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Neuroscience 2012
New Orleans, LA
October 12-17, 2012

313.04: *T. HASHIMOTO, D. FUJII, M. KASHIWAGI, Y. MATSUO, Y. MATSUURA, T. SAKAKURA, H. KOWA, D. WESTAWAY, T. WAKABAYASHI, T. IWATSUBO

Remodeling of the morphology of -amyloid plaques by CLAC in the brains of transgenic mice

344.16/H5: *T. TOMITA, S. Takagi-NIIDOME, T. IWATSUBO

The -helical structure of the hydrophilic loop1 of presenilin 1 contributes to the formation of the substrate binding site

439.02/D42: *G. ITO, S. KAMIKAWAJI, T. IWATSUBO

Molecular mechanism of hypophosphorylation of LRRK2 caused by familial mutations

635.11/B13: *T. TANAKA, T. WAKABAYASHI, T. SATO, A. HARADA, D. FUJII, T. HASHIMOTO, T. IWATSUBO

Terminal arborization of motoneuron bundles requires CLAC-P/Collagen XXV.

635.13/B15: *H. OIZUMI, T. TANAKA, T. HASHIMOTO, T. SATO, A. HARADA, D. FUJII, T. WAKABAYASHI, T. IWATSUBO

Role of CLAC-P/collagen XXV in the development of motor neurons

750.29/E68: *T. MIYAGAWA, Y. MOROHASHI, S. TSUJI, T. TOMITA, T. IWATSUBO

BIN1 negatively modulates A production from cultured cells


Neuroscience 2011
Washington, DC
November 12-16, 2011

54.17/Z32: *H. KUNUGI, R. IHARA, E. KURANAGA, M. MIURA, T. HASHIMOTO, T. WAKABAYASHI, T. IWATSUBO

Overexpression of fused in sarcoma (FUS) causes neurodegeneration in the retinal photoreceptor neurons in Drosophila

147.09/N1: *S. KAMIKAWAJI, G. ITO, T. IWATSUBO

Identification of in vivo autophosphorylation sites of LRRK2

147.12/N4: *G. ITO, S. KAMIKAWAJI, T. IWATSUBO

Identification and functional characterization of novel autophosphorylation sites of LRRK2

354.11/Y28: *A. TOMINAGA, S. TAKAGI, T. TOMITA, T. IWATSUBO

Structural analysis of the transmembrane domain 4 of Presenilin 1 by substituted cysteine accessibility method

354.25/Z6: *Y. MOROHASHI, K. KANATSU, T. TOMITA, T. IWATSUBO

PICALM impacts the production and secretion of A42 in cultured cells

871.02/D55: *K. SUZUKI, Y. HAYASHI, S. NAKAHARA, R. KOYAMA, N. MATSUKI, T. TOMITA, T. IWATSUBO

Proteolytic processing of neuroligin 1 modulates its spinogenic function


SFN 40th Annual Meeting
San Diego, CA
November 13-17, 2010

37.7/D13: *T. TANAKA, T. HASHIMOTO, T. SATO, A. HARADA, D. FUJII, T. WAKABAYASHI, T. IWATSUBO

CLAC-P/Collagen XXV is essential to the survival of motor neurons during development

146.11/H33: *R. IHARA, T. HASHIMOTO, Y. NAGATA, T. WAKABAYASHI, H. TANAKA, Y. HORI, S. TSUJI, E. KURANAGA, M. MIURA, T. IWATSUBO

RNA binding mediates neurotoxicity in the Drosophila transgenic model of TDP-43 proteinopathy

252.14/N6: *H. KUNUGI, G. ITO, T. IWATSUBO

Rotenone treatment enhances apoptosis caused by G2019S familial Parkinson mutant LRRK2

627.8: *T. TOMITA, Y. OHKI, S. YOKOSHIMA, T. HIGO, N. SHIMADA, H. KOIZUMI, S. OSAWA, T. FUKUYAMA, T. IWATSUBO

Structure and function relationship analysis of γ-secretase modulator GSM-1

629.13: *G. ITO, T. IWATSUBO

Biochemical characterization of the dimerization of LRRK2

854.7/H29: *K. TAKEO, N. WATANABE, T. TOMITA, T. IWATSUBO

Contribution of γ-secretase cofactors to the formation of catalytic pore of presenilin 1

