Publications

2000

  • "Highly Zinc-Selective Fluorescent Sensor Molecules Suitable for Biological Applications" Tomoya Hirano, Kazuya Kikuchi, Yasuteru Urano, Tsunehiko Higuchi and Tetsuo Nagano, J. Am. Chem. Soc., 122, 12399-12400(2000).
  • "First Synthetic NO-heme-thiolate Complex Relevant to Nitric Oxide Synthase and Cytochrome P450nor" Noriyuki Suzuki, Tsunehiko Higuchi, Yasuteru Urano, Kazuya Kikuchi, Takeshi Uchida, Masahiro Mukai, Teizo Kitagawa and Tetsuo Nagano, J. Am. Chem. Soc., 122, 12059-12062 (2000).
  • "Fluorescence Switching by O-dearylation of 7-Aryloxycoumarines. -Development of Novel Fluorescence Probes to Detect Reactive Oxygen Species with High Selectivity-" Ken-ichi Setsukinai, Yasuteru Urano, Kazuya Kikuchi, Tsunehiko Higuchi and Tetsuo Nagano, Perkin Transaction 2, 2453-2457 (2000).
  • "Development of Time-Resolved Fluorometric Detection System Using Diffusion-Enhanced Energy Transfer" Mitsunori Koresawa, Kazuya Kikuchi, Shin Mizukami, Hirotatsu Kojima, Yasuteru Urano, Tsunehiko Higuchi and Tetsuo Nagano, Analytical Chemistry, 72, 4904-4907 (2000).
  • "Design and Synthesis of Intramolecular Resonance Energy Transfer Probes for Use in Aqueous Solution" Yasutomo Kawanishi, Kazuya Kikuchi, Hideo Takakusa, Shin Mizukami, Yasuteru Urano, Tsunehiko Higuchi and Tetsuo Nagano, Angewandte Chemie, Int. Ed., 39, 3438-3440 (2000).
  • "Novel Zinc Fluorescent Probes Excitable with Visible Light for Biological Applications" Tomoya Hirano, Kazuya Kikuchi, Yasuteru Urano, Tsunehiko Higuchi and Tetsuo Nagano, Angewandte Chemie Int. Ed., 39, 1052-1054(2000).
  • A New Thioether-Ligated Iron Porphyrin as a Model of a Protonated Form of P450 Active Site" Takashi Dokoh, Noriyuki Suzuki, Tsunehiko Higuchi, Yasuteru Urano, Kazuya Kikuchi and Tetsuo Nagano, Journal of Inorganic Biochemistry, 82, 127-132 (2000).
  • "Fluorescent Indicators for Nitric Oxide Based on Rhodamine Chromophore" Hirotatsu Kojima, Miki Hirotani,Yasuteru Urano, Kazuya Kikuchi, Tsunehiko Higuchi and Tetsuo Nagano, Tetrahedron Lett., 41, 69-72 (2000).
  • "Remarkable Axial Thiolate Ligand Effects on the Oxidation of Hydrocarbons by Active Intermediate of Iron Porphyrin and Cytochrome P450" Tomoe Ohno, Noriyuki Suzuki, Takashi Dokoh, Yasuteru Urano, Kazuya Kikuchi, Masaaki Hirobe, Tsunehiko Higuchi and Tetsuo Nagano, Journal of Inorganic Biochemistry, 82, 123-125 (2000).
  • "Determination and Bioimaging Method for Nitric Oxide in Biological Specimens by Diaminofluorescein Fluorometry" Yoshinori Itoh, Fu Hai Ma, Hanae Hoshi, Michiko Oka, Kumiko Noda, Yojiro Ukai, Hirotatsu Kojima, Tetsuo Nagano and Noboru Toda, Analytical Biochemistry, 287, 203-209(2000).
  • "Fluorescent Indicators for Nitric Oxide" Hirotatsu Kojima and Tetsuo Nagano, Advanced Materials, 12, 763-765 (2000).
  • "Synthesis and Superoxide Dismutase Activity of Novel Iron Complexes" Masakazu Tamura, Yasuteru Urano, Kazuya Kikuchi, Tsunehiko Higuchi, Masaaki Hirobe and Tetsuo Nagano, J. Organomet. Chem., 611, 586-592 (2000).
  • "Superoxide Dismutase Activity of Iron(II)TPEN Complex and Its Derivatives" Masakazu Tamura, Yasuteru Urano, Kazuya Kikuchi, Tsunehiko Higuchi, Masaaki Hirobe and Tetsuo Nagano, Chem. Pharm. Bull., 48, 1514-1518 (2000).
  • "Mechanism of Superoxide Dismutase Activity of Fe(II) and Fe(III) Complexes of Tetrakis-N,N,N',N' (2-pyridylmethyl)ethylenediamine" Tomohisa Hirano, Masaaki Hirobe, Kazuo Kobayashi, Akira Odani, Osamu Yamauchi, Masanori Ohsawa, Yoshinori Satow and Tetsuo Nagano, Chem. Pharm. Bull., 48, 223-230 (2000).
  • "Characterization of Proton-Transfer Catalysis by Serum Albumins" Florian Hollfelder, Anthony J. Kirby, Dan S. Tawfik, Kazuya Kikuchi, and Donald Hilvert, J. Am. Chem. Soc., 122, 1022-1029 (2000).
  • "Effects of Tetrahydrobiopterin on Endothelial Dysfunction in Rats with Ischemic Acute Renal Failure" Masao Kakoki, Yasunobu Hirata, Hiroshi Hayakawa, Etsu Suzuki, Daisuke Nagata, Akihiro Tojo, Hiroaki Nishimatsu, Kazuya Kikuchi, Tetsuo Nagano and Masao Omata, J. Am. Soc. Nephrol., 11, 301-309 (2000).
  • "Synthesis of Various Water-Soluble C60 Derivatives and Their Superoxide-Quenching Activity" Kensuke Okuda, Takashi Hirota, Masaaki Hirobe, Tetsuo Nagano, Masataka Mochizuki and Tadahiko Mashino, Fullerene Science and Technology, 8, 89-104 (2000).
  • "Adrenomedullin and Nitric Oxide Inhibit Human Endothelial Cell Apoptosis via a Cyclic GMP-Independent　Mechanism" Masataka Sata, Masao Kakoki, Daisuke Nagata, Hiroaki Nishimatsu, Etsu Suzuki, Teruhiko Aoyagi,　Seiryo Sugiura, Hirotatsu Kojima, Tetsuo Nagano, Kenji Kangawa, Hisayuki Matsuo, Masao Omata, Ryozo Nagai and Yasunobu Hirata, Hypertension, 36, 83-88 (2000).

