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Professor Ikuro ABE

Graduate School of Pharmaceutical Sciences
The University of Tokyo
7-3-1 Hongo, Bunkyo-ku,
Tokyo 113-0033, Japan
Tel: +81-3-5841-4740
Fax: +81-3-5841-4744


DEGREES
1984 B.S., The University of Tokyo, Japan
1986 M.S., The University of Tokyo, Japan
1989 Ph.D., The University of Tokyo, Japan


RESEARCH & PROFESSIONAL EXPERIENCE

1989

Boursier du Gouvernement Francais and Boursier Maxwell de l'Academie des Sciences, Institut de Chimie des Substances Naturells (C.N.R.S), and Ecole Nationale Superieure de Chimie de Mulhouse (Professors Guy Ourisson and Michel Rohmer)

1991

Research Assistant Professor, Department of Chemistry, State University of New York at Stony Brook (Professor Glenn D. Prestwich)

1996 Research Assistant Professor, Department of Medicinal Chemistry, The University of Utah (Professor Glenn D. Prestwich)
1998 Assistant Professor, School of Pharmaceutical Sciences, University of Shizuoka
2008 Associate Professor, School of Pharmaceutical Sciences, University of Shizuoka
2009-current Professor, Graduate School of Pharmaceutical Sciences, The University of Tokyo
2014 Visiting Professor, The University of British Columbia, Canada
2014 Guest Professor, Jinan University, Guangzhou, China
2016-2021 Project Leader, Grant-in-Aid for Reserach on Innovative Areas, Creation of Complex Functional Molecules by Rational Redesign of Biosynthetic Machineries



AWARDS

1998

The Encouraging Awards for Young Scientists, The Research Foundation of Pharmaceutical Sciences, Japan

2003

The Japanese Society of Pharmacognosy, The JSP Award for Young Scientists

2007 The Japanese Society of Pharmacognosy, The JSP Award for Scientific Contributions
2008 The Pharmaceutical Society of Japan Award for Divisional Scientific Promotions
2015 FAOBMB Osamu Hayaishi Lecture Award
2017 The Japanese Society of Pharmacognosy, The JSP Award
2017 Sumiki Umezawa Memorial Prize


ACTIVITIES

President: The Japanese Society of Pharmacognosy(2018-2019)

President: The Pharmaceutical Society of Japan, Division of Natural Medicines(2015-2017)

Fellow of The Royal Society of Chemistry(2013-)

Faculty Member: Faculty of 1000(2011-)

Editorial Board Member: Natural Product Reports(2012-2017)

Editorial Board Member: Frontiers in Plant Science(2010-2017)

Editorial Board Member: Natural Products and Bioprospecting(2013-)

Editorial Board Member: Journal of Chinese Pharmaceutical Sciences(2014-)

Executive Committee Member: TERPNET (2017-)

Advisory Member: Phytochemical Society of Asia (2015-)

Co-organizer: PACIFICHEM, Biosynthesis of Natural Products(2005, 2010, 2015)

Co-organizer: US-Japan Seminar, Biosynthesis of Natural Products(2017)

Organizer: China-Japan Seminar, Biosynthesis of Natural Products(2017)

Member: American Chemical Society(1996-)

Member: American Society of Biochemistry and Molecular Biology(1998-)

Member: American Society of Pharmacognosy(2014-)



SELECTED PUBLICATIONS

Molecular basis for the unusual ring reconstruction in fungal meroterpenoid biogenesis
Mori, T., Iwabuchi, T., Hoshino, S., Wang, H., Matsuda, Y., Abe, I.
Nature Chem. Biol., 13, in press (2017) Link | Press Release

Characterization of giant modular PKSs provides insight into genetic mechanism for structural diversification of aminopolyol polyketides
Zhang, L., Hashimoto, T., Qin, B., Hashimoto, J., Kozone, I., Kawahara, T., Okada, M., Awakawa, T., Ito, T., Asakawa, Y., Ueki, M., Takahashi, S., Osada, H., Wakimoto, T., Ikeda, H., Shin-ya, K., Abe, I.
Angew. Chem. Int. Ed., 56, 1740-1745 (2017) Link | Hot Paper | Frontispiece | Press Release

