東京大学大学院 薬学系研究科
生理化学教室

      1. Miharu Maeda, Kota Saito, and Toshiaki Katada
        Distinct isoform-specific complexes of TANGO1 cooperatively facilitate collagen secretion from the endoplasmic reticulum
        Mol. Biol. Cell 2016 mbc.E16-03-0196; →PubMed
      2. Tomoya Tanabe, Miharu Maeda, Kota Saito, and Toshiaki Katada
        Dual function of cTAGE5 in collagen export from the endoplasmic reticulum
        Mol. Biol. Cell 2016 27:13 2008-2013; →PubMed
      3. Nagata Y, Kontani K, Enami T, Kataoka K, Ishii R, Totoki Y, Kataoka TR, Hirata M, Aoki K, Nakano K, Kitanaka A, Sakata-Yanagimoto M, Egami S, Shiraishi Y, Chiba K, Tanaka H, Shiozawa Y, Yoshizato T, Suzuki H, Kon A, Yoshida K, Sato Y, Sato-Otsubo A, Sanada M, Munakata W, Nakamura H, Hama N, Miyano S, Nureki O, Shibata T, Haga H, Shimoda K, Katada T, Chiba S, Watanabe T, Ogawa S.
        Variegated RHOA mutations in adult T-cell leukemia/lymphoma.
        J Biol Chem., 2016 Feb 4;127(5):596-604.→PubMed
      4. Hirota Y, Sawada M, Huang SH, Ogino T, Ohata S, Kudo A, Sawamoto K.
        Roles of Wnt signaling in the neurogenic niche of the adult mouse ventricular-subventricular zone.
        Neurochemical Research, 2016 Feb;41(1-2):222-30.→PubMed
      5. Ohata S, Alvarez-Buylla A.
        Planar organization of multiciliated ependymal (E1) cells in the brain ventricular epithelium
        Trends Neurosci., in press
      1. Fukuyama M, Kontani K, Katada T, Rougvie AE.
        The C. elegans hypodermis couples progenitor cell quiescence to the dietary state.
        Current Biology, 2015. 25,1241-1248→PubMed
      2. Saito K, Katada T.
        Mechanisms for exporting large-sized cargoes from the endoplasmic reticulum.
        Cell Mol Life Sci., 2015 Oct;72(19):3709-20.→PubMed
      3. Ogita Y, Egami S, Ebihara A, Ueda N, Katada T, Kontani K.
        Di-Ras2 Protein Forms a Complex with SmgGDS Protein in Brain Cytosol in Order to Be in a Low Affinity State for Guanine Nucleotides.
        J Biol Chem., 2015 Aug 14;290(33):20245-56.→PubMed
      1. Ohata S*, Herranz-Pérez V, Boletta A, García-Verdugo JM, Álvarez-Buylla A.
        Mechanosensory genes Pkd1 and Pkd2 contribute to the planar polarization of brain ventricular epithelium
        J. Neurosci.
        2015 Aug 5;35(31):11153-68. →PubMed
        *, corresponding author
        Cover of the issue
        Image of the Week: Cushioning the Brain; BrainFacts.org

      1. 福山 征光
        栄養状態による細胞休眠の遺伝学的制御. 生化学 87 (1): 129‒132 (2015)
      1. Saito K, Yamashiro K, Shimazu N, Tanabe T, Kontani K, Katada T.
        Concentration of Sec12 at ER exit sites via interaction with cTAGE5 is required for collagen export
        J Cell Biol., 2014. 206:751-762.→PubMed
      1. Ohata S, Nakatani J, Herranz-Pérez V, Belinson H, Inubushi T, Snider WD, García-Verdugo JM, Wynshaw-Boris A, Álvarez-Buylla A.
        Loss of Dishevelleds disrupts planar polarity in ependymal motile cilia and results in hydrocephalus.
        Neuron.
        2014 Aug 6;83: 558-571. →PubMed
        Press Release
        International Research Team Discovers Genetic Dysfunction Connected to Hydrocephalus (for Ohata et al., 2014)
      1. 福山 征光
        幹・前駆細胞の栄養応答とその分子機構の最前線 インスリン経路とマイクロRNAの関与. ファルマシア 50 (6): 512-516. (2014)
      2. 紺谷 圏二
        Arf-like GTPaseによる膜オルガネラ動態の制御 生化学 86 (1): 98–102 (2014)
      3. 畠 星治、堅田 利明、仁科 博史
        器官サイズを調節する転写共役因子YAPの活性制御 生化学 86 (4): 464–468 (2014)
      4. 大畑慎也, 中谷仁, Wynshaw-Boris A, Álvarez-Buylla A.
