2011年／平成23年

【原著論文（英文）】
1)Kajiho H, Sakurai K, Minoda T, Yoshikawa M, Nakagawa S, Fukushima S, Kontani K, Katada T.
Characterization of RIN3 as a Guanine Nucleotide Exchange Factor for the Rab5 Subfamily GTPase Rab31.
J Biol Chem. 2011 Jul 8;286(27):24364-73.

2) Saito K, Yamashiro K, Ichikawa Y, Erlmann P, Kontani K, Malhotra V, Katada T.
cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites.
Mol Biol Cell. 2011 Jul;22(13):2301-8.

3) Takahashi S, Ebihara A, Kajiho H, Kontani K, Nishina H, and Katada T.
RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phospholylated-MKK7.
Cell Death Differ. 2011 Apr;18(4):645-55.

4) Takahashi S, Sakurai K, Ebihara A, Kajiho H, Saito K, Kontani K, Nishina H, Katada T
RhoA activation participates in rearrangement of processing bodies and release of nucleated AU-rich mRNAs.
Nucleic Acids Res. 2011 Apr;39(8):3446-57.

2010年／平成22年

【原著論文（英文）】
1) Nakae I, Fujino T, Kobayashi T, Sasaki A, Kikko Y, Fukuyama M, Gengyo-Ando K, Mitani S, Kontani K, Katada T.
The arf-like GTPase Arl8 mediates delivery of endocytosed macromolecules to lysosomes in Caenorhabditis elegans.
Mol Biol Cell. 21(14):2434-42. (2010)

2) Cevik S, Hori Y, Kaplan OI, Kida K, Toivenon T, Foley-Fisher C, Cottell D, Katada T, Kontani K, Blacque OE.
Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in Caenorhabditis elegans.
J Cell Biol. 188(6):953-69. (2010)

3) Ruan L, Osawa M, Hosoda N, Imai S, Machiyama A, Katada T, Hoshino S, Shimada I.
Quantitative characterization of Tob interactions provides the thermodynamic basis for translation termination-coupled deadenylase regulation.
J Biol Chem. 285(36):27624-31. (2010)

4) Seo J, Asaoka Y, Nagai Y, Hirayama J, Yamasaki T, Namae M, Ohata S, Shimizu N, Negishi T, Kitagawa D, Kondoh H, Furutani-Seiki M, Penninger JM, Katada T, Nishina H.
Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation.
J Cell Biochem. 110(4):1022-37. (2010)

5) Klassen MP, Wu YE, Maeder CI, Nakae I, Cueva JG, Lehrman EK, Tada M, Gengyo-Ando K, Wang GJ, Goodman M, Mitani S, Kontani K, Katada T, Shen K.
An Arf-like small G protein, ARL-8, promotes the axonal transport of presynaptic cargoes by suppressing vesicle aggregation.
Neuron. 66(5):710-23. (2010)

6) Nagai Y, Asaoka Y, Namae M, Saito K, Momose H, Mitani H, Furutani-Seiki M, Katada T, Nishina H.
The LIM protein Ajuba is required for ciliogenesis and left-right axis determination in medaka.
Biochem Biophys Res Commun. 396(4):887-93. (2010)

7) Wu J, Kubota J, Hirayama J, Nagai Y, Nishina S, Yokoi T, Asaoka Y, Seo J, Shimizu N, Kajiho H, Watanabe T, Azuma N, Katada T, Nishina H.
p38 Mitogen-activated protein kinase controls a switch between cardiomyocyte and neuronal commitment of murine embryonic stem cells by activating myocyte enhancer factor 2C-dependent bone morphogenetic protein 2 transcription.
Stem Cells Dev. 19(11):1723-34. (2010)

8) Nakagawa K, Sugahara M, Yamasaki T, Kajiho H, Takahashi S, Hirayama J, Minami Y, Ohta Y, Watanabe T, Hata Y, Katada T, Nishina H.
Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation.
Biochem J. 427(2):237-45. (2010)

9) Negishi T, Nagai Y, Asaoka Y, Ohno M, Namae M, Mitani H, Sasaki T, Shimizu N, Terai S, Sakaida I, Kondoh H, Katada T, Furutani-Seiki M, Nishina H. Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression in medaka.
Hepatology. 51(3): 1037-1045 (2010)

【著書・総説，その他（和文）】
1) 堅田 利明 金保安則　訳：インテグレーテッドシリーズ１：ペリー生化学 東京化学同人 (2010)

2）Tanemura S, Yamasaki T, Katada T and Nishina H[review]
Utility and limitations of SP600125, an inhibitor of stress-
responsive c-Jun N-terminal kinase.
Curr. Enzym. Inhib. 6, 26-33. (2010)

3）堅田利明：分子細胞生物学 第6版 (Lodish et al.) （翻訳分担） 東京化学同人 (2010)

4）堅田利明：生物学事典、東京化学同人（執筆分担）(2010)

【国際会議・学会での発表等】
1) Hori Y, Nagashima S, Kontani K, Katada T. [Poster]
Analysis of domain architecture of the atypical Arf-family GTPase involved in cilia formation
FASEB Summer Research Conferences: The Biology of Cilia and Flagella, Saxtons River, Vermont, USA

2) Kontani K, Nakae I, Sasaki A, Gengyo-Ando K, Mitani S, Katada T. [Oral]
A role for C. elegans ARL-8 in endocytic delivery to lysosomes
FASEB Summer Research Conferences: Arf family G Proteins, Carefree, AZ, USA

3) Saito K, Yamashiro K, Ichikawa Y, Erlmann P, Malhotra V, Katada T. [Oral]
cTAGE5 is involved in the endoplasmic reticulum to golgi trafficking in mammalian cells.
ASBMB Special Symposia, Biochemistry of Membrane Traffic: Secretory and
Endocytic Pathways. Lake Tahoe, CA, USA.

4) 福島慎一、梶保博昭、堅田利明 [口頭発表]
新規タンパク質RINLの機能解析
BMB2010 神戸

2009年／平成21年

【原著論文（英文）】
1) Tanemura S, Momose H, Shimizu N, Kitagawa D, Seo J, Yamasaki T, Nakagawa K, Kajiho H, Penninger JM, Katada T, Nishina H.
Fcepsilon receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signalling pathway.
J Biochem. 145: 345-354 (2009)　[JB論文賞受賞]

2) Ohata S, Nawa M, Kasama T, Yamasaki T, Sawanobori K, Hata S, Nakamura T, Asaoka Y, Watanabe T, Okamoto H, Hara T, Terai S, Sakaida I, Katada T, Nishina H.
Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells.
Biochem Biophys Res Commun. 379: 817-823 (2009)

3) Kobayashi T, Hori Y, Ueda N, Kajiho H, Muraoka S, Shima F, Kataoka T, Kontani K, Katada T.
Biochemical characterization of missense mutations in the Arf/Arl-family small GTPase Arl6 causing Bardet-Biedl syndrome.
Biochem Biophys Res Commun. 381: 439-442 (2009)

4) Shimizu N, Watanabe H, Kubota J, Wu J, Saito R, Yokoi T, Era T, Iwatsubo T, Watanabe T, Nishina S, Azuma N, Katada T, Nishina H.
Pax6-5a promotes neuronal differentiation of murine embryonic stem cells.
Biol. Pharm. Bull. 32 (6): 999-1003 (2009)

5) Saito R, Yamasaki T, Nagai Y, Wu J, Kajiho H, Yokoi T, Noda E, Nishina S, Niwa H, Azuma N, Katada T, Nishina H.
CrxOS maintains the self-renewal capacity of murine embryonic stem cells.
Biochem. Biophys. Res. Commun. 390 (4): 1129-1135 (2009)

［教室在籍者の他研究機関での業績］
6) Saito, K., Chen, M., Bard, F., Chen, S., Zhou, H., Woodley, D., Polischuk, R., Schekman, R. and Malhotra, V.
TANGO1 facilitates cargo loading at Endoplasmic Reticulum exit sites.
Cell, 136, 891-902 (2009)

【国際会議・学会での発表等】
1) Fukuyama M, Sakuma K, Astumi Y, Shimomura H, Kasuga H, Rougvie A and Katada T.
[Poster]: Distinct control of survival, and somatic and germline development during L1 diapause by the insulin/IGF signaling and AMPK pathway
[17th International C.elegans Meeting] Los Angeles, CA, USA, 2009年6月26日

2) Nakae I, Fujino T, Kobayashi T, Kikko Y, Harada S, Fukuyama M, Gengyo-Ando K, Mitani S, Kontani K and Katada T.
[Poster]: The Arf-like GTPase ARL-8 is required for lysosome biogenesis in C. elegans
[17th International C.elegans Meeting] Los Angeles, CA, USA, 2009年6月27日

3) Katada T and Kontani K.
[Oral]: The Arf-like GTPase Arl8 is required for lysosome biogenesis in C. elegans.
[IUPS 2009: PSJ Symposium, VI-5; Recent progress on G-protein signalings] Kyoto, Japan, 2009年7月28日

【著書・総説，その他（和文）】
1)　齋藤康太他　細胞工学, 28, 392-393. (2009)

2008年／平成20年

【原著論文（英文）】
1) Wada T, Stepniak E, Hui L, Leibbrandt A, Katada T, Nishina H, Wagner EF, Penninger JM.
Antagonistic control of cell fates by JNK and p38-MAPK signaling.
Cell Death Differ. 15: 89-93 (2008)

2) Hara-Yokoyama M, Kimura T, Kaku H, Wakiyama M, Kaitsu Y, Inoue M, Kusano S, Shirouzu M, Yokoyama S, Katada T, Hirabayashi Y, Takatsu K, Yanagishita M.
Alteration of enzymatic properties of cell-surface antigen CD38 by agonistic anti-CD38 antibodies that prolong B cell survival and induce activation.
Int. Immunopharmacol. 8: 59-70 (2008)　

3) Ohsawa S, Watanabe T, Katada T, Nishina H, Miura M.
Novel antibody to human BASP1 labels apoptotic cells post-caspase activation.
Biochem. Biophys. Res. Commun. 371: 639-643 (2008)

4) Yoshikawa M, Kajiho H, Sakurai K, Minoda T, Nakagawa S, Kontani K, Katada T.
Tyr-phosphorylation signals translocate RIN3, the small GTPase Rab5-GEF, to early endocytic vesicles.
Biochem. Biophys. Res. Commun. 372: 168-172 (2008)

5) Hori Y, Kobayashi T, Kikko Y, Kontani K, Katada T.
Domain architecture of the atypical Arf-family GTPase Arl13b involved in cilia formation.
Biochem. Biophys. Res. Commun. 373: 119-124 (2008)