Discovery of key dioxygenases that diverged the paraherquonin and acetoxydehydroaustin pathways in Penicillium brasilianum
Matsuda, Y.,# Iwabuchi,T.,# Fujimoto, T., Awakawa,T., Nakashima, Y., Mori, T., Zhang, H., Hayashi, F., Abe, I. (#equall contribution)
J. Am. Chem. Soc., 138, 12671-12677 (2016) Link

Genome-based discovery of an unprecedented cyclization mode in fungal sesterterpenoids biosynthesis
Okada, M.,# Matsuda, Y.,# Mitsuhashi, T., Hoshino, S., Mori, T., Nakagawa, K., Quan, Z., Qin, B., Zhang, H., Hayashi, F., Kawaide, H., Abe, I. (#equall contribution)
J. Am. Chem. Soc., 138, 10011-10018 (2016) Link | JACS Spotlights

Manipulation of prenylation reactions by structure-based engineering of bacterial indolactam prenyltransferases
Mori, T., Zhang, L., Awakawa, T., Hoshino, S., Okada, M., Morita, H., Abe, I.
Nature Commun., 7, 10849 (2016) Link | Open Access | Press Release

Astellifadiene, a unique tetracyclic fungal sesterterpene: structure determination by an NMR-coupled crystalline sponge method and elucidation of its biosynthesis
Matsuda, Y.,# Mitsuhashi,T.,# Lee, S.,# Hoshino, M., Mori, T., Okada, M., Zhang, H., Hayashi, F., Fujita, M., Abe, I. (#equall contribution)
Angew. Chem. Int. Ed., 55, 5785-5788 (2016) Link

An unusual chimeric diterpene synthase from Emericella variecolor and its functional conversion to a sesterterpene synthase by domain swapping
Qin, B., Matsuda, Y., Mori, T., Okada, M., Quan, Z., Mitsuhashi, T., Wakimoto, T., Abe, I.
Angew. Chem. Int. Ed., 55, 1658-1661 (2016) Link | Front Cover | Press Release

Biosynthesis of fungal meroterpenoids
Matsuda, Y., Abe, I.
Nat. Prod. Rep., 33, 26-53 (2016) Link | Open Access

Nature's way of making the sponge-derived cytotoxin
Wakimoto, T., Egami, Y., Abe, I.
Nat. Prod. Rep., 33, 751-760 (2016) Link | Open Access | Front Cover

Rational control of polyketide extender units by structure-based engineering of a crotonyl-CoA carboxylase/reductase in antimycin biosynthesis
Zhang, L., Mori, T., Zheng, Q., Awakawa, T., Yan, Y., Liu, W., Abe, I.
Angew. Chem. Int. Ed., 54, 13462-13465 (2015) Link | Press Release

Uncovering the unusual D-ring construction in terretonin biosynthesis by collaboration of a multifunctional cytochrome P450 and a unique isomerase
Matsuda, Y., Iwabuchi, T., Wakimoto, T., Awakawa, T., Abe, I.
J. Am. Chem. Soc., 137, 3393-3401 (2015) Link

Complete biosynthetic pathway of anditomin: nature's sophisticated synthetic route to a complex fungal meroterpenoid
Matsuda, Y., Wakimoto, T., Mori, T., Awakawa, T., Abe, I.
J. Am. Chem. Soc., 136, 15326–15336 (2014) Link | Front Cover | JACS Spotlights

Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont
Wakimoto, T., Egami, Y., Nakashima, Y., Wakimoto,Y., Mori, T., Awakawa,T., Ito, T., Kenmoku, H., Asakawa, Y., Piel, J., Abe, I.
Nature Chem. Biol., 10, 648-655 (2014) Link | News & Views | Press Release