        運動性繊毛の平面細胞極性形成・調整・維持におけるDishevelledの役割 実験医学 2014 Dec 32(19):3090-3093
      1. Cevik, Sebiha; Sanders, Anna A; Van Wijk, Erwin; Boldt, Karsten; Clarke, Lara; van Reeuwijk, Jeroen; Hori, Yuji; Horn, Nicola; Hetterschijt, Lisette; Wdowicz, Anita; Mullins, Andrea; Kida, Katarzyna; Kaplan, Oktay I; van Beersum, Sylvia E; Man Wu Ka; Letteboer, Stef J; Mans, Dorus A; Katada, Toshiaki; Kontani, Kenji; Ueffing, Marius; Roepman, Ronald; Kremer, Hannie; Blacque, Oliver E
        Active transport and diffusion barriers restrict Joubert Syndrome-associated ARL13B/ARL-13 to an Inv-like ciliary membrane subdomain.
        PLoS genetics., 2013 9(12):e1003977→PubMed
      2. Su, Steven; Phua, Siew C; DeRose, Robert; Chiba, Shuhei; Narita, Keishi; Kalugin, Peter N; Katada, Toshiaki; Kontani, Kenji; Takeda, Sen; Inoue, Takanari.
        Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia.
        Nature methods , 2013 10(11):1105-7→PubMed
      3. Kasuga, H., Fukuyama, M., Kitazawa, A., Kontani, K., Katada, T.
        The microRNA mir-235 couples blast cell quiescence to the nutritional state.
        Nature, →PubMed 総説はこちら 一般の方向けの解説はこちら
      4. Sasaki, A., Nakae, I., Nagasawa, M., Hashimoto, K., Abe, F., Saito, K., Fukuyama, M., Gengyo-Ando, A., Mitani, S., Katada, T., Kontani, K.
        Arl8/ARL-8 functions in apoptotic cell removal by mediating phagolysosome formation in C. elegans.
        Mol Biol Cell, →PubMed
      5. Kawazu, M., Ueno, T., Kontani, K., Ogita, Y., Ando, M., Fukumura, K., Yamato, A., Soda, M., Takeuchi, K., Miki, Y., Yamaguchi H., Yasuda T., Naoe, T., Yamashita, Y., Katada, T., Choi, Y. L., Mano, H. Transforming mutations of RAC guanosine triphosphatases in human cancers. Proc. Natl. Acad. Sci. USA, 110, 3029-3034. →PubMed
      6. Takasuga, S., Horie, Y., Sasaki, J., Sun-Wada, G. H., Kawamura, N., Iizuka, R., Mizuno, K., Eguchi, S., Kofuji, S., Kimura, H., Yamazaki, M., Horie, C., Odanaka, E., Sato, Y., Chida, S., Kontani, K., Harada, A., Katada, T., Suzuki, A., Wada, Y., Ohnishi, H., Sasaki, T.
        Critical roles of type III phosphatidylinositol phosphate kinase in murine embry onic visceral endoderm and adult intestine.
