Last modified: 1st February 2003.

[Japanese]/[English]

‰ÄŠ¡@‰pº@Hideaki Natsugari, Professor.

[—ª@—ð]

1944”N12ŒŽ12“ú _“ސ쌧¶‚Ü‚ê
1969”N3ŒŽ “Œ‹ž‘åŠw–òŠwŒn‘åŠw‰@CŽm‰Û’öC—¹
1969”N4ŒŽ •“c–ò•iH‹ÆiŠ”j“üŽÐA‰»ŠwŒ¤‹†Š‚É”z‘®
ˆÈŒãAˆã–òŒ¤‹†ŠA‘n–òŒ¤‹†Š‚ȂǂňêŠÑ‚µ‚ÄŠî‘b’Tõ‡¬Œ¤‹†
1980”N “Œ‹ž‘åŠwE–òŠw”ŽŽm
1983”N`1984”N •Ä‘ƒyƒ“ƒVƒ‹ƒxƒjƒAB—§‘åŠw‰»Šw‰ÈiProf. S. M. Weinrebj—¯Šw
1995”N10ŒŽ •“c–ò•iH‹ÆiŠ”j‘n–ò‘æˆêŒ¤‹†ŠEƒŠƒT[ƒ`ƒ}ƒlƒWƒƒ[i‡¬j
1997”N10ŒŽ •“c–ò•iH‹ÆiŠ”j‘n–òŒ¤‹†ŠŠ’·
i’†•_ŒoŒnE‰º•””A˜HŒnŽ¾Š³Ž¡—Öò’S“–j
2000”N10ŒŽ •“c–ò•iH‹ÆiŠ”j‘n–òŒ¤‹†–{•”EŽŸ¢‘ãˆã–ò•iŒ¤‹†ŽºiŽº’·j
2001”N4ŒŽ “Œ‹ž‘åŠw‘åŠw‰@–òŠwŒnŒ¤‹†‰È‹qˆõ•‹³Žö
2002”N4ŒŽ “Œ‹ž‘åŠw‘åŠw‰@–òŠwŒnŒ¤‹†‰È‹qˆõ‹³Žö

[Žå‚ÈŒ¤‹†—ð]

1969`1976”N@BenzodiazepineŒn‡–°“±“üÜEƒ†[ƒƒWƒ“Žü•Ó‚̍‡¬‰»Šw“IŒ¤‹†

1976`1983”N@CephalosporinŒnR‹ÛÜƒxƒXƒgƒR[ƒ‹‚̐»•i‰»iÅIÜŒ^E1/2‰–Ž_‰–Œ‹»‚̍ìoj

1984`1989”N@”®y¶ŽY•¨‚̉»ŠwCü

1989`1992”N@R‚Ž‰ŒŒÇŽ¡—Öò‚ÌŒ¤‹†ŠJ”­iACAT‘jŠQ–òETMP-153‡¬Œ¤‹†’S“–j

1992`1997”N@ƒ^ƒLƒLƒjƒ“hR–ò‚Ì‘n–òŒ¤‹†iTAK-637jŒ¤‹†Žå’S

[Šw‰ïŠˆ“®]

1995”N`2001”N@‹ß‹E‰»Šw‹¦‰ï‡¬•”‰ïŠ²Ž–

1995”N`Œ»Ý@@ƒtƒ@ƒCƒ“ƒPƒ~ƒJƒ‹ƒYŒ¤‹†‰ï(‘åãŽsHŒ¤ŽåÃ)ˆÏˆõ

1998”N`2001”N@“ú–{–òŠw‰ï‹ß‹EŽx•”Š²Ž–

1998”N`Œ»Ý@@Chem. Pharm. Bull. •ÒWˆÏˆõ

2000”N`Œ»Ý@@‹ß‹E‰»Šw‹¦‰ï‹@ŠÖŽi‹ß‰»Žj•ÒWˆÏˆõ

2001”N`Œ»Ý@@“ú–{–òŠw‰ï—Ž–

2001”N`Œ»Ý@@“ú–{–òŠw‰ïˆã–ò‰»Šw•”‰ïŠ²Ž–

[Œ´’˜˜_•¶]

(1) K. Meguro, H. Natsugari, H. Tawada, and Y. Kuwada
Heterocycles. IV. Reactions of 2-amino-3H-1,4-benzodiazepines with primary amines and hydroxylamines
Chem. Pharm. Bull., 21, 2366|2374 (1973)

