東京大学大学院薬学系研究科 天然物化学教室
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阿部 郁朗 教授
Ikuro Abe, Ph.D.

東京大学大学院薬学系研究科
〒113-0033 東京都文京区本郷7-3-1
Tel: 03-5841-4740
Fax: 03-5841-4744


学 歴
1984年 東京大学薬学部薬学科卒業(三川 潮 教授)
1986年 東京大学大学院薬学系研究科修士課程修了(三川 潮 教授)
1989年 東京大学大学院薬学系研究科博士課程修了(海老塚 豊 助教授)


職 歴

1989年

仏国国立天然物化学研究所、ミュールーズ国立高等化学院
仏政府給費留学生、CNRS研究員(Guy Ourisson 教授、Michel Rohmer 教授)

1991年

米国ニューヨーク州立大学ストーニーブルック校化学科・上級博士研究員、
生化学科・研究助教授(Glenn Prestwich 教授)

1996年 米国ユタ大学医薬化学科・研究助教授(Glenn Prestwich 教授)
1998年 静岡県立大学薬学部講師
2005年 

科学技術振興機構 戦略的創造研究推進事業
さきがけタイプ「代謝と機能制御」領域 研究者(兼任)

2008年 静岡県立大学薬学部准教授
2009年 東京大学大学院薬学系研究科教授(現職)
2014年 ブリティッシュ・コロンビア大学(カナダ)客員教授
2014年 曁南大学(中国)客座教授
2016-2021年 

新学術領域研究(研究領域提案型)「生物合成系の再設計による複雑骨格機能分子の革新的創成科学(生合成リデザイン)」領域代表



受 賞

1999年

日本化学会 第14回若い世代の特別講演会賞

2003年

日本生薬学会 学術奨励賞

2007年  日本生薬学会 学術貢献賞
2008年 日本薬学会 学術振興賞
2015年 FAOBMB Osamu Hayaishi Lecture Award
2017年  日本生薬学会 学会賞
2017年  住木・梅澤記念賞


学会等での主な活動

Fellow of The Royal Society of Chemistry(2013-)

Faculty Member: Faculty of 1000(2011-)

Editorial Board Member: Natural Product Reports(2012-2017)

Section Editor: Comprehensive Natural Products IIII(2017-2020)

Editorial Board Member: Frontiers in Plant Science(2010-2017)

Editorial Board Member: Natural Products and Bioprospecting(2013-)

Editorial Board Member: Journal of Chinese Pharmaceutical Sciences(2014-)

Executive Committee Member: TERPNET (2017-)

Advisory Member: Phytochemical Society of Asia (2015-)

Co-organizer: PACIFICHEM, Biosynthesis of Natural Products(2005, 2010, 2015)

Co-organizer: US-Japan Seminar, Biosynthesis of Natural Products(2017)

Organizer: China-Japan Seminar, Biosynthesis of Natural Products(2017)

Member: American Chemical Society(1996-)

Member: American Society of Biochemistry and Molecular Biology(1998-)

Member: American Society of Pharmacognosy(2014-)

日本薬学会 生薬天然物部会 常任世話人(2011-)、庶務幹事(2013-15)、部会長(2015-17)

日本生薬学会 評議員(2010-)、常務理事(2014-18)、副会長(2017-18)、会長(2018-19)

天然有機化合物討論会 世話人(2009-)

酵素工学研究会 役員(委員)(2013-)

植物化学研究会(植物化学シンポジウム)世話人(2010-)、代表(2014-)

公益財団法人 薬理研究会 評議員(2012-)

日本学術振興会 科学研究費委員会 専門委員

日本学術振興会 特別研究員等審査会、国際事業委員会 専門委員

農業・食品産業技術総合研究機構競争的資金事業 専門委員

厚生労働省 薬事・食品衛生審議会 臨時委員

厚生労働省 食品規格部 会員

文部科学省 大学設置・学校法人審議会 専門委員

日本薬学会年会シンポジウム 世話人(2005, 2007, 2009, 2010, 2011, 2012, 2013, 2014, 2016, 2017)



代表的な論文

Molecular basis for the unusual ring reconstruction in fungal meroterpenoid biogenesis
Mori, T., Iwabuchi, T., Hoshino, S., Wang, H., Matsuda, Y., Abe, I.
Nature Chem. Biol., 13, 1066-1073 (2017) Link | Press Release