        Proc. Natl. Acad. Sci. USA. 110, 1726-1731. →PubMed
      1. 春日秀文・福山征光
        ライフサイエンス新着論文レビュー "First Author's"
      1. 福山征光、春日秀文、北澤文、小川拓也、粂優彦、紺谷圏二、堅田利明
        線虫のマイクロRNA miR-235は幼生発生開始の栄養チェックポイントとして機能する [Oral]
        第36回日本分子生物学会年会、神戸、2013年12月4日
      2. 齋藤康太、福島槙一、堅田利明
        肝線維化時のコラーゲン分泌機構の解析 [Oral]
        第20回肝細胞研究会, 大阪, 2013年9月27日
      3. 福山 征光、春日 秀文、北澤 文、紺谷 圏ニ、堅田 利明
        microRNAであるmiR-235は前駆細胞の休眠と栄養状態を結びつける [Oral]
        日本動物学会第84回大会、岡山、2013年9月28日
      4. 紺谷 圏二
        リソソームへの物質輸送に介在する低分子量Gタンパク質ARL8 [Oral]
        細胞内ロジスティクス シンポジウム, 淡路島, 2013年9月18日
      5. 粂優彦、春日秀文、福山征光、紺谷圏ニ、堅田利明
        miR-235による神経前駆細胞の栄養応答性の休眠制御機構 [Oral]
        第12回次世代を担う若手ファーマ・バイオフォーラム2013, 東京大学本郷キャンパス, 2013年9月14日
        [優秀発表賞受賞]
      6. 田辺共哉、嶋津典子、齋藤康太、堅田利明
        cTAGE5は低分子量Gタンパク質Sar1の活性化を制御することでコラーゲン分泌に関与する [Oral]
        第12回次世代を担う若手ファーマ・バイオフォーラム2013, 東京大学本郷キャンパス, 2013年9月15日
      7. Shinohara K, Saito K, Katada T
        Mechanisms of collagen secretion regulated by the small GTPase Sar1 [Poster and Oral]
        第86回日本生化学会大会, 横浜, 2013年9月11-13日
      8. Keisuke Hashimoto, Maya Nagasawa, Fumiko Abe, Keiko Gengyo-Ando, Shohei Mitani, Kenji Kontani, Toshiaki Katada
        ARL-8 GTPase functions in apoptotic cell removal by mediating phagolysosome formation in C. elegans [Poster and Oral]
        第86回日本生化学会大会, 横浜, 2013年9月11-13日[鈴木紘一メモリアル賞受賞]
      9. 荻田佳孝, 江上幸子, 紺谷圏二, 堅田利明
        低分子量Gタンパク質Di-Ras2とSmgGDSの相互作用に関する生化学的解析[Poster and Oral]
        第86回日本生化学会大会, 横浜, 2013年9月11-13日[鈴木紘一メモリアル賞受賞]
      10. Kontani, K., Sasaki, A., Hashimoto, K., Gengyo-Ando, K., Mitani, S., Katada, T.
        ARL8 mediates phagolysosome formation for apoptotic cell clearance in C. elegans [Oral]
        FASEB Summer Research Conferences: ARF and Rab family G Proteins, Snowmass Village, Colorado, USA, 2013年7月31日
      11. Saito, K., Yamashiro, K.,Shimazu, N., Tanabe, T. and Katada, T.
        The tight regulation of Sar1 GTPase cycle is necessary for collagen secretion. [Poster]
        Gordon Research Conferences, Molecular Membrane Biology. Andover, New Hampshire, USA. 2013年7月14-19日
      12. K. Iki, Y. Ito, Y. Shimomura, H. kajiho, M. Fukuyama, K. Kontani, T. Katada
        C. elegans Rag genes are involved in endosome / lysosome biogenesis in a TORC1-independent fashion. [Poster]
        19th International C. elegans Meeting, University of California Los Angeles, California, USA, 2013年6月29日
      13. 齋藤康太、山城 昂、嶋津 典子、田辺 共哉、堅田 利明.
        低分子量Gタンパク質Sar1の活性制御に着目したコラーゲン輸送機構の解明. [Oral]
        第65回日本細胞生物学会大会、名古屋, 2013年6月19日
      14. 紺谷 圏二、佐々木 文佳、堅田 利明
        リソソームへの物質輸送に介在する低分子量Gタンパク質ARL8 [Oral]
        第8回トランスポーター研究会, 熊本, 2013年6月16日
      15. Masamitsu Fukuyama, Hidefumi Kasuga, Aya Kitazawa, Masahiko Kume, Takuya Ogawa, Kenji Kontani, Toshiaki Katada
        The microRNA mir-235 suspends growth and development during starvation [Oral]
        第46回日本発生生物学会、松江、2013年5月31日
      1. Fukuyama M, Sakuma K, Park R, Kasuga H, Nagaya R, Atsumi Y, Shimomura Y, Takahashi S, Kajiho H, Rougvie A, Kontani K, Katada T.
        C. elegans AMPKs promote survival and arrest germline development during nutrient stress.
        Biology Open 1, 929-36 (2012) →PubMed
      2. Tada M, Gengyo-Ando K, Kobayashi T, Fukuyama M, Mitani S, Kontani K, Katada T.
        The neuronally expressed Ras-family GTPase Di-Ras modulates synaptic activity in Caenorhabditis elegans.
        Genes Cells 17, 778-89 (2012) →PubMed
      3. Hata S, Hirayama J, Kajiho H, Nakagawa K, Hata Y, Katada T, Furutani-Seiki M, Nishina H.
        A novel acetylation cycle of transcription co-activator Yes-associated protein that is downstream of Hippo pathway is triggered in response to SN2 alkylating agents.
