Groups and Members

A01: Creation of Artificial Biosynthetic MachineriesA02: Construction of Biological System for Mass-productionA03 Structure and Function of Biosynthetic Machineries

Research Program A01: Creation of Artificial Biosynthetic Machineries

Ikuro ABE

Name / Affiliation

Ikuro ABE
Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo

Research Project

The Next Generation Natural Products Chemistry by Rational Reprogramming of Biosynthetic Machineries

Hiroaki SUGA

Name / Affiliation

Hiroaki SUGA
Professor, Graduate School of Science, The University of Tokyo

Research Project

In vitro Synthetic Biology for Pseudo-Natural Products

Yoshimitsu HAMANO

Name / Affiliation

Yoshimitsu HAMANO
Professor, Faculty of Bioscience, FUKUI Prefectural University

Research Project

Biosynthetic Redesign of Bioactive Small Compounds for Simultaneous Enhancement of Cell Membrane Permeability and Hydrophilicity

Atsushi MINAMI

Name / Affiliation

Atsushi MINAMI
Associate Professor, Graduate School of Science, Hokkaido University

Research Project

Reprogramming Biosynthetic Machineries for the Development of Novel Biologically Active Polyketides

Research Program A02: Construction of Biological Systems for Mass Production

Haruo IKEDA

Name / Affiliation

Haruo IKEDA
Professor, Graduate School of Infection Control Sciences, Kitasato University

Research Project

Comprehensive Metabolic Analysis in the Secondary Metabolite Production of an Engineered Versatile Streptomyces Host

Toshiyuki WAKIMOTO

Name / Affiliation

Toshiyuki WAKIMOTO
Professor, Graduate School of Pharmaceutical Sciences, Hokkaido University

Research Project

Heterologous Production of Bioactive Metabolites derived from Uncultured Bacteria

Kenji WATANABE

Name / Affiliation

Kenji WATANABE
Professor, Department of Pharmaceutical Sciences, University of Shizuoka

Research Project

Genetic Indoctrination of Microorganism for Innovative Drug Discovery

Daisuke UMENO

Name / Affiliation

Daisuke UMENO
Associate Professor, Department of Applied Chemistry, Chiba University

Research Project

Evolutionary Engineering of Robustness of the Synthetic Natural Product Pathways

Research Program A03: Structure and Function of Biosynthetic Enzymes

Tadashi EGUCHI

Name / Affiliation

Tadashi EGUCHI
Professor, Department of Chemistry, Tokyo Institute of Technology

Research Project

Mechanistic Enzymology of Biosynthetic Enzymes toward Metabolic Redesign for Unnatural Natural Products

Tohru DAIRI

Name / Affiliation

Tohru DAIRI
Professor, Faculty of Engineering, Hokkaido University

Research Project

Comprehension of Biosynthetic Machinery for Development of High-functional Biomolecules.

Tomohisa KUZUYAMA

Name / Affiliation

Tomohisa KUZUYAMA
Associate Professor, Biotechnology Research Center, The University of Tokyo

Research Project

Innovation of Biosynthetic Machineries for Natural Products

Mami YAMAZAKI

Name / Affiliation

Mami YAMAZAKI
Associate Professor, Graduate School of Pharmaceutical Sciences, Chiba University

Research Project

Designed Biosynthesis Based on Knowledge from the Evolution of Plant Specialized Metabolisms

A01: Creation of Artificial Biosynthetic MachineriesA02: Construction of Biological System for Mass-productionA03 Structure and Function of Biosynthetic Machineries

Research Program A01: Creation of Artificial Biosynthetic Machineries

Min YAO

Name / Affiliation

Min YAO
Professor, Faculty of Advanced Life Science, Hokkaido University

Research Project

TBuilding a Biosynthesis Pathway of Non-natural Adrenergic Drug

Teigo ASAI

Name / Affiliation

Teigo ASAI
Associate Professor, Graduate School of Arts and Sciences, The University of Tokyo