Biosynthesis of helvolic acid and identification of an unusual C-4-demethylation process distinct from sterol biosynthesis
Lv, J.-M., Hu, D., Gao, H., Kushiro, T., Awakawa, T., Chen, G.-D., Wang, C.-X., Abe, I., Yao, X.-S.
Nature Commun., 8, 1644 (2017) Link | Open Access | Press Release

Characterization of giant modular PKSs provides insight into genetic mechanism for structural diversification of aminopolyol polyketides
Zhang, L., Hashimoto, T., Qin, B., Hashimoto, J., Kozone, I., Kawahara, T., Okada, M., Awakawa, T., Ito, T., Asakawa, Y., Ueki, M., Takahashi, S., Osada, H., Wakimoto, T., Ikeda, H., Shin-ya, K., Abe, I.
Angew. Chem. Int. Ed., 56, 1740-1745 (2017) Link | Hot Paper | Frontispiece | Press Release

Discovery of key dioxygenases that diverged the paraherquonin and acetoxydehydroaustin pathways in Penicillium brasilianum
Matsuda, Y.,# Iwabuchi,T.,# Fujimoto, T., Awakawa,T., Nakashima, Y., Mori, T., Zhang, H., Hayashi, F., Abe, I. (#equall contribution)
J. Am. Chem. Soc., 138, 12671-12677 (2016) Link

Genome-based discovery of an unprecedented cyclization mode in fungal sesterterpenoids biosynthesis
Okada, M.,# Matsuda, Y.,# Mitsuhashi, T., Hoshino, S., Mori, T., Nakagawa, K., Quan, Z., Qin, B., Zhang, H., Hayashi, F., Kawaide, H., Abe, I. (#equall contribution)
J. Am. Chem. Soc., 138, 10011-10018 (2016) Link | JACS Spotlights

Manipulation of prenylation reactions by structure-based engineering of bacterial indolactam prenyltransferases
Mori, T., Zhang, L., Awakawa, T., Hoshino, S., Okada, M., Morita, H., Abe, I.
Nature Commun., 7, 10849 (2016) Link | Open Access | Press Release

Astellifadiene, a unique tetracyclic fungal sesterterpene: structure determination by an NMR-coupled crystalline sponge method and elucidation of its biosynthesis
Matsuda, Y.,# Mitsuhashi,T.,# Lee, S.,# Hoshino, M., Mori, T., Okada, M., Zhang, H., Hayashi, F., Fujita, M., Abe, I. (#equall contribution)
Angew. Chem. Int. Ed., 55, 5785-5788 (2016) Link | Press Release

An unusual chimeric diterpene synthase from Emericella variecolor and its functional conversion to a sesterterpene synthase by domain swapping
Qin, B., Matsuda, Y., Mori, T., Okada, M., Quan, Z., Mitsuhashi, T., Wakimoto, T., Abe, I.
Angew. Chem. Int. Ed., 55, 1658-1661 (2016) Link | Front Cover | Press Release

Biosynthesis of fungal meroterpenoids
Matsuda, Y., Abe, I.
Nat. Prod. Rep., 33, 26-53 (2016) Link | Open Access

Nature's way of making the sponge-derived cytotoxin
Wakimoto, T., Egami, Y., Abe, I.
Nat. Prod. Rep., 33, 751-760 (2016) Link | Open Access | Front Cover

Rational control of polyketide extender units by structure-based engineering of a crotonyl-CoA carboxylase/reductase in antimycin biosynthesis
Zhang, L., Mori, T., Zheng, Q., Awakawa, T., Yan, Y., Liu, W., Abe, I.
Angew. Chem. Int. Ed., 54, 13462-13465 (2015) Link | Press Release

Uncovering the unusual D-ring construction in terretonin biosynthesis by collaboration of a multifunctional cytochrome P450 and a unique isomerase
Matsuda, Y., Iwabuchi, T., Wakimoto, T., Awakawa, T., Abe, I.
J. Am. Chem. Soc., 137, 3393-3401 (2015) Link