6) Takahashi S, Araki Y, Ohya Y, Sakuno T, Hoshino S, Kontani K, Nishina H, Katada T.
Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast.
RNA 14: 1950-1958 (2008)

【著書・総説，その他（和文）】

1) 堅田 利明：クーパー細胞生物学第4版（翻訳分担；3、13、15章）東京化学同人 (2008)

2) 堅田 利明：ストライヤー生化学第6版（翻訳分担；14、16章）東京化学同人 (2008)

【国際会議・学会での発表等】

Hiroaki Kajiho, Manabu Yoshikawa, Kyoko Sakurai, Tomohiro Minoda, Satoshi Nakagawa, Kenji Kontani, and Toshiaki Katada.
[Poster]: Tyr-phosphorylation signals translocate RIN3, the small GTPase Rab5-GEF, to early endocytic vesicles.
48th ASCB Annual Meeting. 米国、サンフランシスコ、2008年12月

2007年／平成19年

【原著論文（英文）】
1) Shintani M, Tada M, Kobayashi T, Kajiho H, Kontani K, Katada T.
Characterization of Rab45/RASEF containing EF-hand domain and a coiled-coil motif as a self-associating GTPase.
Biochem Biophys Res Commun. 357: 661-667 (2007)

2) Ura S, Nishina H, Gotoh Y, Katada T.
Activation of the JNK patyway by MST1 is essential and sufficient for the induction of chromatin condensation during apoptosis.
Mol. Cell. Biol. 27, 5514-5522. (2007)

3) Funakoshi Y, Doi Y, Hosoda N, Uchida N, Osawa M, Shimada I, Tsujimoto M, Suzuki T, Katada T, Hoshino S.
Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases.
Genes Dev. 23: 3135-3148 (2007)

［教室在籍者の他研究機関での業績］

4) Kobayashi T, Gengyo-Ando K, Ishihara T, Katsura I, Mitani S.
IFT-81 and IFT-74 are required for intraflagellar transport in C. elegans.
Genes Cells 12: 593-602 (2007)

5) Wang X, Wang J, Gengyo-Ando K, Gu L, Sun C-L, Yang C, Shi Y, Kobayashi T, Shi Y, Mitani S, Xie X-S, Xue D.C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells Through phospholipid scramblase SCRM-1.
Nat. Cell Biol. 9: 541-549 (2007)

【著書・総説，その他（和文）】

1) 多田 稔、小林 哲夫、紺谷 圏二、堅田 利明：低分子量Ｇタンパク質研究の進歩；日薬理誌 130: 373-379 (2007)

2006年／平成18年

2) Kitagawa D, Kajiho H, Negishi T, Ura S, Watanabe T, Wada T, Ichijo H, Katada T, Nishina H.
Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation.
EMBO J. 25: 3286-3297 (2006)

3) Fukuyama M, Rougvie AE, Rothman JH.
C. elegans DAF-18/PTEN mediates nutrient-dependent arrest of cell cycle and growth in the germline.
Curr. Biol. 16: 773-779 (2006)

4) Nakano-Kobayashi A, Yamazaki M, Unoki T, Hongu T, Murata C, Taguchi R, Katada T, Frohman MA, Yokozeki T, Kanaho Y.
Role of activation of PIP5Kγ661 by AP-2 complex in synaptic vesicle endocytosis.
EMBO J. 26: 1105-1116 (2007)

5) Ito G, Okai T, Fujino G, Takeda K, Ichijo H, Katada T, Iwatsubo T.
GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson’s disease.
Biochemistry 46: 1380-1388 (2007)

6) Takahashi S, Kontani K, Araki Y, Katada T.
Caf1 regulates translocation of ribonucleotide reductase by releasing nucleoplasmic Spd1-Suc22 assembly.
Nucleic Acid Res. 35: 1187-1197 (2007)

8) Gengyo-Ando K, Kuroyanagi H, Kobayashi T, Murate H, Fujimoto K, Okabe S, Mitani S.
The SM protein VPS-45 is required for RAB-5-dependent endocytic transport in Caenorhabditis elegans.
EMBO Rep. in press (2007)

【著書・総説，その他（和文）】

1) 北川 大樹、堅田 利明、仁科 博史：新規核内複合体Daxx-RASSF1CはDNA損傷センサーとして機能してシグナルを核から細胞質へと伝達する；
細胞工学 25: 1178-1179 (2006)

2) 堅田 利明：細胞のシグナル伝達系に介在する諸種のGTP結合性制御蛋白質の機能解析（持田記念学術賞受賞者の研究概要）；
持田記念財団年報 平成18年 pp. 19-24 (2006)

3) 堅田 利明： New生化学第2版（堅田 利明、菅原 一幸、富田 基郎 編）［執筆分担：生命のしくみ、代謝調節］；pp. 3-12 & 374-393 廣川書店 (2006)

4) 堅田 利明：エッセンシャル生化学（翻訳分担）東京化学同人 (2006)

2005年／平成17年

2) Im DS, Nagano K, Katada T, Okajima F, Ui M. Differential change of Ins-P3-Ca2+ signaling during culture of rat hepatocytes.
Cell Signal. 17: 83-91 (2005)

3) Im YJ, Im DS, Lee YK, Lee EH, Sato K, Tomura H, Katada T, Ui M, Okajima F. Study on action mode of sphingosine 1-phosphate in rat hepatocytes.
J. Pharmacol. Sci. 97: 443-446 (2005)

4) Kontani K, Moskowitz IPG, Rothman JH. Repression of cell-cell fusion by components of the C. elegans vacuolar ATPase complex.
Dev. Cell 8: 787-794 (2005)

5) Kontani K, Rothman JH. Cell fusion: EFF is enough.
Curr. Biol. 15: R252-254 (2005)

6) Saito K, Kajiho H, Araki Y, Kurosu H, Kontani K, Nishina H, Katada T. Purification and analysis of RIN family -novel Rab5 GEFs.
Methods Enzymol. 403: 276-283 (2005)

【著書・総説，その他（和文）】

1) Nishina H, Katada T. The biological function of JNKKs (MKK4/MKK7 knockout mice). The JNK signaling pathway (Lin A, ed.) pp. 41-49, Landes Bioscience, Texas (2005)

2) 堅田利明：αβγ３量体GTP結合タンパク質と細菌毒素によるADPリボシル化；生物薬科学実験講座７、情報伝達物質II （石橋貞彦、市川厚、堅田利明 編）pp. 253-263 廣川書店 (2005)

3) 仁科博史、堅田利明：MAPキナーゼ；生物薬科学実験講座７、情報伝達物質II （石橋貞彦、市川厚、堅田利明 編）pp. 424-433 廣川書店 (2005)

4) 堅田利明：受容体と情報伝達：GTP結合タンパク質の役割；医系薬理学 改訂2版（遠藤仁，橋本敬太郎，後藤勝年，金井好克 編） pp. 20-31 中外医学社 (2005)

5) 堅田利明：生命の基本単位としての細胞；薬学生のための細胞生物学（堅田利明 編）pp. 1-6 廣川書店 (2005)

6) 堅田利明：細胞の情報伝達；薬学生のための細胞生物学（堅田利明 編）pp. 161-187 廣川書店 (2005)

7) 堅田利明：細胞内情報伝達；スタンダード薬学シリーズ４ 生物系薬学 II．細胞をミクロに理解する（日本薬学会 編）pp. 316-335 東京化学同人 (2005)

2004年／平成16年

2) Nishitai G, Shimizu N, Negishi T, Kishimoto H, Nakagawa K, Kitagawa D, Watanabe T, Momose M, Ohata S, Tanemura S, Asaka S, Kubota J, Saito R, Yoshida H, Mak TW, Wada T, Penninger JM, Azuma N, Hiroshi N, Katada T. Stress induces mitochondria-mediated apoptosis independent of SAPK/JNK activation in embryonic stem cells.
J. Biol. Chem. 279: 1621-1626 (2004)

3) Yamamoto N, Terai S, Ohata S, Watanabe T, Omori K, Shinoda K, Miyamoto K, Katada T, Sakaida I, Nishina H, Okita K. A subpopulation of bone marrow cells depleted by a novel antibody, anti-Liv8, is useful for cell therapy to repair damaged liver.
Biochem. Biophys. Res. Commun. 313: 1110-1118 (2004)

4) Wada T, Joza N, Cheng HY, Sasaki T, Kozieradzki I, Bachmaier K, Katada T, Schreiber M, Wagner EF, Nishina H, Penninger JM. MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence.
Nat. Cell Biol. 6: 215-226 (2004)

5) Furutani-Seiki M, Sasado T, Morinaga C, Suwa H, Niwa K, Yoda H, Deguchi T, Hirose Y, Yasuoka A, Henrich T, Watanabe T, Iwanami N, Kitagawa D, Saito K, Asaka S, Osakada M, Kunimatsu S, Momoi A, Elmasri H, Winkler C, Ramialison M, Loosli F, Quiring R, Carl M, Grabher C, Winkler S, Del Bene F, Shinomiya A, Kota Y, Yamanaka T, Okamoto Y, Takahashi K, Todo T, Abe K, Takahama Y, Tanaka M, Mitani H, Katada T, Nishina H, Nakajima N, Wittbrodt J, Kondoh H. A systematic genome-wide screen for mutations affecting organogenesis in Medaka, Oryzias latipes.
Mech. Dev. 121: 647-658 (2004)

6) Elmasri H, Winkler C, Liedtke D, Sasado T, Morinaga C, Suwa H, Niwa K, Henrich T, Hirose Y, Yasuoka A, Yoda H, Watanabe T, Deguchi T, Iwanami N, Kunimatsu S, Osakada M, Loosli F, Quiring R, Carl M, Grabher C, Winkler S, Del Bene F, Wittbrodt J, Abe K, Takahama Y, Takahashi K, Katada T, Nishina H, Kondoh H, Furutani-Seiki M. Mutations affecting somite formation in the Medaka (Oryzias latipes).
Mech. Dev. 121: 659-671 (2004)

7) Kitagawa D, Watanabe T, Saito K, Asaka S, Sasado T, Morinaga C, Suwa H, Niwa K, Yasuoka A, Deguchi T, Yoda H, Hirose Y, Henrich T, Iwanami N, Kunimatsu S, Osakada M, Winkler C, Elmasri H, Wittbrodt J, Loosli F, Quiring R, Carl M, Grabher C, Winkler S, Del Bene F, Momoi A, Katada T, Nishina H, Kondoh H, Furutani-Seiki M. Genetic dissection of the formation of the forebrain in Medaka, Oryzias latipes.
Mech. Dev. 121: 673-685 (2004)