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1999

  • "Novel Iron Porphyrin-Alkanethiolate Complex with Intramolecular NH…S Hydrogen Bond: Synthesis, Spectroscopy and Reactivity" Noriyuki Suzuki, Tsunehiko Higuchi, Yasuteru Urano, Kazuya Kikuchi, Hidehiro Uekusa, Yuji Ohashi, Takeshi Uchida, Teizo Kitagawa and Tetsuo Nagano, J. Am. Chem. Soc., 121, 11571-11572 (1999).
  • "Fluorescent Indicators for Imaging Nitric Oxide Production" Hirotatsu Kojima, Yasuteru Urano, Kazuya Kikuchi, Tsunehiko Higuchi and Tetsuo Nagano, Angewandte Chemie Int. Ed., 38, 3209-3212 (1999).
  • "Novel Fluorescent Probes for Singlet Oxygen" Naoki Umezawa, Kumi Tanaka, Yasuteru Urano, Kazuya Kikuchi, Tsunehiko Higuchi and Tetsuo Nagano, Angewandte Chemie Int. Ed., 38, 2899-2901 (1999).
  • "Imaging of Caspase-3 Activation in HeLa Cells Stimulated with Etoposide Using a Novel Fluorescent Probe" Shin Mizukami, Kazuya Kikuchi, Tsunehiko Higuchi, Yasuteru Urano, Tetsuo Mashima, Takashi Tsuruo and Tetsuo Nagano, FEBS Lett., 453, 356-360 (1999).
  • "Synthesis and Evaluation of 1-Position-modified Inositol 1,4,5-Trisphosphate Analogs" T. Inoue, K. Kikuchi, K. Hirose, M. Iino and T. Nagano, Bioorganic and Medicinal Chemistry Letters, 9, 1697-1702 (1999).
  • "Practical Methods for Detection of Nitric Oxide" Tetsuo Nagano, Luminescence, 14, 283-290 (1999).
  • "Dipeptides Containing L-Arginine Analogs: New Isozyme-selective Inhibitors of Nitric Oxide Synthase" Nobutaka Kobayashi, Tsunehiko Higuchi, Yasuteru Urano, Kazuya Kikuchi, Masaaki Hirobe and Tetsuo Nagano, Biol. Pharm. Bull., 22 (9) 936-940 (1999)
  • "Absolute Configuration of Cathine" Kentaro Yamaguchi, Yukiko Makino, Yasuteru Urano and Tetsuo Nagano, Analytical Science, 15, 1039-1040 (1999).
  • "Effects of Hypertension, Diabetes Mellitus and Hypercholesterolemia on Endothelin Type B Receptor-Mediated Nitric Oxide Release From Rat Kidney" Kakoki M, Hirata Y, Hayakawa H, Tojo A, Nagata D, Suzuki E, Kimura K, Goto A, Kikuchi K, Nagano T and Omata M, Circulation, 99, 1242-1248 (1999).
  • "Role of Nitric Oxide-cGMP Pathway in Adrenomedullin-induced Vasodilation in the Rat" Hayakawa H, Hirata Y, Kakoki M, Suzuki Y, Nishimatsu H, Nagata D, Suzuki E, Kikuchi K, Nagano T, Kangawa K, Matsuo H, Sugimoto T, Omata M, Hypertension, 33, 689-693 (1999).
  • "Effects of Vasodilatory β-Adrenoceptor Antagonists on Endothelium-Derived Nitric Oxide Release in Rat Kidney" Kakoki M, Hirata Y, Hayakawa H, Nishimatsu H, Suzuki Y, Nagata D, Suzuki E, Kikuchi K, Nagano T, Omata M, Hypertension, 33, 467-471 (1999).
  • " Inhibition of E. coli Growth by Fullerene Derivatives and Inhibition Mechanism" Tadahiko Mashino, Kensuke Okuda, Takashi Hirota, Masaaki Hirobe, Tetsuo Nagano and Masataka Mochizuki, Bioorganic and Medicinal Chemistry Letters, 9, 2959-2962 (1999).