(2) H. Natsugari, K. Meguro, and Y. Kuwada
Heterocycles. X. Synthesis and reactions of 1,4,5-benzotriazocinium salts
Chem. Pharm. Bull., 27, 2084|2092 (1979)

(3) H. Natsugari, K. Meguro, and Y. Kuwada
Heterocycles. XI. Synthesis of 2-amino-6-phenyl-3,4-dihydro-1,5-benzodiazocines
Chem. Pharm. Bull., 27, 2589|2595 (1979)

(4) H. Natsugari, K. Meguro, and Y. Kuwada
Heterocycles. XII. Synthesis of 2-amino-5-phenyl-1,4- benzodiazepine 1-oxides and 2-amino-6-phenyl-1,5-benzodiazocine 1-oxides and their reactions with acylating agents
Chem. Pharm. Bull., 27, 2608|2617 (1979)

(5) H. Natsugari and Y. Kuwada
Heterocycles. XIII. Reactions of 2-amino-1,4-benzodiazepine 1-oxides and 2-amino-1,5-benzo-diazocines 1-oxides with acetylenecarboxylates
Chem. Pharm. Bull., 27, 2618|2626 (1979)

(6) H. Natsugari, K. Meguro, and Y. Kuwada
Heterocycles. XIV. Reactions of 2-amino-5-phenyl-1,4-benzodiazepines and 2-amino-6-phenyl-1,5-benzodiazocines with diketene
Chem. Pharm. Bull., 27, 2927|2937 (1979)

(7) M. Ochiai, A. Morimoto, T. Miyawaki, Y. Matsushita, T. Okada, H. Natsugari, and M. Kida
Synthesis and structure-activity relationships of 7-b-[1-(2-aminothiazol-4- acetamido]cephalosporin derivatives. V. Synthesis and antibacterial activity of 7-b-[1-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido] cephalosporin derivatives and related compounds
J. Antibiot., 34, 171|185 (1981)

(8) H. Natsugari, Y. Matsushita, N. Tamura, K. Yoshioka, M. Kondo, and K. Okonogi
Synthesis and structure-activity relationships of carbapenems related to C-19393H2
J. Antibiot., 36, 855|875 (1983)

(9) H. Natsugari, Y. Matsushita, N. Tamura, K. Yoshioka, and M. Ochiai
Synthesis of 5,6-cis-carbapenems related to C-19393H2
J. Chem. Soc., Perkin Trans. 1, 1983, 403|411

(10) H. Natsugari, R. R. Whittle, and S. M. Weinreb
Stereocontrolled synthesis of unsaturated vicinal diamines from Diels-Alder Adducts of sulfur dioxide bis(imides)
J. Am. Chem. Soc., 106, 7867|7872 (1984)

(11) N. Tamura, H. Natsugari, Y. Kawano, Y. Matsushita, K. Yoshioka, and M. Ochiai
Synthesis of carbapenems with a sulfonyl group in the C-6 side chain and their biological activity
Chem. Pharm. Bull., 35, 996|1015 (1987)

(12) H. Natsugari, E. Turos, S. M. Weireb, and R. J. Cvetovich
Further studies on stereoselective synthesis of vicinal diamines from 3,6-dihydrothiazine-1-imines
Heteocycles, 25, 19|24 (1987)

(13) H. Natsugari, Y. Kawano, A. Morimoto, K. Yoshioka, and M. Ochiai
Synthesis of lactivicin and its derivatives
J. Chem. Soc., Chem. Commun., 1987, 62|63

(14) K. Yoshioka, Y. Kawano, A. Morimoto, Y. Matsushita, S. Harada, and H. Natsugari
Synthesis and antibacterial activity of lactivicin derivatives
J. Pharm. Sci., 76, S175-S175 (1987)

(15) S. Hashiguchi, H. Natsugari, and M. Ochiai
Synthesis of g-lactam analogues of carbapenems with substituted-thio groups at the C-3 position
J. Chem. Soc., Perkin Trans. 1, 1988, 2345|2352

(16) S. Hashiguchi, A. Kawada, and H. Natsugari
Stereoselective synthesis of sperabillins and related compounds
J. Chem. Soc., Perkin Trans. 1, 1991, 2435|2444

(17) S. Hashiguchi, A. Kawada, and H. Natsugari
Bakerfs yeast reduction of N-protected methyl 4-amino-3-oxobutanoates and -3-oxopentanoates
Synthesis, 1992, 403|408

(18) T. Hida, S. Tsubotani, N. Katayama, Y. Funabashi, H. Natsugari, and S. Harada
Synthesis and antimicrobial activity of sperabillin derivatives
J. Antibiot., 46, 803|812 (1993)