8) Watanabe T, Asaka S, Kitagawa D, Saito K, Kurashige R, Sasado T, Morinaga C, Suwa H, Niwa K, Henrich T, Hirose Y, Yasuoka A, Yoda H, Deguchi T, Iwanami N, Kunimatsu S, Osakada M, Loosli F, Quiring R, Carl M, Grabher C, Winkler S, Del Bene F, Wittbrodt J, Abe K, Takahama Y, Takahashi K, Katada T, Nishina H, Kondoh H, Furutani-Seiki M. Mutations affecting liver development and function in Medaka, Oryzias latipes, screened by multiple criteria.
Mech. Dev. 121: 791-802 (2004)

9) Matsuoka M, Igisu H, Nakagawa K, Katada T, Nishina H. Requirement of MKK4 and MKK7 for CdCl2- or HgCl2-induced activation of c-Jun NH2-terminal kinase in mouse embryonic stem cells.
Toxicol. Lett. 152: 175-181 (2004)

10) Okai T, Araki Y, Tada M, Tateno T, Kontani K, Katada T. Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation.
J. Cell Sci. 117: 4705-4715 (2004)

11) Kobayashi T, Funakoshi Y, Hoshino S, Katada T. The GTP-binding release factor eRF3 as a key mediator coupling translation termination to mRNA decay.
J. Biol. Chem. 279: 45693-45700 (2004)

12) Im DS, Nagano K, Katada T, Okajima F, Ui M. Differential change of Ins-P3-Ca2+ signaling during culture of rat hepatocytes.
Cell Signal. 17: 83-91 (2004)

13) Sakuno T, Araki Y, Ohya Y, Kofuji S, Takahashi S, Hoshino S, Katada T. Decapping reaction of mRNA requires Dcp1 in fission yeast: Its characterization in different species from yeast to human.
J. Biochem. 136: 805-812 (2004)

14) Sakaida I, Terai S, Yamamoto N, Aoyama K, Ishikawa T, Nishina H, Okita K. Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice.
Hepatology 40: 1304-1311 (2004)

15) Omori K, Terai S, Ishikawa T, Aoyama K, Sakaida I, Nishina H, Shinoda K, Uchimura S, Hamamoto Y, Okita K. Molecular signature associated with plasticity of bone marrow cell under persistent liver damage by self-organizing-map-based gene expression.
FEBS Lett. 578: 10-20 (2004)

16) F. Loosli, F. Del Bene, R. Quiring, M. Rembold, J.R. Martinez-Morales, M. Carl, C. Grabher, C. Iquel, A. Krone, B. Wittbrodt, S. Winkler, T. Sasado, C. Morinaga, H. Suwa, K. Niwa, T. Henrich, T. Deguchi, Y. Hirose, N. Iwanami, S. Kunimatsu, M. Osakada, T. Watanabe, A. Yasuoka, H. Yoda, C. Winkler, H. Elmasri, H. Kondoh, M. Furutani-Seiki, J. Wittbrodt. Mutations affecting retina development in Medaka.
Mech. Dev. 121: 703-714 (2004)

17) H. Yoda, Y. Hirose, A. Yasuoka, T. Sasado, C. Morinaga, T. Deguchi, T. Henrich, N. Iwanami, T. Watanabe, M. Osakada, S. Kunimatsu, J. Wittbrodt, H. Suwa, K. Niwa, Y. Okamoto, T. Yamanaka, H. Kondoh, M. Furutani-Seiki. Mutations affecting retinotectal axonal pathfinding in Medaka, Oryzias latipes.
Mech. Dev. 121: 715-728 (2004)

18) C. Morinaga, T. Tomonaga, T. Sasado, H. Suwa, K. Niwa, A. Yasuoka, T. Henrich, T. Watanabe, T. Deguchi, H. Yoda, Y. Hirose, N. Iwanami, S. Kunimatsu, Y. Okamoto, T. Yamanaka, A. Shinomiya, M. Tanaka, H. Kondoh, M. Furutani-Seiki. Mutations affecting gonadal development in Medaka, Oryzias latipes.
Mech. Dev. 121: 829-840 (2004)

19) K. Aizawa, H. Mitani, N. Kogure, A. Shimada, Y. Hirose, T. Sasado, C. Morinaga, A. Yasuoka, H. Yoda, T. Watanabe, N. Iwanami, S. Kunimatsu, M. Osakada, H. Suwa, K. Niwa, T. Deguchi, T. Hennrich, T. Todo, A. Shima, H. Kondoh, M. Furutani-Seiki. Identification of radiation-sensitive mutants in the Medaka, Oryzias latipes.
Mech. Dev. 121: 895-902 (2004)

20) Sasado, T., Niwa, K., Morinaga, C., Shinomiya, A., Yasuoka, A., Suwa, H., Hirose, Y., Henrich, T., Okamoto, Y., Kota, Y., Yamanaka, T., Deguchi, T., Iwanami, N., Kunimatsu, S., Osakada, M., Watanabe, T., Yoda, H., Tanaka, M., Kondoh, H. and Furutani-Seiki, M. Mutations affecting early distribution of primordial germ cells in Medaka (Oryzias latipes) embryo.
Mech. Dev. 121: 817-828 (2004)

【著書・総説，その他（和文）】

1) Nishina H, Watanabe T, Nakagawa K, Ohata S, Asaka S, Katada T. SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kappaB- induced anti-apoptosis. [Review] Stem Cell and Liver Regeneration: (Okita K. eds.) pp. 1-14, Springer-Verlag, Tokyo (2004)

2) Nishina H, Wada T, Katada T [review] Physiological roles of SAPK/JNK signaling pathway. J. Biochem. 136: 123-126 (2004)

3) 堅田 利明：薬学領域における生物・薬理系研究の進歩と展望：シグナル伝達研究から創薬へ；薬事日報；第9856号　28-28 (2004)

4) 和田 悌司、仁科 博史、堅田 利明、Josef M Penninger：MKK7のストレス応答によるG2/M期進行、細胞老化抑止の制御；実験医学 22：1398-1400 (2004)

5) 仁科 博史、中川 健太郎、堅田 利明：SAPK/JNK系の活性化機構と生理的役割；実験医学 22：1551-1556 (2004)

6) 渡辺 智美、仁科 博史：メダカを用いた肝形成および肝機能の解明；生化学 76：1454-1458 (2004)

7) 仁科 博史：細胞を利用した治療；スタンダード薬学シリーズ８「医薬品の開発と生産」（日本薬学会 編）pp 108-112　東京化学同人 (2004)

2003年／平成15年

1) Savarino A, Bensi T, Chiocchetti A, Bottarel F, Mesturini R, Ferrero E, Calosso L, Deaglio S, Ortolan E,
Butto S, Cafaro A, Katada T, Ensoli B, Malavasi F, Dianzani U. Human CD38 interferes with HIV-1
fusion through a sequence homologous to the V3 loop of the viral envelope glycoprotein gp120.
FASEB J. 17: 461-463 (2003)

2) Kishimoto H, Nakagawa K, Watanabe T, Kitagawa D, Momose H, Seo J, Nishitai G, Shimizu N, Ohata S,
Tanemura S, Asaka S, Goto T, Fukushi H, Yoshida H, Suzuki A, Sasaki T, Wada T, Penninger JM,
Nishina H, Katada T. Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced
activated protein kinase SAPK/JNK in embryonic stem cells.
J. Biol. Chem. 278: 16595-16601 (2003)

3) Okamura-Oho Y, Miyashita T, Nagao K, Shima S, Ogata Y, Katada T, Nishina H, Yamada M.
Dentatorubral-pallidoluysian atrophy protein is phosphorylated by c-Jun NH2-terminal kinase.
Hum. Mol. Genet. 12:1535-1542 (2003)

4) Takahashi S, Araki Y, Sakuno T, Katada T. Interaction between Ski7p and Upf1p is required for nonsense-mediated 3'-to-5' mRNA decay in yeast.
EMBO J. 22: 3951-3959 (2003)

5) Hosoda N, Kobayashi T, Uchida N, Funakoshi Y, Kikuchi Y, Hoshino S, Katada T. Translation
termination factor eRF3 mediates mRNA decay through the regulation of deadenylation.
J. Biol. Chem. 278: 38287-38291 (2003)

6) Kajiho H, Saito K, Tsujita K, Kontani K, Araki Y, Kurosu H, Katada T. RIN3: a novel Rab5 GEF
interacting with amphiphysin II involved in the early endocytic pathway.
J. Cell Sci. 116: 4159-4168 (2003)

7) Momose H, Kurosu H, Tsujimoto N, Kontani K, Tsujita K, Nishina H, Katada T. Dual phosphorylation of
phosphoinositide 3-kinase adaptor Grb2-associated binder 2 is responsible for superoxide formation
synergistically stimulated by Fcgamma and formyl-methionyl-leucyl-phenylalanine receptors in
differentiated THP-1 cells.
J. Immunol. 171: 4227-4234 (2003)

8) Terai S, Sakaida I, Yamamoto N, Omori K, Watanabe T, Ohata S, Katada T, Miyamoto K, Shinoda K,
Nishina H, Okita K. An in vivo model for monitoring trans-differentiation of bone marrow cells into
functional hepatocytes.
J. Biochem. (Tokyo) 134: 551-558 (2003)

9) Saibil SD, Ohteki T, White FM, Luscher M, Zakarian A, Elford A, Shabanowitz J, Nishina H, Hugo P,
Penninger J, Barber B, Hunt DF, Ohashi PS. Weak agonist self-peptides promote selection and tuning of
virus-specific T cells.
Eur. J. Immunol. 33, 685-696 (2003)

10) Inamura N, Hoshino S, Uchiumi T, Nawa H, Takei N. Cellular and subcellular distributions of translation
initiation, elongation and release factors in rat hippocampus.
Brain Res. Mol. Brain Res. 111: 165-174 (2003)

11) Hegde R, Srinivasula SM, Datta P, Madesh M, Wassell R, Zhang Z, Cheong N, Nejmeh J, Fernandes-
Alnemri T, Hoshino S, Alnemri ES. The polypeptide chain releasing factor GSPT1/eRF3 is proteolytically
processed into an IAP-binding protein.
J. Biol. Chem. 278: 38699-38706 (2003)

【著書・総説，その他（和文）】

1) Yokoyama MH, Katada T, Sugiya H, Furuyama S, Hirabayashi Y. Complex gangliosides as cell surface
inhibitors for the ecto-NAD+ glycohydrolase of CD38. [review]
Methods Enzymol. 363: 319-24 (2003)

