HOME > Publications 2007 and before


  1. Hamazaki, J., Sasaki, K., Kawahara, H., Hisanaga, S., Tanaka, K. and Murata, S. (2007): Rpn10-mediated degradation of ubiquitinated proteins is essential for mammalian development., Mol Cell Biol 27, 6629-6638. [abstract]
  2. Isono, E., Nishihara, K., Saeki, Y., Yashiroda, H., Kamata, N., Ge, L., Ueda, T., Kikuchi, Y., Tanaka, K., Nakano, A. and Toh-e, A.: The assembly pathway of the 19S regulatory particle of the yeast 26S proteasome., Mol Biol. Cell 18, 569-80 [abstract]
  3. Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, Hamazaki J, Nishito Y, Iemura S, Natsume T, Yanagawa T, Uwayama J, Warabi E, Yoshida H, Ishii T, Kobayashi A, Yamamoto M, Yue Z, Uchiyama Y, Kominami E, Tanaka K.: Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice., Cell. 131(6):1149-63. [abstract]
  4. Miyamoto, H., Moriishi, K., Moriya, K., Murata, S., Tanaka, K., Suzuki, T., Miyamura, T., Koike, K., and Matsuura, Y. (2007): Involvement of the PA28g-dependent pathway in insulin resistance induced by hepatitis C virus core protein., J Virol 81, 1727-1735 [abstract]
  5. Moriishi, K., Mochizuki, R., Moriya, K., Miyamoto, H., Mori, Y., Abe, T., Murata, S., Tanaka, K., Miyamura, T., Suzuki, T., Koike, K., and Matsuura, Y. (2007): Critical role of PA28g in hepatitis C virus-associated steatogenesis and hepatocarcinogenesis., Proc Natl Acad Sci U S A 104, 1661-1666 [abstract]
  6. Murata, S., Sasaki, K., Kishimoto, T., Hayashi, H., Niwa, S., Takahama, Y., and Tanaka, K. (2007): Regulation of CD8+ T cell development by thymus-specific proteasomes., Science 316, 1349-1353. [abstract]


  1. Duan, X., Hisaeda, H., Shen, J., Tu, L., Imai, T., Chou, B., Murata, S., Chiba, T., Tanaka, K., Fehling, H. J., Koga, T., Sueishi, K., and Himeno, K. (2006): The ubiquitin-proteasome system plays essential roles in presenting an 8-mer CTL epitope expressed in APC to corresponding CD8+ T cells., Int Immunol 18, 679-687. [abstract]
  2. Hamazaki, J., Iemura, SI., Natsume, T., Yashiroda, H., Tanaka, K., and Murata S.(2006): A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasome., EMBO J. 25, 4524-4536. [abstract]
  3. Hirano, Y., Hayashi, H., Iemura, S., Hendil, K. B., Niwa, S., Kishimoto, T., Kasahara, M., Natsume, T., Tanaka, K., and Murata, S. (2006): Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes., Mol Cell 24, 977-984. [abstract]
  4. Ishii, K., Hisaeda, H., Duan, X., Imai, T., Sakai, T., Fehling, H. J., Murata, S., Chiba, T., Tanaka, K., Hamano, S., Sano, M., Yano, A., and Himeno, K. (2006): The involvement of immunoproteasomes in induction of MHC class I-restricted immunity targeting Toxoplasma SAG1., Microbes Infect 8, 1045-1053. [abstract]
  5. Kirisako, T., Kamei, K., Murata, S., Kato, M., Fukumoto, H., Kanie, M., Sano, S., Tokunaga, F., Tanaka, K., and Iwai, K. (2006): A ubiquitin ligase complex assembles linear polyubiquitin chains., EMBO J 25, 4877-4887. [abstract]
  6. Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., and Tanaka, K. (2006): Loss of autophagy in the central nervous system causes neurodegeneration in mice., Nature 441, 880-884. [abstract]
  7. Murata, S. (2006): Multiple chaperone-assisted formation of mammalian 20S proteasomes., IUBMB Life 58, 344-348 [abstract]


