東京大学大学院薬学系研究科 天然物化学教室
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2017

TBA
Nakashima, Y. et al.
submitted for publication (2017) Link

Molecular basis for the unusual ring reconstruction in fungal meroterpenoid biogenesis
Mori, T., Iwabuchi, T., Hoshino, S., Wang, H., Matsuda, Y., Abe, I.
Nature Chem. Biol., 13, 1066-1073 (2017) Link | Press Release

TBA
Lv, J.-M. et al.
submitted for publication (2017) Link

Characterization of giant modular PKSs provides insight into genetic mechanism for structural diversification of aminopolyol polyketides
Zhang, L., Hashimoto, T., Qin, B., Hashimoto, J., Kozone, I., Kawahara, T., Okada, M., Awakawa, T., Ito, T., Asakawa, Y., Ueki, M., Takahashi, S., Osada, H., Wakimoto, T., Ikeda, H., Shin-ya, K., Abe, I.
Angew. Chem. Int. Ed., 56, 1740-1745 (2017) Link | Hot Paper | Frontispiece | Press Release

TBA
Wong, C. P. et al.
manuscript in preparation (2017) Link

Mechanistic characterization of two chimeric sesterterpene synthases from Penicillium
Mitsuhashi, T.,# Rinkel, J.,# Okada, M., Abe, I., Dickschat, J. S. (#equall contribution)
Chem. Eur. J., 23, 10053-10057 (2017) Link

Unique chemistry of non-heme iron dependent enzymes in fungal biosynthetic pathway
Nakamura, H., Abe, I.
Nat. Prod. Rep., manuscript in preparation (2017) Link

TBA
Awakawa, T., Abe, I.
Org. Biomol. Chem., manuscript in preparation (2017) Link

Combinatorial biosynthesis of (+)-daurichromenic acid and its halogenated analogue
Okada, M., Saito, K., Wong, C. P., Li, C., Wang, D., Iijima, M., Taura, F., Kurosaki, F., Awakawa, T., Abe, I.
Org. Lett., 19, 3183-3186 (2017) Link

Mycolic acid-containing bacterium stimulates tandem cyclization of polyene macrolactam in a lake sediment-derived rare actinomycete
Hoshino, S., Okada, M., Awakawa, T., Asamizu, S., Onaka, H., Abe, I.
Org. Lett., 19, in press (2017) Link

Identification of chimeric αβγ diterpene synthases possessing both type II terpene cyclase and prenyltransferase activities
Mitsuhashi, T., Okada, M., Abe, I.
ChemBioChem, 18, in press (2017) Link | Very Important Paper

2-Alkylquinolone alkaloid biosynthesis by collaboration of two novel type III polyketide synthases in Evodia rutaecarpa
Matsui, T., Kodama, T., Mori, T., Tadakoshi, T., Noguchi, H., Abe, I., Morita, H.
J. Biol. Chem., 292, 9117-9135 (2017) Link

Identification of pyridinium with three indole moieties as an antimicrobial agent
Okada, M., Sugita,T., Wong, C. P., Wakimoto, T., Abe, I.
J. Nat. Prod., 80, 1205-1209 (2017) Link

Posttranslational isoprenylation of tryptophan in bacteria
Okada, M., Sugita, T., Abe, I.
Beilstein J. Org. Chem., 13, 338-346 (2017) Link

Identification and characterization of daurichromenic acid synthase active in anti-HIV biosynthesis
Iijima, M., Munakatab, R., Takahashi, H., Kenmoku, H., Nakagawa, R., Kodama, T., Asakawa, Y., Abe, I., Yazaki, K., Kurosaki, F., Taura, F.
Plant Physiol., 174, 2213-2230 (2017) Link

3,5-Dimethylorsellinic acid derived meroterpenoids from Penicillium chrysogenum MT-12, an endophytic fungus isolated from Huperzia serrata
Qi, B., Liu, X., Mo, T., Zhu, Z., Li, J. Wang, J., Shi, X., Zeng, K., Wang, X., Tu, P., Abe, I., Shi, S.
J. Nat. Prod., accepted for publication (2017) Link

Labdane diterpenoids from Curcuma amada rhizomes collected in Myanmar and their antiproliferative activities
Win, N. N, Ito, T., Ngwe, H., Win, Y. Y., Prema, Okamoto, Y., Tanaka, M., Asakawa, Y., Abe, I., Morita, H.
Fitoterapia, 32, 34-39 (2017) Link

Naturally occurring Vpr inhibitors from medicinal plants of Myanmar
Win, N. N., Ngwe, H., Abe, I., Morita, H.
J. Nat. Med., in press (2017) Link

Bifunctionality of ActIV as a cyclase-thioesterase revealed by in vitro reconstitution of actinorhodin biosynthesis in Streptomyces coelicolor A3(2)
Taguchi, T.,# Awakawa, T.,# Nishihara, Y., Kawamura, M., Ohnishi, Y., Ichinose, K. (#equall contribution)
ChemBioChem, 18, 316-323 (2017) Link

A new strategy for aromatic ring alkylation in cylindrocyclophane biosynthesis
Nakamura, H., Schultz, E. E., Balskus, E. P.
Nature Chem. Biol., 13, 916-921 (2017) Link

