2012

Novel applications of plant polyketide synthases
Abe, I.
Current Opinion in Chemical Biology, 16, 179-185 (2012) Link

Biosynthesis: an HR-PKS stereo surprise
Abe, I.
Nature Chemical Biology, 8, 322-323 (2012) Link

Engineering of plant type III polyketide synthases
Wakimoto, T., Morita, H., Abe, I.
Methods in Enzymology, in press (2012) Link

Labile natural products
Wakimoto, T., Abe, I.
MedChemComm, 3, in press (2012) Link

Calyxamides A and B, cytotoxic cyclic peptides from the marine sponge Discodermia calyx
Kimura, M., Wakimoto, T., Egami, Y., Tan, K. C., Ise, Y., Abe, I.
J. Nat. Prod., 75, 290-294 (2012) Link

Expression, purification, and crystallization of an indole prenyltransferase from Aspergillus fumigatus
Chen, J., Morita, H., Kato, R., Noguchi, H., Sugio, S., Abe, I.
Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun., 68, 355-358 (2012) Link

Molecular cloning and characterization of copper amine oxidase from Huerzia serrata
Sun, J., Morita, H., Chen, G., Noguchi, H., Abe, I.
submitted for publication (2012) Link

Benzophenone synthase from Garcinia mangostana L. Pericarp
Nualkaew, N., Morita, H., Shimokawa, Y., Kinjo K., Kushiro, T., De-Eknamkul, W., Ebizuka, Y., Abe, I.
Phytochemistry, 77, 60-69 (2012) Link

Benzalacetone synthase
Shimokawa, Y., Morita, H., Abe, I.
Frontiers in Plant Science, 3, Article 57 (2012) Link

A heptaketide naphthaldehyde produced by a polyketide synthase from Nectria haematococca
Awakawa, T., Kaji, T., Wakimoto, T., Abe, I.
Bioorg. Med. Chem. Lett., in press (2012) Link

The Oxidosqualene cyclases: one substrate , diverse products
Abe, I.
Natural Products: Discourse, Diversity and Design, Wiley-Blackwell, Chapter, in preparation (2012) Link

Identification of a key prenyltransferase involved in biosynthesis of the most abundant fungal meroterpenoids derived from 3,5-dimethylorsellinic acid
Itoh, T., Tokunaga, K., Radhakrishnan, E. K., Fujii, I., Abe, I., Ebizuka, Y., Kushiro, T.
ChemBioChem, 13, in press (2012) Link

Matsuda, Y., Awakawa, T., Itoh, T., Wakimoto, T., Kushiro, T., Fujii, I., Ebizuka, Y., Abe, I.
submitted for publication (2012) Link

Matsuda, Y., Awakawa, T., Kushiro, T., Abe, I.
manuscript in preparation (2012) Link

Chen, J., Morita, H., Wakimoto, T., Mori, T., Noguchi, H., Abe, I.
manuscript in preparation (2012) Link

He, R., Wakimoto, T., Takeshige, Y., Egami, Y., Kenmoku, H., Ito, T, Wang, B., Asakawa, Y., Abe, I.
submitted for publication (2012) Link

2011

Synthesis of unnatural alkaloid scaffolds by exploiting plant polyketide synthase
Morita, H., Yamashita, M., Shi, S.-P., Wakimoto, T., Kondo, S., Kato, R., Sugio, S., Kohno, T., Abe, I.
Proc. Natl. Acad. Sci. USA, 108, 13504-13509 (2011) Link

Cytotoxic tetramic acid derivative produced by a plant type III polyketide synthase
Wakimoto, T., Mori, T., Morita, H., Abe, I.
J. Am. Chem. Soc., 133, 4746-4749 (2011) Link

Furan fatty acid as an anti-inflammatory component from green-lipped mussel Perna canaliculus
Wakimoto, T., Kondo, H., Nii, H., Kimura, K., Egami, Y., Oka, Y., Yoshida, M., Kida, E., Ye, Y.-p., Akahoshi, S., Asakawa, T., Matsumura, K., Ishida, H., Nukaya, H., Tsuji, K., Kan, T., Abe, I.
Proc. Natl. Acad. Sci. USA, 108, 17533-17537 (2011) Link

Crystallization and preliminary X-ray analysis of 4-coumarate:CoA ligase from Arabidopsis thaliana
Morita, H., Mori, T., Wanibuchi, K., Kato, R., Sugio, S., Abe, I.
Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun., 67, 409-411 (2011) Link

Enzymatic formation of an aromatic dodecaketide by engineered plant polyketide synthase
Wanibuchi, K., Morita, H., Noguchi, H., Abe, I.
Bioorg. Med. Chem. Lett., 21, 2083-2086 (2011) Link

Proof of the existence of an unstable amino acid, pleurocybellaziridine, in Pleurocybella porrigens (angel's wing mushroom)
Wakimoto, T., Asakawa, T., Akahoshi, S., Suzuki, T., Nagai, K., Kawagishi, H., Kan, T.
Angew. Chem. Int. Ed., 50, 1168-1170 (2011) Link

