研究業績 Publications

2012年

  • "Rational Evolution of a Novel Type of Potent and Selective Proviral Integration Site in Moloney Murine Leukemia Kinase 1 (PIM1) Inhibitor from a Screening-hit Compound" Hirofumi Nakano, Nae Saito, Lorien Parker, Yukio Tada, Masanao Abe, Keiko Tsuganezawa, Shigeyuki Yokoyama, Akiko Tanaka, Hirotatsu Kojima, Takayoshi Okabe and Tetsuo Nagano, J. Med. Chem., in press.
  • "Red Fluorescent Scaffold for Highly Sensitive Protease Activity Probes" Yu Kushida, Kenjiro Hanaoka, Toru Komatsu, Takuya Terai, Tasuku Ueno, Kengo Yoshida, Masanobu Uchiyama, Tetsuo Nagano, Bioorg. Med. Chem. Lett., in press.
  • "Development of 5’- and 7’-Substituted Luciferin Analogues as Acid-Tolerant Substrates of Firefly Luciferase" Hideo Takakura, Ryosuke Kojima, Takeaki Ozawa, Tetsuo Nagano and Yasuteru Urano, ChemBiolChem, in press.
  • "Near-infrared Fluorescence Probes for Enzymes Based on Binding Affinity Modulation of Squarylium Dye Scaffold" Daihi Oushiki, Hirotatsu Kojima, Yuki Takahashi, Toru Komatsu, Takuya Terai, Kenjiro Hanaoka, Makiya Nishikawa, Yoshinobu Takakura and Tetsuo Nagano, Anal. Chem., 84, 4404-4410 (2012).
  • "Salicyclic Acid Derivatives as Antennae for Ratiometric Luminescent Probes Based on Lanthanide Complexes" Takuya Terai, Hiroki Ito, Kazuya Kikuchi, and Tetsuo Nagano, Chemistry-A European Journal, in press.
  • "Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells" Robert DeRose, Christopher Pohlmeyer, Nobuhiro Umeda, Tasuku Ueno, Tetsuo Nagano, Scot Kuo, and Takanari Inoue, Journal of Visualized Experiments, in press.
  • "Blockade of Inflammatory Responses by a Small-Molecule Inhibitor of the Rac Activator DOCK2" Akihiko Nishikimi, Takehito Uruno, Xuefeng Duan, Qinhong Cao, Yuji Okamura, Takashi Saitoh, Nae Saitoh, Shunsuke Sakaoka, Yao Du, Atsushi Suenaga, Mutsuko Kukimoto-Niino, Kei Miyano, Kazuhito Gotoh, Takayoshi Okabe, Fumiyuki Sanematsu, Yoshihiko Tanaka, Hideki Sumimoto, Teruki Honma, Shigeyuki Yokoyama, Tetsuo Nagano, Daisuke Kohda, Motomu Kanai and Yoshinori Fukui, Chem. & Biol., 19, 488-497 (2012).
  • "Development of NIR Fluorescent Dyes Based on Si-Rhodamine for In Vivo Imaging" Yuichiro Koide, Yasuteru Urano, Kenjiro Hanaoka, Wen Piao, Moriaki Kusakabe, Nae Saito, Takuya Terai, Takayoshi Okabe and Tetsuo Nagano, J. Am. Chem. Soc., 134, 5029-5031 (2012).
  • "Development of of hypoxia-sensitive Gd3+-based MRI contrast agents" Shimpei Iwaki, Kenjiro Hanaoka, Wen Piao, Toru Komatsu, Tasuku Ueno, Takuya Terai and Tetsuo Nagano, Bioorg. Med. Chem. Lett., 22, 2798-2802 (2012).
  • "A Reversible Near-Infrared Fluorescence Probe for Reactive Oxygen Species Based on Te-rhodamine" Yuichiro Koide, Mitsuyasu Kawaguchi, Yasuteru Urano, Kenjiro Hanaoka, Toru Komatsu, Takuya Terai and Tetsuo Nagano, Chem. Commun., 48, 3091-3093 (2012).
  • "Visible-Light-Triggered Release of Nitric Oxide from N-Pyramidal Nitrosamines" Fumika Karaki, Yoji Kabasawa, Takahiro Yanagimoto, Nobuhiro Umeda,Yasuteru Urano, Tetsuo Nagano, Yuki Otani and Tomohiko Ohwada, Chemistry-A European Journal, 18, 1127-1141(2012).
  • "A Long-Lived Luminescent Probe to Sensitively Detect Arylamine N-Acetyltransferase (NAT) Activity of Cells" Takuya Terai, Kazuya Kikuchi, Yasuteru Urano, Hirotatsu Kojima and Tetsuo Nagano, Chem. Commun., 48, 2234-2236(2012).
  • "A Practical Strategy to Create Near-Infrared Luminescent Probes: Conversion from Fluorescein-Based Sensors" Takuya Terai, Yasuteru Urano, Saki Izumi, Hirotatsu Kojima and Tetsuo Nagano, Chem. Commun., 48, 2840-2842(2012).
  • "A Novel Pim-1 Kinase Inhibitor Targeting Residues that Bind the Substrate Peptide" Keiko Tsuganezawa, Hisami Watanabe, Lorien Parker, Hitomi Yuki, Shigenao Taruya, Yukari Nakagawa, Daisuke Kamei, Masami Mori, Naoko Ogawa, Yuri Tomabechi, Noriko Handa, Teruki Honma, Shigeyuki Yokoyama, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano and Akiko Tanaka, J. Mol. Biol., 417, 240-252 (2012).
  • "機能性MRI造影剤の分子設計および動脈硬化イメージング" 花岡健二郎, 『疾患克服を目指したケミカルバイオロジー』、実験医学(増刊号), 30, 1120-1127(2012)
  • "誰もが使える化合物ライブラリーの構築によるスクリーニングから始める創薬研究の加速" 小島宏建、岡部隆義、長野哲雄, 『疾患克服を目指したケミカルバイオロジー』、実験医学(増刊号), 30, 1234-1239(2012)
  • "3章　バイオセンシングの歴史と将来展望" 花岡健二郎、長野哲雄, 『CSJカレントレビュー第10巻』化学同人, 印刷中
  • "創薬研究への応用を目指した蛍光プローブの開発" 寺井琢也、長野哲雄, 化学工業, 63, 47-53(2012)

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