研究業績 Publications

Archive by Year

2018

  • "Synthesis of Unsymmetrical Si-Rhodamine Fluorophores and Application to A Far-Red to Near-Infrared Fluorescence Probe for Hypoxia"  Kenjiro Hanaoka, Yu Kagami, Wen Piao, Takuya Myochin, Koji Numasawa, Yugo Kuriki, Takayuki Ikeno, Tasuku Ueno, Toru Komatsu, Takuya Terai, Tetsuo Nagano and Yasuteru Urano

    Chem. Commun.

    , 54, 6939-6942 (2018) doi:10.1039/c8cc02451k
  • "Development of a Series of Practical Fluorescent Chemical Tools To Measure pH Values in Living Samples"  Shodai Takahashi, Yu Kagami, Kenjiro Hanaoka, Takuya Terai, Toru Komatsu, Tasuku Ueno, Masanobu Uchiyama, Ikuko Koyama-Honda, Noboru Mizushima, Tomohiko Taguchi, Hiroyuki Arai, Tetsuo Nagano, and Yasuteru Urano

    J. Am. Chem. Soc.

    , 140, 5925-5933 (2018) doi:10.1021/jacs.8b00277
  • "N-Acetyl Cysteine Functions as a Fast-Acting Antioxidant by Triggering Intracellular H2S and Sulfane Sulfur Production"  Daria Ezerin‚ Yoko Takano, Kenjiro Hanaoka, Yasuteru Urano and Tobias P. Dick

    Cell Chem. Biol.

    , in press doi:10.1016/j.chembiol.2018.01.011
  • "A Protein-Coupled Fluorescent Probe For Organelle-Specific Imaging of Na+ "  Ryo Taguchi, Takuya Terai, Tasuku Ueno, Toru Komatsu, Kenjiro Hanaoka, Yasuteru Urano

    Sens. Act. B: Chem.

    , 265, 575-581 (2018) doi:10.1016/j.snb.2018.03.090
  • "Establishment of Molecular Design Strategy To Obtain Activatable Fluorescent Probes for Carboxypeptidases" Yugo Kuriki, Mako Kamiya, Hidemasa Kubo, Toru Komatsu, Tasuku Ueno, Ryo Tachibana, Kento Hayashi, Kenjiro Hanaoka, Suguru Yamashita, Takeaki Ishizawa, Norihiro Kokudo, and Yasuteru Urano

    J. Am. Chem. Soc.

    , 140, 1767-1773 (2018) doi:10.1021/jacs.7b11014

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2017年

  • "An Activatable Photosensitizer Targeted to γ-Glutamyltranspeptidase"  Mayumi Chiba, Yuki Ichikawa, Mako Kamiya, Toru Komatsu, Tasuku Ueno, Kenjiro Hanaoka, Tetsuo Nagano, Norbert Lange and Yasuteru Urano

    Angew. Chem. Int. Ed.

    , 56, 10418-10422 (2017)  doi:10.1002/anie.201704793
  • "Molecular imaging of aberrant crypt foci in the human colon targeting glutathione S-transferase P1-1" Naoki Muguruma, Koichi Okamoto, Tadahiko Nakagawa, Katsutaka Sannomiya, Shota Fujimoto, Yasuhiro Mitsui, Tetsuo Kimura, Hiroshi Miyamoto, Jun Higashijima, Mitsuo Shimada, Yoko Horino, Shinya Matsumoto, Kenjiro Hanaoka, Tetsuo Nagano, Makoto Shibutani and Tetsuji Takayama

    Sci. Rep.

    , 7, Article number: 6536 (2017) doi:10.1038/s41598-017-06857-x
  • "Development of an Azo-based Photosensitizer Activated under Mild Hypoxia for Photodynamic Therapy" Wen Piao, Kenjiro Hanaoka, Tomotsumi Fujisawa, Satoshi Takeuchi, Toru Komatsu, Tasuku Ueno, Takuya Terai, Tahei Tahara, Tetsuo Nagano and Yasuteru Urano

    J. Am. Chem. Soc.

    , 139, 13713–13719 (2017)   doi:10.1021/jacs.7b05019
  • "Potential of Enzymomics Methodologies to Characterize Disease-Related Protein Functions" Toru Komatsu

    Chem.Pharm.Bull.,

    65, 605-610 (2017)  doi:10.1248/cpb.c17-00144
  • "Hydrogen Sulfide Donor Micelles Protect Cardiomyocytes from Ischemic Cell Death" Tomoka Takatani-Nakase, Miku Katayama, Chihiro Matsui, Kenjiro Hanaoka, André J. van der Vlies, Koichi Takahashi, Ikuhiko Nakase and Urara Hasegawa

    Mol. Biosys.

