. (1997)

Shirakabe, K., Yamaguchi, K., Shibuya, H., Irie, K., Matsuda, S., Moriguchi, T., Gotoh, Y., Matsumoto, K. and Nishida, E.
TAK1 mediates the ceramide signaling to SAPK/JNK.
J. Biol. Chem. 272, 8141-8144. (1997)

Ichijo, H., Nishida, E., Irie, K., ten Dijke, P., Saitoh, M., Moriguchi, T., Takagi, M., Matsumoto, K., Miyazono, K. and Gotoh, Y.
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways.
Science 275, 90-94. (1997)

Kawasaki, H., Moriguchi, T., Matsuda, S., Li, H.Z., Nakamura, S., Shimohama, S., Kimura, J., Gotoh, Y., and Nishida, E.
Ras-dependent and Ras-independent activation pathways for the stress-activated-protein kinase cascade.
Eur. J. Biochem. 241, 315-321.(1996)

Toda, T., Dhut, S., Superti-Furga, G., Gotoh, Y., Nishida, E., Sugiura, R. and Kuno, T.
Fission yeast pmk1+ gene encodes a novel MAPK homologue which regulates cell integrity and functions coordinately with the PKC pathway.
Mol. Cell. Biol. 16, 6752-6764. (1996)

Gotoh, Y. and Nishida, E.
Signals for mesoderm induction- Roles of fibroblast growth factor (FGF) / mitogen-activated protein kinase (MAPK) pathway.
Biochim. Biophys. Acta Reviews on Cancer 1288, F1-7. (1996)

Kosako, H., Akamatsu, Y., Tsurushita, N., Lee, K.K., Gotoh, Y. and Nishida, E.
Isolation and characterization of neutralizing single-chain antibodies against Xenopus mitogen-activated protein kinase kinase from phage display libraries.
Biochemistry 35, 13212-13221. (1996)

Kamata, H., Tanaka, C., Yagisawa, H., Matsuda, S., Gotoh, Y., Nishida, E., and Hirata, H.
Suppression of nerve growth factor-induced neuronal differentiationi of PC12 cells. N-acetylcysteine uncouples the signal transduction from Ras to the mitogen-activated protein kinase cascade.
J. Biol. Chem. 271, 33018-33025. (1996)

Moriguchi, T., Toyoshima, F., Gotoh, Y., Iwamatsu, A., Irie, K., Mori, E., Kuroyanagi, N., Hagiwara, M., Matsumoto, K. and Nishida, E.
Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of MAPKK6 by osmotic shock, tumor necrosis factor-α and H2O2.
J. Biol. Chem. 271, 26981-26988. (1996)

Fukuda, M., Gotoh, I., Gotoh, Y. and Nishida, E.
Cytoplasmic localization of MAP kinase kinase directed by its N-terminal, leucine-rich short aino acid sequence which acts as a nuclear export signal.
J. Biol. Chem. 271, 20024-20028. (1996)

Moriguchi, T., Kuroyanagi, N., Yamaguchi, K., Gotoh, Y., Irie, K., Kano, T., Shirakabe, K., Muro, Y., Shibuya, H., Matsumoto, K., Nishida, E. and Hagiwara, M.
A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3.
J. Biol. Chem. 13675-13679. (1996)

Shibuya, H., Yamaguchi, K., Shirakabe, K., Tonegawa, A., Gotoh, Y., Ueno, N., Irie, K., Nishida, E. and Matsumoto, K.
TAB1: An activator of TAK1 MAPKKK in TGF-βsignal transduction.
Science 272, 1179-1182. (1996)

Gotoh, Y. and Nishida, E.
The MAP kinase cascade: Its role in Xenopus oocytes, eggs and embryos.
Progress in Cell Cycle Research, 1, 287-297. (Meijer, L., Guidet, S. and Tung, H.Y.L., eds.) Plenum Press, New York, USA. (1995)

Kato, S., Endo, H., Masuhiro, Y., Kitamoto, T., Uchiyama, S., Sasaki, H., Masushige, S., Gotoh, Y., Nishida, E., Kawashima, H., Metzger, D. and Chambon, P.
Activation of the Estrogen Receptor through phosphorylation by mitogen-activated protein kinase.
Science 270, 1491-1494. (1995)

Moriguchi, T., Gotoh, Y. and Nishida, E.
Activation of two isoforms of mitogen-activated protein kinase kinase in response to epidermal growth factor and nerve growth factor.
Eur. J. Biochem. 234, 32-38. (1995)

Gotoh, Y., Masuyama, N., Dell, K., Shirakabe, K. and Nishida, E.
Initiation of Xenopus oocyte maturation by activation of the mitogen-activated protein kinase cascade.
J. Biol. Chem. 270, 25898-25904. (1995)

Gotoh, Y. and Nishida, E.
Activation mechanism and function of the MAP kinase cascade.
Molecular Reproduction and Development 42, 486-492. (1995)

