機能病態学教室における業績リスト

原著論文
  1994
  1995
  1996
  1997
総説
単行書
その他
招待講演
学会発表



原著論文 (1994年以降)

1.Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y: Visualization of Abeta42(43) and Abeta40 in senile plaques with end-specific Abeta monoclonals: Evidence that an initially deposited species is Abeta42(43). Neuron 13:45-53,1994

2. Suzuki N, IwatsuboT, Odaka A, Ishibashi Y, Kitada C, Ihara Y: High tissue content of soluble beta 1-40 is linked to cerebral amyloid angiopathy. Am J Pathol145:452-460, 1994

3. IwatsuboT, Hasegawa M, Ihara Y: Neuronal and glial tau-positive inclusions in diverse neurologic diseases share common phosphorylation characteristics. Acta Neuropathol 88:129-136, 1994

4. Arai H, HiguchiS, Muramatsu T, Iwatsubo T, Sasaki H, Trojanowski JQ: ApolipoproteinE gene in diffuse Lewy body disease with or without co-existing Alzheimer's disease. Lancet 344:1307, 1994



5.Saido TC, Iwatsubo T, Mann DMA, Ihara Y, Shimada H, KawashimaS: Dominant and differential deposition of distinct beta amyloid peptide species,AbetaN3(pE), in senile plaques. Neuron 14:457-466, 1995

6. IwatsuboT, Mann DMA, Odaka A, Suzuki N, Ihara Y: Amyloid beta protein (Abeta)deposition: Abeta42(43) precedes Abeta40 in Down syndrome. Ann Neurol 37:294-299,1995

7. Mann DMA, Pickering-BrownS, Siddons MA, Iwatsubo T, Ihara Y, Odaka A, Suzuki N: The extent of amyloid deposition in brain in Down's syndrome does not depend upon the apolipoprotein E genotype. Neurosci Lett 196:105-108, 1995

8. Mann DMA, IwatsuboT, Ihara Y, Fukumoto H, Odaka A, Suzuki N: Microglial cells and amyloid beta protein (Abeta) deposition; association with Abeta40 containing plaques. Acta Neuropathol 90:472-477, 1995



9.Fukumoto H, Asami-Odaka A, Suzuki N, Shimada H, Ihara Y,Iwatsubo T: Amyloid beta protein (Abeta) deposition in normal aging has the same characteristics as that in Alzheimer's disease: predominance ofAbeta42(43) and association of Abeta40 with cored plaques. Am J Pathol 148:259-266,1996

10. FukumotoH, Asami-Odaka A, Suzuki N, Iwatsubo T: Association of Abeta40-positive senile plaques with microglial cells in the brains of patients with Alzheimer's disease and in non-demented aged individuals. Neurodegeneration 5:13-17, 1996

11. Nakano I, IwatsuboT, Otsuka N, Kamei M, Matsumura K, Mannen T: Some unusual astrocytic responses against ghost tangles in a long survival case of juvenile Alzheimer's disease--An electron microscopic study-- J Neurol Sci 136:41-46, 1996

12. Kume H, MaruyamaK, Tomita T, Iwatsubo T, Saido TC, Obata K: Molecular cloning of a novel basic helix-loop-helix protein from rat brain.Biochem Biophys Res Comm 219:526-530, 1996

13. Mann DMA,Iwatsubo T, Ihara Y, Cairns NJ, Lantos PL, Bogdanovic N, LannfeltL, Winblad B, Maat-Schieman MLC, Rossor MN: Predominant deposition of amyloidbeta42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral haemorrhage associated with mutations in the APP gene. Am J Pathol 148:1257-1266,1996

14. IwatsuboT, Yamaguchi H, Fujimuro M, Yokosawa H, Ihara Y,Trojanowski JQ, Lee VM-Y: Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease. Am J Pathol148:1517-1529, 1996

15. Yamatsuji T,Matsui T, Okamoto T, Komatsuzaki K, Takeda S, Fukumoto H,Iwatsubo T, Suzuki N, Asami-Odaka A, Ireland S, Kinane B, GiambarellaU, Nishimoto I: G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP. Science 272:1349-1352,1996

16. IwatsuboT, Yamaguchi H, Fujimuro M, Yokosawa H, Ihara Y,Trojanowski JQ, Lee VM-Y: Lewy bodies: purification from diffuse Lewy body disease brains. Ann NY Acad Sci 786:195-205, 1996

17. Mann DMA,Iwatsubo T, Snowden JS: Atypical amyloid (Abeta) deposition in the cerebellum in Alzheimer's disease: an immunohistochemical study using end-specific Abeta monoclonal antibodies. Acta Neuropathol 91:647-653, 1996