Enzymatic C-H amidation in the production of natural and unnatural thiotetronate antibiotics with potentiated bioactivity
Li, J., Tang, X., Awakawa, T., Moore, B. S.
Angew. Chem. Int. Ed., 56, in press (2017) Link

微生物由来テルペンインドールアルカロイド-テレオシジン生合成
淡川孝義, 阿部郁朗
アルカロイドの化学, 化学同人, 第7章, pp. 134-148 (2017)

納豆のネバネバを引き起こす翻訳後修飾によりトリプトファン残基がイソプレニル化された修飾ペプチド
岡田正弘, 阿部郁朗
バイオサイエンスとインダストリー, in press (2017)

プチドのトリプトファンプレニル化酵素の新展開
岡田正弘
化学と工業, in press (2017) Link

2016

Manipulation of prenylation reactions by structure-based engineering of bacterial indolactam prenyltransferases
Mori, T., Zhang, L., Awakawa, T., Hoshino, S., Okada, M., Morita, H., Abe, I.
Nature Commun., 7, 10849 (2016) Link | Open Access | Press Release

Structural insight into the enzymatic formation of bacterial stilbene
Mori, T., Awakawa, T., Shimomura, K., Saito, Y., Yang, D., Morita, H., Abe, I.
Cell Chem. Biol., 23, 1468-1479 (2016) Link | Preview

Discovery of key dioxygenases that diverged the paraherquonin and acetoxydehydroaustin pathways in Penicillium brasilianum
Matsuda, Y.,# Iwabuchi,T.,# Fujimoto, T., Awakawa,T., Nakashima, Y., Mori, T., Zhang, H., Hayashi, F., Abe, I. (#equall contribution)
J. Am. Chem. Soc., 138, 12671-12677 (2016) Link

Genome-based discovery of an unprecedented cyclization mode in fungal sesterterpenoids biosynthesis
Okada, M.,# Matsuda, Y.,# Mitsuhashi, T., Hoshino, S., Mori, T., Nakagawa, K., Quan, Z., Qin, B., Zhang, H., Hayashi, F., Kawaide, H., Abe, I. (#equall contribution)
J. Am. Chem. Soc., 138, 10011-10018 (2016) Link | JACS Spotlights

Astellifadiene, a unique tetracyclic fungal sesterterpene: structure determination by an NMR-coupled crystalline sponge method and elucidation of its biosynthesis
Matsuda, Y.,# Mitsuhashi,T.,# Lee, S.,# Hoshino, M., Mori, T., Okada, M., Zhang, H., Hayashi, F., Fujita, M., Abe, I. (#equall contribution)
Angew. Chem. Int. Ed., 55, 5785-5788 (2016) Link

An unusual chimeric diterpene synthase from Emericella variecolor and its functional conversion to a sesterterpene synthase by domain swapping
Qin, B.,# Matsuda, Y.,# Mori, T., Okada, M., Quan, Z., Mitsuhashi, T., Wakimoto, T., Abe, I. (#equall contribution)
Angew. Chem. Int. Ed., 55, 1658-1661 (2016) Link | Front Cover | Press Release

Engineering of Candida glabrata Ketoreductase 1 for asymmetric reduction of α-halo ketones
Qin, F., Qin, B., Mori, T., Wang, Y., Meng, L., Zhang, X., Jia, Z., Abe, I., You, S.
ACS Catalysis, 6, 6135-6140 (2016) Link

Metagenomic analysis of the sponge Discodermia reveals the production of the cyanobacterial natural product kasumigamide by 'Entotheonella'
Nakashima, Y., Egami, Y., Kimura, M., Wakimoto, T., Abe, I.
PLoS ONE, 11(10): e0164468 (2016) Link | Open Access

Biosynthesis of fungal meroterpenoids
Matsuda, Y., Abe, I.
Nat. Prod. Rep., 33, 26-53 (2016) Link | Open Access

Nature's way of making the sponge-derived cytotoxin
Wakimoto, T., Egami, Y., Abe, I.
Nat. Prod. Rep., 33, 751-760 (2016) Link | Open Access | Front Cover

Unusual chemistries in fungal meroterpenoid biosynthesis
Matsuda, Y., Awakawa, T., Mori, T., Abe, I.
Curr. Opin. Chem. Biol., 31, 1-7 (2016) Link

Cytochrome P450 for citreohybridonol synthesis: oxidative derivatization of andrastin scaffold
Matsuda, Y.,# Quan, Z.,# Mitsuhashi, T., Li, C., Abe, I. (#equall contribution)
Org. Lett., 18, 296-299 (2016) Link

Stereospecific prenylation of tryptophan by a cyanobacterial post-translational modification enzyme
Okada, M., Sugita, T., Akita, K., Nakashima, Y., Tian, T., Li, C., Mori, T., Abe, I.
Org. Biomol. Chem., 14, 9639-9644 (2016) Link | Open Access

Sulfoureido lipopeptides from the marine sponge Discodermia kiiensis
Tan, K. C., Wakimoto, T., Abe, I.
J. Nat. Prod., 79, 2418–2422 (2016) Link

Structural diversification of lyngbyatoxin A by host-dependent heterologous expression of the tleABC biosynthetic gene cluster
Zhang, L., Hoshino, S., Awakawa, T., Wakimoto, T., Abe, I.
ChemBioChem, 17, 1407-1411 (2016) Link