(19) T. Hida, S. Tsubotani, A. Hori, M. Murakami, H. Natsugari, Y. Kozai, and S. Harada
Chemistry and antitumor activity of sperabillin polymers
Chem. Pharm. Bull., 41, 889|893 (1993)

(20) H. Tawada, H. Natsugari, E. Ishikawa, Y. Sugiyama, H. Ikeda, and K. Meguro
Synthesis of 3-ureido derivatives of coumarin and 2-quinolone as potent acyl-CoA:cholesterol acyltransferase inhibitors
Chem. Pharm. Bull., 43, 616|625 (1995)

(21) H. Natsugari, Y. Ikeura, Y. Kiyota, Y. Ishichi, T. Ishamaru, O. Saga, H. Shirafuji, T. Tanaka, I. Kamo, T. Doi, and M. Otsuka
Novel, potent, and orally active substance P antagonists: synthesis and antagonist activity of N-benzylcarboxamide derivatives of pyrido[3,4-b]pyridine
J. Med. Chem., 38, 3106|3120 (1995)

(22) Y. Ikeura, T. Tanaka, Y. Kiyota, S. Morimoto, M. Ogino, T. Ishamaru, T. Tanaka, I. Kamo, T. Doi, and H. Natsugari
Potent NK1 receptor antagonists: synthesis and antagonistic activity of various heterocycles with an N-[3,5-bis(trifluoromethyl)benzyl]-N-methylcarbamoyl substituent
Chem. Pharm. Bull., 45, 1642|1652 (1997)

(23) Y. Ikeura, T. Ishamaru, T. Doi, M. Kawada, A. Fujishima, and H. Natsugari
Enantioselective synthesis of an axially chiral 1,7-naphthyridine-6-carboxamide derivative having potent antagonistic activity at the NK1 receptor
Chem. Commun., 1998, 2141|2142

(24) Y. Ikeura, Y. Ishichi, T. Tanaka, A. Fujishima, M. Murabayashi, M. Kawada, T. Ishamaru, I. Kamo, T. Doi, M. Kawada, and H. Natsugari
Axially chiral N-benzyl-N,7-dimethyl-5-phenyl-1,7-naphthyridine-6-caroxamide derivatives as tachykinin NK1 receptor antagonists: determination of the absolute stereochemical requirements
J. Med. Chem., 41, 4232|4239 (1998)

(25) H. Natsugari, Y. Ikeura, I. Kamo, T. Ishimaru, Y. Ishichi, A. Fujishima, T. Tanaka, F. Kasahara, M. Kawada, and T. Doi
Axially chiral 1,7-naphthyridine-6-carboxamide derivatives as orally active tachykinin NK1 receptor antagonists: synthesis, antagonistic activity, and effects on bladder functions
J. Med. Chem., 42, 3982|3993 (1999)

(26) T. Doi, I. Kamo, S. Imai, S. Okanishi, T. Ishimaru, Y. Ikeura, and H. Natsugari
Effects of TAK-637, a tachykinin receptor antagonist on lower urinary tract function in the guinea pigs
Eur. J. Pharmacol., 383, 297|303 (1999)

(27) Y. Ikeura and H. Natsugari
Novel tachykinin NK1 receptor antagonists: design, synthesis and stereochemistry
J. Takeda Res. Lab., 58, 1|51 (1999)

(28) T. Doi, I. Kamo, S. Imai, S. Okanishi, Y. Ikeura, and H. Natsugari
Effects of TAK-637, a tachykinin receptor antagonist, on the micturition reflex in guinea pigs
Eur. J. Pharmacol., 395, 241|246 (2000)

(29) S. Okano, H. Nagaya, Y. Ikeura, H. Natsugari, and N. Inatomi
Effects of TAK-637, a novel neurokinin-1 receptor antagonist, on colonic function in vivo
J. Pharmacol. Exp. Ther., 298, 559|564 (2001)

(30) N. Tarui, Y. Ikeura, H. Natsugari, and K. Nakahama
Microbial synthesis of three metabolites of a tachykinin receptor antagonist, TAK-637
J. Biosci. Bioeng., 92, 285|287 (2001)

(31) N. Tarui, Y. Ikeura, H. Natsugari, and K. Nakahama
Microbial synthesis of a deuterium-labelled metabolite of an NK1 receptor antagonist, TAK-637
J. Labelled Compd. Radiopharm., 44, 865|870 (2001)