  1. Hirano, Y., Hendil, K. B., Yashiroda, H., Iemura, S., Nagane, R., Hioki, Y., Natsume, T., Tanaka, K. and *Murata, S.: A novel heterodimeric complex that promotes the assembly of mammalian 20S proteasomes. Nature., 437, 1381-1385, 2005.
  2. Hirano, Y., Murata, S., and Tanaka, K. (2005): Large- and Small-Scale Purification of Mammalian 26S Proteasomes. Methods Enzymol 399, 227-240.
  3. Jana, N. R., Dikshit, P., Goswami, A., Kotliarova, S., Murata, S., Tanaka, K., and *Nukina, N. (2005): Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes., J Biol Chem 280, 11635-11640.
  4. Komatsu, M., Waguri, S., Ueno, T., Iwata, J., Murata, S., Tanida, I., Ezaki, J., Mizushima, N., Ohsumi, Y., Uchiyama, Y., Kominami, E., Tanaka, K., and *Chiba, T. (2005): Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice., J Cell Biol 169, 425-434.
  5. Murata, S., Minami, M., and Minami, Y. (2005): Purification and assay of the chaperone-dependent ubiquitin ligase of the carboxyl terminus of Hsc70-interacting protein., Methods Enzymol 398, 271-279
  6. Sahara, N., Murayama, M., Mizoroki, T., Urushitani, M., Imai, Y., Takahashi, R., Murata, S., Tanaka, K., and Takashima, A. (2005): In vivo evidence of CHIP up-regulation attenuating tau aggregation.,J Neurochem 94, 1254-1263.
  7. Tanaka, K., Yashiroda, H. and Tanahashi, N.: Preparation of proteasomes. “Cell Biology: A Laboratory Handbook” (Ed. By J. E. Celis) 3rd edition., Academic Press New York. 91-97, 2005.
  8. Zhang, M., Obata, C., Hisaeda, H., Ishii, K., Murata, S., Chiba, T., Tanaka, K., Li, Y., Furue, M., Chou, B., Imai, T., Duan, X., and *Himeno, K. (2005) A novel DNA vaccine based on ubiquitin-proteasome pathway targeting 'self'-antigens expressed in melanoma/melanocyte.: Gene Ther 12, 1049-1057.


  1. Obata, C., Zhang, M., Moroi, Y., Hisaeda, H., Tanaka, K., Murata, S., Furue, M., and Himeno, K. (2004): Formalin-fixed tumor cells effectively induce antitumor immunity both in prophylactic and therapeutic conditions., J Dermatol Sci 34, 209-219.
  2. Tateishi, Y., Kawabe, Y., Chiba, T., Murata, S., Ichikawa, K., Murayama, A., Tanaka, K., Baba, T., Kato, S., and Yanagisawa, J. (2004): Ligand-dependent switching of ubiquitin-proteasome pathways for estrogen receptor., EMBO J 23, 4813-4823.
  3. Tenno, T., Fujiwara, K., Tochio, H., Iwai, K., Morita, E. H., Hayashi, H., Murata, S., Hiroaki, H., Sato, M., Tanaka, K., and *Shirakawa, M. (2004): Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains., Genes Cells 9, 865-875.
  4. Yashiroda, H. and *Tanaka, K.: Hub1 is an essential ubiquitin-like protein without functioning as a typical modifier in fission yeast., Genes Cells. 9, 1189-1197, 2004.
  5. Zhang, M., Ishii, K., Hisaeda, H., Murata, S., Chiba, T., Tanaka, K., Li, Y., Obata, C., Furue, M., and *Himeno, K. (2004): Ubiquitin-fusion degradation pathway plays an indispensable role in naked DNA vaccination with a chimeric gene encoding a syngeneic cytotoxic T lymphocyte epitope of melanocyte and green fluorescent protein., Immunology 112, 567-574.


  1. Hirano, Y., Murata, S., Tanaka, K., Shimizu, M., and Sato, R. (2003) Sterol regulatory element-binding proteins are negatively regulated through SUMO-1 modification independent of the ubiquitin/26 S proteasome pathway., J Biol Chem 278, 16809-16819.
  2. Imai, J., Maruya, M., Yashiroda, H., Yahara, I. and Tanaka, K.: The molecular chaperone Hsp90 plays a role in the assesmbly and maintenance of the 26S proteasome., EMBO, J. 22, 3557-3567, 2003
  3. Imai, J., Yashiroda, H., Maruya, M., Yahara, I. and Tanaka, K.: Proteasomes and molecular chaperones: cellular machinery responsible for folding and destruction of unfolded proteins., Cell Cycle 2, 585-590, 2003
  4. Moriishi, K., Okabayashi, T., Nakai, K., Moriya, K., Koike, K., Murata, S., Chiba, T., Tanaka, K., Suzuki, R., Suzuki, T., Miyamura, T., and *Matsuura, Y. (2003): Proteasome activator PA28g-dependent nuclear retention and degradation of hepatitis C virus core protein., J Virol 77, 10237-10249.
  5. Yashiroda, H. and *Tanaka, K.: But1 and But2 proteins bind to Uba3, a catalytic subunit of E1 for neddylation, in fission yeast. Biochem. Biophys. Res. Commun. 311, 691-695, 2003