2) Nishina H, Nakagawa K, Azuma N, Katada T. Activation Mechanism and Physiological Roles of Stress -Activated Protein Kinase/c-Jun NH2-Terminal Kinase in Mammalian Cells. [review]
J. Biol. Regul. Homeost. Agents. in press (2003)

3) 梶保博昭、齋藤康太、荒木保弘、堅田利明：極性細胞での小胞輸送−Rabファミリーによる
制御機構.　特集「上皮組織ベクトル輸送の分子基盤と機能制御」
蛋白質 核酸 酵素48:133-139 (2003)

4) 堅田利明：内分泌系（１９章）第２版「分子生物学」（田沼靖一 編）pp. 268-284　
丸善 (2003)

5) 堅田利明：ファーマ・バイオフォーラム2002を開催して.　
ファルマシア 39: 167 (2003)

6) 仁科博史、渡辺智美、大畑慎也、浅香聡、堅田利明：初期肝形成時のシグナル伝達機構.　
肝胆膵 46: 295 302 (2003)

7) 打田直行、星野真一、堅田利明、Ann-Bin Shyu：真核細胞におけるmRNAの安定性制御；
増刊 「New バイオテクノロジー」　蛋白質 核酸 酵素 48: 1488-1495 (2003)

8) 堅田利明，富田麗，高橋勝宣：ＧＴＰ結合タンパク質活性測定法.　
生物薬科学実験講座 第11巻　神経（脳）（佐藤公道，野村靖幸編）pp. 75-80　廣川書店 (2003)

9) 堅田利明：Ｇ蛋白質との出会いから学んだこと：柳の下にドジョウが3匹いた.　
日本薬理学雑誌 94: 458-459 (2003)

10) 堅田利明：翻訳終結とmRNA分解を結ぶＧタンパク質.　学術月報 56: 1258-1262 (2003)

11) 星野真一：真核生物mRNAの分解制御.　 蛋白質 核酸 酵素 48: 1229-1240 (2003)

2002年／平成14年

2) Saito K, Murai J, Kajiho H, Kontani K, Kurosu H, & Katada T. A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5.
J. Biol. Chem. 277: 3412-3418 (2002).

3) M. Nishida, K. L. Schey, S. Takagahara, K. Kontani, T. Katada, Y. Urano, T. Nagano, T. Nagao, & H. Kurose. Activation mechanism of Gi and Go by reactive oxygen species.
J. Biol. Chem. 277: 9036-9042 (2002).

4) Yamamoto A, Miyazaki T, Kadono Y, Takayanagi H, Miura T, Nishina H, Katada T, Wakabayashi K, Oda H, Nakamura K, & Tanaka S. Possible involvement of IkappaB kinase 2 and MKK7 in osteoclastogenesis induced by receptor activator of nuclear factor kappaB ligand.
J. Bone Miner. Res. 17: 612-621 (2002).

5) K. Kontani, M. Tada, T. Ogawa, T. Okai, K. Saito, Y. Araki, & T. Katada. Di-Ras: A distinct subgroup of Ras-family GTPases with unique biochemical properties.
J. Biol. Chem. 277: 41070-41078 (2002).

6) N. Ito, T. Yokomizo, T. Sasaki, H. Kurosu, J. Penninger, Y. Kanaho, T. Katada, K. Hanaoka, & T. Shimizu. Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release.
J. Biol. Chem. 277: 44898-44904 (2002).

7) T. Watanabe, K. Nakagawa, S. Ohata, D. Kitagawa, G. Nishitai, J. Seo, S. Tanemura, N. Shimizu, H. Kishimoto, T. Wada, J. Aoki, H. Arai, T. Iwatsubo, M. Mochita, T. Watanabe, M. Satake, Y. Ito, T. Matsuyama, T. W. Mak, J. M. Penninger, H. Nishina, & T. Katada. SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kappaB-induced anti-apoptosis.
Dev Biol. 15: 332-347 (2002).

8) N. Uchida, S. Hoshino, H. Imataka, N. Sonenberg, & T. Katada. A novel role of the mammalian GSPT/eRF3 associating with poly(A)-binding protein in cap/poly(A)-dependent translation.
J. Biol. Chem. 277: 50286-50292 (2002).

9) Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H, Saiura A, Isobe M, Yokochi T, Inoue J, Wagner E F, Mak T W, Kodama T, & Taniguchi T. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling.
Dev. Cell 3: 889-901 (2002).

【著書・総説，その他（和文）】

1) 荒木保弘、星野真一、堅田利明：真核細胞のmRNA動態を制御する新規Ｇタンパク質ファミリー
実験医学　20: 150-157 (2002)

2) 星野真一：GSPTファミリーによる遺伝子発現制御
生化学　74: 1343-1348 (2002)

2001年／平成13年　　

1) M. Hara-Yokoyama, Y. Nagatsuka, O. Katsumata, F. Irie, K. Kontani, S. Hoshino, T. Katada, Y. Ono, J.
Fujita-Yoshigaki, H. Sugiya, S. Furuyama, & Y. Hirabayashi: Complex Gangliosides as Cell Surface
Inhibitors for the Ecto-NAD+ Glycohydrolase of CD38.
Biochemistry 40: 888-895 (2001)
2) T. Wada, K. Nakagawa, G. Nishitai, J. Seo, H. Kishimoto, T. Watanabe, D. Kitagawa, T. Sasaki, J. M.
Penninger, H. Nishina, & T Katada: Impaired synergistic activation of stress-activated protein kinase
SAPK/JNK in ES cells lacking SEK1/MKK4.
J. Biol. Chem. 276: 30892-30897 (2001)

3) H. Kurosu & T. Katada: Association of phosphatidylinositol 3-kinase composed of p110beta-catalytic and
p85-regulatory subunits with the small GTPase Rab5.
J. Biochem. 130: 73-78 (2001)

4) Y. Araki, S. Takahashi, T. Kobayashi, H. Kajiho, S. Hoshino, & T. Katada: Ski7p G protein interacts with
the exosome and the Ski complex for 3'-to-5' mRNA decay in yeast.
EMBO J. 20: 4684-4693 (2001)

5) T. Sasaki, T. Wada, H. Kishimoto, J. Irie-Sasaki, G. Matsumoto, T. Goto, Z. Yao, A. Wakeham, T.W. Mak,
A. Suzuki, T. Katada, H. Nishina, & J.M. Penninger: The stress kinase MKK7 is a negative regulator of
antigen receptor and growth factor receptor induced proliferation in hematopoietic cells.
J. Exp. Med. 17: 757-768 (2001)

6) O. Katsumata, M. Hara-Yokoyama, C. Sautes-Fridman, Y. Nagatsuka T. Katada, Y. Hirabayashi, K.
Shimizu, J. Fujita-Yoshigaki, H. Sugiya, & S. Furuyama: Association of FcgRII with low-density
detergent-resistant membranes is important for cross-linking-dependent initiation of the tyrosine
phosphorylation pathway and superoxide generation.
J. Immunol. 15: 5814-5823 (2001)

7) R. Kuroda, K. Kontani, Y. Kanda, T. Katada, T. Nakano, Y. Satoh, N. Suzuki, & H. Kuroda: Increase of
cGMP, cADP-ribose and inositol 1,4,5-trisphosphate preceding Ca2+ transients in fertilization of sea urchin
eggs. Development 128: 4405-4414 (2001)

8) H.Yoshida, S. Hamano, G. Senaldi, T. Covey, R. Faggioni, S. Mu, M. Xia, A. Wakeham, H. Nishina, J.
Potter, C.J.M. Saris, & T.W. Mak: WSX-1 is required for the initiation of Th1 responses and resistance to
L. major infection.
Immunity 15: 569-578 (2001)

【著書・総説，その他（和文）】

1) 堅田利明：細菌毒素（ADP リボシル化酵素）の標的としてのＧタンパク質；Bio Clinica １６：
49-53 (2001)

2) 堅田利明：Ｇタンパク質 （２章）；シリーズ・バイオサイエンスの新世紀 (9)「シグナル伝達」
（西田栄介、大野茂男 編） pp. 17-30　共立出版 (2001).

2000年／平成12年　　

1) M. Kukimoto, O. Nureki, M. Shirouzu, T. Katada, Y. Hirabayashi, H. Sugiya, S. Furuyama, S. Yokoyama,
M. & Hara-Yokoyama: Crystallization and preliminary X-ray diffraction analysis of the extracellular
domain of the cell surface antigen CD38 complexed with ganglioside.
J. Biochem. 127: 181-184 (2000)
2) W. Wang, M. Seki, Y. Narita, E. Sonoda, S. Takeda, K. Yamada, T. Masuko, T. Katada, & T. Enomoto:
Possible association of BLM in decreasing DNA double strand breaks during DNA replication.
EMBO J. 19: 3428-3435 (2000)

3) R. Kuroda, K. Kontani, Y. Kanda, T. Katada, Y. Satoh, N. Suzuki, & H. Kuroda: Role of guanylyl cyclase
in fertilisation of sea urchin eggs. Zygote 8:
(Suppl. 1) 18-19 (2000)

4) M. Nishida, Y. Murayam, R. Tanaka, K. Kontani, T. Nagao, & H. Kurose: Gai and Gao are target proteins
of rective oxgen species.
Nature 408: 492-495 (2000)

5) K. Bachmaier, C. Krawczyk, I. Kozieradzki, Y-Y. Kong, T. Sasaki, A. Oliveira-dos-Santos, S.
Mariathasan, D. Bouchard, A. Wakeham, A. Itie, J. Le, P. Ohashi, I. Sarosi, H. Nishina, S. Lipkowitz, &
J.M. Penninger: Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor
Cbl-b.
Nature 403: 211-216 (2000)

【著書・総説，その他（和文）】

1) T. Katada, K. Kontani, T. Wada, N. Hosoda, S. Hoshino, & H. Nishina: Enzymic and signal transduction
properties of CD38/NADase and PC-1/phosphodiesterase. [Review]
Chem. Immunol. 75: 60-78 (2000)

2) 堅田利明：三量体Ｇ蛋白質；Vascular Biology ナビゲーター（丸山征郎、安藤譲二、左藤靖史 編）pp.38-39　
メディカルレビュー社 (2000).