A methyltransferase initiates terpene cyclization in teleocidin B biosynthesis
Awakawa, T., Zhang, L., Wakimoto, T., Hoshino, S., Mori, T., Ito, T., Ishikawa, J., Tanner, M. E., Abe, I.
J. Am. Chem. Soc., 136, 9910-9913 (2014) Link | Faculty of 1000

An environmental bacterial taxon with a large and distinct metabolic repertoire
Wilson, M. C., Mori, T., Rückert, C., Uria, A. R., Helf, M. J., Takada, K., Gernert, C., Steffens, U. A. E., Heycke, N., Schmitt, S., Rinke, C., Helfrich, E. J. N., Brachmann, A. O., Gurgui, C., Wakimoto. T., Kracht, M., Crüsemann, M., Hentschel, U., Abe, I., Matsunaga, S., Kalinowski, J., Takeyama, H., Piel, J.
Nature, 506, 58-62 (2014) Link | News & Views

Spiro-ring formation is catalyzed by a multifunctional dioxygenase in austinol biosynthesis
Matsuda, Y., Awakawa, T., Wakimoto, T., Abe, I.
J. Am. Chem. Soc., 135, 10962-10965 (2013) Link

Multiplexing of combinatorial chemistry in antimycin biosynthesis expands the molecular diversity and utility
Yan Y., Chen, J., Zhang, L., Zheng, Q., Han, Y., Zhang, H., Awakawa, T., Abe, I., Liu, W.
Angew. Chem. Int. Ed., 52, 12308-12312 (2013) Link

Synthesis of unnatural alkaloid scaffolds by exploiting plant polyketide synthase
Morita, H., Yamashita, M., Shi, S.-P., Wakimoto, T., Kondo, S., Kato, R., Sugio, S., Kohno, T., Abe, I.
Proc. Natl. Acad. Sci. USA, 108, 13504-13509 (2011) Link

Cytotoxic tetramic acid derivative produced by a plant type III polyketide synthase
Wakimoto, T., Mori, T., Morita, H., Abe, I.
J. Am. Chem. Soc., 133, 4746-4749 (2011) Link

Furan fatty acid as an anti-inflammatory component from green-lipped mussel Perna canaliculus
Wakimoto, T., Kondo, H., Nii, H., Kimura, K., Egami, Y., Oka, Y., Yoshida, M., Kida, E., Ye, Y.-p., Akahoshi, S., Asakawa, T., Matsumura, K., Ishida, H., Nukaya, H., Tsuji, K., Kan, T., Abe, I.
Proc. Natl. Acad. Sci. USA, 108, 17533-17537 (2011) Link

Structural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativa
Morita, H., Wanibuchi, K., Nii, H., Kato, R., Sugio, S., Abe, I.
Proc. Natl. Acad. Sci. USA, 107, 19778-19783 (2010) Link

A structure-based mechanism for benzalacetone synthase from Rheum palmatum
Morita, H., Shimokawa, Y., Tanio, M., Kato, R., Noguchi, H., Sugio, S., Kohno, T., Abe, I.
Proc. Natl. Acad. Sci. USA, 107, 669-673 (2010) Link

Structure and function of the chalcone synthase superfamily of plant type III polyketide synthases
Abe, I., Morita, H.
Nat. Prod. Rep., 27, 809-838 (2010) Link

Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases
Itoh, T., Tokunaga, K., Matsuda, Y., Fujii, I., Abe, I., Ebizuka, Y., Kushiro, T.
Nature Chem., 2, 858-864 (2010) Link | News & Views | Faculty of 1000

Structure-based engineering of a plant type III polyketide synthase: formation of an unnatural nonaketide naphthopyrone
Abe, I., Morita, H., Oguro, S., Noma, H., Wanibuchi, K., Kawahara, N., Goda, Y., Noguchi, H., Kohno, T.
J. Am. Chem. Soc., 129, 5976-5980 (2007) Link