Biosynthesis of LL-Z1272β: discovery of a new member of NRPS-like enzymes for aryl-aldehyde formation
Li, C., Matsuda, Y., Gao, H., Hu, D., Yao, X. S., Abe, I.
ChemBioChem, 17, 904-907 (2016) Link

Structural basis for olivetolic acid formation by a polyketide cyclase from Cannabis sativa
Yang, X., Matsui, T., Kodama, T., Mori, T., Zhou, X., Taura, F., Noguchi, H., Abe, I., Morita, H.
FEBS J., 283, 1088-1106 (2016) Link

Myanmarnicins H−M: new quassinoids from Picrasma javanica collected in Myanmar and their antiproliferative activities
Win, N. N., Ito, T., Ismail, Kodama, T., Win, Y. Y., Tanaka, M., Okamoto, Y., Imagawa, H., Ngwe, H., Asakawa, Y., Abe, I., Morita, H.
Tetrahedron, 72, 746-752 (2016) Link

Isopimarane diterpenoids from Kaempferia pulchra rhizomes Collected in Myanmar and their Vpr inhibitory activity
Win, N. N., Ito, T., Matsui, T., Aimaiti, S., Kodama, T., Ngwe, H., Okamoto, Y., Tanaka, M., Asakawa, Y., Abe, I., Morita, H.
Bioorg. Med. Chem. Lett., 26, 1789-1793 (2016) Link

Quassinoids: viral protein R inhibitors from Picrasma javanica bark collected in Myanmar for HIV infection
Win, N. N., Ito, T., Win, Y. Y., Ngwe, H., Kodama, T., Abe, I., Morita, H.
Bioorg. Med. Chem. Lett., 26, 4620-4624 (2016) Link

Effective production of aromatic polyketides in Streptomyces bacteria using combined-culture method
Hoshino, S., Okada, M., Onaka, H., Abe, I.
Nat. Prod. Commun., 11, 979-981 (2016) Link

Insight into the aroma profile of Bulgarian tobacco absolute oil
Nedeltcheva-Antonovaa, D., Ivanovaa, D., Antonova, L., Abe, I.
Industrial Crops and Products, 94, 226-232 (2016) Link

生合成の新しい設計図を書く
阿部郁朗
実験医学, 羊土社, 34, 2746-2747 (2016)

結晶構造を基盤とした天然物の生合成酵素工学
森貴裕, 阿部郁朗
化学工業, 67, 56-61 (2016)

海綿共生微生物による生物活性物質の生産
江上蓉子, 脇本敏幸, 阿部郁朗
バイオインダストリー, 33, 11-17 (2016)

芳香族化合物
阿部郁朗
パートナー天然物化学 改訂第3版, 南江堂, 第3章 (2016)

2015

Uncovering the unusual D-ring construction in terretonin biosynthesis by collaboration of a multifunctional cytochrome P450 and a unique isomerase
Matsuda, Y.,# Iwabuchi, T.,# Wakimoto, T., Awakawa, T., Abe, I. (#equall contribution)
J. Am. Chem. Soc., 137, 3393-3401 (2015) Link

Rational control of polyketide extender units by structure-based engineering of a crotonyl-CoA carboxylase/reductase in antimycin biosynthesis
Zhang, L., Mori, T., Zheng, Q., Awakawa, T., Yan, Y., Liu, W., Abe, I.
Angew. Chem. Int. Ed., 54, 13462-13465 (2015) Link | Press Release

Structural basis for the β-carboline alkaloids production by the microbial homodimeric enzyme McbB
Mori, T., Hoshino, S., Sahashi, S., Wakimoto, T., Matsui, T., Morita, H., Abe, I.
Chemistry & Biology, 22, 898-906 (2015) Link | Preview

Structural basis for the formation of acylalkylpyrones from two β-ketoacyl units by the fungal type III polyketide synthase CsyB
Mori, T., Yang, D., Matsui, T, Hashimoto, M., Morita, H., Fujii, I., Abe, I.
J. Biol. Chem., 290, 5214-5225 (2015) Link

Molecular basis for stellatic acid biosynthesis: a genome mining approach for discovery of sesterterpene synthases
Matsuda, Y.,# Mitsuhashi, T.,# Quan, Z., Abe, I. (#equall contribution)
Org. Lett., 17, 4644-4647 (2015) Link

Chojalactones A-C, cytotoxic butanolides isolated from Streptomyces sp. cultivated with mycolic acid containing bacterium
Hoshino, S., Wakimoto, T., Onaka, H., Abe, I.
Org. Lett., 17, 1501-1504 (2015) Link

Niizalactams A-C, multicyclic macrolactams isolated from combined-culture of Streptomyces sp. with mycolic acid containing bacterium
Hoshino, S., Okada, M., Wakimoto, T., Zhang, H., Hayashi, F., Onaka, H., Abe, I.
J. Nat. Prod., 78, 3011-3017 (2015) Link

Production of indole antibiotics induced by exogenous gene derived from sponge metagenome
Takeshige, Y., Egami, Y., Wakimoto, T., Abe, I.
Mol. BioSyst., 11, 1290-1294 (2015) Link