18. Mann DMA,Iwatsubo T: Diffuse plaques in the cerebellum and corpus striatumin Down's syndrome contain amyloid beta protein (Abeta) only in the form of Abeta42.Neurodegeneration 5:115-120, 1996

19. Mann DMA, IwatsuboT, Cairns NJ, Lantos PL, Nochlin D, Sumi SM, Bird TD, Poorkaj P,Hardy J, Hutton M, Prihar G, Crook R, Rossor MN, Haltia M: Amyloid beta protein(Abeta) deposition in chromosome 14-linked Alzheimer's disease: predominance of Abeta42(43). Ann Neurol 40:149-156, 1996

20. Kanemaru K,Iwatsubo T, Ihara Y: Comparable amyloid beta protein (Abeta) 42(43)and Abeta40 deposition in the aged monkey brain. Neurosci Lett 214:196-198,1996

21. Saido TC, Yamao-HarigayaW, Iwatsubo T, Kawashima S: Amino- and carboxyl-terminal heterogeneity of beta amyloid peptides deposited in human brain. NeurosciLett 215:173-176, 1996

22. Maruyama K,Tomita T, Shinozaki K, Kume H, Asada H, Saido TC, IshiuraS, Iwatsubo T, Obata K: Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of Abeta42(43). Biochem Biophys Res Comm 227:730-735, 1996

23. IwatsuboT, Saido TC, Mann DMA, Lee VM-Y, Trojanowski JQ: Full-length amyloid-beta(1-42(43))as well as amino-terminally modified and truncated amyloid-beta42(43) deposit in diffuse plaques. Am J Pathol 149:1823-1830, 1996



24.Mann DMA, Iwatsubo T, Nochlin D, Sumi M, Levy-Lahad E, BirdTD: Amyloid (Abeta) deposition in chromosome 1-linked Alzheimer's disease.--The Volga German families. Ann Neurol 41:52-57, 1997

 

25. TomitaT, Maruyama K*, Saido TC, Kume H, Shinozaki K, Tokuhiro S,Capell A, Walter J, Gruenberg J, Haass C, Iwatsubo T*, ObataK: The presenilin 2 mutation (N141I) linked to familial Alzheimer disease(Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue. Proc Natl Acad Sci USA 94:2025-2030, 1997(*shared corresponding author)

26. Mann DMA, IwatsuboT, Pickering-Brown SM, Owen F, Saido TC, Perry RH: Preferential deposition of amyloid beta protein (Abeta) in the form of Abeta40 in Alzheimer's disease is associated with a gene dosage effect of the apolipoprotein EE4 allele. Neurosci Lett 221:81-84, 1997

27. Mann DMA, Pickering-BrownSM, Byatti NN, Wright AE, Owen F, Iwatsubo T, Saido TC: An intronic polymorphism in the presenilin-1 gene does not influence the amount or molecular form of the amyloid beta protein deposition in Alzheimer's disease. Neurosci Lett 222:57-60, 1997

28. Lee J-A, HommaH, Sakai K, Fukushima T, Santa T, Tashiro K, IwatsuboT, Yoshikawa M, Imai K: Immunohistochemical localization of D-aspartate in the rat pineal gland. Biochem Biophys Res Comm 231:505-508, 1997

29. KosakaT, Imagawa M, Seki K, Arai H, Sasaki H, Tsuji S, Asami-Odaka A,Fukushima T, Imai K, Iwatsubo T: The betaAPP717 Alzheimer mutation increases the percentage of plasma amyloid beta protein ending at Abeta42(43).Neurology 48:741-745, 1997

30. Takamatsu J,Kimura T, Kondo A, Iwatsubo T: Subpial amyloid plaques in the cerebellum in a case of Alzheimer's disease. Dement Geriatr Cogn Disord8:157-162, 1997

31. Sakai K, HommaH, Lee J-A, Fukushima T, Santa T, Tashiro K, IwatsuboT, Imai K: D-aspartic acid localization during postnatal development of rat adrenal gland. Biochem Biophys Res Comm 235:433-436, 1997

32. Sakurai Y, MatsumuraK, Iwatsubo T, Momose T: Frontal pure agraphia for Kanjiand Kana: dissociation between morphology and phonology. Neurology (inpress)

33. Galvin JE, LeeVM-Y, Baba M, Mann DMA, Dickson DW, Yamaguchi H,Schmidt ML, Iwatsubo T, Trojanowski JQ: Monoclonal antibodies to purified cortical Lewy bodies recognize the mid-size neurofilament subunit. Ann Neurol (in press)