１９９９年／平成１１年　　

2) T. Nakano, K. Kontani, H. Kurosu, T. Katada, M. Hoshi, and K. Chiba: G-Protein bg subunit-dependent phosphorylation of 62-kDa protein in the early signaling pathway of starfish oocyte maturation induced by 1-methyladenine.
Dev. Biol., 209, 200-209 (1999)

3) S. Hoshino, M. Imai, T. Kobayashi, N. Uchida, and T. Katada: The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA: Direct association of erf3/GSPT with polyadenylate-binding protein.
J. Biol. Chem. 274: 16677-16680 (1999)

4) S. Takasuga, T. Katada , M. Ui, and O. Hazeki: Enhancement by adenosine of insulin-induced activation of phosphoinositide 3-kinase and protein kinase B in rat adipocytes.
J. Biol. Chem., 274, 19545-19550 (1999)

5) N. Hosoda, S. Hoshino, Y. Kanda, and T. Katada: Inhibition of phosphodiesterase/pyrophosphatase activity of PC-1 by its association with glycosaminoglycans.
Eur. J. Biochem., 265, 763-770 (1999)

【総説（英文）】

1) T. Katada, H. Kurosu, T. Okada, T. Suzuki, N. Tsujimoto, S. Takasuga, K. Kontani, O. Hazeki, and M. Ui: Synergistic activation of a family of phosphoinositide 3-kinase via G-protein coupled and tyrosine kinase-related receptors.
Chemistry and Physics of Lipids, 98, 79-86 (1999)

2) S. Deaglio, R. Mallone, G. Baj, A. Arnulfo, E. Ortolan, P. Sposato, C. Ausiello, F. Saccucci, A. Gregorini, C. Cinti, A. Horenstein, M. Zubiaur, J. Sancho, U. Dianzani, E. Ferrero, A. Funaro, T. Katada, K. Mehta, and F. Malavasi: Signaling and activation, calcium and cytokine release, receptorial activities of the human CD38 family of NAD+-converting ectoenzymes.
Curr. Trends Immunology, 2, 19-36 (1999)

3) S. Hoshino, N. Hosoda, Y. Araki, T. Kobayashi, N. Uchida, and T. Katada: Novel function of the Eukaryotic Polypeptide-chain Releasing Factor 3 (eRF3/GSPT) in the Mechanism of mRNA Degradation.
Biochemistry (Moscow), 64, 1367-1372 (1999)

【著書・総説，その他（和文）】

1) 仁科博史，堅田利明：SAPK/JNK系の生理的役割−ノックアウトマウスを用いたSEK1/MKK4の機能解析.
実験医学 １７： 113-118 (1999)

2) 伊東　広，堅田利明，島野　仁，藤岡聡之，西島正弘：現代医学研究のメッカ ダラス 留学体験談.
ファルマシア ３５： 555-560 (1999)

3) 堅田利明：内分泌系（１９章）.
「分子生物学」 （田沼靖一 編） pp. 157-173　丸善 (1999)

4) 堅田利明：脳におけるＧタンパク質を介するシグナル伝達.
イラスト医学＆サイエンスシリーズ「わかる脳と神経」（石浦章一 偏）： pp. 79-87　羊土社 (1999)

5) 黒須　洋，堅田利明：PI3-キナーゼの多様性と機能.
実験医学 １７： 1206-1211 (1999)

6) 堅田利明：三量体Ｇタンパク質の介在するシグナル伝達系.
最近の進歩；実験医学 １７： 1708-1714 (1999)

7) 仁科博史，堅田利明：Ｔ細胞機能とSEK1, SEK2.
臨床免疫 ３２： 518-524 (1999)

8) 堅田利明，高橋勝宣：Ｇ蛋白質.
ニューロサイエンス講座 第３巻　新しい神経伝達研究法-II（三木直正，野村靖幸 編） pp.91-96　廣川書店 (1999)

１９９８年／平成１０年　　

1) S. Takasawa, T. Akiyama, K. Nata, M. Kuroki, A. Tohgo, N. Noguchi, S. Kobayashi, I. Kato, T. Katada, and H. Okamoto: Cyclic ADP-ribose and inositol 1,4,5-trisphosphate as alternate second messengers for intracellular Ca2+ mobilization in normanl and diabetic b-cells.
J. Biol. Chem., 273, 2497-2500 (1998)
2) J.A. Sanchez,T. Gonoi, N. Inagaki, T. Katada, and S. Seino: Modulation of reconstituted ATP-sensitive K+ channels by GTP-binding proteins in a mammalian cell line.
J. Physiol., 507, 315-324 (1998)

3) T. Seki, M. Seki, T. Katada, and T. Enomoto: Isolation of a cDNA encoding mouse DNA topoisomerase III which is highly expressed at the mRNA level in the testis. Biochim.Biophys.
Acta Gene Struct. Expression, 1396, 127-131 (1998)

4) H. Kishimoto, S. Hoshino, M. Ohori, K. Kontani, H. Nishina, M. Suzawa, S. Kato, and T. Katada: Molecular mechanism of human CD38 gene expression by retinoic acid: Identification of retinoic acid response element in the first intron.
J. Biol. Chem., 273, 15429-15434 (1998)

5). A. Smine, X. Xu, K. Nishiyama, T. Katada, P. Gambetti, S.P. Yadav, X. Wu, Y.-C. Shi, S. Yasuhara, V. Homburger, and T. Okamoto: Regulation of brain G-protein Go by Alzheimer's disease gene presenilin-1.
J. Biol. Chem., 273, 16281-16288 (1998)

6) S. Hoshino, M. Imai, M. Mizutani, Y. Kikuchi, F. Hanaoka, M. Ui, and T. Katada: Molecular cloning of a novel member of the eukaryotic polypeptide-chain releasing factors (eRF): Its identification as eRF3 interacting with eRF1.
J. Biol. Chem., 273, 22254-22259 (1998)

7) O. Scruel, T. Wada, K. Kontani, A. Sener, T. Katada, and W.J. Malaisse: Effects of D-glucose and starvation upon the cyclic ADP-ribose content of rat pancreatic islets. Biochem.
Mol. Biol. Int., 45, 783-790 (1998)

8) T. Imanaka, H. Hayashi, K. Kishi, L. Wang, K. Ishii, O. Hazeki, T. Katada, and Y. Ebina: Reconstitution of insulin signaling pathways in rat 3Y1 cells lacking insulin receptor and insulin receptor substrate-1. Evidence that activation of akt is insufficient for insulin-stimulated glycogen synthesis or glucose uptake in rat 3y1 cells.
J. Biol. Chem., 273, 25347-25355 (1998)

8) T. Seki, W.S. Wang, N. Okumura, M. Seki, T. Katada, and T. Enomoto: cDNA cloning of mouse BLM gene, the homologue to human Bloom's syndrome gene, which is highly expressed in the testis at the mRNA level.
Biochim. Biophys. Acta Gene Struct. Expression, 1398, 377-381 (1998)

9) T. Sasaki, T. Maehama, T. Yamamoto, S. Takasuga, S. Hoshino, H. Nishina, O. Hazeki, and T. Katada: Activation of c-Jun N-terminal kinase (JNK) by lysophosphatidic acid in Swiss 3T3 fibroblasts.
J. Biochem., 124, 934-939 (1998)

10) T. Seki, M. Seki, T. Katada, and T. Enomoto: Cloning of cDNA encoding a novel mouse DNA topoisomerase III (Topo IIIb) possessing negatively supercoiled DNA relaxing activity, whose message is highly expressed in the testis.
J. Biol. Chem., 273, 28553-28226 (1998)

11) W.S. Wang, M. Seki, T. Yamaoka, T. Seki, S. Tada, T. Katada, H. Fujimoto, and T. Enomoto: Cloning of two isoforms of mouse DNA helicase Q1 RecQL cDNA; alpha form is expressed ubiquitously and beta form specifically in the testis.
Biochim. Biophys. Acta Gene Struct. Expression, 1443, 198-202 (1998)

12) H. Yoshida, H. Nishina, H. Takimoto, L.E.M. Marengere, A. C. Wakeham, D. Bouchard, Y-Y. Kong, T. Ohteki, A. Shahinian, M. Bachmann, P.S. Ohashi, J.M. Penninger, G.R. Crabtree, and T.W. Mak: The Transcription Factor NF-ATc1 Regulates Lymphocyte Proliferation and Th2 Cytokine Production.
Immunity, 8, 115-124 (1998)

13) K-D. Fischert, Y-Y. Kong, H. Nishina, K. Tedford, L.E.M. Marengere, I. Kozieradzi, T. Sasaki, M. Starr, G. Chan, S. Gardener, M.P. Nghiem, D. Bouchard, M. Barbacid, A. Bernstein, and J.M. Penninger: Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor.
Curr. Biol. 8, 554-562 (1998)

14) H. Nishina, L. Radvanyi, K. Raju, T. Sasaki, I. Kozieradzki, and J.M. Penninger: Impaired TCR-mediated apoptosis and Bcl-XL expresssion in T cells lacking the stress kinase activator SEK1/MKK4.
J. Immunol. 161, 3416-3420 (1998)

【総説（英文）】

1) O. Hazeki, T. Okada, H. Kurosu, S. Takasuga, T. Suzuki, and T. Katada: Activation of PI 3-kinase by G protein bg subunits.
Life Sci., 62, 1555-1559 (1998)

【著書・総説，その他（和文）】

1) 紺谷圏二，堅田利明：NAD代謝とサイクリックADP-リボース.
化学と生物 ３６： 497-503 (1998)

2) 堅田利明：Ｇタンパク質（１３章）
細胞機能と代謝マップ II. 細胞の動的機能 （日本生化学会 編） pp. 93-99　東京化学同人 (1998)

3) 堅田利明：細胞内情報伝達（８章）
「病態生理・生化学」I（生命薬学テキストシリーズ） （井上圭三，富田基郎 編） pp. 157-173　共立出版 (1998)

１９９７年／平成９年　　　

3) W.J. Malasisse, Y. Kanda, K. Inageda, O. Scruel, A. Sener, and T. Katada: Cyclic ADP-ribose measurements in rat pancreatic islets.
Biochem. Biophys. Res. Commun., 231, 546-548 (1997)

4) T. Ebina, J. Kawabe, T. Katada, S. Ohno, C.J. Homcy, and Y. Ishikawa: Conformation-dependent activation of type II adenylyl cyclase by protein kinase C.
J. Cell. Biochem., 64, 492-498 (1997)

5) N. Tsujimoto, K. Kontani, S. Inoue, S. Hoshino, O. Hazeki, F. Malavasi and T. Katada: Potentiation of chemotactic peptide-induced superoxide generation by CD38 ligation in human myeloid cell lines.
J. Biochem., 121, 949-956 (1997)

6) M. Masuda, S. Takenaka, K. Inageda, H. Nishina, K. Takahashi, T. Katada, S. Tsuyama, H. Inui, K. Miyatake, and Y. Nakano: Oscillation of ADP-ribosyl cyclase activity during the cell cycle and function of cyclic ADP-ribose in a unicellular organism, Euglena gracilis.
FEBS Lett., 405, 104-106 (1997)

7) D.S. Im, T. Fujioka, T. Katada, Y. Kondo, M. Ui, and F. Okajima: Characterization of sphingosine 1-phosphate-induced actions and its signaling pathways in rat hepatocytes.
Am. J. Physiol. Gastrointest. Liver Physiol., 272, G1091-G1099 (1997)

8) T. Seki, S. Tada, T. Katada, and T. Enomoto: Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: Discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL.
Biochem. Biophys. Res. Commun., 234, 48-53 (1997).