854.16/H38: *Y. OHKI, S. YOKOSHIMA, T. HIGO, N. SHIMADA, H. KOIZUMI, S. OSAWA, T. FUKUYAMA, T. TOMITA, T. IWATSUBO

γ-Secretase modulator GSM-1 directly targets the N-terminal fragment of presenilin 1


SFN 39th Annual Meeting
Chicago, IL
October 17-21, 2009

144.6: *S. KAMIKAWAJI, G. ITO, T. IWATSUBO

Systematic characterization of autophosphorylation of LRRK2

400.5: *T. TOMITA, Y. IMAMURA, N. WATANABE, T. IWATSUBO, N. KATO, N. UMEZAWA, T. HIGUCHI

Helical β-peptide foldamers specifically inhibit the γ-secretase activity

527.14: *S. TAKAGI, C. SATO, T. TOMITA, T. IWATSUBO

Transmembrane domain 1 of Presenilin 1 contributes to the formation of the catalytic pore of γ-secretase

627.21: *Y. HORI, T. HASHIMOTO, H. NOMOTO, T. IWATSUBO

Isoform-specific effects of apolipoprotein E on the stability of protofibrils and amyloid deposition

731.23: *G. ITO, S. KAMIKAWAJI, T. IWATSUBO

Autophosphorylation in the kinase domain of LRRK2: Relevance to kinase activity


SFN 38th Annual Meeting
Washington, DC
November 15-19, 2008

339.15: *H. ISSHIKI, N. TAKASUGI, K. SUZUKI, T. TOMITA, T. IWATSUBO

Identification and analysis of a substrate-specific genetic modulator for γ-secretase activity

342.9: *G. ITO, S. KAMIKAWAJI, T. IWATSUBO

Functional characterization of phosphorylation of LRRK2

325.13: *Y. HAYASHI, T. TOMITA, R. KOPAN, T. IWATSUBO

Notch ligands expressed in nonneuronal cells increase synaptic vesicle proteins in glutamatergic neurons

441.22: *T. HASHIMOTO, Y. NAGATA, Y. HORI, E. KURANAGA, M. MIURA, T. IWATSUBO

Progressive retinal degeneration in transgenic Drosophila melanogaster overexpressing human TDP-43

609.7: *T. TOMITA, C. SATO, S. TAKAGI, T. IWATSUBO

Both the N- and C-terminal fragments of Presenilin 1 participate in the formation of the catalytic pore in γ-secretase

741.4: *T. KUWAHARA, A. KOYAMA, S. KOYAMA, S. YOSHINA, C.-H. REN, T. KATO, S. MITANI, T. IWATSUBO

A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in α-synuclein transgenic C. elegans


SFN 37th Annual Meeting
San Diego, CA
November 3-7, 2007

13.4: *T.TOMITA, I.HAYASHI, H.IWANARI, T.KODAMA, T.HAMAKUBO, T.IWATSUBO

Neutralization of the γ-secretase activity by a monoclonal antibody against extracellular domain of nicastrin

151.5: *G.ITO, S.KAMIKAWAJI, T.IWATSUBO

Characterization of phosphorylation of LRRK2

151.9: *S.TAKATORI, G.ITO, T.IWATSUBO

N-terminal processing and proteasomal degradation of PINK1

152.2: *T.HASHIMOTO, Y.HORI, H.NOMOTO, Y.NAGATA, T.IWATSUBO;

Isoform-specific effects of apolipoprotein E isoforms on the stability of amyloid Aβ peptide protofibrils

690.11: *C.SATO, S.TAKAGI, T.TOMITA, T.IWATSUBO

Structural analysis of the C-terminal fragment of Presenilin 1 by substituted cysteine accessibility method

690.12: *N.ISOO, C.SATO, H.MIYASHITA, N.TAKASUGI, S.TSUJI, T.TOMITA, T.IWATSUBO

Aβ42 overproduction associated with structural changes in the catalytic pore of γ-secretase

690.13: *H.MIYASHITA, T.OGURA, K.MIO, C.SATO, T.TOMITA, T.IWATSUBO

Three-dimensional structure of the γ-secretase complex reconstituted in Sf9 cells

885.18: *N.TAKASUGI, H.ISSHIKI, T.TOMITA, T.IWATSUBO

Sphingosine kinase inhibitor diminishes amyloid β production through inhibition of β-secretase activity