34. TashiroK, Hasegawa M, Ihara Y, Iwatsubo T: Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex. Neuroreport (in press)

35. Cook DG, FormanM, Sung JC, Leight S, Kolson DL, Iwatsubo T, Lee VM-Y, DomsRW: Alzheimer Abeta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells. Nature Med (in press)

36. Arai H, KosakaT, Clark CM, Ewbank DC, Matsui T, Iwatsubo T, TerajimaM, Higuchi S, Muramatsu T, Matsushita S, Seki H, Takase S, Lee VM-Y, TrojanowskiJQ, Sasaki H: Sensitivity and specificity of cerebrospinal fluid Abeta1-40,Abeta1-42(43) and tau in the antemortem diagnosis of Alzheimer's disease.(submitted)

37. FukumotoH, Tomita T, Matsunaga H, Ishibashi Y, Saido TC,Iwatsubo T: Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid beta proteins ending at Abeta40 and Abeta42(43). (submitted)

38. HosodaR, Saido TC, Otvos LJr, Arai T, Mann DMA, Lee VM-Y, TrojanowskiJQ, Iwatsubo T: Quantification of modified forms of amyloidbeta peptides in Alzheimer’s disease and Down’s syndrome brains. (submitted)



  総説

1. 岩坪威:アルツハイマー神経原線維変化とその構成蛋白質 代謝 29: 333-342,1992

2. 岩坪威、金光晟:ヒトの錐体路 脳神経 45:21-37, 1993

3. 岩坪威:結核性髄膜炎 Brain Medical 5:367-370, 1993

4. 岩坪威:アルツハイマー病の病理学 臨床医 21:32-35, 1995

5. 岩坪威:βアミロイド:免疫組織化学的研究の現状 医学のあゆみ 174:543-548 1995

6. 岩坪威:アルツハイマー病:最新の知見 JIM 5:1099-1101, 1995

7. 岩坪威:神経系の遺伝子疾患:アルツハイマー病 ブレインサイエンス7:17-22, 1996

8. 岩坪威:アルツハイマー型痴呆、アポリポ蛋白Eのポリモルフィズムとβアミロイド蓄積の相互関係 内科78:780-781, 1996



  単行書

1. 岩坪威:アルツハイマー病脳内蓄積物の免疫組織化学 組織細胞化学 1994日本組織細胞学会(編) 学際企画 東京 1994 p21-24

2. 岩坪威、萬年徹:連続切片標本による脳・脊髄解剖アトラス (翻訳・JamesD. Fix) 医学書院 1994

3. 岩坪威:アルツハイマー病の分子病態 脳と神経科学シリーズ(2)「痴呆解明への新しい展開」高橋徹ら(編) メジカルビュー社 1996 pp.101-116

4. 岩坪威:神経系のアミロイド 他5編 キーワードを読む 脳・神経 岩田誠ら(編) 医学書院1997 p.77

5. 岩坪威:プリオン病;脳神経系の発生;特殊な脳血管障害 神経内科学書 第2版 豊倉康夫(編)朝倉書店1997(印刷中)



  その他

1. 岩坪威:β-amyloidogenesis最近の話題。文部省重点研究  老年痴呆 Newsletter3 (1):4-6 1994

2. 岩坪威:神経変性疾患研究における最近の進歩 日本薬学会シンポジウム高次脳機能障害と予防、治療薬 要旨集 p.37, 1994

3. 岩坪威:学会記:第24回米国神経科学会 文部省重点研究 老年痴呆 Newsletter3 (3):6-9 1995



  招待講演

1. アルツハイマー脳におけるPHF蓄積の病理学 199212月 武田薬品工業開拓第一研究所 筑波

2. 脳老化の病理学的側面 19939月 武田薬品工業創薬第一研究所 大阪

3. アルツハイマー病の最近の進歩 1994325日 第4回新潟臨床痴呆懇話会 新潟

4. Department of Pathology and Laboratory medicine, University of Pennsylvania, Philadelphia. Isolation and characterization of Lewy body filaments. April 6 1994 Philadelphia

5. The University of Pennsylvania Alzheimer's Center. Abeta1-40 versus Abeta1-42 in AD brain: Immunocytochemical and Enzyme Immunosorbent Assay Studies. April 8 1994 Philadelphia

6. アルツハイマー病脳異常蓄積物の免疫組織化学 第19回組織細胞化学講習会特別講演 1994811日 東京

7. betaamyloidogenesis: C末端からのアプローチ(2)老人斑・血管アミロイドの免疫組織化学的解析 文部省重点研究「老年痴呆」平成6年度夏期ワークショップ 1994823日 大阪