9) H. Kurosu, T. Maehama, T. Okada, T. Yamamoto, S. Hoshino, Y. Fukui, M. Ui, O. Hazeki, and T. Katada: Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110b is synergistically activated by the bg subunits of G proteins and phosphotyrosyl peptide.
J. Biol. Chem., 272, 24252-24256 (1997)

10) S. Inoue, K. Kontani, N. Tsujimoto, Y. Kanda, N. Hosoda, S. Hoshino, O. Hazeki, and T. Katada: Protein-tyrosine phosphorylation by IgG1-subclass CD38 monoclonal antibodies is mediated through stimulation of the FcgII receptors in human myeloid cell lines.
J. Immunol., 159, 5226-5232 (1997)

11) H. Nishina, K.D. Fischer, L. Radvanyi, A. Shahinian, R. Hakem, E.A. Rubie, A. Bernstein, T.W. Mak, J.R. Woodgett,and J.M. Penninger: Stress-signaling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3.
Nature, 385, 350-353 (1997)

12) A. Suzuki, J.L.Pompa, R. Hakem, A. Elia, R. Yoshida, R., Mo, H. Nishina, T. Chuang, A. Wakeham, A. Itie, W. Koo, M. Fukumoto, C.C. Hui, and T.W. Mak: Brca2 is required for embryonic cellular proliferation in the mouse.
Genes Dev., 10, 1242-1252 (1997)

13) H. Nishina, M. Bachmann, A.J. Oliveira-dos-Santos, I. Kozieradzki,K.D. Fischer, B. Odermatt, A. Wakeham, A. Shahinian, H. Takimoto, A. Bernstein, T.W. Mak, J.R. Woodgett, P.S. Ohashi, and J.M. Penninger: Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK kinase 1 (SEK1)/mitogen-activated protein kinase kinase4 (MKK4)-deficient T lymphocytes.
J. Exp. Med., 186, 941-953 (1997)

14) Z. Yao, K. Diener, X.S. Wang, M. Zukowski, G. Matsumoto, G. Zhou, R. Mo, T. Sasaki, H. Nishina, C.C. Hui, T.-H. Tan, J.R. Woodgett, and J.W. Penninger: Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase (MKK7).
J. Biol. Chem., 272, 32378-32383 (1997)

15) K.D. Fischer, C. Nichols, H. Nishina, L. Marengere, I. Kozieradzki, A. Bernstein, and J.M. Penninger: The vav proto-oncoprotein regulates antigen receptor oligomerization and cell cycle progression in T cells.
J. Mol. Med. (Berlin), 75, B191-B192 (1997)

【総説（英文）】

1) T. Maehama and T. Katada: Molecular characterization of rat T lymphocyte alloantigen RT6.1 as an ADP-ribosyltransferase.
Adv. Exp. Med. Biol. 419, 181-183 (1997)

2) K. Kontani, I. Kukimoto, Y. Kanda, S. Inoue, H. Kishimoto, S. Hoshino, H. Nishina, K. Takahashi, O. Hazeki and T. Katada: Signal transduction via the CD38/NAD+ glycohydrolase.
Adv. Exp. Med. Biol. 419, 421-430 (1997)

【著書・総説，その他（和文）】

1) 堅田利明：シグナル伝達における三量体GTP結合蛋白質の役割.
神経精神薬理 19, 7-18 (1997)

2) 堅田利明：三量体GTP結合蛋白質.
特集「脳における情報伝達」 蛋白質 核酸 酵素 42, 353-363 (1997)

3) 堅田利明：生体における情報の受容と伝達機構.
バイオケミストリー；新化学教科書シリーズ 第 10 巻 （三浦謹一郎，渡辺公綱 編）, pp. 156-192　昭晃堂 (1997)

4) 堅田利明：細胞の伝達機構.
生命と物質 （中澤 透 編）, pp. 134-149　放送大学教材 (1997)

5) 仁科博史，堅田利明：シグナル伝達分子三量体GTP結合蛋白質の構造と機能.
生体の科学 48, 229-235 (1997)

6) 堅田利明：受容体と情報伝達：GTP結合タンパク質の役割.
医系薬理学（遠藤 仁，橋本敬太郎，後藤勝年 編）, pp. 36 - 47　中外医学社 (1997)

7) 堅田利明：Ｇタンパク質共役型受容体.
生体の科学 48, 350-351 (1997)

8) 黒須洋，堅田利明：fMLP受容体.
生体の科学 48, 423-425 (1997)

9) 堅田利明：三量体Ｇタンパク質−セカンドメッセンジャー学説の展開−.
細胞内シグナル伝達（宇井理生 編）現代化学 増刊34, pp. 61-70　東京化学同人 (1997)

10) 堅田利明：三量体Ｇ蛋白質の役割.
生命を育む情報−細胞内シグナル伝達の研究，最近の進歩（第 11 回「大学と科学」公開シンポジウム組織委員会 編）, pp. 60-70　クバプロ (1997)

11) 仁科博史，堅田利明：百日咳毒素.
治療学 31, 1475-1478 (1997)

12) 仁科博史，堅田利明：sek1(SAPK/ERK kinase-1).
Molecular Medicine 34ノックアウトマウス・データブック, 452-453 (1997)

１９９６年／平成８年　　　

1) K. Kontani, I. Kukimoto, H. Nishina, S. Hoshino, O. Hazeki, Y. Kanaho, and T. Katada: Tyrosine phosphorylation of the c-cbl proto-oncogene product mediated by cell surface antigen CD38 in HL-60 cells.
J. Biol. Chem., 271, 1534-1537 (1996)
2) T. Matsuo, K. Hazeki, O. Hazeki, T. Katada and M. Ui: Specific association of phosphatidylinositol 3-kinase with the protooncogene product Cbl in Fcg receptor signaling.
FEBS Lett., 382, 11-14 (1996)

3) K. Takahashi, K. Tago, H. Okano Y. Ohya, T. Katada, and Y. Kanaho: Augmentation by calmodulin of ADP-ribosylation factor-stimulated phospholipase D activity in permeabilized rabbit peritoneal neutrophils.
J. Immunol., 156, 1229-1234 (1996)

4) H. Ueda, H. Misawa, N. Fukushima, T. Katada, M. Ui, and M. Satoh: A subtype of k-opioid receptor mediates inhibition of high-affinity GTPase inherent in Gi1 in guinea pig cerebellar membranes.
J. Neurochem., 66, 845-851 (1996)

5) T. Yokozeki, H. Kuribara, T. Katada, K. Touhara and Y. Kanaho: Partially purified RhoA-stimulated phospholipase D activity specifically binds to pyosphatidylinositol 4,5- bisphosphate.
J. Neurochem., 66, 1234-1239 (1996)

6) T. Matsuo, K. Hazeki, O. Hazeki, T. Katada and M. Ui: Activation of phosphatidylinositol 3-kinase by concanavalin A through dual signaling pathways, G protein-coupled and phosphotyrosine-related, and an essential role of the G protein-coupled signals for the lectin-induced respiratory burst in human monocytic THP-1 cells.
Biochem. J., 315, 505-512 (1996)

7) T. Sasaki, K. Hazeki, O. Hazeki, M. Ui and T. Katada: Focal adhesion kinase (p125FAK) and paxillin are substrates for sphingomyelinase-induced tyrosine phosphorylation in Swiss 3T3 fibroblasts.
Biochem. J., 315, 1035-1040 (1996)

8) H. Ueda, S. Tamura, N. Fukushima, T. Katada, M. Ui, and M. Satoh: Inositol 1,4,5-trisphosphate-gated calcium transport through plasma membranes in nerve terminals.
J. Neurosci., 16, 2891-2900 (1996)

9) T. Okada, O. Hazeki, M. Ui and T. Katada: Synergistic activation of PtdIns 3-kinase by tyrosine-phosphoorylated peptide and bg-subunits of GTP-binding proteins.
Biochem. J., 317, 475-480 (1996)

10) M. Hara-Yokoyama, I. Kukimoto, H. Nishina, K. Kontani, Y. Hirabayashi, F. Irie, H. Sugiya, S. Furuyama and T. Katada: Inhibition of NAD+ glycohydrolase and ADP-ribosyl cyclase activities of leukocyte cell surface antigen CD38 by gangliosides.
J. Biol. Chem., 271, 12951-12955 (1996)

11) T. Suzuki, O. Hazeki, K. Hazeki, M. Ui and T. Katada: Involvement of the bg subunits of inhibitory GTP-binding protein in chemoattractant receptor-mediated potentiation of cyclic AMP formation in guinea pig neutrophils.
Biochim. Biophys. Acta, 1313, 72-78 (1996)

12) K. Kontani, I. Kukimoto, Y. Kanda, S. Inoue, H. Kishimoto, S. Hoshino and T. Katada: Induction of CD38/NADase and its monoclonal antibody-induced tyrosine phosphorylation in human leukemia cell lines.
Biochem. Biophys. Res. Commun., 222, 466-471 (1996)

13) I. Kukimoto, S. Hoshino, K. Kontani, K. Inageda, H. Nishina, K. Takahashi and T. Katada: Stimulation of ADP-ribosyl cyclase activity of the cell surface antigen CD38 by zinc ions resulting from inhibition of its NAD+ glycohydrolase activity.
Eur. J. Biochem., 239, 177-182 (1996)

14) T. Maehama, S. Hoshino and T. Katada: Increase in ADP-ribosyltransferase activity of rat T lymphocyte alloantigen RT6.1 by a single amino acid mutation.
FEBS Lett., 388, 189-191 (1996)

15) I. Fujimoto, S. Oiki, T. Kondo, T. Katada, H. Kato, T. Taguchi, M. Kasai, Y. Okada, K. Mikoshiba and K. Ikenaka: GTP-binding protein activation underlines LTP induction by mast cell degranulating peptide.
Neurosci. Res., 25, 229-237 (1996)