        J. Biol. Chem. 287(26): 22089–22098 (2012) →PubMed
      4. Kajiho H, Fukushima S, Kontani K, Katada T.
        RINL, guanine nucleotide exchange factor Rab5-subfamily, is involved in the EphA8-degradation pathway with odin.
        PLoS One 7 (1): e30575 (2012) →PubMed
      5. Osawa M, Hosoda N, Nakanishi T, Uchida N, Kimura T, Imai S, Machiyama A, Katada T, Hoshino S, Shimada I.
        Biological role of the two overlapping poly(A)-binding protein interacting motifs 2 (PAM2) of eukaryotic releasing factor eRF3 in mRNA decay.
        RNA 18 (11): 1957–1967 (2012) →PubMed
      6. Katada T.
        The inhibitory G protein G(i) identified as pertussis toxin-catalyzed ADP-ribosylation.
        Biol. Pharm. Bull. 35 (12): 2103–2111 (2012) →PubMed
      7. Hara-Yokoyama M, Kukimoto-Niino M, Terasawa K, Harumiya S, Podyma-Inoue KA, Hino N, Sakamoto K, Itoh S, Hashii N, Hiruta Y, Kawasaki N, Mishima-Tsumagari C, Kaitsu Y, Matsumoto T, Wakiyama M, Shirouzu M, Kasama T, Takayanagi H, Utsunomiya-Tate N, Takatsu K, Katada T, Hirabayashi Y, Yokoyama S, Yanagishita M.
        Tetrameric interaction of the ectoenzyme CD38 on the cell surface enables its catalytic and raft-association activities.
        Structure 20 (9): 1585–1595 (2012) →PubMed
      1. Yamasaki T, Kawasaki H, Arakawa S, Shimizu K, Shimizu S, Reiner O, Okano H, Nishina S, Azuma N, Penninger JM, Katada T, Nishina H.
        Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex.
        J. Neurosci. 31 (46): 16872–16883 (2011) →PubMed
      2. Kajiho H, Sakurai K, Minoda T, Yoshikawa M, Nakagawa S, Fukushima S, Kontani K, Katada T.
        Characterization of RIN3 as a Guanine Nucleotide Exchange Factor for the Rab5 Subfamily GTPase Rab31.
        J Biol Chem. Jul 8;286(27):24364-73. (2011) →PubMed
      3. Saito K, Yamashiro K, Ichikawa Y, Erlmann P, Kontani K, Malhotra V, Katada T.
        cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites.
        Mol Biol Cell. Jul;22(13):2301-8. (2011) →PubMed
      4. Takahashi S, Ebihara A, Kajiho H, Kontani K, Nishina H, and Katada T.
        RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phospholylated-MKK7.
        Cell Death Differ. Apr;18(4):645-55. (2011) →PubMe
      5. Takahashi S, Sakurai K, Ebihara A, Kajiho H, Saito K, Kontani K, Nishina H, Katada T .
        RhoA activation participates in rearrangement of processing bodies and release of nucleated AU-rich mRNAs.
        Nucleic Acids Res. Apr;39(8):3446-57. (2011) →PubMed
      6. Ohata S, Aoki R, Kinoshita S, Yamaguchi M, Tsuruoka-Kinoshita S, Tanaka H, Wada H, Watabe S, Tsuboi T, Masai I, Okamoto H.
        Dual roles of Notch in regulation of apically restricted mitosis and apicobasal polarity of neuroepithelial cells.
        Neuron., Jan 27;69(2):215-30.→PubMed
        Press Release
        Following directions (for Ohata et al., 2011)
      1. Ohata S, Aoki R, Kinoshita S, Yamaguchi M, Tsuruoka-Kinoshita S, Tanaka H, Wada H, Watabe S, Tsuboi T, Masai I, Okamoto H
        Dual roles of Notch in regulation of apically restricted mitosis and apicobasal polarity of neuroepithelial cells.
        Neuron.
        2011 Jan 27;69(2):215-30. →PubMed
        Press Release
        Following directions (for Ohata et al., 2011)
      1. Nakae I, Fujino T, Kobayashi T, Sasaki A, Kikko Y, Fukuyama M, Gengyo-Ando K, Mitani S, Kontani K, Katada T.
        The arf-like GTPase Arl8 mediates delivery of endocytosed macromolecules to lysosomes in Caenorhabditis elegans.
        Mol Biol Cell. 21(14):2434-42.(2010) →PubMed
      2. Cevik S, Hori Y, Kaplan OI, Kida K, Toivenon T, Foley-Fisher C, Cottell D, Katada T, Kontani K, Blacque OE.
        Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in Caenorhabditis elegans.
