Publications

2017年

  • "Discovery of Cell-type-specific and Disease-related Enzymatic Activity Changes via Global Evaluation of Peptide Metabolism" Jun Onagi, Toru Komatsu, Yuki Ichihashi, Yugo Kuriki, Mako Kamiya, Takuya Terai, Tasuku Ueno, Kenjiro Hanaoka, Hiroyuki Matsuzaki, Keisuke Hata, Toshiaki Watanabe, Tetsuo Nagano, and Yasuteru Urano

    J. Am. Chem. Soc.,

    in press  doi:10.1021/jacs.6b11376
  • "Enzyme-Loaded Polyion Complex Vesicles as in Vivo Nanoreactors Working Sustainably under the Blood Circulation: Characterization and Functional Evaluation"  Daiki Sueyoshi, Yasutaka Anraku, Toru Komatsu, Yasuteru Urano and Kazunori Kataoka

    Biomacromolecules,

    in press  doi:10.1021/acs.biomac.6b01870
  • "Development of an Azoreductase-based Reporter System with Synthetic Fluorogenic Substrates"  Narae Shin, Kenjiro Hanaoka, Wen Piao, Takuya Miyakawa, Tomotsumi Fujisawa, Satoshi Takeuchi, Shodai Takahashi, Toru Komatsu, Tasuku Ueno, Takuya Terai, Tahei Tahara, Masaru Tanokura, Tetsuo Nagano and Yasuteru Urano

    ACS Chem. Biol.,

    12, 558–563 (2017)  doi:10.1021/acschembio.6b00852
  • "Development of Highly Selective Fluorescent Probe Enabling Flow-Cytometric Isolation of ALDH3A1-Positive Viable Cells" Atsushi Yagishita, Tasuku Ueno, Hiroyasu Esumi, Hideyuki Saya, Kazuhiro Kaneko, Katsuya Tsuchihara and Yasuteru Urano

    Bioconjugate Chem.,

    28, 302–306 (2017)  doi:10.1021/acs.bioconjchem.6b00618
  • "Improving The Solubility of Artificial Ligands of Streptavidin to Enable More Practical Reversible Switching of Protein Localization in Cells" Ryo Tachibana, Takuya Terai, Gaelle Boncompain, Shigeru Sugiyama, Nae Saito, Franck Perez and Yasuteru Urano

    ChemBioChem

    18, 358–362 (2017) doi:10.1002/cbic.201600640
  • "Development of a Reversible Fluorescent Probe for Reactive Sulfur Species, Sulfane Sulfur, and its Biological Application" Yoko Takano, Kenjiro Hanaoka, Kazuhito Shimamoto, Ryo Miyamoto, Toru Komatsu, Tasuku Ueno, Takuya Terai, Hideo Kimura, Tetsuo Nagano and Yasuteru Urano

    Chem Commun.,

    53, 1064-1067 (2017)  doi:10.1039/C6CC08372B
  • "Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide" Kenjiro Hanaoka, Kiyoshi Sasakura, Yusuke Suwanai, Sachiko Toma-Fukai, Kazuhito Shimamoto, Yoko Takano, Norihiro Shibuya, Takuya Terai, Toru Komatsu, Tasuku Ueno, Yuki Ogasawara, Yukihiro Tsuchiya, Yasuo Watanabe, Hideo Kimura, Chao Wang, Masanobu Uchiyama, Hirotatsu Kojima, Takayoshi Okabe, Yasuteru Urano, Toshiyuki Shimizu and Tetsuo Nagano

    Sci. Reports

    7, Article number: 40227 (2017)   doi:10.1038/srep40227
  • "Development of Chemical Tools to Monitor and Control Isoaspartyl Peptide Methyltransferase Activity" Yusuke Kimura, Toru Komatsu, Kouichi Yanagi, Kenjiro Hanaoka, Tasuku Ueno, Takuya Terai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, and Yasuteru Urano

    Angew. Chem. Int. Ed.,

    56, 153–157 (2017) doi:10.1002/anie.201608677

2016年

  • "Identification of Lung Inflammation-Related Elevation of Acylamino Acid Releasing Enzyme (APEH) Activity Using an Enzymomics Approach" Toru Komatsu, Kentaro Yoshioka, Kenjiro Hanaoka, Takuya Terai Tasuku Ueno, Tetsuo Nagano and Yasuteru Urano

    Chem. Pharm. Bull.

