Selected Papers
- Watanabe, K., Morishita, K., Zhou, X., Shiizaki, S., Uchiyma, Y., Koike, M., Naguro, I. and Ichijo, H.
Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose).
Nat. Commun., 12,1353 (2021).
- Nakamura, T., Ogawa, M., Kojima, K., Takayanagi, S., Ishihara, S., Hattori, K., Naguro, I. and Ichijo, H.
The mitochondrial Ca2+ uptake regulator, MICU1 is involved in cold stress-induced ferroptosis.
EMBO Rep., 22, e51532 (2021).
- Ogawa, M., Kawarazaki, Y., Fujita, Y., Naguro, I. and Ichijo, H.
FGF21 induced by the ASK1-p38 pathway promotes mechanical cell competition by attracting cells.
Curr. Biol., 31, 1-10 (2021).
- Ito-Kureha, T., Miyao, T., Nishijima, S., Suzuki, T., Koizumi, S., Villar-Briones, A., Takahashi, A., Akiyama, N., Morita, M., Naguro, I., Ishikawa, H., Ichijo, H., Akiyama, T. and Yamamoto, T.
The CCR4-NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression.
Nat. Commun., 11, 6169 (2020).
- Nakamura, R., Numata, T., Kasuya, G., Yokoyama, T., Nishizawa, T., Kusakizako, T., Kato, T., Hagino, T., Dohmae, N., Inoue, M., Watanabe, K., Ichijo, H., Kikkawa, M., Shirouzu, M., Jentsch, T.J., Ishitani, R., Okada, Y., Nureki, O.
Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation.
Commun. Biol., 3, 240 (2020).
- Sugawara, S., Kanamaru, Y., Sekine, S., Maekawa, L., Takahashi, A., Yamamoto, T., Watanabe, K., Fujisawa, T., Hattori, K. and Ichijo, H.
The mitochondrial protein PGAM5 suppresses energy consumption in brown adipocytes by repressing expression of uncoupling protein 1.
J. Biol. Chem., 295, 5588-5601 (2020).
- Homma, K., Takahashi, H., Tsuburaya, N., Naguro, I., Fujisawa, T. and Ichijo, H.
Genome-wide siRNA screening reveals that DCAF4-mediated ubiquitination of optineurin stimulates autophagic degradation of Cu/Zn superoxide dismutase.
J. Biol. Chem., 295, 3148-3158 (2020).
- Tsuburaya, N., Homma, K., Higuchi, T., Balia, A., Yamakoshi, H., Shibata, N., Nakamura, S., Nakagawa, H., Ikeda, S., Umezawa, N., Kato, N., Yokoshima, S., Shibuya, M., Shimonishi, M., Kojima, H., Okabe, T., Nagano, T., Naguro, I., Imamura, K., Inoue, H., Fujisawa, T., and Ichijo, H.
A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model.
Nat. Commun., 9, 2668 (2018).
- Watanabe, K., Umeda, T., Niwa, K., Naguro, I. and Ichijo, H.
A PP6-ASK3 module coordinates the bidirectional cell volume regulation under osmotic stress.
Cell Rep., 22, 2809-2817 (2018).
- Kasuya, G., Nakane, T., Yokoyama, T., Jia, Y., Inoue, M., Watanabe, K., Nakamura, R., Nishizawa, T., Kusakizako, T., Tsutsumi, A., Yanagisawa, H., Dohmae, N., Hattori, M., Ichijo, H., Yan, Z., Kikkawa, M., Shirouzu, M., Ishitani, R., Nureki, O.
Cryo-EM structures of the human volume-regulated anion channel LRRC8.
Nat. Struct. Mol. Biol., 25, 797-804 (2018).
- Imamura, K., Yoshitane, H., Hattori, K., Yamaguchi, M., Yoshida, K., Okubo, T., Naguro, I., Ichijo, H. and Fukada, Y.
ASK family kinases mediate cellular stress and redox signaling to circadian clock.
