Alzheimer's Association International Conference AAIC 2012
July 14-19, 2012
Vancouver, Canada

PICALM regulates Abeta42 production by modulation of gamma-secretase trafficking

Taisuke Tomita, Yuichi Morohashi, Kunihiko Kanatsu, Takeshi Iwatasubo
Poster


Alzheimer's Association International Conference AAIC 2011
July 16-21, 2011
Paris, France

BACE1 activity is modulated by cell-associated sphingosine-1-phosphate

Taisuke Tomita, Nobumasa Takasugi, Tomoki Sasaki, Satoko Osawa, Satoshi Yokoshima, Tohru Fukuyama, Virginia M. Y. Lee, John Q. Trojanowski, Takeshi Iwatsubo
Poster


International Conference on Alzheimer's Disease 2010
July 10-15, 2010
Honolulu, Hawaii

J-ADNI and selection of cognition measures

Takeshi Iwatsubo
Oral

Molecular mechanism of action of gamma-secretase inhibitors and modulators

Taisuke Tomita
Oral


International Conference on Alzheimer's Disease 2009
July 11-16, 2009
Vienna, Austria

Intrabody against immature nicastrin disrupts the proper folding and the glycosyl maturation of the extracellular domain of nicastrin

Ikuo Hayashi, Sho Takatori, Yasuomi Urano, Tatsuhiko Kodama, Takao Hamakubo, Taisuke Tomita, Takeshi Iwatsubo
Poster

Three dimentional structure of signal peptide peptidase

Hiroyuki Miyashita, Yuusuke Maruyama, Toshihiko Ogura, Kazuhiro Mio, Takeshi Iwatsubo, Taisuke Tomita, Chikara Sato
Poster

Single chain variable fragment against Nicastrin inhibits the gamma-secretase activity

Taisuke Tomita, Ikuo Hayashi, Sho Takatori, Yasuomi Urano, Hiroko Iwanari, Tatsuhiko Kodama, Takao Hamakubo, Takeshi Iwatsubo
Oral


International Conference on Alzheimer's Disease 2008
July 26-31, 2008
Chicago, USA

Isoform-specific effects of apolipoprotein E on the stability of Abeta protofibrils

Yukiko Hori, Tadafumi Hashimoto, Hidetoshi Nomoto, Takeshi Iwatsubo
Posters P1. Sunday Posters (P1-478)

Neuron-specific regulation of beta-secretase activity by sphingosine kinase

NOBUMASA TAKASUGI, Kunimichi Suzuki, Hayato Isshiki, Taisuke Tomita, Takeshi Iwatsubo
Posters P3. Tuesday Posters (P3-348)

Structure of the catalytic pore of gamma-secretase

Takeshi Iwatsubo
Symposium S4-01. Disease Mechanisms - Presenilins

Chemical biological analysis of gamma-secretase using arylsulfonamide-type inhibitors

Yasuaki Sugimoto1, Haruhiko Fuwa2, Satoshi Yokoshima3, Tohru Fukuyama3, Makoto Sasaki2, Taisuke Tomita1, Takeshi Iwatsubo1
Posters P4. Wednesday Posters (P4-207)

Transmembrane domain 1 of presenilin 1 contributes to the formation of the catalytic pore of gamma-secretase

Shizuka Takagi, Chihiro Sato, Taisuke Tomita, Takeshi Iwatsubo
Posters P4. Wednesday Posters (P4-208)

The functional roles of transmembrane domains of presenilin 1 in the formation of active gamma-secretase complex

Naoto Watanabe, Taisuke Tomita, Takeshi Iwatsubo
Posters P4. Wednesday Posters (P4-211)

C-terminal PAL motif of presenilin 1 comprises the subsite of gamma-secretase within the catalytic pore

Taisuke Tomita, Chihiro Sato, Shizuka Takagi, Takeshi Iwatsubo
Oral O4-03. Disease Mechanisms: Presenilins


The 10th International Conference on Alzheimer's Disease and Related Disorders
July 15-20, 2006
Madrid, Spain

OVEREXPRESSION OF HUMAN ALPHA-SYNUCLEIN IN TRANSGENIC C. ELEGANS: EFFECTS OF PATHOGENIC MUTATIONS AND PHOSPHORYLATION

Tomoki Kuwahara1, Changhong Ren2, Akihiko Koyama1, Shigeki Arawaka2, Takeo Kato2, Shohei Mitani3, Takeshi Iwatsubo1
Poster P1. Sunday Posters (P1-059)