Complete biosynthetic pathway of anditomin: nature's sophisticated synthetic route to a complex fungal meroterpenoid
Matsuda, Y., Wakimoto, T., Mori, T., Awakawa, T., Abe, I.
J. Am. Chem. Soc., 136, 15326–15336 (2014) Link | Front Cover | JACS Spotlights

Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont
Wakimoto, T., Egami, Y., Nakashima, Y., Wakimoto,Y., Mori, T., Awakawa,T., Ito, T., Kenmoku, H., Asakawa, Y., Piel, J., Abe, I.
Nature Chem. Biol., 10, 648-655 (2014) Link | News & Views | Press Release

A methyltransferase initiates terpene cyclization in teleocidin B biosynthesis
Awakawa, T., Zhang, L., Wakimoto, T., Hoshino, S., Mori, T., Ito, T., Ishikawa, J., Tanner, M. E., Abe, I.
J. Am. Chem. Soc., 136, 9910-9913 (2014) Link | Faculty of 1000

An environmental bacterial taxon with a large and distinct metabolic repertoire
Wilson, M. C., Mori, T., Rückert, C., Uria, A. R., Helf, M. J., Takada, K., Gernert, C., Steffens, U. A. E., Heycke, N., Schmitt, S., Rinke, C., Helfrich, E. J. N., Brachmann, A. O., Gurgui, C., Wakimoto. T., Kracht, M., Crüsemann, M., Hentschel, U., Abe, I., Matsunaga, S., Kalinowski, J., Takeyama, H., Piel, J.
Nature, 506, 58-62 (2014) Link | News & Views | Press Release

Spiro-ring formation is catalyzed by a multifunctional dioxygenase in austinol biosynthesis
Matsuda, Y., Awakawa, T., Wakimoto, T., Abe, I.
J. Am. Chem. Soc., 135, 10962-10965 (2013) Link

Multiplexing of combinatorial chemistry in antimycin biosynthesis expands the molecular diversity and utility
Yan Y., Chen, J., Zhang, L., Zheng, Q., Han, Y., Zhang, H., Awakawa, T., Abe, I., Liu, W.
Angew. Chem. Int. Ed., 52, 12308-12312 (2013) Link

Synthesis of unnatural alkaloid scaffolds by exploiting plant polyketide synthase
Morita, H., Yamashita, M., Shi, S.-P., Wakimoto, T., Kondo, S., Kato, R., Sugio, S., Kohno, T., Abe, I.
Proc. Natl. Acad. Sci. USA, 108, 13504-13509 (2011) Link

Cytotoxic tetramic acid derivative produced by a plant type III polyketide synthase
Wakimoto, T., Mori, T., Morita, H., Abe, I.
J. Am. Chem. Soc., 133, 4746-4749 (2011) Link

Furan fatty acid as an anti-inflammatory component from green-lipped mussel Perna canaliculus
Wakimoto, T., Kondo, H., Nii, H., Kimura, K., Egami, Y., Oka, Y., Yoshida, M., Kida, E., Ye, Y.-p., Akahoshi, S., Asakawa, T., Matsumura, K., Ishida, H., Nukaya, H., Tsuji, K., Kan, T., Abe, I.
Proc. Natl. Acad. Sci. USA, 108, 17533-17537 (2011) Link

Structural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativa
Morita, H., Wanibuchi, K., Nii, H., Kato, R., Sugio, S., Abe, I.
Proc. Natl. Acad. Sci. USA, 107, 19778-19783 (2010) Link

A structure-based mechanism for benzalacetone synthase from Rheum palmatum
Morita, H., Shimokawa, Y., Tanio, M., Kato, R., Noguchi, H., Sugio, S., Kohno, T., Abe, I.
Proc. Natl. Acad. Sci. USA, 107, 669-673 (2010) Link

Structure and function of the chalcone synthase superfamily of plant type III polyketide synthases
Abe, I., Morita, H.
Nat. Prod. Rep., 27, 809-838 (2010) Link

Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases
Itoh, T., Tokunaga, K., Matsuda, Y., Fujii, I., Abe, I., Ebizuka, Y., Kushiro, T.
Nature Chem., 2, 858-864 (2010) Link | News & Views | Faculty of 1000