  1. Kaida D, Yashiroda, H. Toh-e A., Kikuchi Y.: Yeast Whi2 and Psr1-phosphatase form a complex and regulate STRE-mediated gene expression., Genes Cells. 7(6): 543-52 2002.
  2. Niwa, J., Ishigaki, S., Hishikawa, N., Yamamoto, M., Doyu, M., Murata, S., Tanaka, K., Taniguchi, N., and Sobue, G. (2002): Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity., J Biol Chem 277, 36793-36798.
  3. Yamano, T., Murata, S., Shimbara, N., Tanaka, N., Chiba, T., Tanaka, K., Yui, K., and Udono, H. (2002): Two distinct pathways mediated by PA28 and hsp90 in major histocompatibility complex class I antigen processing., J Exp Med 196, 185-196.


  1. Murata, S., Minami, Y., Minami, M., Chiba, T., and Tanaka, K. (2001): CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein., EMBO Rep 2, 1133-1138.
  2. Murata, S., Udono, H., Tanahashi, N., Hamada, N., Watanabe, K., Adachi, K., Yamano, T., Yui, K., Kobayashi, N., Kasahara, M., Tanaka, K., and Chiba, T. (2001): Immunoproteasome assembly and antigen presentation in mice lacking both PA28a and PA28b., EMBO J 20, 5898-5907.
  3. Tanaka K, Kawakami T, Tateishi K, Yashiroda H, Chiba T.: Control of IkBa proteolysis by the ubiquitin-proteasome pathway., Biochemie. 83(3-4): 351-6. 2001.
  4. Yawata, M., Murata, S., Tanaka, K., Ishigatsubo, Y., and Kasahara, M. (2001): Nucleotide sequence analysis of the approximately 35-kb segment containing interferon-gamma-inducible mouse proteasome activator genes., Immunogenetics 53, 119-129.


  1. Kawahara, H., Kasahara, M., Nishiyama, A., Ohsumi, K., Goto, T., Kishimoto, T., Saeki, Y., Yokosawa, H., Shimbara, N., Murata, S., Chiba, T., Suzuki, K., and Tanaka, K. (2000): Developmentally regulated, alternative splicing of the Rpn10 gene generates multiple forms of 26S proteasomes., EMBO J 19, 4144-4153.
  2. Takafuji, S., Miyakuni, Y., Nakagawa, T., Shoji, S., Murata, S., Yamamoto, K., and Ito, K. (2000): Effects of human lung fibroblasts on eosinophil degranulation., Allergy 55, 1170-1178.
  3. Takayanagi, H., Ogasawara, K., Hida, S., Chiba, T., Murata, S., Sato, K., Takaoka, A., Yokochi, T., Oda, H., Tanaka, K., Nakamura, K., and Taniguchi, T. (2000): T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-g., Nature 408, 600-605.


  1. Furukawa, H., Murata, S., Yabe, T., Shimbara, N., Keicho, N., Kashiwase, K., Watanabe, K., Ishikawa, Y., Akaza, T., Tadokoro, K., Tohma, S., Inoue, T., Tokunaga, K., Yamamoto, K., Tanaka, K., and Juji, T. (1999): Splice acceptor site mutation of the transporter associated with antigen processing-1 gene in human bare lymphocyte syndrome., J Clin Invest 103, 755-758.
  2. Murata, S., Kawahara, H., Tohma, S., Yamamoto, K., Kasahara, M., Nabeshima, Y., Tanaka, K., and Chiba, T. (1999): Growth retardation in mice lacking the proteasome activator PA28g., J Biol Chem 274, 38211-38215.
  3. Urano T, Yashiroda H, Muraoka M, Tanaka K, Hosoi T, Inoue S, Ouchi Y, Toyoshima H.: p57(Kip2) is degraded through the proteasome in osteoblasts stimulated to proliferation by transforming growth factor b1., J.Biol. Chem., 274(18):12197-200 1999.