Dietziamides, novel tetramic acid dimers from Dietzia timorensis MZ-3 with antioxidative activity
Hoshino, S., Wakimoto, T., Zhang, H., Hayashi, F., Okada, M., Abe, I.
Bioorg. Med. Chem. Lett., 25, 3953-3955 (2015) Link

Arcyriaflavin E, a new cytotoxic indolocarbazole alkaloid isolated by combined-culture of mycolic acid-containing bacteria and Streptomyces cinnamoneus NBRC 13823
Hoshino, S., Zhang, L., Awakawa, T., Wakimoto, T., Onaka, H., Abe, I.
J. Antibiot., 68, 342-344 (2015) Link

Myanmarnicins A−G, quassinoids from Picrasma javanica collected in Myanmar
Win, N. N., Ito, T., Ismail, Kodama, T., Win, Y. Y., Tanaka, M., Ngwe, H., Asakawa, Y., Abe, I., Morita, H.
J. Nat. Prod., 78, 3024-3030 (2015) Link

Kaempulchraols P−T, diterpenoids from the Kaempferia pulchra rhizomes collected in Myanmar
Win, N. N., Ito, T., Aimaiti, S., Kodama, T., Tanaka, M., Ngwe, H., Asakawa, Y., Abe, I., Morita, H.
J. Nat. Prod., 78, 2306-2309 (2015) Link

Diterpenes kaempulchraols A−J from the rhizomes of Kaempferia pulchra of Myanmar and their antiproliferative activity
Win, N. N., Ito, T., Aimaiti, S., Imagawa, H., Ngwe, H., Abe, I., Morita, H.
J. Nat. Prod., 78, 1113-1118 (2015) Link

Kaempulchraols I−O: New isopimarane diterpenoids from the rhizomes of Kaempferia pulchra collected in Myanmar and their antiproliferative activity
Win, N. N., Ito, T., Aimaiti, S., Kodama, T., Imagawa, H., Ngwe, H., Asakawa, Y., Abe, I., Morita, H.
Tetrahedron, 71, 4707-4713 (2015) Link

Very-long-chain 3-hydroxy fatty acids, 3-hydroxy fatty acid methyl esters and 2-alkanols from cuticular waxes of Aloe arborescens leaves
Racovita, R. C., Peng, C., Awakawa, T., Abe, I., Jetter, R.
Phytochemistry, 113, 183-194 (2015) Link

Crystallization and preliminary X-ray diffraction analysis of a plant polyketide cyclase from Cannabis sativa
Yang, X., Matsui, T., Mori, T., Taura, F., Noguchi, H., Abe, I., Morita, H.
Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun., 71, 1470-1474 (2015) Link

Salinipyrone and pacificanone are biosynthetic byproducts of the rosamicin polyketide synthase
Awakawa, T., Cruesemann, M., Munguia, J., Ziemert, N., Nizet V., Fenical, W., Moore, B. S.
ChemBioChem, 16, 1443-1447 (2015) Link

Chemoenzymatic synthesis of acyl coenzyme A substrates enables in situ labeling of small molecules and proteins
Agarwal, V., Diethelm, S., Ray, L., Garg, N., Awakawa, T., Dorrestein, P. C., Moore, B. S.
Org. Lett., 17, 4452-4455 (2015) Link

Cytotoxic cyclic peptides from the marine sponges
Wakimoto, T., Tan, K. C., Tajima, H., Abe, I.
Handbook of Anticancer Drugs from Marine Origin, Springer, Chapter 6, pp. 113-144 (2015) Link

海綿ー共生微生物系の化学防御機構
脇本敏幸, 江上蓉子, 阿部郁朗
化学と生物, 53, 497-499 (2015)

海綿動物の化学防御を担う共生細菌
江上蓉子, 脇本敏幸, 阿部郁朗
細胞工学, 34, 412-416 (2015)

カイメンー共生バクテリア系の化学防御機構
脇本敏幸, 阿部郁朗
バイオサイエンスとインダストリー, 73, 49-51 (2015)

自然が誇るデザイナー、酸化酵素の生み出す多彩な分子骨格
松田侑大, 阿部郁朗
化学, 70, 66-67 (2015)

ゲノム情報に基づいた天然物生産の試み
阿部郁朗
第二次先端ウォッチング:天然物化学研究の最前線、生合成とケミカルバイオロジーの新展開,日本化学会, pp.25-29 (2015)

2014

Complete biosynthetic pathway of anditomin: nature's sophisticated synthetic route to a complex fungal meroterpenoid
Matsuda, Y., Wakimoto, T., Mori, T., Awakawa, T., Abe, I.
J. Am. Chem. Soc., 136, 15326–15336 (2014) Link | Front Cover | JACS Spotlights

Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont
Wakimoto, T.,# Egami, Y.,# Nakashima, Y., Wakimoto,Y., Mori, T., Awakawa,T., Ito, T., Kenmoku, H., Asakawa, Y., Piel, J., Abe, I. (#equall contribution)
Nature Chem. Biol., 10, 648-655 (2014) Link | News & Views | Press Release

A methyltransferase initiates terpene cyclization in teleocidin B biosynthesis
Awakawa, T., Zhang, L., Wakimoto, T., Hoshino, S., Mori, T., Ito, T., Ishikawa, J., Tanner, M. E., Abe, I.
J. Am. Chem. Soc., 136, 9910-9913 (2014) Link | Faculty of 1000