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1998

  • "Real Time Measurement of Nitric Oxide Release from Cultured Endothelial Cells" Hajimu Kurumatani, Kazuya Kikuchi, Tetsuo Nagano, Masaaki Hirobe, Jun Yamazaki and Taku Nagao, Biol. Pharm. Bull., 21, 1286-1289 (1998).
  • "Improved Nitric Oxide Detection Using 2,3-Diaminonaphthalene and Its Application to the Evaluation of Novel Nitric Oxide Synthase Inhibitors" Naoki Nakatsubo, Hirotatsu Kojima, Kuniko Sakurai, Kazuya Kikuchi, Hiroshi Nagoshi, Yasunobu Hirata, Takaaki Akaike, Hiroshi Maeda, Yasuteru Urano, Tsunehiko Higuchi and Tetsuo Nagano, Biol. Pharm. Bull., 21,1247-1250 (1998).
  • "Selective Deoxygenation of Heteroaromatic N-oxides with Olefins Catalyzed by Ruthenium Porphyrin" Hiroshi Nakagawa, Tsunehiko Higuchi, Kazuya Kikuchi, Yasuteru Urano and Tetsuo Nagano, Chem. Pharm. Bull., 46, 1656-1657(1998).
  • "Direct Evidence of NO Production in Rat Hippocampus and Cortex Using a New Fuorescent Indicator: DAF-2 DA" Hirotatsu Kojima, Naoki Nakatsubo, Kazuya Kikuchi,Yasuteru Urano, Tsunehiko Higuchi, Junji Tanaka, Yoshihisa Kudo and Tetsuo Nagano, NeuroReport, 9, 3345-3348 (1998).
  • "Detection and Imaging of Nitric Oxide with Novel Fluorescent Indicators: Diaminofluoresceins" Hirotatsu Kojima, Naoki Nakatsubo, Kazuya Kikuchi, Shigenori Kawahara, Yataka Kirino, Hiroshi Nagoshi, Yasunobu Hirata and Tetsuo Nagano, Analytical Chemistry, 70, 2446-2453(1998).
  • "Direct Evidence of Nitric oxide production from bovine aortic endothelial cells using new fluorescence indicators: diaminofluoresceins" Naoki Nakatsubo, Hirotatsu Kojima, Kazuya Kikuchi, Hiroshi Nagoshi, Yasunobu Hirata, Daisuke Maeda, Yasuyuki Imai, Tatsuro Irimura and Tetsuo Nagano, FEBS Lett., 427, 263-266(1998).
  • "Development of a Fluorescent Indicator for Nitric Oxide Based on the Fluorescein Chromophore" Hirotatsu Kojima, Kuniko Sakurai, Kazuya Kikuchi, Shigenori Kawahara, Yataka Kirino, Hiroshi Nagashi, Yasunobu Hirata and Tetsuo Nagano, Chem. Pharm. Bull., 46, 373-375 (1998).
  • "Hepatoprotective Effect of Fe-TPEN on Carbon Tetrachloride Induced Liver Injury in Rats" Jeon-Ok Moon, Su-Kyung Park and Tetsuo Nagano, Biol. Pharm. Bull., 21, 284-288 (1998).
  • "Oxygen Homeostasis and Its Dynamics" eds by Y. Ishimura, H. Shimada, M. Suematsu, Springer-Verlag, Tokyo, 1998, "Pronouned Effects of Axial Thiolate Ligand on Oxygen Activation by Iron Porphyrin" Tsunehiko Higuchi, Yasuteru Urano, Masaaki Hirobe and Tetsuo Nagano, pp. 181-188.