16) T. Okamoto, S. Takeda, U. Giambarella, Y. Murayama, T. Matsui, T. Katada, Y. Matsuura and I. Nishimoto: Intrinsic signaling function of APP as a novel target of three V642 mutations linked to familial Alzheimer's disease.
EMBO J., 15, 3769-3777 (1996)

17) T. Matsuo, K. Hazeki, N. Tsujimoto, S. Inoue, H. Kurosu, K. Kontani, O. Hazeki, M. Ui and T. Katada : Association of phosphatidylinositol 3-kinase with the proto-oncogene product Cbl upon CD38 ligation by a specific monoclonal antibody in THP-1 cells.
FEBS Lett., 397, 113-116 (1996)

【総説（英文）】

1) O. Hazeki, K. Hazeki, T. Katada and M. Ui,: Inhibitory effect of wortmannin on phosphatidylinositol 3-kinase-mediated cellular events.
J. Lipid Mediat. Cell Signal., 14, 259-261 (1996)

【著書・総説，その他（和文）】

1) 堅田利明：細胞内情報伝達系と創薬.
ファルマシア, 32, 39-42 (1996)

2) 井上晋一，柊元　巌，星野真一，堅田利明：３量体Ｇ蛋白質.
シグナル伝達実験法 （宇井理生 編）, pp. 98-107 羊土社 (1996)

3) 堅田利明：三量体型GTP結合蛋白質.
実験医学 14, 131-141 (1996)

4) 黒須　洋，櫨木　修，堅田利明，宇井理生：PI3-キナーゼ.
実験医学 14, 195-197 (1996)

5) 紺谷圏二，星野真一，柊元　巌，井上晋一，櫨木　修，高橋勝宣，堅田利明：ヒトリンパ球表面抗原CD38の酵素活性とCD38を介する細胞内蛋白質のチロシンリン酸化.
実験医学 14, 420-423 (1996)

6) 堅田利明：アデノシン5'-ニリン酸リボシル化.
Key Word 1996-'97 炎症・免疫系（柏崎禎夫，室田誠逸，垣生園子 編）, pp. 12-13　先端医学社 (1996)

7) 堅田利明：インスリン分泌活性化蛋白質.
Key Word 1996-'97 炎症・免疫系（柏崎禎夫，室田誠逸，垣生園子 編）, pp. 18-19　先端医学社 (1996)

8) 堅田利明：コレラトキシン.
Key Word 1996-'97 炎症・免疫系（柏崎禎夫，室田誠逸，垣生園子 編）, pp. 96-97　先端医学社 (1996)

9) 堅田利明：Ｇタンパク質によって受容体からの情報が細胞内に伝達される.
英文論文セミナー　現代の細胞生物学（馬渕一誠，山本正幸 編）, pp. 67-81　講談社 (1996)

10) 星野真一，堅田利明：３量体Ｇ蛋白質の立体構造と機能領域.
細胞内情報伝達のしくみ （宇井理生 編）, pp. 40-59　羊土社 (1996)

11) 堅田利明：Ｇタンパク質共役型受容体を介するシグナル伝達と遺伝性疾患.
最新医学 51, 1236-1242 (1996)

12) 堅田利明：Ｇ蛋白質を介する機構.
最新内科学大系　第２巻科学としての内科学（井村裕夫 編）, pp. 127-134　中山書店 (1996)

13) 佐々木雄彦，櫨木修，堅田利明，宇井理生：wortmannin と PI 3 -キナーゼ.
タンパク質の分子間相互作用実験法, pp. 203-210　羊土社 (1996)

１９９５年／平成７年　　　

1) K. Inageda, K. Takahashi, K. Tokita, H. Nishina, Y. Kanaho, I. Kukimoto, K. Kontani, S. Hoshino and T. Katada: Enzyme property of Aplysia ADP-ribosyl cyclase: Comparison with NAD glycohydrolase of CD38 antigen.
J. Biochem., 117, 125-131 (1995)

2) Y. Ohoka, K. Kontani, T. Iiri, H. Nishina and T. Katada: Involvement of pertussis toxin-sensitive mechanism in retinoic acid-induced differentiation of human leukemic HL-60 cells.
J. Biochem., 117, 190-196 (1995)
3) H. Misawa, H. Ueda, T. Katada, M. Ui and M. Satoh: A subtype of opioid kappa-receptor is coupled to inhibition of Gi1-mediated phospholipase C activity in the guinea pig cerebellum.
FEBS Lett., 361, 106-110 (1995)

4) T. Iiri, Y. Homma, Y. Ohoka, J. D. Robishaw, T. Katada and H. R. Bourne: Potentiation of Gi-mediated phospholipase C activation by retinoic acid in HL-60 cells: Possible role of Gg2.
J. Biol. Chem., 270, 5901-5908 (1995)

5) H. Shirai, K. Takahashi, T. Katada and T. Inagami: Mapping of G protein coupling sites of the angiotensin II type 1 receptor.
Hypertension, 25, 726-730 (1995)

6) K. Chiba, F. J. Longo, K. Kontani, T. Katada and M. Hoshi: A periodic network of G protein bg subunit coexisting with cytokeratin filament in starfish oocytes.
Dev. Biol., 169, 415-420 (1995)

7) A. Saitoh, S. Tada, T. Katada and T. Enomoto: Stimulation of mouse DNA primase-catalyzed oligoribonucleotide synthesis by mouse DNA helicase B.
Nucleic Acids Res., 23, 2014-2018 (1995)

8) A. Inanobe, K. Morishige, N. Takahashi, H. Ito, M. Yamada, T. Takumi, H. Nishina, K. Takahashi, Y. Kanaho, T. Katada and Y. Kurachi: Gbg directly binds to the carboxyl terminus of the G protein-gated muscarinic K+ channel, GIRK1.
Biochem. Biophys. Res. Commun., 212, 1022-1028 (1995)

9) S. Inoue, S. Hoshino, I. Kukimoto, M. Ui and T. Katada: Purification and characterization of the G203T mutant ai-2 subunit of GTP-binding protein expressed in baculovirus-infected Sf9 cells.
J. Biochem., 118, 650-657 (1995)

10) T. Maehama, H. Nishina, S. Hoshino, Y. Kanaho and T. Katada: NAD+-dependent ADP-ribosylation of T-lymphocyte alloantigen RT6.1 reversibly proceeding in intact rat lymphocytes.
J. Biol. Chem., 270, 22747-22751 (1995)

11) M. U. Ahmed, K. Hazeki, O. Hazeki, T. Katada and M. Ui: Cyclic AMP-increasing agents interfere with chemoattractant-induced respiratory burst in neutrophils as a result of the inhibition of phosphatidylinositol 3-kinase rather than receptor-operated Ca2+ influx.
J. Biol. Chem., 270, 23816-23822 (1995)

12) T. Wada, K. Inageda, K. Aritomo, K. Tokita, H. Nishina, K. Takahashi, T. Katada and M. Sekine: Structural characterization of cyclic ADP-ribose by NMR spectroscopy.
Nucleosides Nucleotides, 14, 1301-1314 (1995)

13) T. Sasaki, K. Hazeki, O. Hazeki, M. Ui and T. Katada: Permissive effect of ceramide on growth factor-induced cell proliferation.
Biochem. J., 311, 829-834 (1995)

14) K. Takahashi, I. Kukimoto, K. Tokita, K. Inageda, S. Inoue, K. Kontani, S. Hoshino, H. Nishina, Y. Kanaho and T. Katada: Accumulation of cyclic ADP-ribose measured by a specific radioimmunoassay in differentiated human leukemic HL-60 cells with all-trnas-retinoic acid.
FEBS Lett., 371, 204-208 (1995)

15) H. Nishina, K. Nimota, I. Kukimoto, T. Maehama, K. Takahashi, S. Hoshino, Y. Kanaho and T. Katada: Significance of Thr182 in the nucleotide-exchange and GTP-hydrolysis reactions of the a subunit of GTP-binding protein Gi2.
J. Biochem., 118, 1083-1089 (1995)

16) M. Mizuguchi, N. Otsuka, M. Sato, Y. Ishii, S. Kon, M. Yamada, H. Nishina, T. Katada and K. Ikeda: Neuronal localization of CD38 antigen in the human brain.
Brain Res., 697, 235-240 (1995)

17) H. Kuribara, K. Tago, T. Yokozeki, T. Sasaki, Y. Takai, N. Morii, S. Narumiya, T. Katada and Y. Kanaho: Synergistic activation of rat brain phospholipase D by ADP-ribosylation factor and rhoA p21, and its inhibition by Clostridium botulinum C3 exoenzyme.
J. Biol. Chem., 270, 25667-25671 (1995)

18) H. Kurosu, O. Hazeki, I. Kukimoto, S. Honzawa, M. Shibasaki, M. Nakada, M. Ui and T. Katada: Radiolabeling of catalytic subunits of PI3-kinases with 17b-hydroxy-16a-[125I]iodowortmannin: Identification of the Gbg-sensitive isoform as a complex composed of 46-kDa and 100-kDa subunits.
Biochem. Biophys. Res. Commun., 216, 655-661 (1995)

19) S. Honzawa, M. Nakada, H. Kurosu, O. Hazeki, T. Katada and M. Shibasaki: 17b-hydroxy-16a-[125I]iodowortmannin, a sensitive labeling agent for PI 3-kinases.
Chem. Pharm. Bull., 43, 2276-2278 (1995)

20) T. Eki, F. Hanaoka, T. Kohda, M. Seki, M. Ui and T. Enomoto: Efficient replication of polyomavirus DNA in a cell-free system supplemented with Escherichia coli single-stranded DNA binding protein, which exhibits species-specificity in the requirement for DNA polymerase alpha-primase.
J. Biochem., 118, 435-441, (1995)

21) M. Seki, T. Kohda, T. Yano, S. Tada, J. Yanagisawa, T. Eki, M. Ui and T. Enomoto: Characterization of DNA synthesis and DNA-dependent ATPase activity at a restrictive temperature in temperature-sensitive tsFT848 cells with thermolabile DNA helicase B.
Mol. Cell. Biol., 15, 165-172, (1995)

【総説（英文）】

1) T. Katada, T. Iiri, K. Takahashi, H. Nishina and Y. Kanaho: GTP-binding proteins as the substrates of pertussis toxin-catalyzed ADP-ribosylation.
Bacterial Toxins and Virulence Factors in Disease (J. Moss, B. Iglewski, M. Vaughan and T. A. Tu, eds.) Handbook of Natural Toxins, Vil. 8, pp. 459-489, Marcel Dekker, Inc., New York (1995)

2) M. Ui, T. Okada, K. Hazeki and O. Hazeki: Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase.
Trends Biochem. Sci., 20, 303-307 (1995)