An environmental bacterial taxon with a large and distinct metabolic repertoire
Wilson, M. C., Mori, T., Rückert, C., Uria, A. R., Helf, M. J., Takada, K., Gernert, C., Steffens, U. A. E., Heycke, N., Schmitt, S., Rinke, C., Helfrich, E. J. N., Brachmann, A. O., Gurgui, C., Wakimoto. T., Kracht, M., Crüsemann, M., Hentschel, U., Abe, I., Matsunaga, S., Kalinowski, J., Takeyama, H., Piel, J.
Nature, 506, 58-62 (2014) Link | News & Views | Press Release

Lipodiscamides A-C, new cytotoxic lipopeptides from the marine sponge Discodermia kiiensis
Tan, K. C., Wakimoto, T., Abe, I.
Org. Lett., 16, 3256-3259 (2014) Link

Three acyltetronic acid derivatives: noncanonical cryptic polyketides from Aspergillus niger identified by genome mining
Yang, X.-L., Awakawa, T., Wakimoto, T., Abe, I.
ChemBioChem, 15, 1578-1583 (2014) Link

Revised structure of cyclolithistide A, a cyclic depsipeptide from the marine sponge Discodermia japonica
Tajima, H., Wakimoto, T., Takada, K., Ise, Y., Abe, I.
J. Nat. Prod., 77, 154-158 (2014) Link

Phosphocalyculin C as a pyrophosphate protoxin of calyculin C in the marine sponge Discodermia calyx
Egami, Y., Wakimoto, T., Abe, I.
Bioorg. Med. Chem. Lett., 24, 5150-5153 (2014) Link

Expression, purification, and crystallization of a fungal type III polyketide synthase that produces the csypyrones
Yang, D., Mori, T., Matsui, T., Hashimoto, M., Morita, H., Fujii, I., Abe, I.
Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun., 70, 730-733 (2014) Link

Crystallization and preliminary X-ray diffraction analysis of AntE, a crotonyl-CoA carboxylase/reductase from Streptomyces sp. NRRL 2288
Zhang, L., Chen, J., Mori, T., Yan, Y., Liu, W., Abe, I.
Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun., 70, 734-737 (2014) Link

Meroterpenoids
Matsuda, Y., Abe, I.
Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, Springer, Chapter 13, pp. 289-301 (2014) Link

The oxidosqualene cyclases: one substrate, diverse products
Abe, I.
Natural Products: Discourse, Diversity and Design, Wiley, Chapter 16, pp. 297-316 (2014) Link

生合成工学による創薬
阿部郁朗
ファルマシア, 50, 509-511 (2014)

植物ポリケタイド合成酵素の機能制御による非天然型化合物生産
淡川孝義, 森 貴裕, 阿部郁朗
生物工学会誌, 92, 420-423 (2014)

2013

Spiro-ring formation is catalyzed by a multifunctional dioxygenase in austinol biosynthesis
Matsuda, Y., Awakawa, T., Wakimoto, T., Abe, I.
J. Am. Chem. Soc., 135, 10962-10965 (2013) Link

Cloning and structure-function analyses of quinolone- and acridone-producing novel type III polyketide synthases from Citrus microcarpa
Mori, T., Shimokawa, Y., Matsui, T., Kinjo, K., Kato, R., Noguchi, H., Sugio, S., Morita, H., Abe, I.
J. Biol. Chem., 288, 28845-28858 (2013) Link

Multiplexing of combinatorial chemistry in antimycin biosynthesis expands the molecular diversity and utility
Yan Y., Chen, J., Zhang, L., Zheng, Q., Han, Y., Zhang, H., Awakawa, T., Abe, I., Liu, W.
Angew. Chem. Int. Ed., 52, 12308-12312 (2013) Link | Press Release

Pyranonigrin E: a novel PKS-NRPS hybrid metabolite from Aspergillus niger identified by genome mining
Awakawa, T., Yang, X.-L., Wakimoto, T., Abe, I.
ChemBioChem, 14, 2095-2099 (2013) Link

Reconstituted biosynthesis of fungal meroterpenoid andrastin A
Matsuda, Y., Awakawa, T., Abe, I.
Tetrahedron, 69, 8199-8204 (2013) Link

Cycloforskamide, a cytotoxic macrocyclic peptide from the sea slug Pleurobranchus forskalii
Tan, K. C., Wakimoto, T., Takada, K., Ohtsuki, T., Uchiyama, N., Goda, Y., Abe, I.
J. Nat. Prod., 76, 1388-1391 (2013) Link

Ergot alkaloid from the sea slug Pleurobranchus forskalii
Wakimoto, T., Tan, K. C., Abe, I.
Toxicon, 72, 1-4 (2013) Link

FK506 maturation involves a cytochrome P450 protein-catalyzed four-electron C-9 oxidation in parallel with a C-31 O-methylation
Chen, D., Zhang, L., Pang, B., Chen, J., Xu, Z., Abe, I., Liu, W.
J. Bacteriol., 195, 1931-1939 (2013) Link

Induced production of the novel glycolipid ustilagic acid C in the plant pathogen Ustilago maydis
Yang, X.-L., Awakawa, T., Wakimoto, T., Abe, I.
Tet. Lett., 54, 3655-3657 (2013) Link