Proc. Natl. Acad. Sci. USA., 115, 3646-3651 (2018).
- Hirata, Y., Katagiri, K., Nagaoka, K., Morishita, T., Kudoh, Y., Hatta, T., Naguro, I., Kano, K., Udagawa, T., Natsume, T., Aoki, J., Inada, T., Noguchi, T., Ichijo, H. and Matsuzawa, A.
TRIM48 promotes ASK1 activation and cell death through ubiquitination-dependent degradation of the ASK1 negative regulator PRMT1.
Cell Rep., 21, 2447-2457 (2017).
- Hattori, K., Ishikawa, H., Sakauchi, C., Takayanagi, S., Naguro, I. and Ichijo, H.
Cold stress-induced ferroptosis involves the ASK1-p38 pathway.
EMBO Rep., 18, 2067-2078 (2017).
- Kamiyama, M., Shirai, T., Tamura, S., Suzuki-Inoue, K., Ehata, S., Takahashi, K., Miyazono, K., Hayakawa, Y., Sato, T., Takeda, K., Naguro, I. and Ichijo, H.
ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y12 in platelets.
Cell Death Differ., 24, 2066-2076 (2017).
- Chaikuad,A., Chaikuad, A., Filippakopoulos, P., Marcsisin, S. R., Picaud, S., Sekine, S., Ichijo, H., Engen, J. R.,Takeda, K. and Knapp, S.
Structures of PGAM5 provide insight into active site dynamics and multimeric assembly.
Structure, 25, 1089-1099 e3 (2017).
- Imamura, K., Izumi, Y., Watanabe, A., Tsukita, K., Woltjen, K., Yamamoto, T., Hotta, A., Kondo, T., Kitaoka, S., Ohta, A., Tanaka, A., Watanabe, D., Morita, M., Takuma, H., Tamaoka, A., Kunath, T., Wray, S., Furuya, H., Era, T., Makioka, K., Okamoto, K., Fujisawa, T., Nishitoh, H., Homma, K., Ichijo, H., Julien, J.-P., Obata, N., Hosokawa, M., Akiyama, H., Kaneko, S., Ayaki, T., Ito, H., Kaji, R., Takahashi, R., Yamanaka, S. and Inoue, H.
iPSC-based drug repositioning identifies the Src/c-Abl pathway as a therapeutic target for ALS motor neurons.
Sci. Transl. Med., 9, pii: eaaf3962 (2017).
- Koizumi, S., Irie, T., Hirayama, S., Sakurai, Y., Yashiroda, H., Naguro, I., Ichijo, H., Hamazaki, J. and Murata, S.
The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction.
eLIFE, 5, e18357 (2016).
- Hattori, K., Naguro, I., Okabe, K., Funatsu, T., Furutani, S., Takeda, K. and Ichijo, H.
ASK1 signaling regulates brown and beige adipocyte function.
Nat. Commun., 7, 11158 (2016).
- Sekine, S., Yao, A., Hattori, K., Sugawara, S., Naguro, I., Koike, M., Uchiyama, Y., Takeda, K. and Ichijo, H.
The ablation of mitochondrial protein phosphatase Pgam5 confers resistance against metabolic stress.
EBioMedicine, 5, 82-92 (2016).
- Fujisawa, T., Takahashi, M., Tsukamoto, Y., Yamaguchi, N., Nakoji, M., Endo, M., Kodaira, H., Hayashi, Y., Nishitoh, H., Naguro, I., Homma, K. and Ichijo, H.
The ASK1-specific inhibitors K811 and K812 prolong survival in a mouse model of amyotrophic lateral sclerosis.
Hum. Mol. Genet., 25, 245-253 (2016).
- Kadowaki, H., Nagai, A., Maruyama, T., Takami, Y., Fitrah, P.S., Kato, H., Honda, A., Hatta, T., Natsume, T., Sato, T., Kai, H., Ichijo, H. and Nishitoh, H.