Structural insight into chain-length control and product specificity of pentaketide chromone synthase from Aloe arborescens
Morita, H., Kondo, S., Oguro, S., Noguchi, H., Sugio, S., Abe, I., Kohno, T.
Chemistry & Biology, 14, 359-369 (2007) Link

Enzymatic synthesis of cyclic triterpenes
Abe, I.
Nat. Prod. Rep., 24, 1311-1331 (2007) Link

Engineered biosynthesis of plant polyketides: chain length control in an octaketide-producing plant type III polyketide synthase
Abe, I., Oguro, S., Utsumi, Y., Sano, Y., Noguchi, H.
J. Am. Chem. Soc., 127, 12709-12716 (2005) Link

A plant type III polyketide synthase that produces pentaketide chromone
Abe, I., Utsumi, Y., Oguro, S., Morita, H., Sano, Y., Noguchi, H.
J. Am. Chem. Soc., 127, 1362-1363 (2005) Link

Mechanism and stereochemistry of enzymatic cyclization of 24,30-bisnor-2,3-oxidosqualene by recombinant β-amyrin synthase
Abe, I., Sakano, Y., Sodeyama, M., Tanaka, H., Noguchi, H., Shibuya, M., Ebizuka, Y.
J. Am. Chem. Soc., 126, 6880-6881 (2004) Link

Enzymatic cyclization of 22,23-dihydro-2,3-oxidosqualene into euph-7-en-3β-ol and bacchar-12-en-3β-ol by recombinant β-amyrin synthase
Abe, I., Sakano, Y., Tanaka, H., Lou, W., Noguchi, H., Shibuya, M., Ebizuka, Y.
J. Am. Chem. Soc., 126, 3426-3427 (2004) Link

Site-directed mutagenesis of benzalacetone synthase: the role of Phe215 in plant type III polyketide synthases
Abe, I., Sano, Y., Takahashi, Y., Noguchi, H.
J. Biol. Chem., 278, 25218-25226 (2003) Link

Enzymatic formation of an unnatural hexacyclic C35 polyprenoid by bacterial squalene cyclase
Abe, I., Tanaka, H., Noguchi, H.
J. Am. Chem. Soc., 124, 14514-14515 (2002) Link

Substrate specificity of chalcone synthase: enzymatic formation of unnatural polyketides from synthetic cinnamoyl-CoA analogs
Abe, I., Morita, H., Nomura, A., Noguchi, H.
J. Am. Chem. Soc., 122, 11242-11243 (2000) Link

Cyclization of (3S)29-methylidene-2,3-oxidosqualene by bacterial squalene:hopene cyclase: irreversible enzyme inactivation and isolation of an unnatural dammarenoid
Abe, I., Dang, T., Zheng, Y. F., Madden, B. A., Feil, C., Poralla, K., Prestwich, G. D.
J. Am. Chem. Soc., 119, 11333-11334 (1997) Link

Mechanism-based active site modification of oxidosqualene cyclase by tritium labeled 18-thia-2,3-oxidosqualene
Abe, I., Liu, W., Oehlschlagar, A. C., Prestwich, G. D.
J. Am. Chem. Soc., 118, 9180-9181 (1996) Link

Molecular cloning, characterization, and functional expression of rat oxidosqualene cyclase
Abe, I., Prestwich, G. D.
Proc. Natl. Acad. Sci. USA, 92, 9274-9278 (1995) Link

Inhibitors of squalene biosynthesis and metabolism
Abe, I., Tomesch, J. C., Wattanasin, S., Prestwich, G. D.
Nat. Prod. Rep., 11, 279-302 (1994) Link

Active site mapping of affinity labeled rat oxidosqualene cyclase
Abe, I., Prestwich, G. D.
J. Biol. Chem., 269, 802-804 (1994) Link

Enzymatic cyclization of squalene and oxidosqualene to sterols and triterpenes
Abe, I., Rohmer, M., Prestwich, G. D.
Chem. Rev., 93, 2189-2206 (1993) Link