|
|
| 2006 |
| Jul. 10 |
An article of Young-Joo Lee in our lab. ranked number 9 in Febrauary 2006, receiving the 9th greatest numbers of "hits" via the world-wid web in JPET
Congratulations !
|
| Jul. 7 |
Kimio Toyama of our lab. has taken 3rd place in the poster presentation at US-Japan Conference on Drug Development & Rational Drug Design, 2005
US-Japan Conference on Drug
Development & Rational Drug Design had been held on July 31-August 3, 2005
at School of Pharmacy, University of Southern California. Its title was "Kinetic
Analysis of the Transport of Thyroid Hormhones (T4 and T3) Across the
blood-Brain Barrier".
Congratulations !
|
| Feb. 13 |
A Figure of artcle of Lee, Ph.D in our lab. was put on the cover of JPET,
Feb. 2006
Young-Joo Lee, Jun Maeda, Hiroyuki Kusuhara,
Takashi Okauchi, Motoki Inaji, Yuji Nagai, Shigeru Obayashi, Ryuji Nakao,
Kazutoshi Suzuki, Yuichi Sugiyama, and Tetsuya Suhara
In Vivo Evaluation
of P-glycoprotein Function at the Blood-Brain Barrier in Nonhuman Primates Using
[11C]Verapamil
J Pharmacol Exp Ther. 2006
Feb;316:647-653
|
| Jan. 13 |
Prof.Sugiyama archived the 2nd top position for the number of citations
for the last 10 years in the field of "Pharmacology & Toxicology"
According to the information in the website of ISI
Essential Science Indicators (ESI), Thomson Scientific（USA）, Professor Yuichi
Sugiyama achieved the 2nd top position for the number of citations for the last
10 years (Jan 1, 1995 ? Aug 31, 2005) in the field of “Pharmacology &
Toxicology”. The total number of citations for the last 10 years amounted to
4,131 reflecting the important work done by Professor Sugiyama in investigating
the role of drug transporters in drug disposition (pharmacokinetics ). The
researcher who achieved the first position was Dr.G.Burnstock (London,UK) for
his work in the field of pharmacology on receptors.
ESI is a resource that
enables researchers to conduct ongoing, quantitative analyses of research
performance and track trends in science. Covering a multidisciplinary selection
of 11,000+journals from around the world, this in-depth analytical tool offers
data for ranking scientists, institutions, countries, and journals. The database
is available as a ten-year rolling file, ESI covers 10 million articles in 22
specific fields of research, and is updated every two months.
The top 10
scientists in the field of “Pharmacology and Toxicology” were announced in the
website. In the field of drug metabolism and transport, Drs. F.J.Gonzalez（NIH,
US）, D.W Nebert（Cincinnati,US） and F.P.Guengeric（Nashville, US） as well as Dr.
Sugiyama’s former collaborator, Dr.H. Suzuki are in the top 10.
Please refer
to the following website for more detailed information.
http://in-cites.com/top/2005/
Congratulations,
Professor Sugiyama!
|
| 2005 |
| Nov. 07 |
Prof.Sugiyama won the John G. Wagner Pfizer Lectureship Award in Pharmaceutical
Sciences
We are proud to
announce that Prof.YUICHI SUGIYAMA has had the honor of being awarded the John
G. Wagner Pfizer Lectureship Award in Pharmaceutical Sciences
2006.
Associate Professor,
Hiroyuki Kusuhara, congratulates Prof.SUGIYAMA in his own words as
follows.
Prof.YUICHI SUGIYAMA is the twelfth recipient of this award which was created to honor the great achievements of the late Prof.John G. Wagner, one of the pioneers of pharmacokinetic research in the world. Prof.Yuichi Sugiyama is not only the first Japanese recipient but also only the second non-US citizen to receive it (the other is Prof. Malcolm Rowland, UK).
Prof.Sugiyama
remembers clearly how he occasionally had heated discussions with Prof.Wagner at
international scientific meetings when Dr.Sugiyama was a research
associate.
The themes they
argued passionately about were mainly the clearance concept and
physiologically-based pharmacokinetics. Professor Sugiyama remained very
impressed by Prof.Wagner's "Obstinacy, zeal and good intentions in conducting
his research which were not lost even as he grew older" (At that time,
Prof.Wagner was over 60 years of age). Also, Prof.Sugiyama vividly remembers the
scene where Prof. Rowland was having a similar, heated discussion with
Prof.Wagner. Prof.Sugiyama felt that "the wonderfully obstinate nature" of
Prof.Wagner had influenced many researchers.
Prof.Sugiyama said
that he was delighted to get the award named after Prof.Wagner for work in
pharmacokinetics and it was a great honor for
him.
Dr.Sugiyama will give
a lecture at the University of Michigan on February, 2006.
Hiroyuki Kusuhara
|
| Mar. 09 |
Articles of our lab. were put on the top page of journals
Nagata Y, Kusuhara H, Hirono S, Endou H, Sugiyama
Y.