Research Project

Production of Anti-cancer Active Pseudo-natural Products through Artificial Metabolic Pathway Built into Aspergillus oryzae

Masahiro OKADA

Name / Affiliation

Masahiro OKADA
Professor, Department of Material and Life Chemistry, Kanagawa University

Research Project

Redesign of Biosynthesis for Unnatural Sesterterpene Production

Masanobu UCHIYAMA

Name / Affiliation

Masanobu UCHIYAMA
Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo

Research Project

A Challenge for Comprehensive Search and “Re-design”the Biosynthetic Pathways Based on Theoretical Calculation

Hiroki OGURI

Name / Affiliation

Hiroki OGURI
Professor, Graduate School of Engineering, Tokyo University of Agriculture and Technology

Research Project

Chemo-enzymatic Synthesis of Multicyclic Alkaloids

Fumitaka KUDO

Name / Affiliation

Fumitaka KUDO
Associate Professor, Department of Chemistry, Tokyo Institute of Technology

Research Project

Redesigning Biosynthetic Machineries of Antitumor Macrolide Antibiotics

Hiroyuki MORITA

Name / Affiliation

Hiroyuki MORITA
Professor, Institute of Natural Medicine, University of Toyama

Research Project

Discovering Plant-specific Novel Polyketide Cyclases for Engineering Useful Substances

Fumihiro ISHIKAWA

Name / Affiliation

Fumihiro ISHIKAWA
Associate Professor, Faculty of Pharmacy, Kindai University

Research Project

A Chemoproteomics Approach for the Rational Design of Unnatural Natural Products

Masahiro FUJIHASHI

Name / Affiliation

Masahiro FUJIHASHI
Assistant Professor, Department of Chemistry, Graduate School of Science, Kyoto University

Research Project

Mining and Functional Improvement of Enzymes Based on the Crystal Structures of Novel Enzymes

Eiji NAKATA

Name / Affiliation

Eiji NAKATA
Associate Professor, Institute of Advanced Energy, Kyoto University

Research Project

Construction of Non-natural Biosynthetic System in vitro

Kiyotake SUENAGA

Name / Affiliation

Kiyotake SUENAGA
Professor, Department of Chemistry, Faculty of Science and Technology, Keio University

Research Project

Studies on Biosynthesis and Production of Artificial Analogs of Marine Lipopeptides with Unique Chemical Structure

Naoki KATO

Name / Affiliation

Naoki KATO
Reseracher, RIKEN Center for Sustainable Resource Science

Research Project

Functional Analysis of Fsa2-family Diels-Alderases and Creation of New Decalin Derivatives with Unnatural Configurations

Maiko UMEMURA

Name / Affiliation

Maiko UMEMURA
Researcher, National Institute of Advanced Industrial Science and Technology (AIST)

Research Project

Fungal RiPPs Library Construction for Design and Synthesis of Artificial Cyclic Peptides

Research Program A02: Construction of Biological Systems for Mass Production

Taro OZAKI

Name / Affiliation

Taro OZAKI
Assistant Professor, Graduate School of Science, Hokkaido University

Research Project

Heterologous Production of Infection-specific Fungal Secondary Metabolites

Jun-ichi MARUYAMA

Name / Affiliation

Jun-ichi MARUYAMA
Associate Professor, Department of Biotechnology, The University of Tokyo

Research Project

Development of Genome Editing-based Technology for Rapid and Multiple Gene Modification in Heterologous Production of Secondary Metabolites in Aspergillus oryzae

Kazufumi YAZAKI

Name / Affiliation

Kazufumi YAZAKI
Professor, Research Institute for Sustainable Humanosphere, Kyoto University

Research Project

Redesign of Biosynthetic Machinery for Prenylated Polyphenols via Integration of Metabolic and Transport Engineering

Satoru WATANABE

Name / Affiliation

Satoru WATANABE
Assistant Professor, Department of Bioscience, Tokyo University of Agriculture