Preemptive quality control protects the ER from protein overload via the proximity of ERAD components and SRP.
Cell Rep., 113, 944-956 (2015).
- Miyakawa, K., Matsunaga, S., Kanou, K., Matsuzawa, A., Morishita, R., Kudoh, A., Shindo, K., Yokoyama, M., Sato, H., Kimura, H., Tamura, T., Yamamoto, N., Ichijo, H., Takaori-Kondo, A. and Ryo, A.
ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction.
Nat. Commun., 6, 6945 (2015).
- Okazaki, T., Higuchi, M., Takeda, K., Iwatsuki-Horimoto, K., Kiso, M., Miyagishi, M., Yanai, H., Kato, A., Yoneyama, M., Fujita, T., Taniguchi, T., Kawaoka, Y., Ichijo, H. and Gotoh, Y.
The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response.
Sci. Signal., 8, ra78 (2015).
- Mosallanejad, K., Sekine, Y., Ishikura-Kinoshita, S., Kumagai, K., Nagano, T., Matsuzawa, A.,Takeda, K., Naguro, I. and Ichijo, H.
The DEAH-Box RNA Helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses.
Sci. Signal., 7, ra40 (2014).
- Maruyama, T., Araki, T., Kawarazaki, Y., Naguro, I., Heynen, S., Aza-Blanc, P., Ronai, Z., Matsuzawa, A., Ichijo, H.
Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses.
Sci. Signal., 7, ra8 (2014).
- Homma, K., Fujisawa, T., Tsuburaya, N., Yamaguchi, N., Kadowaki, H., Takeda, K., Nishitoh, H., Matsuzawa, A., Naguro, I., and Ichijo, H.
SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency.
Mol. Cell, 52, 75-86 (2013).
- Naguro, I., Umeda, T., Kobayashi, Y., Maruyama, J., Hattori, K., Shimizu, Y., Kataoka, K., Kim-Mitsuyama, S., Uchida, S., Vandewalle, A., Noguchi, T., Nishitoh, H., Matsuzawa, A., Takeda, K. and Ichijo, H.
ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney.
Nat. Commun., 3, 1285 (2012).
- Sekine, Y., Hatanaka, R., Watanabe, T., Sono, N., Iemura, S., Natsume, T., Kuranaga, E., Miura, M., Takeda, K. and Ichijo, H.
The kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.
Mol. Cell, 48, 692-704 (2012).
- Sekine,S., Kanamaru, Y., Koike, M., Nishihara, A., Okada, M., Kinoshita, H., Kamiyama, M., Maruyama, J., Uchiyama, Y., Ishihara, N., Takeda, K. and Ichijo, H.
Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.
J. Biol. Chem., 287, 34635-34645 (2012).
- Fujisawa, T., Homma, K., Yamaguchi, N., Kadowaki, H., Tsuburaya, N., Naguro, I., Matsuzawa, A., Takeda, K., Takahashi, Y., Goto, J., Tsuji, S., Nishitoh, H. and Ichijo, H.
A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants.
Ann. Neurol., 72, 739-749 (2012).
- Hayakawa, Y., Hirata, Y., Nakagawa, H., Sakamoto, K., Hikiba, Y., Kinoshita, H., Nakata, W., Takahashi, R., Tateishi, K., Tada, M., Akanuma, M., Yoshida, H., Takeda, K., Ichijo, H., Omata, M., Maeda, S., Koike, K.
Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer.
Proc. Natl. Acad. Sci. USA., 108, 780-785 (2011).
- Sekine,Y., Takagahara,S., Hatanaka, R., Watanabe, T., Oguchi, H., Noguchi, T., Naguro, I., Kobayashi, K., Tsunoda, M., Funatsu, T., Nomura, H., Toyoda, T., Matsuki, N., Kuranaga, E., Miura, M., Takeda, K. and Ichijo,H.
p38 MAP kinase regulates the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors.