        J Cell Biol. 188(6):953-69. (2010) →PubMed
      3. Ruan L, Osawa M, Hosoda N, Imai S, Machiyama A, Katada T, Hoshino S, Shimada I.
        Quantitative characterization of Tob interactions provides the thermodynamic basis for translation termination-coupled deadenylase regulation.
        J Biol Chem. 285(36):27624-31. (2010) →PubMed
      4. Seo J, Asaoka Y, Nagai Y, Hirayama J, Yamasaki T, Namae M, Ohata S, Shimizu N, Negishi T, Kitagawa D, Kondoh H, Furutani-Seiki M, Penninger JM, Katada T, Nishina H.
        Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation.
        J Cell Biochem. 110(4):1022-37. (2010) →PubMed
      5. Klassen MP, Wu YE, Maeder CI, Nakae I, Cueva JG, Lehrman EK, Tada M, Gengyo-Ando K, Wang GJ, Goodman M, Mitani S, Kontani K, Katada T, Shen K.
        An Arf-like small G protein, ARL-8, promotes the axonal transport of presynaptic cargoes by suppressing vesicle aggregation. Neuron.
        Neuron. 66(5):710-23. (2010) →PubMed
      6. Nagai Y, Asaoka Y, Namae M, Saito K, Momose H, Mitani H, Furutani-Seiki M, Katada T, Nishina H.
        The LIM protein Ajuba is required for ciliogenesis and left-right axis determination in medaka.
        Biochem Biophys Res Commun. 396(4):887-93. (2010) →PubMed
      7. Wu J, Kubota J, Hirayama J, Nagai Y, Nishina S, Yokoi T, Asaoka Y, Seo J, Shimizu N, Kajiho H, Watanabe T, Azuma N, Katada T, Nishina H.
        p38 Mitogen-activated protein kinase controls a switch between cardiomyocyte and neuronal commitment of murine embryonic stem cells by activating myocyte enhancer factor 2C-dependent bone morphogenetic protein 2 transcription.
        Stem Cells Dev. 19(11):1723-34. (2010) →PubMed
      8. Nakagawa K, Sugahara M, Yamasaki T, Kajiho H, Takahashi S, Hirayama J, Minami Y, Ohta Y, Watanabe T, Hata Y, Katada T, Nishina H.
        Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation.
        Biochem J. 427(2):237-45. (2010) →PubMed
      9. Negishi T, Nagai Y, Asaoka Y, Ohno M, Namae M, Mitani H, Sasaki T, Shimizu N, Terai S, Sakaida I, Kondoh H, Katada T.
        Furutani-Seiki M, Nishina H. Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression in medaka.
        Hepatology. 51(3): 1037-1045 (2010) →PubMed
      1. 堅田利明 金保安則 [訳]
        インテグレーテッドシリーズ1:ペリー生化学 東京化学同人
      2. Tanemura S, Yamasaki T, Katada T and Nishina H [review]
        Utility and limitations of SP600125, an inhibitor of stress-responsive c-Jun N-terminal kinase.
        Curr. Enzym. Inhib. 6, 26-33. (2010)
      3. 堅田利明 [翻訳分担]
        分子細胞生物学 第6版 (Lodish et al.) 東京化学同人
      4. 堅田利明 [執筆分担]
        生物学事典 東京化学同人
      1. Hori Y, Nagashima S, Kontani K, Katada T.
        Analysis of domain architecture of the atypical Arf-family GTPase involved in cilia formation [Poster]
        FASEB Summer Research Conferences: The Biology of Cilia and Flagella, Saxtons River, Vermont, USA
      2. Kontani K, Nakae I, Sasaki A, Gengyo-Ando K, Mitani S, Katada T.
        A role for C. elegans ARL-8 in endocytic delivery to lysosomes [Oral]
        FASEB Summer Research Conferences: Arf family G Proteins, Carefree, AZ, USA
      3. Saito K, Yamashiro K, Ichikawa Y, Erlmann P, Malhotra V, Katada T.
        cTAGE5 is involved in the endoplasmic reticulum to golgi trafficking in mammalian cells. [Oral]
        ASBMB Special Symposia, Biochemistry of Membrane Traffic: Secretory and Endocytic Pathways. Lake Tahoe, CA, USA.