8. βアミロイド研究最近の動向 武田薬品工業創薬第一研究所 1994824日 大阪

9. アルツハイマー病の分子病理学 第27回若手放射線生物学研究会 芦ノ湖シンポジウム 199499日 箱根

10. アルツハイマー病におけるβアミロイド形成機序に関する最近の知見 東北大学老人科 19941024日 仙台

11. The 12th International Congress of Pathophysiology. Immunocytochemical studies on beta amyloidogenesis. November1994 Kyoto

12. 中枢神経系におけるタウ蛋白のリン酸化について 東京都精神医学総合研究所神経病理部門 1995125日 東京

13. The University of Pennsylvania Alzheimer's Center. Pathogenetic mechanism of Abeta deposition in Alzheimer's disease and Down's syndrome. February 3 1995 Philadelphia

14. beta amyloid生成機序 24回日本医学会総会シンポジウム 199548日名古屋

15. The 15th International Society for Neurochemistry Satellite Symposium "Alzheimer's Disease: Emerging Therapeutic Strategies" Amyloid beta protein deposition in Alzheimer's disease and Down's syndrome: an immunocytochemical study. July 1995 Kyoto

16. Department of Pathology and Laboratory medicine, University of Pennsylvania, Philadelphia. Lewy body isolation and characterization October 24, 1995 Philadelphia

17. アルツハイマー病脳に蓄積する蛋白質の構造変化 第一回Dアミノ酸情報交換会 1996319日 東京

18. Athena Neurosciences Inc. Amyloid beta protein: analyses using end- and modification-specific antibodies. March29, 1996 South San Francisco

19. Lewy小体のpathobiology 三菱化学生命科学研究所 199657日 東京

20. アルツハイマー病研究最近の進歩 武田薬品工業創薬第一研究所1996723日 大阪

21. The fifth International Conference on Alzheimer's Disease and Related Disorders. "APP Processing: The Potential for Therapeutic Approaches to Treat Alzheimer's Disease". Generation and deposition of amyloid beta protein: analyses using end- and modification-specific Abeta antibodies. July 1996 Osaka

22. Department of Pathology and Laboratory medicine, University of Pennsylvania, Philadelphia. Amyloid beta protein and presenilins. August 5, 1996 Philadelphia

23. 神経変性疾患と薬理:アルツハイマー病 慶応大学医学部薬理学教室 1996928日 東京

24. アルツハイマー病:Abeta42presenilinをめぐって第23回ニューロサイエンスクラブ 東京大学神経内科 1997114日 東京

25. Tokyo Institute of Psychiatry The 11th International Symposium. The Molecular Biology of Alzheimer's Disease and Animal Models: Routes to the Development of New Therapies.Abeta42, presenilins, and Alzheimer's disease. March 4, 1997, Tokyo

26 アルツハイマー病の分子病態:βアミロイドとプレセニリンをめぐって 第6回アルカイックシンポジウム 1997329日 尼崎

27. アルツハイマー病:βアミロイドペプチドとプレセニリン蛋白をめぐる最近の話題 第4回クロマトグラフィーシンポジウム 199762日 仙台

28. βアミロイドとpresenilinをめぐる最近の話題 兵庫県立高齢者脳機能研究センター 1997711日 姫路



  学会発表(国際学会)

 

1. Iwatsubo T, SuzukiN, Odaka A, Nukina N, Mizusawa H, Ihara Y: Predominance of Abeta42(43) overAbeta40 in Alzheimer's disease. XIIth International Congress of Neuropathology. September 1994 Toronto (Brain Pathol 4: 544, 1994)

2. Iwatsubo T, MannDMA, Odaka A, Suzuki N, Saito H, Ihara Y: Abeta deposition: Abeta42(43) precedesAbeta40 in Down's syndrome brain. 24th annual meeting, Society for Neuroscience. November 1994 Miami (Soc Neurosci Abstr 24:607, 1994)

3. Iwatsubo T, YamaguchiH, Fujimuro M, Yokosawa H, Ihara Y, Trojanowski JQ, Lee VM-Y: Lewy bodies: purification from diffuse Lewy body disease brains. Sixth Congress for the International Association of Biomedical Gerontology. August 1995,Makuhari (International Gerontology Week Abstract p.29, 1995)

4. Iwatsubo T, YamaguchiH, Fujimuro M, Yokosawa H, Ihara Y, Trojanowski JQ, Lee VM-Y: Lewy bodies: purification from diffuse Lewy body disease brains and identification of Lewy body-associated polyubiquitin chains. 9th Annual Symposium on Etiology, Pathogenesis and Treatment of Parkinson's disease. October 1995, Washington D.C. (Movement Disorders 10: 688-689, 1995)