【著書・総説，その他（和文）】

1) 堅田利明：細胞の外側からのシグナルを内側に運ぶＧタンパク質の発見者 M. ロッドベルと A. G.ギルマン.
現代化学, 286, 40-45 (1995)

2) 堅田利明：レセプターの構造と機能.
Clinical Neuroscience, 13, 515-518 (1995)

3) 星野真一，堅田利明：三量体Ｇ蛋白質のターゲットと認識部位.
実験医学, 13, 657-666 (1995)

4) 岡田太郎，堅田利明，櫨木修：PI 3-キナーゼ阻害薬 Wortmannin.
実験医学, 13, 772-777 (1995)

5) 堅田利明，仁科博史，高橋勝宣，星野真一，紺谷圏二，前濱朝彦，柊元 巌：シグナル伝達系に登場した新しいNAD+代謝酵素.
蛋白質 核酸 酵素, 40, 1900-1911 (1995)

6) 堅田利明：NAD+代謝酵素
蛋白質 核酸 酵素, 40, 1942 (1995)

7) 堅田利明，紺谷圏二，柊元 巌，井上晋一，星野真一，櫨木 修，高橋勝宣，仁科博史：シグナル伝達系におけるNAD+代謝酵素とサイクリックADPリボース.
日薬理誌, 106 (suppl. 1), 45P-49P (1995)

8) 櫨木 薫，ムスレウッデインアフメド，櫨木 修，堅田利明，宇井理生：サイクリックAMPによる食細胞の活性酸素産生抑制機構.
日薬理誌, 106 (suppl. 1), 132P-137P (1995)

9) 堅田利明，星野真一：細胞の外側のシグナルを内側に運ぶＧ蛋白質−最近の進歩−.
呼吸, 14, 1045-1051 (1995)

10) 堅田利明：Ｇ蛋白質.
Key Word 1995-'96 癌（赤沢修吾茂，塚越　茂，新津洋司郎 編）, pp. 138-139　先端医学社 (1995)

11) 高橋勝宣，堅田利明：ＡＲＦ（ADP-ribosylation factor）.
ニューロサイエンス講座 第５巻（宇井理生，野村靖幸 編）情報変換物質−Ｇ蛋白質, pp. 116-123, 廣川書店 (1995)

12) 櫨木修：ホスファチジルイノシトール３-キナーゼ阻害薬ワルトマニンの作用特性.
生化学, 67, 33-36 (1995)

13) 櫨木修，宇井理生：細胞内情報伝達系とワートマニン.
バイオサイエンスとインダストリー, 53, 313-317 (1995)

14) 櫨木修，宇井理生：ワートマニンとインスリン作用.
分子糖尿病学の進歩-基礎から臨床まで-1995（矢崎義雄監修；春日雅人，清野進，渥美義仁，門脇孝編）, pp. 62-68, 金原出版 (1995)

15) 櫨木修，宇井理生：百日咳毒素.
ニューロサイエンス講座 第５巻（宇井理生，野村靖幸 編）情報変換物質−Ｇ蛋白質, pp. 151-159, 広川書店（1995）

16) 星野真一：三量体Ｇ蛋白質の構造、機能ドメイン
ニューロサイエンス講座 第５巻（宇井理生，野村靖幸 編）情報変換物質−Ｇ蛋白質, pp. 1-18, 広川書店 (1995)

１９９４年／平成６年

2) A. Inanobe, K. Takahashi, and T. Katada: Association of the bg subunits of trimeric GTP-binding proteins with heat shock protein, hsp90.
J. Biochem., 115, 486-492 (1994)

3) Y. Takei, K. Takahashi,Y. Kanaho, and T. Katada: Possible involvement of a pertussis toxin-sensitive GTP-binding protein in protein transport into nuclei isolated from rat liver.
J. Biochem., 115, 578-583 (1994)

4) M. Yamada, Y. K. Ho, R. H. Lee, K. Kontani, K. Takahashi, T. Katada and Y. Kurachi: Muscarinic K+ channels are activated by bg subunits and inhibited by the GDP-bound form of a subunit of transducin.
Biochem. Biophys. Res. Commun., 200, 1484-1490 (1994)

5) A. Terzic, R. T. Tung, A. Inanobe, T. Katada and Y. Kurachi: G proteins activate ATP-sensitive K+ channels by antagonizing ATP-dependent gating.
Neuron, 12, 885-893 (1994)

6) T. Okamoto, Y. Murayama, S. M. Strittmatter, T. Katada, S. Asano, E. Ogata and I. Nishimoto: An intrinsic guanine nucleotide exchange inhibitor in Gi2a: Significance of G-protein self-suppression which antagonizes receptor signal.
J. Biol. Chem., 269, 13756-13759 (1994)

7) J. Kawabe, G. Iwami, T. Ebina, S. Ohno, T. Katada, Y. Ueda, C. J. Homcy and Y. Ishikawa: Differential activation of adenylyl cyclase by protein kinase C isoenzymes.
J. Biol. Chem., 269, 16554-16558 (1994)

8) T. Maehama, H. Nishina, and T. Katada: ADP-ribosylarginine glycohydrolase catalyzing the release of ADP-ribose from the cholera toxin-modified a-subunits of GTP-binding proteins.
J. Biochem., 116, 1134-1138 (1994)

9) H. Nishina, K. Inageda, K. Takahashi, K. S. Hoshino, K. Ikeda, and T. Katada: Cell surface antigen CD38 identified as ecto-enzyme of NAD glycohydrolase has hyaluronate-binding activity.
Biochem. Biophys. Res. Commun., 203, 1318-1323 (1994)

10) T. Maehama, N. Sekine, H. Nishina, K. Takahashi, and T. Katada: Characterization of butulinum C3-catalyzed ADP-ribosylation of rho proteins and identification of mammalian C3-like ADP-ribosyltransferase.
Mol. Cell. Biol., 138, 135-140 (1994)

11) K. Kimura, M. Saijo, M. Ui and T. Enomoto: Growth state- and cell cycle-dependent fluctuation in the expression of two forms of DNA topoisomerase II and possible specific modification of the higher molecular weight form in the M phase.
J. Biol. Chem., 269, 1173-1176 (1994)

12) C. Masutani, K. Sugasawa, J. Yanagisawa, T. Sonoyama, M. Ui, T. Enomoto, K. Takio, K. Tanaka, Van, der, Spek, Pj, D. Bootsma, J. Hoeijmakers and F. Hanaoka: Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23.
EMBO J., 13, 1831-1843 (1994)

13) M. Seki, J. Yanagisawa, T. Kohda, T. Sonoyama, M. Ui and T. Enomoto: Purification of two DNA-dependent adenosinetriphosphatases having DNA helicase activity from HeLa cells and comparison of the properties of the two enzymes.
J. Biochem., 115, 523-531 (1994)

14) K. Kimura, N. Nozaki, M. Saijo, A. Kikuchi, M. Ui and T. Enomoto: Identification of the nature of modification that causes the shift of DNA topoisomerase IIb to apparent higher molecular weight forms in the M phase.
J. Biol. Chem., 269, 24523-24526 (1994)

15) M. Seki, H. Miyazawa, S. Tada, J. Yanagisawa, T. Yamaoka, S. Hoshino, K. Ozawa, T. Eki, M. Nogami, K. Okumura, H. Taguchi, F. Hanaoka and T. Enomoto: Molecular cloning of cDNA encoding human DNA helicase Q1 which has homology to Escherichia coli Rec Q helicase and localization of the gene at chromosome 12p12.
Nucleic Acids Res., 22, 4566-4573 (1994)

16) T. Okada, L. Sakuma, Y. Fukui, O. Hazeki and M. Ui: Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase.
J. Biol. Chem., 269, 3563-3567 (1994)

17) T. Okada, Y. Kawano, T. Sakakibara, O. Hazeki and M. Ui: Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.
J. Biol. Chem., 269, 3568-3573 (1994)

18) N. Ninomiya, K. Hazeki, Y. Fukui, T. Seya, T. Okada, O. Hazeki and M. Ui: Involvement of phosphatidylinositol 3-kinase in Fcg receptor signaling.
J. Biol. Chem., 269, 22732-22737 (1994)

19) K. Hazeki, T. Seya, O. Hazeki and M. Ui: Involvement of the pertussis toxin-sensitive GTP-binding protein in regulation of expression and function of granulocyte complement receptor type 1 and type 3.
Mol. Immunol., 31, 511-518 (1994)

20) I. H. Chowdhury, Y. Koyanagi, O. Hazeki, M. Ui and N. Yamamoto: Pertussis toxin inhibits induction of human immunodeficiency virus type 1 in infected monocytes.
Virology, 203, 378-383 (1994)

21) T. Uehara, S. Hoshino, M. Ui, Y. Tokumitsu and Y. Nomura: Possible involvement of phosphatidylinositol-specific phospholipase C related to pertussis toxin-sensitive GTP-binding proteins during adipocyte differentiation of 3T3-L1 fibroblasts: negative regulation of protein kinase C.
Biochim. Biophys. Acta, 1224, 302-310 (1994)

【総説（英文）】

1) T. Katada, K. Kontani, A. Inanobe, I. Kobayashi, Y. Ohoka, H. Nishina, and K. Takahashi: Purification and separation of closely related members of pertussis toxin-substrate G proteins.
Methods in Enzymology, Vol. 237, (Heterotrimeric G Proteins; R. Iyengar, ed.) pp. 131-139 (1994)

【著書・総説，その他（和文）】

1) 金保安則，堅田利明：細胞膜情報伝達に関与する三量体GTP結合タンパク質の構造と機能.
膜, 19, 33-39 (1994)

2) 金保安則，堅田利明：三量体Ｇ蛋白質により調節される効果器系.
GTP結合蛋白質（宇井理生 編）, pp. 44-61　メジカルビュー社 (1994)

3) 堅田利明，金保安則：三量体GTP結合蛋白質.
臨床分子生物学（村松正實 編）, pp.169-174　日本臨床社 (1994)

4) 星野真一，堅田利明：三量体Ｇタンパク質の構造と基本的特性.
日薬理誌, 103, 249-262 (1994)

5) 堅田利明：Ｇ蛋白質.
Key Word 1994-'95 炎症・免疫系（柏崎禎夫，室田誠逸 編）, pp. 142-143　先端医学社 (1994)

6) 櫨木修，堀添達央，長野圭介，宇井理生：細胞内情報伝達.
GTP 結合蛋白質　膜学実験シリ−ズ　第１巻生体膜編（日本膜学会編）, pp. 37-43　共立出版 (1994)

7) 櫨木修：wortmannin
生化学, 66, 1539 (1994)