PATHOLOGICAL EFFECTS OF CLAC IN THE BRAINS OF APP/CLAC-P DOUBLE TRANSGENIC MICE

Tadafumi Hashimoto1, Daisuke Fujii1, Yuko Matsuo1, Yusuke Matsuura1, David Westaway2, Takeshi Iwatsubo1
Poster P1. Sunday Posters (P1-114)

DIFFERENT ACTIONS OF DIPEPTIDIC COMPOUNDS ON PRESENILINS DEFINE THE ENZYME SPECIFICITY OF -SECRETASE INHIBITOR

Taisuke Tomita1, Yasuko Takahashi1, Haruhiko Fuwa2, Yu Konno2, Yuichi Morohashi1, Toshiyuki Kan3, Yasuaki Sugimoto1, Tohru Fukuyama1, Makoto Sasaki2, Hideaki Natsugari1, Takeshi Iwatsubo1
Oral O1-02. Disease Mechanisms (Presenilins/-Secretase) 1 (O1-02-07)

STRUCTURE AND FUNCTION OF -SECRETASE

Takeshi Iwatsubo, Taisuke Tomita
Symposia S2-03. Disease Mechanisms (Presenilins/- Secretase) (S2-03-04)

GENERATION OF MONOCLONAL ANTIBODIES AGAINST THE EXTRACELLULAR DOMAIN OF NICASTRIN

Ikuo Hayashi1, Yasuomi Urano2, Hiroko Iwanari3, Tatsuhiko Kodama2, Takao Hamakubo2, Taisuke Tomita1, Takeshi Iwatsubo1
Poster P3. Tuesday Poster (P3-412)

PROBING THE STRUCTURAL CHANGES OF PRESENILIN 1 BY SUBSTITUTED-CYSTEINE ACCESSIBILITY METHOD

Chihiro Sato, Naoto Watanabe, Yuichi Morohashi, Taisuke Tomita, Takeshi Iwatsubo
Poster P3. Tuesday Poster (P3-416)

MODELING AMYLOID -PEPTIDE TRANSPORT ACROSS THE BLOOD-BRAIN BARRIER IN TR-BBB CELLS

Kaoru Yamada1, Chiori Yabuki1, Masanori Tachikawa2, Sumio Ohtsuki2, Dudley K. Strickland3, Guojun Bu4, Tetsuya Terasaki2, Tadafumi Hashimoto1, Takeshi Iwatsubo1
Poster P4. Wednesday Posters (P4-069)


The 9th International Conference on Alzheimer's Disease and Related Disorders
July 17-22, 2004
Pennsylvania, USA

CLAC-POSITIVE SENILE PLAQUES IN ALZHEIMER BRAINS: MUTUALLY EXCLUSIVE DISTRIBUTION TO A40 AND ACQUISITION OF PROTEASE RESISTANCE

Hisatomo Kowa1, Tomoko Sakakura1, Yusuke Matsuura1, Tomoko Wakabayashi1, Shoji Tsuji1, David M. Mann2, Tadafumi Hashimoto1, Takeshi Iwatsubo1
P1. Poster Session (P1-235)

BIOCHEMICAL CHARACTERIZATION OF THE CORE STRUCTURE OF TAU FILAMENT

Sayuri Taniguchi1,2, Takashi Nonaka2, David Mann3, Kunimasa Arima4, Takeshi Iwatsubo1, Masato Hasegawa2
P3. Poster Session (P3-262)

ROLES OF PRESENILIN COFACTORS IN THE ASSEMBLY AND ACTIVITY OF -SECRETASE COMPLEX

Manabu Niimura, Sayaka Tanaka, Mitsuru Shinohara, Yasuko Takahashi, Yuichi Morohashi, Takeshi Iwatsubo
O3-05 Oral Presentation (O3-05-04)

FORMATION AND FUNCTION OF THE GAMMA-SECRETASE COMPLEX

Takeshi Iwatsubo
Plenary Lecture (PL-4)

FUNCTIONAL ANALYSIS OF NICASTRIN AND PEN-2 IN -SECRETASE COMPLEX

Isoo Noriko1,2, Tsuruoka Makiko1, Miyagishi Makoto3, Taira Kazunari3, Tsuji Shoji2, Tomita Taisuke1, Iwatsubo Takeshi1
P4. Poster Session (P4-306)