      4. 福島慎一、梶保博昭、堅田利明 [口頭発表]
        新規タンパク質RINLの機能解析
        BMB2010 神戸
      5. 壹岐和哉、伊藤有佳子、下村裕美、梶保博昭、福山征光、紺谷圏二、堅田利明 [ポスター発表]
        低分子量G蛋白質Ragの機能解析
        BMB2010 神戸
      1. Tanemura S, Momose H, Shimizu N, Kitagawa D, Seo J, Yamasaki T, Nakagawa K, Kajiho H, Penninger JM, Katada T, Nishina H.
        Fcepsilon receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signalling pathway.
        J Biochem. [JB論文賞受賞] 145:345-354 (2009) →PubMed
      2. Ohata S, Nawa M, Kasama T, Yamasaki T, Sawanobori K, Hata S, Nakamura T, Asaoka Y, Watanabe T, Okamoto H, Hara T, Terai S, Sakaida I, Katada T, Nishina H.
        Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells.
        Biochem Biophys Res Commun. 379: 817-823 (2009) →PubMed
      3. Ohata S, Kinoshita S, Aoki R, Tanaka H, Wada H, Tsuruoka-Kinoshita S, Tsuboi T, Watabe S, Okamoto H.
        Neuroepithelial cells require fucosylated glycans to guide the migration of vagus motor neuron progenitors in the developing zebrafish hindbrain.
        Development., 2009 May;136(10):1653-63.→PubMed
      4. Kobayashi T, Hori Y, Ueda N, Kajiho H, Muraoka S, Shima F, Kataoka T, Kontani K, Katada T.
        Biochemical characterization of missense mutations in the Arf/Arl-family small GTPase Arl6 causing Bardet-Biedl syndrome.
        Biochem Biophys Res Commun. 381: 439-442 (2009) →PubMed
      5. Shimizu N, Watanabe H, Kubota J, Wu J, Saito R, Yokoi T, Era T, Iwatsubo T, Watanabe T, Nishina S, Azuma N, Katada T, Nishina H.
        Pax6-5a promotes neuronal differentiation of murine embryonic stem cells.
        Biol. Pharm. Bull. 32(6): 999-1003 (2009) →PubMed
      6. Saito R, Yamasaki T, Nagai Y, Wu J, Kajiho H, Yokoi T, Noda E, Nishina S, Niwa H, Azuma N, Katada T, Nishina H.
        CrxOS maintains the self-renewal capacity of murine embryonic stem cells.
        Biochem. Biophys. Res. Commun. 390 (4): 1129-1135 (2009) →PubMed
      1. Ohata S, Kinoshita S, Aoki R, Tanaka H, Wada H, Tsuruoka-Kinoshita S, Tsuboi T, Watabe S, Okamoto H.
        Neuroepithelial cells require fucosylated glycans to guide the migration of vagus motor neuron progenitors in the developing zebrafish hindbrain.
        Development.
        2009 May;136(10):1653-63. →PubMed
      2. Saito, K., Chen, M., Bard, F., Chen, S., Zhou, H., Woodley, D., Polischuk, R., Schekman, R. and Malhotra, V.
        TANGO1 facilitates cargo loading at Endoplasmic Reticulum exit sites.
        Cell 136, 891-902 →PubMed
      1. Fukuyama M, Sakuma K, Astumi Y, Shimomura H, Kasuga H, Rougvie A and Katada T.
        Distinct control of survival, and somatic and germline development during L1 diapause by the insulin/IGF signaling and AMPK pathway [Poster]
        [17th International C.elegans Meeting] Los Angeles, CA, USA, 2009年6月26日
      2. Nakae I, Fujino T, Kobayashi T, Kikko Y, Harada S, Fukuyama M, Gengyo-Ando K, Mitani S, Kontani K and Katada T.
        The Arf-like GTPase ARL-8 is required for lysosome biogenesis in C. elegans [Poster]
        17th International C.elegans Meeting Los Angeles, CA, USA, 2009年6月27日
      3. Katada T and Kontani K.
        The Arf-like GTPase Arl8 is required for lysosome biogenesis in C. elegans. [Oral]
        IUPS 2009: PSJ Symposium, VI-5; Recent progress on G-protein signalings Kyoto, Japan, 2009年7月28日
      1. 齋藤康太他
        細胞工学, 28, 392-393.
      1. Wada T, Stepniak E, Hui L, Leibbrandt A, Katada T, Nishina H, Wagner EF, Penninger JM.
        Antagonistic control of cell fates by JNK and p38-MAPK signaling.