Induced production of novel prenyldepside and coumarins in endophytic fungi Pestalotiopsis acaciae
Yang, X.-L., Awakawa, T., Wakimoto, T., Abe, I.
Tet. Lett., 54, 5814-5817 (2013) Link

Indole-porphyrin hybrids produced by metagenomics
Yang, X.-L., Wakimoto, T., Takeshige, Y., He, R., Egami, Y., Abe, I.
Bioorg. Med. Chem. Lett., 23, 3810-3813 (2013) Link

Induced biosyntheses of a novel butyrophenone and two aromatic polyketides in the plant pathogen Stagonospora nodorum
Yang, X.-L., Awakawa, T., Wakimoto, T., Abe, I.
Nat. Prod. Bioprospect., 3, 141-144 (2013) Link

Epigenetic modifier-induced biosynthesis of novel fusaric acid derivatives in endophytic fungi from Datura stramonium L.
Chen, H., Awakawa, T., Sun, J., Wakimoto, T., Abe, I.
Nat. Prod. Bioprospect., 3, 20-23 (2013) Link

Replacement of a quinone by a 5-O-acetylhydroquinone abolishes accidental necrosis-inducing effect while preserving apoptosis-inducing effect of renieramycin M in lung cancer cells
Cheun-Arom, T., Chanvorachote, P., Sirimangkalakitti, N., Chuanasa, T., Saito, N., Abe, I., Suwanborirux, K.
J. Nat. Prod., 76, 1468-1474 (2013) Link

Cyclodipeptides from metagenomic library of a Japanese marine sponge
He, R., Wang, B., Wakimoto, T., Wang, M., Zhu, L., Abe, I.
J. Braz. Chem. Soc., 24, 1926-1932 (2013) Link

3-Methyl-6-(3'-oxoalkan-2'-yl)-2-pyrone syntheses by a type III polyketide synthase from Rhodospirillum centenum
Awakawa, T., Sugai, Y., Otsutomo, K., Ren, S., Masuda, S., Katsuyama, Y., Ohnishi, Y., Horinouchi, S.
ChemBioChem, 14, 1006-1013 (2013) Link

糸状菌由来メロテルペノイドの生合成研究とその応用
松田侑大, 阿部郁朗
酵素工学ニュース, 第69号, 26-30 (2013)

2012

Novel applications of plant polyketide synthases
Abe, I.
Curr. Opin. Chem. Biol., 16, 179-185 (2012) Link

Biosynthesis: an HR-PKS stereo surprise
Abe, I.
Nature Chem. Biol., 8, 322-323 (2012) Link

Engineering of plant type III polyketide synthases
Wakimoto, T., Morita, H., Abe, I.
Methods in Enzymology, 515, 337-358 (2012) Link

Prenylation of a nonaromatic carbon of indolylbutenone by a fungal indole prenyltransferase
Chen, J., Morita, H., Wakimoto, T., Mori, T., Noguchi, H., Abe, I.
Org. Lett., 14, 3080-3083 (2012) Link

Terretonin biosynthesis requires methylation as essential step for cyclization
Matsuda, Y., Awakawa, T., Itoh, T., Wakimoto, T., Kushiro, T., Fujii, I., Ebizuka, Y., Abe, I.
ChemBioChem, 13, 1738-1741 (2012) Link

Biosynthetic pathway for highly structural diversity of a common dilactone core in antimycin production
Yan, Y., Zhang, L., Ito, T., Qu, X., Asakawa, Y., Awakawa, T., Abe, I., Liu, W.
Org. Lett., 14, 4142-4145 (2012) Link

Labile natural products
Wakimoto, T., Abe, I.
MedChemComm, 3, 866-870 (2012) Link

Calyxamides A and B, cytotoxic cyclic peptides from the marine sponge Discodermia calyx
Kimura, M., Wakimoto, T., Egami, Y., Tan, K. C., Ise, Y., Abe, I.
J. Nat. Prod., 75, 290-294 (2012) Link

Allos-hemicalyculin A, a photochemically converted calyculin from the marine sponge Discodermia calyx
Kimura, M., Wakimoto, T., Abe, I.
Tet. Lett., 54, 114-116 (2012) Link

A heptaketide naphthaldehyde produced by a polyketide synthase from Nectria haematococca
Awakawa, T., Kaji, T., Wakimoto, T., Abe, I.
Bioorg. Med. Chem. Lett., 22, 4338-4340 (2012) Link

Porphyrins from a metagenomic library of the marine sponge Discodermia calyx
He, R., Wakimoto, T., Takeshige, Y., Egami, Y., Kenmoku, H., Ito, T, Wang, B., Asakawa, Y., Abe, I.
Mol. BioSyst., 6, 2334-2338 (2012) Link

Heterologously expressed β-hydroxyl fatty acids from a metagenomic library of a marine sponge
He, R., Wakimoto, T., Egami, Y., Kenmoku, H., Ito, T, Asakawa, Y., Abe, I.
Bioorg. Med. Chem. Lett., 22, 7322-7325 (2012) Link

Expression, purification, and crystallization of an indole prenyltransferase from Aspergillus fumigatus
Chen, J., Morita, H., Kato, R., Noguchi, H., Sugio, S., Abe, I.
Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun., 68, 355-358 (2012) Link