    , 13, 1705-1708 (2017)  doi:10.1039/C7MB00191F
  • "Polysulfides (H2Sn) Produced from the Interaction of Hydrogen Sulfide (H2S) and Nitric Oxide (NO) Activate TRPA1 Channels" Ryo Miyamoto, Shin Koike, Yoko Takano, Norihiro Shibuya, Yuka Kimura, Kenjiro Hanaoka, Yasuteru Urano, Yuki Ogasawara and Hideo Kimura

    Sci. Rep.

    , 7 Article number: 45995 (2017) doi:10.1038/srep45995
  • "Fluorescent Probes and Selective Inhibitors for Biological Studies of Hydrogen Sulfide- and Polysulfide-Mediated Signaling" Yoko Takano, Honami Echizen and Kenjiro Hanaoka Abstract

    Antioxid. Redox Signal.

    , 27, 669-683 (2017)  doi:10.1089/ars.2017.7070
  • "Fluorescence Detection of Serum Albumin with a Turnover-based Sensor Utilizing Kemp Elimination"  Shingo Sakamoto, Toru Komatsu, Tasuku Ueno, Kenjiro Hanaoka and Yasuteru Urano

    Bioorg. Med. Chem. Lett.,

      27, 3464-3467 (2017)  doi:10.1016/j.bmcl.2017.05.076
  • "Meeting Proceedings ICBS2016 - Translating the Power of Chemical Biology to Clinical Advances"  Yugo Kuriki, Toru Komatsu, Peter D. Ycas, Sara K. Coulup, Erick J. Carlson, and William C. K. Pomerantz

    ACS Chem. Biol.,

    12, 869–877 (2017) doi:10.1021/acschembio.7b00205
  • "Synthesis of Practical Red Fluorescent Probe for Cytoplasmic Calcium Ions with Greatly Improved Cell-membrane Permeability" Kazuhisa Hirabayashi, Kenjiro Hanaoka, Takahiro Egawa, Chiaki Kobayashi, Shodai Takahashi, Toru Komatsu, Tasuku Ueno, Takuya Terai, Yuji Ikegaya and Tetsuo Nagano

    Data in Brief

    , 12, 351-357 (2017) doi:10.1016/j.dib.2017.04.011
  • "Silicon-substituted Xanthene Dyes and their Unique Photophysical Properties for Fluorescent probes" Takayuki Ikeno, Tetsuo Nagano, Kenjiro Hanaoka

    Chem. Asian

    , 12, 1435–1446 (2017) doi:10.1002/asia.201700385
  • "Discovery of Cell-type-specific and Disease-related Enzymatic Activity Changes via Global Evaluation of Peptide Metabolism" Jun Onagi, Toru Komatsu, Yuki Ichihashi, Yugo Kuriki, Mako Kamiya, Takuya Terai, Tasuku Ueno, Kenjiro Hanaoka, Hiroyuki Matsuzaki, Keisuke Hata, Toshiaki Watanabe, Tetsuo Nagano, and Yasuteru Urano

    J. Am. Chem. Soc.,

    139, 3465–3472 (2017)  doi:10.1021/jacs.6b11376
  • "Enzyme-Loaded Polyion Complex Vesicles as in Vivo Nanoreactors Working Sustainably under the Blood Circulation: Characterization and Functional Evaluation"  Daiki Sueyoshi, Yasutaka Anraku, Toru Komatsu, Yasuteru Urano and Kazunori Kataoka

    Biomacromolecules,

    18, 1189–1196 (2017)  doi:10.1021/acs.biomac.6b01870
  • "Development of an Azoreductase-based Reporter System with Synthetic Fluorogenic Substrates"  Narae Shin, Kenjiro Hanaoka, Wen Piao, Takuya Miyakawa, Tomotsumi Fujisawa, Satoshi Takeuchi, Shodai Takahashi, Toru Komatsu, Tasuku Ueno, Takuya Terai, Tahei Tahara, Masaru Tanokura, Tetsuo Nagano and Yasuteru Urano