Enantioselective total synthesis of aperidine
Wakimoto, T., Miyata, K., Ohuchi, H., Asakawa, T., Nukaya, H., Suwa, Y., Kan, T.
Org. Lett., 13, 2789-2791 (2011) Link

Characterization of the biosynthesis gene cluster for alkyl-O-dihydrogeranyl-methoxyhydroquinones in Actinoplanes missouriensis
Awakawa, T., Fujita, N., Hayakawa, M., Ohnishi, Y., Horinouchi, S.
ChemBioChem, 12, 439-448 (2011) Link

Enzymatic synthesis of unnatural cyclic triterpenes
Abe, I.
Isoprenoid Synthesis in Plants and Microorganisms, Springer, Chapter X, in press (2011) Link

2010

A structure-based mechanism for benzalacetone synthase from Rheum palmatum
Morita, H., Shimokawa, Y., Tanio, M., Kato, R., Noguchi, H., Sugio, S., Kohno, T., Abe, I.
Proc. Natl. Acad. Sci. USA, 107, 669-673 (2010) Link

Structural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativa
Morita, H., Wanibuchi, K., Nii, H., Kato, R., Sugio, S., Abe, I.
Proc. Natl. Acad. Sci. USA, 107, 19778-19783 (2010) Link

Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases
Itoh, T., Tokunaga, K., Matsuda, Y., Fujii, I., Abe, I., Ebizuka, Y., Kushiro, T.
Nature Chemistry, 2, 858-864 (2010) Link

Alkylresorcinol synthases expressed in Sorghum bicolor root hairs play an essential role in the biosynthesis of the allelopathic benzoquinone sorgoleone
Cook,D., Rimando, A. M., Clemente, T. E., Schröder, J., Dayan, F. E., Nanayakkara, N. P. D., Pan, Z., Noonan, B. P., Fishbein, M., Abe, I., Duke, S. O., Baerson, S. R.
Plant Cell, 22, 867-887 (2010) Link

Structure and function of the chalcone synthase superfamily of plant type III polyketide synthases
Abe, I., Morita , H.
Nat. Prod. Rep., 27, 809-838 (2010) Link

Enzymatic synthesis of plant polyketides
Abe, I.
Topics in Current Chemistry, 297, 45-66 (2010) Link

Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase
Kimura, M., Kushiro, T., Shibuya, M., Ebizuka, Y., Abe, I.
Biochem. Biophys. Res. Commun., 391, 899-902 (2010) Link

Expression, purification and crystallization of a plant type III polyketide synthase that produces diarylheptanoids
Morita, H., Wanibuchi, K., Kato, R., Sugio, S., Abe, I.
Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun., 66, 948-950 (2010) Link

Structure-based engineering of benzalacetone synthase
Shimokawa, Y., Morita, H., Abe, I.
Bioorg. Med. Chem. Lett., 20, 5099-5103 (2010) Link

Bacterial squalene cyclase
Abe, I.
Comprehensive Natural Products II: Chemistry and Biology, Vol. 1, Elsevier, 709-732 (2010) Link

Plant polyketide synthase
Morita, H., Abe, I., Noguchi, H.
Comprehensive Natural Products II: Chemistry and Biology, Vol. 1, Elsevier, 171-225 (2010) Link

Enzymatic synthesis of cyclic triterpenes
Kushiro, T., Abe, I.
Pentacyclic Triterpenes as Promising Agents in Cancer, Nova Publishers, Chapter 2 (2010) Link

Triterpene
Kushiro , T., Ebizuka, Y.
Comprehensive Natural Products II: Chemistry and Biology, Vol. 1, Elsevier, 673-708 (2010) Link

2009

Enzymatic formation of unnatural novel chalcone, stilbene, and benzophenone scaffolds by plant type III polyketide synthase
Shi, S.-P., Wanibuchi, K., Morita, H., Endo, K., Noguchi, H. Abe, I.
Org. Lett., 11, 551-554 (2009) Link

Novel type III polyketide synthases from Aloe arborescens
Mizuuchi, Y., Shi, S.-P., Wanibuchi, K., Kojima, A., Morita, H., Noguchi, H., Abe, I.
FEBS J., 276, 2391-2401(2009) Link

Enzymatic formation of unnatural novel polyketide scaffolds by plant type III polyketide synthase
Shi, S.-P., Morita, H., Wanibuchi, K., Noguchi, H., Abe, I.
Tetrahedron Lett., 50, 2150-2153 (2009) Link

Biosynthesis of steroidal antibiotic fusidanes: functional analysis of oxidosqualene cyclase and subsequent tailoring enzymes from Aspergillus fumigatus
Mitsuguchi, H., Seshime, Y., Fujii, I., Shibuya, M., Ebizuka, Y., Kushiro, T.
J. Am. Chem. Soc., 131, 6402-6411 (2009) Link