    , 11, 1533-1538 (2016) doi:10.1248/cpb.c16-00540
  • "A Single Fluorescent Probe to Visualize Hydrogen Sulfide and Hydrogen Polysulfides with Different Fluorescence Signals" Wei Chen, Armando Pacheco, Yoko Takano, Jacob J. Day, Kenjiro Hanaoka and Ming Xian

    Angew. Chem. Int. Ed.

    , 55, 9993-9996 (2016) doi:10.1002/anie.201604892
  • "Rapid and sensitive detection of early esophageal squamous cell carcinoma with fluorescence probe targeting dipeptidylpeptidase IV" Haruna Onoyama, Mako Kamiya, Yugo Kuriki, Toru Komatsu, Hiroyuki Abe, Yosuke Tsuji, Koichi Yagi, Yukinori Yamagata, Susumu Aikou, Masato Nishida, Kazuhiko Mori, Hiroharu Yamashita, Mitsuhiro Fujishiro, Sachiyo Nomura, Nobuyuki Shimizu, Masashi Fukayama, Kazuhiko Koike, Yasuteru Urano and Yasuyuki Seto

    Sci. Rep.,

    6, 26399 (2016) doi:10.1038/srep26399
  • "Development of Practical Red Fluorescent Probe for Cytoplasmic Calcium Ions with Greatly Improved Cell-membrane Permeability"  Kazuhisa Hirabayashi, Kenjiro Hanaoka, Takahiro Egawa, Chiaki Kobayashi, Shodai Takahashi, Toru Komatsua, Tasuku Ueno, Takuya Terai, Yuji Ikegaya, Tetsuo Nagano, and Yasuteru Urano

    Cell Calcium

    60, 256–265 (2016). doi:10.1016/j.ceca.2016.06.002
  • "Unexpected photo-instability of 2,6-sulfonamide-substituted BODIPYs and its application to development of caged GABA"  Aoi Takeda, Toru Komatsu, Hiroshi Nomura, Naka Masamitsu, Norio Matsuki, Yuji Ikegaya, Takuya Terai, Tasuku Ueno, Kenjiro Hanaoka, Tetsuo Nagano, and Yasuteru Urano

    ChemBioChem

    , 17, 1-9 (2016)  doi:10.1002/cbic.201600097
    Note: Selected for cover article doi:10.1002/cbic.201600325
  • "Broad-spectrum Antimicrobial Photocatalysis Mediated by Titanium Dioxide and UVA is Potentiated by Addition of Bromide Ion via Formation of Hypobromite" Ximing Wua, Ying-Ying Huang, Yu Kushida, Brijesh Bhayana, and Michael R. Hamblin

    Free Radic. Biol. Med.

    , 95, 74-81 (2016).  doi:10.1016/j.freeradbiomed.2016.03.012
  • "Detection of NAD(P)H-dependent Enzyme Activity by Time-domain Ratiometry of Terbium Luminescence"  Takuya Terai, Hiroki Ito, Kenjiro Hanaoka, Toru Komatsu, Tasuku Ueno, Tetsuo Nagano, Yasuteru Urano

    Bioorg. Med. Chem. Lett.,

    6, 2314–2317, 2016,  doi:doi:10.1016/j.bmcl.2016.03.038
  • "Discovery of pyruvylated peptide-metabolizing enzyme using a fluorescent substrate-based protein discovery technique"  Kentaro Yoshioka, Toru Komatsu, Kenjiro Hanaoka, Tasuku Ueno, Takuya Terai, Tetsuo Nagano, and Yasuteru Urano

    Chem. Commun.,

    52, 4377-4380 (2016)  doi:10.1039/C6CC00829A
  • "A Protein-Coupled Fluorescent Probe to Visualize Potassium Ion Transition on Cellular Membranes"  Tomoya Hirata, Takuya Terai, HisaoYamamura, Manabu Shimonishi, Toru Komatsu, Kenjiro Hanaoka, Tasuku Ueno, Yuji Imaizumi, Tetsuo Nagano, and Yasuteru Urano

    Anal. Chem.,

     88, 2693–2700 (2016)  doi:10.1021/acs.analchem.5b03970
  • "Editorial overview:Molecular Imaging Section"
    Yasuteru Urano, Ji-Xin Cheng

    Curr Opin Chem Biol.,

     33, Pages v (2016)  doi:10.1016/j.cbpa.2016.08.007
  • "ICBS and ECBS Chemical Biology Meeting 2015 - Let Them Come to Berlin"
    Toru Komatsu and Satpal Virdee

    ACS Chem. Biol.