PRESENILIN-1 IS A MOLECULAR TARGET OF A DIPEPTIDIC -SECRETASE INHIBITOR, DAPT

Yuichi Morohashi, Yusuke Tominari, Naoto Watanebe, Toshiyuki Kan, Haruhiko Fuwa, Hideaki Natsugari, Tohru Fukuyama, Taisuke Tomita, Takeshi Iwatsubo
P4. Poster Session (P4-322)


The 8th International Conference on Alzheimer's Disease and Related Disorders
July 20-25, 2002
Stockholm, Sweden

Presentation (Abstract number: 770):
MOLECULAR CHARACTERIZATION OF A NOVEL COLLAGEN-LIKE ALZHEIMER AMYLOID PLAQUE COMPONENT, CLAC AND ITS PRECURSOR, CLAC-P

Tomoko Wakabayashi1, Tadafumi Hashimoto1, Yoshihide Osada2, David Mann3, Takeshi Iwatsubo4
Session: Non-beta-amyloidosis - P2
Type: Poster Presentations

Presentation (Abstract number: 772):
INTERACTION OF CLAC, A COLLAGEN-LIKE ALZHEIMER AMYLOID PLAQUE COMPONENT, WITH AMYLOID PEPTIDES

Tadafumi Hashimoto, Akiko Nishimura, Tomoko Wakabayashi, Yoshihide Osada, Takeshi Iwatsubo
Session: Non-beta-amyloidosis - P2
Type: Poster Presentations

Presentation (Abstract number: 1035):
FUNCTIONAL ANALYSIS OF PRESENILIN COMPLEX AND -SECRETASE ACTIVITY

Taisuke Tomita, Yasuko Takahashi, Ikuo Hayashi, Yuichi Morohashi, Sayaka Tanaka, Noriko Isoo, Tomonari Watabiki, Makiko Tsuruoka, Nobumasa Takasugi, Takeshi Iwatsubo
Session: Presenilin I - Structure function and interactions - M10
Type: Oral Presentations

Presentation (Abstract number: 1060): STRUCTURE AND FUNCTION OF PRESENILINS

Takeshi Iwatsubo
Session: Presenilins - T3
Type: Symposia


World Alzheimer Congress 2000
Washington Hilton and Towers, Washington D.C., U.S.A.
July 9-18 2000

Poster Presentations - Molecular and Cellular Biology II
The integrity of carboxyl terminus of Presenilin 2 is essential for its functions.

Taisuke Tomita, Nobumasa Takasugi, Rie Takikawa, Tomonari Watabiki, Yuichi Morohashi, Takeshi Iwatsubo
Univ of Tokyo, Tokyo Japan
Category: Molecular and cellular biology - Keywords: A-beta, Presenilin, Presenilin Associated Protein

Symposia - C5 Presenilins and Alzheimer's Disease - Part II
Structure, Function Studies of Presenilin

Takeshi Iwatsubo, Taisuke Tomita, Rie Takikawa, Tomonari Watabiki, Yuichi Morohashi, Nobumasa Takasugi
University of Tokyo, Tokyo Japan


The 6th INTERNATIONAL CONFERENCE ON ALZHEIMER'S DISEASE AND RELATED DISORDERS
Amsterdam RAI
18-23 JULY 1998

Poster Session: Molecular Pathology IV
Program Number: 452
Title: Analysis of the mechanism of -cleavage of APP in cultured cells.

Authors: H. IWATA*, T. TOMITA, T. -Y. CHANG, K. KODAMA, AND T. IWATSUBO
Inst: UNIV. OF TOKYO, JAPAN

Poster Session: Molecular Pathology IV
Program Number: 485
Title: Novel 50/100 kDa proteins in amyloid plaques of Alzheimer's disease and Down's syndrome brains as revealed by a monoclonal antibody 9D2.

Authors: T. HASHIMOTO, R. HOSODA, A. WATANABE, T. ARAI, K. TAKIO, D.M. A. MANN AND T. IWATSUBO
Inst: UNIV. OF TOKYO, JAPAN

Poster Session: Molecular Pathology V
Program Number: 802
Title: Molecular dissection of mutant presenilin 2protein that promote the overproduction A42.

Authors: T. TOMITA, S. TOKUHIRO, K. AIBA, A. KOYAMA, N. TAKASUGI, T.HASHIMOTO, T. C. SAIDO, K. MARUYAMA AND T. IWATSUBO
Inst: UNIV. OF TOKYO, JAPAN