SFN 36th Annual Meeting
Atlanta, GA
October 14-18, 2006

170.11: *Y.HORI, T.HASHIMOTO, Y.WAKUTANI, M.M.CONDRON, S.TSUBUKI, T.C.SAIDO, D.B.TEPLOW, T.IWATSUBO

Intra-Aβ mutations (H6R and D7N) linked to familial Alzheimer's disease enhance the β-amyloid fibril formation without accumulation of protofibrils

172.14: *N.WATANABE, C.SATO, T.TOMITA, T.IWATSUBO

The roles of transmembrane domains of presenilin 1 in the acquisition of γ-secretase activity

172.16: *N.TAKASUGI, M.SHINOHARA, H.ISSHIKI, N.ISOO, T.TOMITA, T.IWATSUBO

Search for modulators of gamma-secretase activity by systematic RNAi screening in Drosophila cells

276.6: *G.ITO, T.OKAI, G.FUJINO, K.TAKEDA, H.ICHIJO, T.KATADA, T.IWATSUBO

Relationship between GTP binding and protein kinase activity of LRRK2

823.15: *T.HASHIMOTO, Y.MATSUURA, Y.NAGAE, D.FUJII, Y.MATSUO, S.OSAWA, M.MIURA, F.OYAMA, N.NUKINA, T.IWATSUBO

Motor neuronopathy caused by chronic accumulation of misfolded CLAC-P in ER membrane


SFN 35th Annual Meeting
Washington, DC
November 12-16, 2005

83.2: T.Hashimoto*; Y.Matsuura; D.Fujii; Y.Matsuo; H.Kowa; D.Westaway; T.Iwatsubo

PATHOLOGICAL ROLES OF CLAC IN β-AMYLOID DEPOSITION IN THE BRAINS OF TRANSGENIC MICE IN VIVO

245.3: T.Tomita*; M.Niimura; N.Takasugi; M.Shinohara; N.Isoo; C.Chijiiwa; H.Miyashita; Y.Takahashi; Y.Sugimoto; I.Hayashi; Y.Morohashi; T.Iwatsubo

THE ROLES OF CONSERVED HYDROPHILIC RESIDUES IN TRANSMEMBRANE DOMAINS OF APH-1 IN THE FORMATION AND FUNCTION OF γ-SECRETASE COMPLEX

423.19: K.Yamada*; C.Yabuki; M.Tachikawa; S.Ohtsuki; D.K.Strickland; T.Terasaki; T.Hashimoto; T.Iwatsubo

CHARACTERIZATION OF THE TRANSPORT SYSTEM OF AMYLOID β-PEPTIDE ACROSS THE BLOOD--BRAIN BARRIER IN VITRO

543.10: C.Sato*; N.Watanabe; Y.Morohashi; T.Tomita; T.Iwatsubo

STRUCTURAL ANALYSIS OF PRESENILIN 1 BY SUBSTITUTED-CYSTEINE ACCESSIBILITY METHOD

1005.10: G.Ito*; H.Ariga; Y.Nakagawa; M.Miyagishi; K.Taira; T.Maehama; T.Iwatsubo

MOLECULAR AND CELL BIOLOGICAL ANALYSIS OF THE FUNCTION OF DJ-1, A CAUSATIVE GENE FOR PARK7

1007.14: Y.Hanno*; G.Ito; M.Yoshimoto; N.Mizushima; T.Iwatsubo

ANALYSIS OF FACTORS INVOLVED IN AGGREGATION AND DEPOSITION OF α-SYNUCLEIN


SFN 34th Annual Meeting
San Deigo, CA
October 23-27, 2004

90.3: S.Tanaka*; T.Tomita; T.Iwatsubo

PROTEOLYTIC PROCESSING OF EPHRINB1 BY THE GAMMA-SECRETASE-LIKE ACTIVITY

90.10: I.Hayashi*; Y.Urano; R.Fukuda; N.Isoo; T.Kodama; T.Hamakubo; T.Tomita; T.Iwatsubo

RECONSTITUTION OF γ-SECRETASE ACTIVITIES IN BUDDED BACULOVIRAL PARTICLES

218.4: T.Hashimoto*; Y.Hori; K.Yamada; Y.Wakutani; M.M.Condron; S.Tsubuki; T.C.Saido; D.B.Teplow; T.Iwatsubo