    , 11, 1159-1166 (2016)  doi:10.1021/acschembio.6b00268
  • "Toward Total Synthesis of Cell Function: Reconstituting Cell Dynamics with Synthetic Biology"  Allen K. Kim, Robert DeRose, Tasuku Ueno, Benjamin Lin, Toru Komatsu, Hideki Nakamura, and Takanari Inoue

    Sci. Signaling

    , 9, re1 (2016)  doi:10.1126/scisignal.aac4779
  • "Chemical Tools for The Study of Hydrogen Sulfide (H2S) and Sulfane Sulfur and Their Applications to Biological Studies."  Yoko Takano, Kazuhito Shimamoto, Kenjiro Hanaoka

    J. Clin. Biochem. Nutr.,

      58, 7-15 (2016)  doi:10.3164/jcbn.15-91
  • "ケイ素置換キサンテン蛍光団の創製と蛍光プローブへの応用"
    花岡 健二郎、浦野 泰照  有機合成化学協会誌 Vol.74, No.5, pp512-520 (2016)
  • "第24章 ケミカルバイオロジーの最前線 細胞の中で生きた酵素の働きを「見る」"
    小松徹,浦野泰照  天然物の化学(科学のとびら60),東京化学同人 (2016)

2015年

  • "Development of a Sensitive Bioluminogenic Probe for Imaging Highly Reactive Oxygen Species in Living Rats"  Ryosuke Kojima, Hideo Takakura, Mako Kamiya, Eiji Kobayashi, Toru Komatsu, Tasuku Ueno, Takuya Terai, Kenjiro Hanaoka, Tetsuo Nagano, and Yasuteru Urano

    Angew. Chem. Int. Ed.,

      54, 14768–14771 (2015)   doi:10.1002/anie.201507530 & doi:10.1002/ange.201507530
  • "Identification of tissue-restricted bio-reaction suitable for in vivo targeting by fluorescent substrate library-based enzyme discovery" Kentaro Yoshioka, Toru Komatsu, Akihiro Nakada, Jun Onagi, Yugo Kuriki, Mitsuyasu Kawaguchi, Takuya Terai, Tasuku Ueno, Kenjiro Hanaoka, Tetsuo Nagano, and Yasuteru Urano

    J. Am. Chem. Soc.,

     137, 12187-12190 (2015)  doi:10.1021/jacs.5b05884
  • "Artificial Ligands of Streptavidin (ALiS): Discovery, Characterization, and Application for Reversible Control of Intracellular Protein Transport" Takuya Terai, Moe Kohno, Gaelle Boncompain, Shigeru Sugiyama, Nae Saito, Ryo Fujikake, Tasuku Ueno, Toru Komatsu, Kenjiro Hanaoka, Takayoshi Okabe, Yasuteru Urano, Franck Perez, and Tetsuo Nagano

    J. Am. Chem. Soc.,

     137, 10464–10467 (2015)  doi:10.1021/jacs.5b05672
  • "Analysis of Chemical Equilibrium of Si-substituted Fluorescein and its Application to Develop a Scaffold for Red Fluorescent Probes"  Kazuhisa Hirabayashi, Kenjiro Hanaoka, Toshio Takayanagi, Yuko Toki, Takahiro Egawa, Mako Kamiya, Toru Komatsu, Tasuku Ueno, Takuya Terai, Kengo Yoshida, Masanobu Uchiyama, Tetsuo Nagano, and Yasuteru Urano

    Anal. Chem.,

     87, 9061–9069 (2015)  doi:10.1021/acs.analchem.5b02331
  • "Detection of NAD(P)H-dependent Enzyme Activity with Dynamic Luminescence Quenching of Terbium Complexes" Hiroki Ito, Takuya Terai, Kenjiro Hanaoka, Tasuku Ueno, Toru Komatsu, Tetsuo Nagano and Yasuteru Urano