Fukuda, M., Gotoh, Y., Tachibana, T., Dell, K., Hattori, S., Yoneda, Y. and Nishida, E.
Induction of neurite outgrowth by MAP kinase in PC12 cells.
Oncogene 11, 239-244. (1995)

Shiina, N., Gotoh, Y. and Nishida, E.
Microtubule-severing activity in M phase.
Trends Cell Biol. 5, 283-286. (1995)

Moriguchi, T., Kawasaki, H., Matsuda, S., Gotoh, Y. and Nishida, E.
Evidence for multiple activators for stress-activated protein kinases / c-Jun amino-terminal kinases. Existence of novel activators.
J. Biol. Chem. 270, 12969-12972. (1995)

Matsuda, S., Kawasaki, H., Moriguchi, T., Gotoh, Y. and Nishida, E.
Activation of protein kinase cascades by osmotic shock.
J. Biol. Chem. 270, 12781-12786. (1995)

Gotoh, Y., Masuyama, N., Suzuki, A., Ueno, N. and Nishida, E.
Involvement of the MAP kinase cascade in Xenopus mesoderm induction.
EMBO J. 14, 2491-2498. (1995)

Fukuda, M., Gotoh, Y., Kosako, H., Hattori, S. and Nishida, E.
Analysis of the Ras p21/mitogen-activated protein kinase signaling in vitro and in Xenopus oocytes.
J. Biol. Chem. 269, 33097-33101. (1994)

Kosako, H., Gotoh, Y. and Nishida, E.
Mitogen-activated protein kinase kinase is required for the Mos-induced metaphase arrest.
J. Biol. Chem. 269, 28354-28358. (1994)

Kosako, H., Gotoh, Y. and Nishida, E.
Regulation and function of the MAP kinase cascade in Xenopus oocytes.
J. Cell Sci. 18 (supple.), 115-119. (1994)

Matsuda, S., Gotoh, Y. and Nishida, E.
Signaling pathways mediated by the mitogen-activated protein (MAP) kinase kinase/MAP kinase cascade.
J. Leukoc. Biol. 56, 548-553. (1994)

Shiina, N., Gotoh, Y., Kubomura, J., Iwamatsu, A. & Nishida, E.
Microtubule severing by elongation factor-1α.
Science 266, 282-285. (1994)

Irie, K., Gotoh, Y., Yasher, B.M., Errede, B., Nishida, E. and Matsumoto, K.
Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase.
Science 265, 1716-1719. (1994)

Gotoh, Y., Matsuda, S., Takenaka, K., Hattori, S., Iwamatsu, A., Ishikawa, M., Kosako, H. & Nishida, E.
Characterization of recombinant Xenopus MAP kinase kinases mutated at potential phosphorylation sites.
Oncogene 9, 1891-1898. (1994)

Kosako, H., Gotoh, Y. & Nishida, E.
Requirement for the MAP kinase kinase/MAP kinase cascade in Xenopus oocyte maturation.
EMBO J. 13, 2131-2138. (1994)

Ueki, K., Matsuda, S., Tobe, K., Gotoh, Y., Tamemoto, H., Yachi, M., Akanuma, Y., Yazaki, Y., Nishida, E. and Kadowaki, T.
Feedback regulation of mitogen-activated protein kinase kinase kinase activity of c-Raf-1 by insulin and phorbol ester stimulation.
J. Biol. Chem. 269, 15756-15761. (1994)

Bito, H., Mori, M., Sakanaka, C., Takano, T., Honda, Z., Gotoh, Y., Nishida, E. & Shimizu, T.
Functional coupling of SSTR4, a major hippocampal samatostatin receptor, to adenylate cyclase inhibition, arachidonate release, and activation of the mitogen-activated protein kinase cascade.
J. Biol. Chem. 269, 12722-12730. (1994)

Mizoguchi, T., Gotoh, Y., Nishida, E., Yamaguchi-Shinozaki, K., Hayashida, N., Iwasaki, T., Kamada, H. & Shinozaki, K.
Characterization of two cDNAs that encode MAP kinase homologues in Arabidopsis thaliana and analysis of the possible role of auxin in activating such kinase activities in cultured cells.
Plant J. 5, 111-122. (1994)

Honda, Z., Takano, T., Gotoh, Y., Nishida, E., Ito, K. & Shimizu, T.
Transfected Platelet-activating factor activates mitogen-activated protein kinase and MAP kinase kinase in chinese hamster ovary cells.
J. Biol. Chem. 269, 2307-2315. (1994)

Gotoh, Y., Nishida, E., Shimanuki, M., Toda, T., Imai, Y. & Yamamoto, M.
Schizosaccharomyces pombe Spk1 is a tyrosine-phosphorylated protein functionally related to Xenopus mitogen-activated protein kinase.
Mol. Cell. Biol. 13, 6427-6431. (1993)

Nishida, E. & Gotoh, Y.
The MAP kinase cascade is essential for diverse signal tansduction pathways.
Trends Biochem. Sci. 18, 128-131. (1993)