APP (H6R AND D7N) MUTATIONS LINKED TO FAMILIAL ALZHEIMER'S DISEASE ALTER Aβ AMYLOID ASSEMBLY BUT NOT APP PROCESSING

558.10: T.Kuwahara*; A.Koyama; K.Gengyo-Ando; S.Mitani; T.Iwatsubo

DOPAMINE NEURON DYSFUNCTION IN TRANSGENIC CELEGANS EXPRESSING FAMILIAL PARKINSON MUTANT α-SYNUCLEIN


SFN 33rd Annual Meeting
New Orleans, LA
November 8-12, 2003

239.1: T.Tomita*; N.Takasugi; M.Niimura; N.Isoo; M.Tsuruoka; C.Sato; Y.Morohashi; T.Iwatsubo

Roles of presenilin cofactors in the formation of γ-secretase complex.

295.7: Y.Takahashi* ; I.Hayashi; S.Tanaka; Y.Morohashi; T.Kan; H.Natsugari; T.Fukuyama; T.Tomita; T.Iwatsubo

Differential inhibitory mechanisms of γ-secretase activities by sulindac sulfide and other g-secretase inhibitors.

841.23: T.Hashimoto* ; A.Nishimura; T.Sakakura; Y.Matuura; K.Yamada; Y.Osada; T.Wakabayashi; H.Kowa; T.Iwatsubo

in vitro and in vivo analyses of the pathogenic roles of CLAC in Alzheimer's brains.

944.18: Y.Osada* ; T.Hashimoto; T.Wakabayashi; A.Nishimura; T.Iwatsubo

Interaction of CLAC with Aβ is mediated by basic amino acid clusters on CLAC.


SFN 32nd Annual Meeting
Orlando, FL
November 2-7, 2002

327.8: T. Tomita*; Y. Takahashi; I. Hayashi; M. Tsuruoka; N. Isoo; S. Tanaka; Y. Morohashi; N. Takasugi; T. Iwatsubo

FUNCTIONAL ASSESSMENT OF PRESENILIN COMPLEX AND γ-SECRETASE ACTIVITY

590.11: T. Hashimoto*; A. Nishimura; T. Wakabayashi; Y. Osada; T. Iwatsubo

INTERACTION OF CLAC, A COLLAGEN-LIKE ALZHEIMER AMYLOID PLAQUE COMPONENT, WITH AMYLOID β PEPTIDE

590.12: H. Kowa*; T. Sakakura; T. Wakabayashi; T. Hashimoto; I. Kanazawa; D.M.A. Mann; T. Iwatsubo

DISTRIBUTION OF CLAC, Aβ40 AND Aβ42 IN SENILE PLAQUES OF ALZHEIMER AND DOWN SYNDROME BRAINS

689.9: T. Iwatsubo*; H. Fujiwara; A. Kawashima; A. Koyama; K. Gengyo-Ando; S. Mitani; M. Takahashi; H. Kanuka; M. Miura; M. Hasegawa

POSTTRANSLATIONAL MODIFICATIONS OF α-SYNUCLEIN IN SYNUCLEINOPATHY LESIONS


SFN 31st Annual Meeting
San Diego, CA
November 10-15, 2001

244.9: T. Tomita*; R. Takikawa; Y. Takahashi; T. Watabiki; Y. Morohashi; N. Takasugi; T. Iwatsubo

STRUCTURAL REQUIREMENTS OF PRESENILINS FOR REPLACEMENT, STABLE COMPLEX FORMATION AND γ-SECRETASE ACTIVITIES

323.17: T. Wakabayashi; T. Hashimoto; D.M.A. Mann; T. Iwatsubo

MOLECULAR CHARACTERIZATION OF CLAC, A COLLAGEN-LIKE ALZHEIMER AMYLOID PLAQUE COMPONENT, DEPOSITED IN ALZHEIMER BRAINS

323.18: T. Hashimoto*; T. Wakabayashi; Y. Osada; T. Iwatsubo

INTERACTION OF CLAC, A COLLAGEN-LIKE ALZHEIMER AMYLOID PLAQUE COMPONENT, WITH AMYLOID beta PEPTIDES

545.3: T. Iwatsubo; H. Fujiwara; A. Kawashima; N. Dohmae; K. Takio; M. Hasegawa

PHOSPHORYLATION AT SERINE 129 OF α-SYNUCLEIN IN SYNUCLEINOPATHY LESIONS THAT PROMOTES α-SYNUCLEIN FIBRILLIZATION

545.10: H. Fujiwara; M. Hasegawa; N. Dohmae; K. Takio; T. Iwatsubo

PHOSPHORYLATION OF α-SYNUCLEIN AT SER 129 IN THE BRAINS OF PATIENTS WITH DEMENTIA WITH LEWY BODIES

650.14: Y. Morohashi; N. Hatano; S. Ohya; T. Watabiki; N. Takasugi; Y. Takahashi; T. Tomita; Y. Imaizumi; T. Iwatsubo