    ACS Chem. Biol.,

    12, 558–563 (2017)  doi:10.1021/acschembio.6b00852
  • "Development of Highly Selective Fluorescent Probe Enabling Flow-Cytometric Isolation of ALDH3A1-Positive Viable Cells" Atsushi Yagishita, Tasuku Ueno, Hiroyasu Esumi, Hideyuki Saya, Kazuhiro Kaneko, Katsuya Tsuchihara and Yasuteru Urano

    Bioconjugate Chem.,

    28, 302–306 (2017)  doi:10.1021/acs.bioconjchem.6b00618
  • "Improving The Solubility of Artificial Ligands of Streptavidin to Enable More Practical Reversible Switching of Protein Localization in Cells" Ryo Tachibana, Takuya Terai, Gaelle Boncompain, Shigeru Sugiyama, Nae Saito, Franck Perez and Yasuteru Urano

    ChemBioChem

    18, 358–362 (2017) doi:10.1002/cbic.201600640
  • "Development of a Reversible Fluorescent Probe for Reactive Sulfur Species, Sulfane Sulfur, and its Biological Application" Yoko Takano, Kenjiro Hanaoka, Kazuhito Shimamoto, Ryo Miyamoto, Toru Komatsu, Tasuku Ueno, Takuya Terai, Hideo Kimura, Tetsuo Nagano and Yasuteru Urano

    Chem Commun.,

    53, 1064-1067 (2017)  doi:10.1039/C6CC08372B
  • "Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide" Kenjiro Hanaoka, Kiyoshi Sasakura, Yusuke Suwanai, Sachiko Toma-Fukai, Kazuhito Shimamoto, Yoko Takano, Norihiro Shibuya, Takuya Terai, Toru Komatsu, Tasuku Ueno, Yuki Ogasawara, Yukihiro Tsuchiya, Yasuo Watanabe, Hideo Kimura, Chao Wang, Masanobu Uchiyama, Hirotatsu Kojima, Takayoshi Okabe, Yasuteru Urano, Toshiyuki Shimizu and Tetsuo Nagano

    Sci. Reports

    7, Article number: 40227 (2017)   doi:10.1038/srep40227
  • "Development of Chemical Tools to Monitor and Control Isoaspartyl Peptide Methyltransferase Activity" Yusuke Kimura, Toru Komatsu, Kouichi Yanagi, Kenjiro Hanaoka, Tasuku Ueno, Takuya Terai, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, and Yasuteru Urano

    Angew. Chem. Int. Ed.,

    56, 153–157 (2017) doi:10.1002/anie.201608677

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2016年

  • "Identification of Lung Inflammation-Related Elevation of Acylamino Acid Releasing Enzyme (APEH) Activity Using an Enzymomics Approach" Toru Komatsu, Kentaro Yoshioka, Kenjiro Hanaoka, Takuya Terai Tasuku Ueno, Tetsuo Nagano and Yasuteru Urano

    Chem. Pharm. Bull.

    , 11, 1533-1538 (2016) doi:10.1248/cpb.c16-00540
  • "A Single Fluorescent Probe to Visualize Hydrogen Sulfide and Hydrogen Polysulfides with Different Fluorescence Signals" Wei Chen, Armando Pacheco, Yoko Takano, Jacob J. Day, Kenjiro Hanaoka and Ming Xian

    Angew. Chem. Int. Ed.

    , 55, 9993-9996 (2016) doi:10.1002/anie.201604892
  • "Rapid and sensitive detection of early esophageal squamous cell carcinoma with fluorescence probe targeting dipeptidylpeptidase IV" Haruna Onoyama, Mako Kamiya, Yugo Kuriki, Toru Komatsu, Hiroyuki Abe, Yosuke Tsuji, Koichi Yagi, Yukinori Yamagata, Susumu Aikou, Masato Nishida, Kazuhiko Mori, Hiroharu Yamashita, Mitsuhiro Fujishiro, Sachiyo Nomura, Nobuyuki Shimizu, Masashi Fukayama, Kazuhiko Koike, Yasuteru Urano and Yasuyuki Seto

    Sci. Rep.,

    6, 26399 (2016) doi:10.1038/srep26399
  • "Development of Practical Red Fluorescent Probe for Cytoplasmic Calcium Ions with Greatly Improved Cell-membrane Permeability"  Kazuhisa Hirabayashi, Kenjiro Hanaoka, Takahiro Egawa, Chiaki Kobayashi, Shodai Takahashi, Toru Komatsua, Tasuku Ueno, Takuya Terai, Yuji Ikegaya, Tetsuo Nagano, and Yasuteru Urano