Structure-based engineering of a plant type III polyketide synthase: formation of an unnatural nonaketide naphthopyrone
Abe, I., Morita, H., Oguro, S., Noma, H., Wanibuchi, K., Kawahara, N., Goda, Y., Noguchi, H., Kohno, T.
J. Am. Chem. Soc., 129, 5976-5980 (2007) Link

Structural insight into chain-length control and product specificity of pentaketide chromone synthase from Aloe arborescens
Morita, H., Kondo, S., Oguro, S., Noguchi, H., Sugio, S., Abe, I., Kohno, T.
Chemistry & Biology, 14, 359-369 (2007) Link

Enzymatic synthesis of cyclic triterpenes
Abe, I.
Nat. Prod. Rep., 24, 1311-1331 (2007) Link

Engineered biosynthesis of plant polyketides: chain length control in an octaketide-producing plant type III polyketide synthase
Abe, I., Oguro, S., Utsumi, Y., Sano, Y., Noguchi, H.
J. Am. Chem. Soc., 127, 12709-12716 (2005) Link

A plant type III polyketide synthase that produces pentaketide chromone
Abe, I., Utsumi, Y., Oguro, S., Morita, H., Sano, Y., Noguchi, H.
J. Am. Chem. Soc., 127, 1362-1363 (2005) Link

Mechanism and stereochemistry of enzymatic cyclization of 24,30-bisnor-2,3-oxidosqualene by recombinant β-amyrin synthase
Abe, I., Sakano, Y., Sodeyama, M., Tanaka, H., Noguchi, H., Shibuya, M., Ebizuka, Y.
J. Am. Chem. Soc., 126, 6880-6881 (2004) Link

Enzymatic cyclization of 22,23-dihydro-2,3-oxidosqualene into euph-7-en-3β-ol and bacchar-12-en-3β-ol by recombinant β-amyrin synthase
Abe, I., Sakano, Y., Tanaka, H., Lou, W., Noguchi, H., Shibuya, M., Ebizuka, Y.
J. Am. Chem. Soc., 126, 3426-3427 (2004) Link

Site-directed mutagenesis of benzalacetone synthase: the role of Phe215 in plant type III polyketide synthases
Abe, I., Sano, Y., Takahashi, Y., Noguchi, H.
J. Biol. Chem., 278, 25218-25226 (2003) Link

Enzymatic formation of an unnatural hexacyclic C35 polyprenoid by bacterial squalene cyclase
Abe, I., Tanaka, H., Noguchi, H.
J. Am. Chem. Soc., 124, 14514-14515 (2002) Link

Substrate specificity of chalcone synthase: enzymatic formation of unnatural polyketides from synthetic cinnamoyl-CoA analogs
Abe, I., Morita, H., Nomura, A., Noguchi, H.
J. Am. Chem. Soc., 122, 11242-11243 (2000) Link

Cyclization of (3S)29-methylidene-2,3-oxidosqualene by bacterial squalene:hopene cyclase: irreversible enzyme inactivation and isolation of an unnatural dammarenoid
Abe, I., Dang, T., Zheng, Y. F., Madden, B. A., Feil, C., Poralla, K., Prestwich, G. D.
J. Am. Chem. Soc., 119, 11333-11334 (1997) Link

Mechanism-based active site modification of oxidosqualene cyclase by tritium labeled 18-thia-2,3-oxidosqualene
Abe, I., Liu, W., Oehlschlagar, A. C., Prestwich, G. D.
J. Am. Chem. Soc., 118, 9180-9181 (1996) Link

Molecular cloning, characterization, and functional expression of rat oxidosqualene cyclase
Abe, I., Prestwich, G. D.
Proc. Natl. Acad. Sci. USA, 92, 9274-9278 (1995) Link

Inhibitors of squalene biosynthesis and metabolism
Abe, I., Tomesch, J. C., Wattanasin, S., Prestwich, G. D.
Nat. Prod. Rep., 11, 279-302 (1994) Link

Active site mapping of affinity labeled rat oxidosqualene cyclase
Abe, I., Prestwich, G. D.
J. Biol. Chem., 269, 802-804 (1994) Link

Enzymatic cyclization of squalene and oxidosqualene to sterols and triterpenes
Abe, I., Rohmer, M., Prestwich, G. D.
Chem. Rev., 93, 2189-2206 (1993) Link