        Cell Death Differ. 15: 89-93 (2008) →PubMed
      2. Hara-Yokoyama M, Kimura T, Kaku H, Wakiyama M, Kaitsu Y, Inoue M, Kusano S, Shirouzu M, Yokoyama S, Katada T, Hirabayashi Y, Takatsu K, Yanagishita M.
        Alteration of enzymatic properties of cell-surface antigen CD38 by agonistic anti-CD38 antibodies that prolong B cell survival and induce activation.
        Int. Immunopharmacol. 8: 59-70 (2008) →PubMed
      3. Ohsawa S, Watanabe T, Katada T, Nishina H, Miura M.
        Novel antibody to human BASP1 labels apoptotic cells post-caspase activation.
        Biochem. Biophys. Res. Commun. 371: 639-643 (2008) →PubMed
      4. Yoshikawa M, Kajiho H, Sakurai K, Minoda T, Nakagawa S, Kontani K, Katada T.
        Tyr-phosphorylation signals translocate RIN3, the small GTPase Rab5-GEF, to early endocytic vesicles.
        Biochem. Biophys. Res. Commun. 372: 168-172 (2008) →PubMed
      5. Hori Y, Kobayashi T, Kikko Y, Kontani K, Katada T.
        Domain architecture of the atypical Arf-family GTPase Arl13b involved in cilia formation.
        Biochem. Biophys. Res. Commun. 373: 119-124 (2008) →PubMed
      6. Takahashi S, Araki Y, Ohya Y, Sakuno T, Hoshino S, Kontani K, Nishina H, Katada T.
        Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast.
        RNA 14: 1950-1958 (2008) →PubMed
      1. Hiroaki Kajiho, Manabu Yoshikawa, Kyoko Sakurai, Tomohiro Minoda, Satoshi Nakagawa, Kenji Kontani, and Toshiaki Katada.
        Tyr-phosphorylation signals translocate RIN3, the small GTPase Rab5-GEF, to early endocytic vesicles. [Poster]
        48th ASCB Annual Meeting. 米国、サンフランシスコ、2008年12月
      1. 堅田利明
        クーパー細胞生物学第4版(翻訳分担;3、13、15章) 東京化学同人
      2. 堅田利明
        ストライヤー生化学第6版(翻訳分担;14、16章) 東京化学同人
      1. Shintani M, Tada M, Kobayashi T, Kajiho H, Kontani K, Katada T.
        Characterization of Rab45/RASEF containing EF-hand domain and a coiled-coil motif as a self-associating GTPase.
        Biochem Biophys Res Commun. 357: 661-667 (2007) →PubMed
      2. Ura S, Nishina H, Gotoh Y, Katada T.
        Activation of the JNK patyway by MST1 is essential and sufficient for the induction of chromatin condensation during apoptosis.
        Mol. Cell. Biol. 27, 5514-5522. (2007) →PubMed
      3. Funakoshi Y, Doi Y, Hosoda N, Uchida N, Osawa M, Shimada I, Tsujimoto M, Suzuki T, Katada T, Hoshino S.
        Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases.
        Genes Dev. 23:3135-3148 (2007) →PubMed
      1. 多田稔、小林哲夫、紺谷圏二、堅田利明
        低分子量Gタンパク質研究の進歩;日薬理誌 130: 373-379
      1. Kofuji S, Sakuno T, Takahashi S, Araki Y, Doi Y, Hoshino S, Katada T.
        The decapping enzyme Dcp1 participates in translation termination through its interaction with the release factor eRF3 in budding yeast.
        Biochem. Biophys. Res. Commun. 344: 547-553 (2006) →PubMed
      2. Kitagawa D, Kajiho H, Negishi T, Ura S, Watanabe T, Wada T, Ichijo H, Katada T, Nishina H.
        Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation.
        EMBO J. 25: 3286-3297 (2006) →PubMed
      3. Fukuyama M, Rougvie AE, Rothman JH.
        C. elegans DAF-18/PTEN mediates nutrient-dependent arrest of cell cycle and growth in the germline.
        Curr. Biol. 16:773-779 (2006) →PubMed
      4. Nakano-Kobayashi A, Yamazaki M, Unoki T, Hongu T, Murata C, Taguchi R, Katada T, Frohman MA, Yokozeki T, Kanaho Y.
        Role of activation of PIP5Kγ661 by AP-2 complex in synaptic vesicle endocytosis.