Research Project

Metabolic and Evolutional Engineering of Cyanobacteria for Effective Production of Strigolactone and its Derivatives

Nobukazu SHITAN

Name / Affiliation

Nobukazu SHITAN
Professor, Kobe Pharmaceutical University

Research Project

Development of Efficient Alkaloid Production System using Tolerance and Transport Proteins in Synthetic Biology

Shunji TAKAHASHI

Name / Affiliation

Shunji TAKAHASHI
Researcher, RIKEN Center for Sustainable Resource Science

Research Project

Construction of Biosynthetic Platform Focused on Terpenoid Production using Streptomyces Host and Creation of Novel Secondary Metabolites

Wataru KITAGAWA

Name / Affiliation

Wataru KITAGAWA
Researcher, National Institute of Advanced Industrial Science and Technology (AIST)

Research Project

Development of a Reversed-evolved Host Microorganism for Bioproduction

Research Program A03: Structure and Function of Biosynthetic Enzymes

Yuko CHO

Name / Affiliation

Yuko CHO
Assistant Professor, Graduate School of Agricultural Science, Tohoku University

Research Project

Development of Basic Technique for the Search of the Toxin Biosynthetic Machinery and Genome Analysis of the Organism having Huge Genome

Tomonobu TOYOMASU

Name / Affiliation

Tomonobu TOYOMASU
Professor, Faculty of Agriculture, Yamagata University

Research Project

Evolution of Functions of Diterpene Cyclases in Rice

Yohei KATSUYAMA

Name / Affiliation

Yohei KATSUYAMA
Associate Professor, Graduate School of Agricultural and Life Sciences, The University of Tokyo

Research Project

Study on Biosynthetic Machinery of Nonribosomal Peptide Synthetase

Futoshi TAUR

Name / Affiliation

Futoshi TAUR
Associate Professor, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama

Research Project

Functional Re-design of the Biosynthetic Enzymes Producing Pharmacologically Active Plant Meroterpenoids based on Crystal Structure Analyses

Hisashi HEMMI

Name / Affiliation

Hisashi HEMMI
Associate Professor, Graduate School of Bioagricultural Sciences, Nagoya University

Research Project

Machinery of Condensation Reactions between Isoprene Units that Generate the Structural Variety of Isoprenoid

Hikaru SEKI

Name / Affiliation

Hikaru SEKI
Associate Professor, Graduate School of Engineering, Osaka University

Research Project

Reconstruction of Plant-derived Rare Sesquiterpenoids Biosynthetic Pathways

Shingo NAGANO

Name / Affiliation

Shingo NAGANO
Professor, Graduate School of Engineering, Tottori University

Research Project

Biosynthetic Mechanism of Highly Strained Ladderane Lipids in Anammox Bacteria

Kenji ARAKAWA

Name / Affiliation

Kenji ARAKAWA
Associate Professor, Graduate School of Advanced Sciences of Matterialas, Hiroshima University

Research Project

Mechanistic Study and Biosynthetic Redesign of Silent Secondary Metabolites Produced by Rational Modification of Metabolic Pathway

Nobutaka FUNA

Name / Affiliation

Nobutaka FUNA
Associate Professor, Department of Food and Nutritional Sciences, University of Shizuoka

Research Project

Dissecting Biosynthetic Machinery of Aromatic Polyketides for Functional Reconstitution in E. coli

Tetsuro SHINADA

Name / Affiliation

Tetsuro SHINADA
Professor, Graduate School of Science, Osaka City University

Research Project

Synthetic Studies of Acyclic Terpene Probes to Elucidate the Reaction Mechanism of Terpenoid Biosynthesis

Isao FUJII

Name / Affiliation

Isao FUJII
Professor, Iwate Medical University

Research Project

Functional and Structural Analyses of Eletrocyclization Enzymes Involved in Fungal Natural Product Biosynthesis