MOLECULAR CLONING AND CHARACTERIZATION OF CALP/KCHIP4, A NOVEL EF-HAND PROTEIN INTERACTING WITH C TERMINUS OF PRESENILIN2


SFN 30th Annual Meeting
New Orleans, LA
November 4-9, 2000

201.13: T. Iwatsubo; T. Hashimoto; T. Wakabayashi; A. Watanabe; R. Hosoda; T. Arai; D.M.A. Mann; K. Takio

IDENTIFICATION OF A NOVEL ALZHEIMER AMYLOID PLAQUE COMPONENT DERIVED FROM A TRANSMEMBRANE COLLAGEN-LIKE PROTEIN.

298.12: T. Tomita*; T. Watabiki; R. Takikawa; Y. Morohashi; N. Takasugi; T. Iwatsubo

HIGHLY CONSERVED C-TERMINAL MOTIF OF PRESENILINS IS REQUIRED FOR ITS ASSEMBLY, STABILIZATION AND FUNCTION.

474.15: N. Takasugi; T. Tomita; R. Takikawa; T. Watabiki; C. Saura; G. Thinakaran; K. Maruyama*; T. Iwatsubo

DIFFERENTIAL REQUIREMENTS OF DOMAINS IN PRESENILIN 2 FOR Aβ GENERATION AND APOPTOSIS.

764.6: T. Hashimoto; T. Wakabayashi; A. Watanabe; R. Hosoda; T. Arai; T. Miyagawa*; K. Takio; D.M.A. Mann; T. Iwatsubo

SECRETION OF A NOVEL COLLAGEN-LIKE ALZHEIMER AMYLOID PLAQUE COMPONENT FROM ITS PRECURSOR IS MEDIATED BY FURIN CONVERTASE.


SFN 29th Annual Meeting
Miami Beach, FL
October 23-28, 1999

29.7: T. TOMITA, R. TAKIKAWA, Y. MOROHASHI, N. TAKASUGI, A. KOYAMA AND T. IWATSUBO

Stabilization of presenilins mediated by their carboxyl terminal domains is crucial for the induction of abnormal γ-cleavage of βAPP.

240.1: H. IWATA, T. TOMITA, A. IWAI, K. MARUYAMA AND T. IWATSUBO.

Identification of the intracellular site of Aβ42 generation that is influenced by mutant presenilins.

426.11: T. IWATSUBO*, T. TOMITA, R. TAKIKAWA, Y. MOROHASHI, N. TAKASUGI AND A. KOYAMA.

Caroboxyl-terminus of presenilins is required for overproduction of Aβ42 through stabilization of presenilins.


SFN 28th Annual Meeting
Los Angels, CA
November 7-12, 1998

8.12: T. IWATSUBO*, T. TOMITA, S. TOKUHIRO, T. HASHIMOTO, A. KOYAMA, N. TAKASUGI, K. AIBA, T.C. SAIDO AND K. MARUYAMA.

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of Aβ42.

181.21: T. TOMITA*, A. KOYAMA. N. TAKASUGI, K. AIBA, S. TOKUHIRO, T.C. SAIDO, K. MARUYAMA AND T. IWATSUBO.

Differential effcts of truncation of amino- and carboxyl-terminal domains of presenilin 2.


SFN 27th Annual Meeting
New Orleans, LA
October 25-30, 1997

871.8: T. IWATSUBO*, T. TOMITA, S. TOKUHIRO, T. HASHIMOTO, T.C. SAIDO AND K. MARUYAMA.

PRESENILIN 2 MUTATIONS LINKED TO FAMILIAL ALZHEIMER'S DISEASE INCREASE THE PRODUCTION OF Aβ42.

733.7: T. TOMITA*, S. TOKUHIRO, T. HASHIMOTO, K. AIBA, T.C. SAIDO, C. HAASS, K. MARUYAMA AND T. IWATSUBO.

PROCESSING OF PRESENILIN 2 IN CULTURED CELLS AND MURINE TISSUES.