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1997

  • "Receptor Subtype for Vasopressin-induced Release of Nitric Oxide from Rat Kidney" Yasunobu Hirata, Hiroshi Hayakawa, Masao Kakoki, Akihiro Tojo, Etsu Suzuki, Daisuke Nagata, Kenjiro Kimura, Atsuo Goto, Kazuya Kikuchi, Tetsuo Nagano, Masaaki Hirobe and Masao Omata, Hypertension, 29 Part 1, 58-64 (1997).s
  • "A Dual Effect of 1-Methyl-4-phenylpyridinum (MPP+) Analogs on the Respiratory Chain of Bovine Heart Mitochondria" Eiji Hasegawa, Dongchon Kang, Kei Sakamoto, Atsushi Mitsumoto, Tetsuo Nagano, Shigeki Minakami and Koichiro Takeshige, Arch. Biochem. Biophys., 337, 69-74 (1997).
  • "Changes of Energy Metabolism Induced by 1-Methyl-4-Phenylpyridinum (MPP+)-related Compounds in Rat Phenochromocytoma PC 12 Cells" Dongchon Kang, Kenichi Miyako, Futoshi Kuribayashi, Atsushi Mitsumoto, Tetsuo Nagano and Koichiro Takeshige, Arch. Biochem. Biophys., 337, 75-80 (1997).
  • "Singlet Oxygen Production fron Fullerene Derivatives: Effect of Sequential Functionalization of Fullerene Core" Takeshi Hamano, Kensuke Okuda, Tadahiko Mashino, Masaaki Hirobe, Kumi Arakane, Akemi Ryu, Shinrou Mashiko and Tetsuo Nagano, Chem. Commun., 21, (1997).
  • "The Regio- and Stereoselective Oxidation of Steroids with 2,6-Dichloropyridine N-oxide Catalyzed by Ruthenium Porphyrines" T. Shingaki, K. Miura, T. Higuchi, M. Hirobe and T. Nagano, J. Chem. Soc. Chem. Comm., 801 (1997).
  • "Participation of Reactive Oxygen Species in Photodermatosis Induced by Quinolone Antibacterial Agents" Naoki Umezawa, Kumi Arakane, Akemi Ryu, Shinro Mashiko, Masaaki Hirobe and Tetsuo Nagano, Arch. Biochem. Biophys., 342, 275-281 (1997).
  • "Cross-linking of Collagen by Singlet Oxygen Generated with UV-A" Akemi Ryu, Eiji Naru, Kumi Arakane, Takuji Masunaga, Kouichi Shinmoto, Tetsuo Nagano, Masaaki Hirobe and Shinrou Mashiko, Chem. Pharm. Bull., 45, 1243-1247 (1997).
  • "Activation of Human Neutrophile Procollagenase by Nitrogen Dioxide and Peroxynitrite: A Novel Mechanism for Procollagenase Activation Involving Nitric Oxide" Tatsuya Okamoto, Takaaki Akaike, Tetsuo Nagano, Seiya Miyajima, Moritaka Suga, Masayuki Ando, Koji Ichimori, Hiroe Nakazawa and Hiroshi Maeda, Arch. Biochem. Biophys., 342, 261-274 (1997).
  • "Development of a Fluorescent Indicator for Bioimaging of Nitric Oxide" Hirotatsu Kojima, Kuniko Sakurai, Kazuya Kikuchi, Shigenori Kawahara, Yutaka Kirino, Hiroshi Nagoshi, Yasunobu Hirata, Takaaki Akaike, Hiroshi Maeda and Tetsuo Nagano, Biol. Pharm. Bull., 20 (12), 1229-1232 (1997).
  • "Inhibitory Effects of a Fullerene Derivative, Dimalonic Acid C60, on Nitric Oxide-Induced Relaxation of Rabbit Aorta" Mitsutoshi Satoh, Kazuhiro Matsuo, Hitoshi Kiriya, Tadahiko Mashino, Tetsuo Nagano, Masaaki Hirobe and Issei Takayanagi, European Journal of Pharmacology, 327, 175-181 (1997).
  • "Real-time Measurement of Nitric Oxide Production in Rat Brain by the Combination of Luminol-H2O2 Chemiluminescence and Microdialysis" Hirotatsu Kojima, Kazuya Kikuchi, Masaaki Hirobe and Tetsuo Nagano, Neuroscience Letters, 233, 157-159 (1997).
  • "Pronounced Axial Thiolate Ligand Effect on the Reactivity of High-valent Oxo-iron Porphyrin Intermediate" Yasuteru Urano, Tsunehiko Higuchi, Masaaki Hirobe and Tetsuo Nagano, J. Am. Chem. Soc., 119, 12008-12009 (1997).