5. Iwatsubo T, SaidoTC, Mann DMA, Fukumoto H, Asami-Odaka A, Suzuki N, Ihara Y: Carboxyl- and amino-terminal properties of deposited Abeta in Alzheimer and Down's syndrome brains. 25th annual meeting, Society for Neuroscience. November 1995 San Diego (Soc Neurosci Abstr 25:1478,1995)

6. Saido TC, Iwatsubo T,Shimada H, Ihara Y, Kawashima S: In vivo modifications of beta amyloid peptide providing protection from major aminopeptidases. 25th annual meeting, Society for Neuroscience. November 1995 San Diego (Soc Neurosci Abstr 25:1477 1995)

7. Kosaka T, ImagawaM, Seki K, Arai H, Sasaki H, Tsuji S, Asami-Odaka A, Fukushima T, ImaiK, Iwatsubo T: The betaAPP717 Alzheimer mutation increases the percentage of plasma amyloid beta protein ending at Abeta42(43). 5th International Conference on Alzheimer's disease and related disorders. July 1996 Osaka (Neurobiol Aging 17:S82, 1996)

8. Fukumoto H, Asami-OdakaA, Suzuki N, Shimada H, Ihara Y, Iwatsubo T: Amyloid beta protein(Abeta) deposition in normal aging has the same characteristics as that in Alzheimer's disease: predominance of Abeta42(43) and association of Abeta40 with cored plaques and microglial cells. 5th International Conference on Alzheimer's disease and related disorders. July 1996 Osaka (Neurobiol Aging 17:S132,1996)\

9. Tashiro K, HasegawaM, Ihara Y, Iwatsubo T: Distribution of phosphorylated tau in juvenile and adult rat brains. 5th International Conference on Alzheimer's disease and related disorders. July 1996 Osaka (Neurobiol Aging 17:S126,1996)

10. Tomita T, MaruyamaK, Saido TC, Hosoda R, Tokuhiro S, Kume H,Kuzume H, Asada H, Kawamura Y, Iwatsubo T, Obata K: Characterization of presenilins overexpressed in cultured cells. 5th International Conference on Alzheimer's disease and related disorders. July 1996 Osaka (Neurobiol Aging 17:S15, 1996)

11. Maruyama K, Tomita T,Ishiura S, Kume H, Kuzume H, Asada H, Kawamura Y, Kanbara N, Saido TC,Iwatsubo T, Obata K: The familial Alzheimer disease-linked mutations of Val717 of amyloid precursor protein is specific for the increased secretion of the longer Abeta. 5th International Conference on Alzheimer's disease and related disorders. July 1996 Osaka (Neurobiol Aging 17:S100,1996)

12. Saido TC, Iwatsubo T,Yokota S, Kawashima S: Post-secretory catabolism of beta amyloid in brain.5th International Conference on Alzheimer's disease and related disorders. July 1996 Osaka (Neurobiol Aging 17:S197-198, 1996)

13. Hosoda R, SaidoTC, Otvos LJr, Arai T, Iwatsubo T: Detection of L-isoaspartyl form of amyloid beta protein in Alzheimer's disease brains. 5th International Conference on Alzheimer's disease and related disorders. July 1996 Osaka (Neurobiol Aging 17:S175, 1996)

14. Iwatsubo T, MannDMA, Tomita T, Kosaka T, Tokuhiro S,Hosoda R, Obata K, Saido TC, Maruyama K: Effects of presenilin mutations on the deposition and production of amyloid beta protein. Society for Neuroscience. November 1996 Washington D.C. (Soc Neurosci Abstr 26:278,1996)

15. Arai H, Terajima M, NakagawaT, Kosaka Y, Matsui T, Higuchi S, Muramatsu T, MatsushitaS, Iwatsubo T, Kosaka T, Miura M, Machida T,Clark C, Lee VM-Y, Trojanowski JQ, Sasaki H: Cerebrospinal fluid tau and Abeta protein levels as biological markers for clinical diagnosis of Alzheimer's disease. Society for Neuroscience. November 1996 Washington D.C. (Soc Neurosci Abstr 26: 1422, 1996)

16. Iwatsubo T, TomitaT, Mann DMA, Hashimoto T, Tokuhiro S,Obata K, Saido TC, Maruyama K: Mutations in presenilin genes increase the secretion and deposition of amyloid beta42(43) 1997 Keystone Symposium "Molecular Mechanisms in Alzheimer's Disease. February 1997 Tamarron, Colorado



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