    Chem. Commun.,

     51, 8319-8322 (2015)  doi:10.1039/c5cc01613d
  • "Sensitive β-galactosidase-targeting fluorescence probe for visualizing small peritoneal metastatic tumours in vivo." Daisuke Asanuma, Masayo Sakabe, Mako Kamiya, Kyoko Yamamoto, Jun Hiratake, Mikako Ogawa, Nobuyuki Kosaka, Peter L. Choyke, Tetsuo Nagano, Hisataka Kobayashi and Yasuteru Urano

    Nat. Commun.,

      6, Article number:6463 (2015)  doi:10.1038/ncomms7463
  • "Development of a Series of Near-infrared Dark Quenchers Based on Si-rhodamines and Their Application to Fluorescent Probes" Takuya Myochin, Kenjiro Hanaoka, Shimpei Iwaki, Tasuku Ueno, Toru Komatsu, Takuya Terai, Tetsuo Nagano, and Yasuteru Urano

    J. Am. Chem. Soc.,

      137, 4759-4765 (2015)  doi:10.1021/jacs.5b00246
  • "New Class of Bioluminogenic Probe Based on Bioluminescent Enzyme-induced Electron Transfer: BioLeT" Hideo Takakura, Ryosuke Kojima, Mako Kamiya, Eiji Kobayashi, Toru Komatsu, Tasuku Ueno, Takuya Terai, Kenjiro Hanaoka, Tetsuo Nagano, and Yasuteru Urano

    J. Am. Chem. Soc.,

      137, 4010-4013 (2015)  doi:10.1021/ja511014w
  • "Gliotoxin Suppresses NF-κB Activation by Selectively Inhibiting Linear Ubiquitin Chain Assembly Complex (LUBAC)" Hiroki Sakamoto, Shinichiro Egashira, Nae Saito, Takayoshi Kirisako, Simon Miller, Yoshiteru Sasaki, Tadahiko Matsumoto, Manabu Shimonishi, Toru Komatsu, Takuya Terai, Tasuku Ueno, Kenjiro Hanaoka, Hirotatsu Kojima, Takayoshi Okabe, Soichi Wakatsuki, Kazuhiro Iwai, and Tetsuo Nagano

    ACS Chem. Biol.,

      10, 675-681 (2015)  doi:10.1021/cb500653y
  • "Fluorescent Probes for Hydrogen Sulfide (H2S) and Sulfane Sulfur and Their Applications to Biological Studies" Kazuhito Shimamoto and Kenjiro Hanaoka

    Nitric Oxide,

      46, 72-79 (2015)  doi:10.1016/j.niox.2014.11.008
  • "Development of Photo-controllable Hydrogen Sulfide Donor Applicable in Live Cells" Naoki Fukushima, Naoya Ieda, Mitsuyasu Kawaguchi, Kiyoshi Sasakura, Tetsuo Nagano, Kenjiro Hanaoka, Naoki Miyata, Hidehiko Nakagawa

    Bioorg. Med. Chem. Lett.,

      25, 175-178 (2015)  doi:10.1016/j.bmcl.2014.11.084
  • "Compartmentalized AMPK Signaling Illuminated by Genetically Encoded Molecular Sensors and Actuators" Takafumi Miyamoto, Elmer Rho, Vedangi Sample, Hiroki Akano, Masaki Magari, Tasuku Ueno, Kirill Gorshkov, Melinda Chen, Hiroshi Tokumitsu, Jin Zhang, Takanari Inoue

    Cell Reports

      11, 657-670 (2015)  doi:10.1016/j.celrep.2015.03.057
  • "Silicon-substituted Xanthene Dyes and Their Applications in Bioimaging"
    Yu Kushida, Tetsuo Nagano and Kenjiro Hanaoka

    Analyst,

      140, 685-695 (2015)  doi:10.1039/c4an01172d
  • "Evaluation of Enzymatic Activities in Living Systems with Small-molecular Fluorescent Substrate Probes" Toru Komatsu and Yasuteru Urano

    Anal. Sci.,

      31, 257-265 (2015)  doi:10.2116/analsci.31.257

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