        EMBO J. 26:1105-1116 (2007) →PubMed
      5. Ito G, Okai T, Fujino G, Takeda K, Ichijo H, Katada T, Iwatsubo T.
        GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson’s disease.
        Biochemistry 46:1380-1388 (2007) →PubMed
      6. Takahashi S, Kontani K, Araki Y, Katada T.
        Caf1 regulates translocation of ribonucleotide reductase by releasing nucleoplasmic Spd1-Suc22 assembly.
        Nucleic Acid Res. 35:1187-1197 (2007) →PubMed
      1. Kuroyanagi H, Kobayashi T, Mitani S, Hagiwara M. Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanism in vivo. Nat. Methods. 11: 909-15 →PubMed
      2. Gengyo-Ando K, Kuroyanagi H, Kobayashi T, Murate H, Fujimoto K, Okabe S, Mitani S. The SM protein VPS-45 is required for RAB-5-dependent endocytic transport in Caenorhabditis elegans. EMBO Rep. in press →PubMed
      1. 北川大樹、堅田利明、仁科博史
        新規核内複合体Daxx-RASSF1CはDNA損傷センサーとして機能してシグナルを核か ら細胞質へと伝達する; 細胞工学 25: 1178-1179
      2. 堅田利明
        細胞のシグナル伝達系に介在する諸種のGTP結合性制御蛋白質の機能解析(持田記念学術賞受 賞者の研究概要); 持田記念財団年報 平成18年 pp. 19-24
      3. 堅田利明
        New生化学第2版(堅田利明、菅原一幸、富田基郎 編)[執筆分担:生命のしくみ、代謝調節];pp. 3-12 & 374-393 廣川書店
      4. 堅田利明
        エッセンシャル生化学(翻訳分担) 東京化学同人
      1. Saito K, Araki Y, Kontani K, Nishina H, Katada T.
        Novel role of the small GTPase Rheb: Its implication in endocytic pathway independent of the activation of mammalian target of rapamycin.
        J. Biochem. 137:423-430 (2005) →PubMed
      2. Im DS, Nagano K, Katada T, Okajima F, Ui M.
        Differential change of Ins-P3-Ca2+ signaling during culture of rat hepatocytes.
        Cell Signal. 17:83-91 (2005) →PubMed
      3. Im YJ, Im DS, Lee YK, Lee EH, Sato K, Tomura H, Katada T, Ui M, Okajima F.
        Study on action mode of sphingosine 1-phosphate in rat hepatocytes.
        J. Pharmacol. Sci. 97:443-446 (2005) →PubMed
      4. Kontani K, Moskowitz IPG, Rothman JH.
        Repression of cell-cell fusion by components of the C. elegans vacuolar ATPase complex.
        Dev. Cell 8:787-794 (2005) →PubMed
      5. Kontani K, Rothman JH.
        Cell fusion: EFF is enough.
        Curr. Biol. 15:R252-254 (2005) →PubMed
      6. Saito K, Kajiho H, Araki Y, Kurosu H, Kontani K, Nishina H, Katada T.
        Purification and analysis of RIN family-novel Rab5 GEFs.
        Methods Enzymol. 403:276-283 (2005) →PubMed
      1. Nishina H, Katada T.
        The biological function of JNKKs (MKK4/MKK7 knockout mice). The JNK signaling pathway (Lin A, ed.) pp. 41-49, Landes Bioscience, Texas
      2. 堅田利明
        αβγ3量体GTP結合タンパク質と細菌毒素によるADPリボシル化;生物薬科学実験講座 7、情報伝達物質II (石橋貞彦、市川厚、堅田利明 編)pp. 253-263 廣川書店
      3. 仁科博史、堅田利明
        MAPキナーゼ;生物薬科学実験講座7、情報伝達物質II (石橋貞彦、市川厚、堅田利明 編)pp. 424-433 廣川書店
      4. 堅田利明
        GTP結合タンパク質の役割;医系薬理学 改訂2版(遠藤仁,橋本敬太郎,後藤勝年,金井好克 編) pp. 20-31 中外医学社
      5. 堅田利明
        生命の基本単位としての細胞;薬学生のための細胞生物学(堅田利明 編)pp. 1-6 廣川書店
      6. 堅田利明
        細胞の情報伝達;薬学生のための細胞生物学(堅田利明 編)pp. 161-187 廣川書店
      7. 堅田利明
        細胞内情報伝達;スタンダード薬学シリーズ4 生物系薬学 II.細胞をミクロに理解する(日本薬学会 編)pp. 316-335 東京化学同人