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1996

  • "Measurement of 1268 nm Emission for Comparison of Singlet Oxygen (1Dg)Production Efficiency of Various Dyes" Kumi Arakane, Akemi Ryu, Kenji Takarada, Takuji Masunaga, Kouichi Shinmoto, Reijirou Kobayashi, Shinrou Mashiko, Tetsuo Nagano and Masaaki Hirobe, Chem. Pharm. Bull., 44, 1-4 (1996).
  • "Novel Detection Method of Nitric Oxide Using Horseradish Peroxidase" Kazuya Kikuchi, Tetsuo Nagano and Masaaki Hirobe, Biol. Pharm. Bull., 19, 649-651 (1996).
  • "Nitric Oxide Release from Kidneys of Hypertensive Rats Treated with Imidapril" Yasunobu Hirata, Hiroshi Hayakawa, Masao Kakoki, Akihiro Tojo, Etsu Suzuki, Kenjiro Kimura, Atsuo Goto, Kazuya Kikuchi, Tetsuo Nagano, Masaaki Hirobe and Masao Omata, Hypertension, 27 Part 2, 672-678 (1996).
  • "Singlet Oxygen (1Dg) Generation from Coproporphyrin in Propionibacterium acnes on Irradiation" Kumi Arakane, akemi Ryu, Chikako Hayashi, Takuji Masunaga, Kouichi Shinmoto, Shinrou Mashiko, Tetsuo Nagano and Masaaki Hirobe, Biochem. Biophs. Res. Comm., 223, 578-582 (1996).
  • "Determination of Nitric Oxide by Chemiluminescence in the Reaction with Luminol and Hydrogen Peroxide" Kazuya Kikuchi and Tetsuo Nagano, Joseph S. Beckman, in Methods in Nitric Oxide Research ed. by M. Feelisch and J. S. Stamler, John Wiley & sons, pp. 479-488 (1996).
  • "Successful Isolation of an Intermediate to [Ni(aldose 3-tren)]2+ (aldose 3-tren = tris(N-aldosyl-2-aminoethyl)amine): X-ray Crystal Structure of {tris(N-L-rhamnosyl-　2-aminoethyl)amine}(sulfate) nikel(II) Hydrate Trimethanol Solvate: [Ni(L-Rha)3-tren)(SO4)・H2O・3CH3OH (Rha = rhamnose)" Shigenobu Yano, Mayumi Doi, Masako Kato, Ichiro Okura, Tetsuo Nagano, Yasuhiro Yamamoto and Tomoaki Tanase, Inorg. Chim. Acta, 249, 1-3 (1996).
  • "Novel Hydroxy-lactonization of g, d- and b, g-Unsaturated Carboxylic Acids with Iron Porphyrin - Iodosylbenzene System." M. Komuro, T. Higuchi and M. Hirobe J. Chem. Soc. Perkin Trans. 1, 2309-2314 (1996)
  • "Substrate-dependent Changes of Oxidative O-Dealkylation Mechanism of Several Chemical and Biological Oxidizing System." Y. Urano, T. Higuchi and M. Hirobe J. Chem. Soc. Perkin Trans. 2, 1169-1173 (1996)
  • "Four Recent Studies in Cytochrome P450 Modelings: A Stable Iron Porphyrin Coordinated by a Thiolate Ligand; A Robust Ruthenium Porphyrin - Pyridine N-Oxide derivatives System; Polypeptide-bound Iron Porphyrin; Application to Drug Metabolism Studies." T. Higuchi and M. Hirobe J. Mol. Cat. A: Chemical, 113, 403-422 (1996)
  • "Albumin-catalyzed Proton Transfer." K. Kikuchi, S. N. Thorn and D.Hilvert J. Am. Chem. Soc., 118, 8184-8185 (1996).
  • "Antibody Catalysis via Strategic Use of Haptenic Charge." K. Kikuchi and D. Hilvert Acta Chem. Scand., 50, 333-336(1996).

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