Molecular cloning and characterization of copper amine oxidase from Huerzia serrata
Sun, J., Morita, H., Chen, G., Noguchi, H., Abe, I.
Bioorg. Med. Chem. Lett., 22, 5784-5790 (2012) Link

Induced production of mycotoxins in an endophytic fungus from the medicinal plant Datura stramonium
Sun, J., Awakawa, T., Noguchi, H., Abe, I.
Bioorg. Med. Chem. Lett., 22, 6397-6400 (2012) Link

Benzophenone synthase from Garcinia mangostana L. Pericarp
Nualkaew, N., Morita, H., Shimokawa, Y., Kinjo K., Kushiro, T., De-Eknamkul, W., Ebizuka, Y., Abe, I.
Phytochemistry, 77, 60-69 (2012) Link

Benzalacetone synthase
Shimokawa, Y., Morita, H., Abe, I.
Frontiers in Plant Science, 3, 57 (2012) Link

Identification of a key prenyltransferase involved in biosynthesis of the most abundant fungal meroterpenoids derived from 3,5-dimethylorsellinic acid
Itoh, T., Tokunaga, K., Radhakrishnan, E. K., Fujii, I., Abe, I., Ebizuka, Y., Kushiro, T.
ChemBioChem, 13, 1132-1135 (2012) Link

Stereocontrolled total synthesis of (+)-UCS1025A
Uchida, T., Ogawa, T., Yasuda, Y., Mimura, H., Fujimoto, T., Fukuyama, T., Wakimoto, T., Asakawa, T., Hamashima, Y., Kan, T.
Angew. Chem. Int. Ed., 51, 12850-12853 (2012) Link

Enzymatic synthesis of unnatural cyclic triterpenes
Abe, I.
Isoprenoid Synthesis in Plants and Microorganisms, Springer, Chapter 27, pp. 393-403 (2012) Link

2011

Synthesis of unnatural alkaloid scaffolds by exploiting plant polyketide synthase
Morita, H., Yamashita, M., Shi, S.-P., Wakimoto, T., Kondo, S., Kato, R., Sugio, S., Kohno, T., Abe, I.
Proc. Natl. Acad. Sci. USA, 108, 13504-13509 (2011) Link

Cytotoxic tetramic acid derivative produced by a plant type III polyketide synthase
Wakimoto, T., Mori, T., Morita, H., Abe, I.
J. Am. Chem. Soc., 133, 4746-4749 (2011) Link

Furan fatty acid as an anti-inflammatory component from green-lipped mussel Perna canaliculus
Wakimoto, T., Kondo, H., Nii, H., Kimura, K., Egami, Y., Oka, Y., Yoshida, M., Kida, E., Ye, Y.-p., Akahoshi, S., Asakawa, T., Matsumura, K., Ishida, H., Nukaya, H., Tsuji, K., Kan, T., Abe, I.
Proc. Natl. Acad. Sci. USA, 108, 17533-17537 (2011) Link

Crystallization and preliminary X-ray analysis of 4-coumarate:CoA ligase from Arabidopsis thaliana
Morita, H., Mori, T., Wanibuchi, K., Kato, R., Sugio, S., Abe, I.
Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun., 67, 409-411 (2011) Link

Enzymatic formation of an aromatic dodecaketide by engineered plant polyketide synthase
Wanibuchi, K., Morita, H., Noguchi, H., Abe, I.
Bioorg. Med. Chem. Lett., 21, 2083-2086 (2011) Link

Molecular cloning, modeling and site-directed mutagenesis of type III polyketide synthase from Sargassum binderi
Baharum, H., Morita, H., Tomitsuka, A., Lee, F.-C., Ng, K.-Y., Rahim, R. A., Abe, I., Ho, C.-L.
Marine Biotech., 13, 845-856 (2011) Link

Proof of the existence of an unstable amino acid, pleurocybellaziridine, in Pleurocybella porrigens (angel's wing mushroom)
Wakimoto, T., Asakawa, T., Akahoshi, S., Suzuki, T., Nagai, K., Kawagishi, H., Kan, T.
Angew. Chem. Int. Ed., 50, 1168-1170 (2011) Link

Enantioselective total synthesis of aperidine
Wakimoto, T., Miyata, K., Ohuchi, H., Asakawa, T., Nukaya, H., Suwa, Y., Kan, T.
Org. Lett., 13, 2789-2791 (2011) Link

Characterization of the biosynthesis gene cluster for alkyl-O-dihydrogeranyl-methoxyhydroquinones in Actinoplanes missouriensis
Awakawa, T., Fujita, N., Hayakawa, M., Ohnishi, Y., Horinouchi, S.
ChemBioChem, 12, 439-448 (2011) Link

植物ポリケタイド合成酵素による生物活性テトラミン酸誘導体の合成
森貴裕, 脇本敏幸, 森田洋行, 阿部郁朗
バイオサイエンスとインダストリー, 69, 308-310 (2011)

二次代謝酵素の機能制御と生合成工学
森田洋行, 阿部郁朗
化学工業, 62, 102-108 (2011)