Carrier-mediated uptake of H2-receptor antagonists by the rat
choroid plexus: involvement of rat organic anion transporter 3.
Drug Metab
Dispos. 2004 Sep;32(9):1040-7
Lee YJ, Kusuhara H, Jonker JW, Schinkel AH,
Sugiyama Y.
Investigation of efflux transport of dehydroepiandrosterone
sulfate and mitoxantrone at the mouse blood-brain barrier: a minor role of
breast cancer resistance protein.
J Pharmacol Exp Ther. 2005 Jan;312(1):44-52
|
| Mar. 09 |
Article of our lab. won the Drug Metabolism and Disposition Best Paper
Award for 2004. Will be awarded at Experimental Biology 2005, held on Apr.
2 to 6, 2005, San Diego
Nagata Y, Kusuhara H, Hirono S, Endou H, Sugiyama
Y.
Carrier-mediated uptake of H2-receptor antagonists by the rat
choroid plexus: involvement of rat organic anion transporter 3.
Drug Metab
Dispos. 2004 Sep;32(9):1040-7
|
| 2004 |
| Jul. 06 |
Sachiko Mita of our laboratory has taken third place in the poster presentation
at the Falk Symposium
Summary of abstract
Construction of Madin-Darby Canine Kidney (MDCK) cells
expressing both rat Na+ Taurocholate Cotransporting Polypeptide (NTCP/SLC10A1)
and rat Bile Salt Export Pump (BSEP/ABCB11)
Vectorial transcellular
transport of bile salts across hepatocytes consists of uptake across the
basolateral membrane from the portal blood followed by excretion across the
apical membrane into the canalicular space. Basolateral uptake transporter Na+
Taurocholate Cotransporting Polypeptide (NTCP/SLC10A1) and canalicular efflux
transporter Bile Salt Export Pump (BSEP/ABCB11), respectively, are thought to be
mainly responsible for these processes. In the present study, by constructing a
co-expression system of rat Ntcp and rat Bsep, we were able to establish an
experimental model which could reproduce the hepatoclellular transcellular
transport of bile salts in vitro. We transfected rat Ntcp and rat Bsep into
polarized Madin-Darby canine kidney (MDCK) cells and characterized the transport
properties of these cells. Immunohistochemical staining demonstrated that Ntcp
was expressed at the basolateral domains whereas Bsep was expressed at the
apical domains. The basal-to-apical flux of taurocholate across Ntcp/Bsep- MDCK
monolayers was more than 100 times higher than the opposite flux and was
significantly higher than that across control monolayers: vector-transfected
MDCK, Ntcp-MDCK, and Bsep-MDCK. Kinetic analysis of the basal-to-apical
transport of taurocholate gave an apparent Km value of 13.9 ± 4.7 μM for
Ntcp-MDCK and 22.2 ± 4.5 for Ntcp/Bsep-MDCK. The Vmax values were 15.8
pmol/min/mg protein (Ntcp alone) and 60.8 (both transporters). Transcellular
transport of cholate, glycocholate, taurochenodeoxycholate, chenodeoxycholate,
glycochenodeoxycholate, tauroursodeoxycholate, ursodeoxycholate, and
glycoursodeoxycholate, but not lithocholate, was also observed across the double
transfectant. This system can be used as a model to investigate the vectorial
transport of bile salts across hepatocytes under physiological conditions.
|
| 2003 |
| Dec. 10 |
Prof.Sugiyama has won the AAPS Dintinguished Pharmaceutical Scientist Award
Dr. Sugiyama has been selected as the 2003
recipient of the AAPS Distinguished Pharmaceutical Scientist Award.
This
award is the highest honor conferred by the AAPS. There have only been seven
scientists selected in the past,
and Dr. Sugiyama is the first non-American
scientist to win the award.
We are proud that his achievements
have been rated so highly, like his area of research, “the integration of
Molecular and Cell Biology with enzyme and transporter mediated Pharmacokinetics
/ Pharmacodynamics.”
The AAPS Annual Meeting and Exposition is a key meeting
for those engaged in drug discovery science research, and involves around 7,000
participants and 1,100 exhibition booths. It was held from Oct. 26 to Oct. 30 in
Salt Lake City this year. At the opening ceremony of this annual meeting, Dr.
Sugiyama was honored and his research results were introduced at a roundtable
session the next day.
The previous recipients
are:
Leslie Z. Benet, Ph.D. in 1989
Dale E.
Wurster, Ph. D in 1991
Robert S. Langer, Sc.D. in
1993
George Zografi, Ph.D. in 1995
Ronald T.
Borchardt, Ph. D. in 1997
Joseph R. Robison, Ph.D. in
1999
Wolfgang Sadee, Ph.D. in
2001
Below you will find the text which appeared in the “2003 Awards Program”
booklet for the ceremony
held on Oct 26,
2003 at Salt Lake City, Utah
|
|
|