Lee, K.S., Irie, K., Gotoh, Y., Watanabe, Y., Araki, H., Nishida, E., Matsumoto, K. & Levin, D.E.
A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C.
Mol. Cell. Biol. 13, 3067-3075. (1993)

Kosako, H., Nishida, E. & Gotoh, Y.
cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates.
EMBO J. 12, 787-794. (1993)

Matsuda, S., Gotoh, Y. & Nishida, E.
Phosphorylation of Xenopus MAP kinase kinase by MAP kinase kinase kinase and MAP kinase.
J. Biol. Chem. 268, 3277-3281. (1993)

Shiina, N., Gotoh, Y. & Nishida, E.
A novel homo-oligomeric protein responsible for an MPF-dependent microtubule-severing activity.
EMBO J. 11, 4723-4731. (1992)

Shiina, N., Moriguchi, T., Ohta, K., Gotoh, Y. & Nishida, E.
Regulation of a major microtubule-associated protein by MPF and MAP kinase.
EMBO J. 11, 3977-3984. (1992)

Hattori, S., Fukuda, M., Yamashita, T., Nakamura, S., Gotoh, Y. & Nishida, E.
Activation of MAP kinase and its activator by ras in intact cells and in a cell-free system.
J. Biol. Chem. 267, 20346-20351. (1992)

Shirakabe, K., Gotoh, Y. & Nishida, E.
A MAP kinase activating factor in mammalian mitogen-stimulated cells is homologous to Xenopus M phase MAP kinase activator.
J. Biol. Chem. 267, 16685-16690. (1992)

Kosako, H., Gotoh, Y., Matsuda, S., Ishikawa, M. & Nishida, E.
Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation.
EMBO J. 11, 2903-2908. (1992)

Nishida, E. & Gotoh, Y.
MAP kinase and cytoskeleton in mitogenic signal transduction.
Int. Rev. Cytol. 138, 211-238. (1992)

Matsuda, S., Kosako, H., Takenaka, K., Moriyama, K., Sakai, H., Akiyama, T., Gotoh, Y. & Nishida, E.
Xenopus MAP kinase activator : identification and function as a key intermediate in the phosphorylation cascade.
EMBO J. 11, 973-982. (1992)

Hoshi, M., Ohta, K., Gotoh, Y., Mori, A., Murofushi, H., Sakai, H. & Nishida, E.
Mitogen-activated-protein-kinase-catalyzed phosphorylation of microtubule-associated proteins, microtubule-associated protein 2 and microtubule-associated protein 4, induces an alteration in their function.
Eur. J. Biochem. 203, 43-52. (1992)

Gotoh, Y., Moriyama, K., Matsuda, S., Okumura, E., Kishimoto, T., Kawakami, H., Suzuki, K., Yahara, I., Sakai, H. & Nishida, E.
Xenopus M phase MAP kinase : isolation of its cDNA and activation by MPF.
EMBO J. 10, 2661-2668. (1991)

Shinohara-Gotoh, Y., Nishida, E., Hoshi, M. & Sakai, H.
Activation of microtubule-associated protein kinase by microtubule disruption in quiescent rat 3Y1 cells.
Exp. Cell Res. 193, 161-166. (1991)

Gotoh, Y., Nishida, E., Matsuda, S., Shiina, N., Kosako, H., Shiokawa, K., Akiyama, T., Ohta, K. & Sakai, H.
In vitro effects on microtubule dynamics of purified Xenopus M phase-activated MAP kinase.
Nature 349, 251-254. (1991)

Gotoh, Y., Nishida, E. & Sakai, H.
Okadaic acid activates MAP kinase in quiescent fibroblastic cells.
Eur. J. Biochem. 193, 671-674. (1990)

Gotoh, Y., Nishida, E., Yamashita, T., Hoshi, M., Kawakami, M. & Sakai, H.
MAP kinase activated by nerve growth factor and epidermal growth factor in PC12 cells. Identity with the mitogen-activated MAP kinase of fibroblastic cells.
Eur. J. Biochem. 193, 661-669. (1990)

Shinohara, Y., Nishida, E. & Sakai, H.
Initiation of DNA synthesis by microtubule disruption in rat 3Y1 cells.
Eur. J. Biochem. 183, 275-280. (1989)

Shinohara, Y., Nishida-E. and Sakai, E.
Colchicine acts as a progression factor to initiate DNA synthesis in quiescent Balb/c 3T3 cells.
FEBS lett. 236, 19-22. (1988)

Hoshi, M., Akiyama, T., Shinohara, Y., Miyata, Y., Ogawara, H., Nishida, E. and Sakai, H.
Protein-kinase-C-catalyzed phosphorylation of the microtubule-binding domain of microtubule-associated protein 2 inhibits its ability to induce tubulin polymerization.
Eur. J. Biochem. 174, 225-230. (1988)