海からの抗炎症活性物質
脇本敏幸, 阿部郁朗
薬事日報「研究戦略・YAKU学」, 第10966号, 2011年4月8日

結晶構造を基盤とした植物ポリケタイド合成酵素の触媒機能の拡張
森田洋行
酵素工学ニュース, 第66号, 6-11 (2011)

2010

A structure-based mechanism for benzalacetone synthase from Rheum palmatum
Morita, H., Shimokawa, Y., Tanio, M., Kato, R., Noguchi, H., Sugio, S., Kohno, T., Abe, I.
Proc. Natl. Acad. Sci. USA, 107, 669-673 (2010) Link

Structural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativa
Morita, H., Wanibuchi, K., Nii, H., Kato, R., Sugio, S., Abe, I.
Proc. Natl. Acad. Sci. USA, 107, 19778-19783 (2010) Link

Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases
Itoh, T., Tokunaga, K., Matsuda, Y., Fujii, I., Abe, I., Ebizuka, Y., Kushiro, T.
Nature Chem., 2, 858-864 (2010) Link | News & Views | Faculty of 1000

Alkylresorcinol synthases expressed in Sorghum bicolor root hairs play an essential role in the biosynthesis of the allelopathic benzoquinone sorgoleone
Cook, D., Rimando, A. M., Clemente, T. E., Schröder, J., Dayan, F. E., Nanayakkara, N. P. D., Pan, Z., Noonan, B. P., Fishbein, M., Abe, I., Duke, S. O., Baerson, S. R.
Plant Cell, 22, 867-887 (2010) Link

Structure and function of the chalcone synthase superfamily of plant type III polyketide synthases
Abe, I., Morita, H.
Nat. Prod. Rep., 27, 809-838 (2010) Link | Front Cover

Enzymatic synthesis of plant polyketides
Abe, I.
Topics in Current Chemistry, 297, 45-66 (2010) Link

Protostadienol synthase from Aspergillus fumigatus: functional conversion into lanosterol synthase
Kimura, M., Kushiro, T., Shibuya, M., Ebizuka, Y., Abe, I.
Biochem. Biophys. Res. Commun., 391, 899-902 (2010) Link

Expression, purification and crystallization of a plant type III polyketide synthase that produces diarylheptanoids
Morita, H., Wanibuchi, K., Kato, R., Sugio, S., Abe, I.
Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun., 66, 948-950 (2010) Link

Structure-based engineering of benzalacetone synthase
Shimokawa, Y., Morita, H., Abe, I.
Bioorg. Med. Chem. Lett., 20, 5099-5103 (2010) Link

Bacterial squalene cyclase
Abe, I.
Comprehensive Natural Products II: Chemistry and Biology, Vol. 1, Elsevier, Chapter 19, pp. 709-732 (2010) Link

Plant polyketide synthase
Morita, H., Abe, I., Noguchi, H.
Comprehensive Natural Products II: Chemistry and Biology, Vol. 1, Elsevier, Chapter 6, pp. 171-225 (2010) Link

Enzymatic synthesis of cyclic triterpenes
Kushiro, T., Abe, I.
Pentacyclic Triterpenes as Promising Agents in Cancer, Nova Publishers, Chapter 2, pp. 13-47 (2010) Link

Triterpene
Kushiro , T., Ebizuka, Y.
Comprehensive Natural Products II: Chemistry and Biology, Vol. 1, Elsevier, Chapter 18, pp. 673-708 (2010) Link

天然薬物の生合成工学
阿部郁朗
戦略的創薬科学の魅力:東京大学大学院薬学系研究科からの発信, 廣川書店,119-134 (2010)

2009

Enzymatic formation of unnatural novel chalcone, stilbene, and benzophenone scaffolds by plant type III polyketide synthase
Shi, S.-P., Wanibuchi, K., Morita, H., Endo, K., Noguchi, H. Abe, I.
Org. Lett., 11, 551-554 (2009) Link

Novel type III polyketide synthases from Aloe arborescens
Mizuuchi, Y., Shi, S.-P., Wanibuchi, K., Kojima, A., Morita, H., Noguchi, H., Abe, I.
FEBS J., 276, 2391-2401(2009) Link

Enzymatic formation of unnatural novel polyketide scaffolds by plant type III polyketide synthase
Shi, S.-P., Morita, H., Wanibuchi, K., Noguchi, H., Abe, I.
Tetrahedron Lett., 50, 2150-2153 (2009) Link

Biosynthesis of steroidal antibiotic fusidanes: functional analysis of oxidosqualene cyclase and subsequent tailoring enzymes from Aspergillus fumigatus
Mitsuguchi, H., Seshime, Y., Fujii, I., Shibuya, M., Ebizuka, Y., Kushiro, T.
J. Am. Chem. Soc., 131, 6402-6411 (2009) Link

植物ポリケタイド合成酵素研究の最前線
森田洋行, 阿部郁朗
化学と生物, 47, 772-780 (2009)

植物ポリケタイド合成酵素の生合成工学
阿部郁朗
第二次先端ウォッチング:融合領域の創製 生合成工学,日本化学会, pp. 17-20 (2009)

糸状菌メロテルペノイド骨格合成酵素の機能解析
海老塚豊, 久城哲夫
第二次先端ウォッチング:融合領域の創製 生合成工学,日本化学会, pp. 11-15 (2009)