    Cell Calcium

    60, 256–265 (2016). doi:10.1016/j.ceca.2016.06.002
  • "Unexpected photo-instability of 2,6-sulfonamide-substituted BODIPYs and its application to development of caged GABA"  Aoi Takeda, Toru Komatsu, Hiroshi Nomura, Naka Masamitsu, Norio Matsuki, Yuji Ikegaya, Takuya Terai, Tasuku Ueno, Kenjiro Hanaoka, Tetsuo Nagano, and Yasuteru Urano

    ChemBioChem

    , 17, 1-9 (2016)  doi:10.1002/cbic.201600097
    Note: Selected for cover article doi:10.1002/cbic.201600325
  • "Broad-spectrum Antimicrobial Photocatalysis Mediated by Titanium Dioxide and UVA is Potentiated by Addition of Bromide Ion via Formation of Hypobromite" Ximing Wua, Ying-Ying Huang, Yu Kushida, Brijesh Bhayana, and Michael R. Hamblin

    Free Radic. Biol. Med.

    , 95, 74-81 (2016).  doi:10.1016/j.freeradbiomed.2016.03.012
  • "Detection of NAD(P)H-dependent Enzyme Activity by Time-domain Ratiometry of Terbium Luminescence"  Takuya Terai, Hiroki Ito, Kenjiro Hanaoka, Toru Komatsu, Tasuku Ueno, Tetsuo Nagano, Yasuteru Urano

    Bioorg. Med. Chem. Lett.,

    6, 2314–2317, 2016,  doi:doi:10.1016/j.bmcl.2016.03.038
  • "Discovery of pyruvylated peptide-metabolizing enzyme using a fluorescent substrate-based protein discovery technique"  Kentaro Yoshioka, Toru Komatsu, Kenjiro Hanaoka, Tasuku Ueno, Takuya Terai, Tetsuo Nagano, and Yasuteru Urano

    Chem. Commun.,

    52, 4377-4380 (2016)  doi:10.1039/C6CC00829A
  • "A Protein-Coupled Fluorescent Probe to Visualize Potassium Ion Transition on Cellular Membranes"  Tomoya Hirata, Takuya Terai, HisaoYamamura, Manabu Shimonishi, Toru Komatsu, Kenjiro Hanaoka, Tasuku Ueno, Yuji Imaizumi, Tetsuo Nagano, and Yasuteru Urano

    Anal. Chem.,

     88, 2693–2700 (2016)  doi:10.1021/acs.analchem.5b03970
  • "Editorial overview:Molecular Imaging Section"
    Yasuteru Urano, Ji-Xin Cheng

    Curr Opin Chem Biol.,

     33, Pages v (2016)  doi:10.1016/j.cbpa.2016.08.007
  • "ICBS and ECBS Chemical Biology Meeting 2015 - Let Them Come to Berlin"
    Toru Komatsu and Satpal Virdee

    ACS Chem. Biol.

    , 11, 1159-1166 (2016)  doi:10.1021/acschembio.6b00268
  • "Toward Total Synthesis of Cell Function: Reconstituting Cell Dynamics with Synthetic Biology"  Allen K. Kim, Robert DeRose, Tasuku Ueno, Benjamin Lin, Toru Komatsu, Hideki Nakamura, and Takanari Inoue

    Sci. Signaling

    , 9, re1 (2016)  doi:10.1126/scisignal.aac4779
  • "Chemical Tools for The Study of Hydrogen Sulfide (H2S) and Sulfane Sulfur and Their Applications to Biological Studies."  Yoko Takano, Kazuhito Shimamoto, Kenjiro Hanaoka

    J. Clin. Biochem. Nutr.,

      58, 7-15 (2016)  doi:10.3164/jcbn.15-91
  • "ケイ素置換キサンテン蛍光団の創製と蛍光プローブへの応用"
    花岡 健二郎、浦野 泰照  有機合成化学協会誌 Vol.74, No.5, pp512-520 (2016)
  • "第24章 ケミカルバイオロジーの最前線 細胞の中で生きた酵素の働きを「見る」"
    小松徹,浦野泰照  天然物の化学(科学のとびら60),東京化学同人 (2016)

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