J. Cell Sci., 124, 3006-3016 (2011).
- Hayakawa, T., Kato, K., Hayakawa, R., Hisamoto, N., Matsumoto, K., Takeda, K. and Ichijo, H.
Regulation of anoxic death in Caenorhabditis elegans by mammalian apoptosis signal-regulating kinase (ASK) family proteins
Genetics, 187, 785-792 (2011).
- Maruyama, T., Kadowaki, H., Okamoto, N., Nagai, A., Naguro, I., Matsuzawa, A., Shibuya, H., Tanaka, K., Murata, S., Takeda, K., Nishitoh, H. and Ichijo, H. CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response.
EMBO J., 29, 2501-2514 (2010).
- Seong, H.A., Jung, H., Ichijo, H. and Ha, H.
Reciprocal negative regulation of PDK1 and ASK1 signaling by direct interaction and phosphorylation.
J. Biol. Chem., 285, 2397-2414 (2010)
- Nagai, H,, Noguchi, T., Homma, K., Katagiri, K., Takeda, K., Matsuzawa, A. and Ichijo, H.
Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death.
Mol. Cell, 36, 805-818 (2009).
- Cekic, C., Casella, C.R., Eaves, C.A., Matsuzawa, A., Ichijo, H. and Mitchell, T.C.
Selective activation of the p38 MAPK pathway by synthetic monophosphoryl lipid A.
J. Biol. Chem., 284, 31982-31991 (2009).
- Takeda, K., Komuro, Y., Hayakawa, T., Oguchi, H., Ishida, Y., Murakami,
S., Noguchi, T., Kinoshita, H., Sekine, Y., Iemura, S., Natsume, T., and Ichijo, H.
Mitochondrial Phosphoglycerate mutase 5 uses alternate catalytic
activity as a protein serine/threonine phosphatase to activate ASK1.
Proc. Natl. Acad. Sci. USA., 106, 12301-12305 (2009).
- Kundu, M., Pathak, S.K., Kumawat, K., Basu, S., Chatterjee, G., Pathak, S., Noguchi, T.,
Takeda, K., Ichijo, H., Thien, C.B., Langdon, W.Y. and Basu, J.
A TNF- and c-Cbl-dependent
FLIP(S)-degradation pathway and its function in Mycobacterium
tuberculosis-induced macrophage apoptosis.
Nat. Immunol., 10, 918-926 (2009).
- Zhou, J., Shao, Z., Kerkela, R., Ichijo, H., Muslin, A., Pombo, C. and Force, T.
Serine 58 of 14-3-3{zeta} is a molecular switch regulating ASK1 and oxidant stress-induced cell death.
Mol Cell Biol., 29, 4167-4176 (2009).
- Waak, J., Weber, S. S., Gorner, K., Schall, C., Ichijo, H., Stehle, T. and Kahle, P. J.
Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1.
J. Biol. Chem., 284, 14245-14257 (2009).
- Iriyama, T., Takeda, K., Nakamura, H., Morimoto, Y., Kuroiwa, T., Mizukami, J., Umeda, T., Noguchi, T., Naguro, I., Nishitoh, H., Saegusa, K., Tobiume, K., Homma, T., Shimada, Y., Tsuda, H., Aiko, S., Imoto, I., Inazawa, J., Chida, K., Kamei, Y., Kozuma, S., Taketani, Y., Matsuzawa, A. and Ichijo, H.
ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.
EMBO J., 28, 843-853 (2009).
- Nishitoh, H., Kadowaki, H., Nagai, A., Maruyama, T., Yokota, T., Fukutomi,
H., Noguchi, T., Matsuzawa, A., Takeda, K. and Ichijo, H.
ALS-linked
mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by
targeting Derlin-1.
Genes. Dev., 22, 1451-1464 (2008).
- Noguchi, T., Ishii, K., Fukutomi, H., Naguro, I., Matsuzawa, A., Takeda, K.
and Ichijo, H.
Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAP kinase pathway for extracelluler ATP-induced apoptosis in macrophage.
J. Biol. Chem., 283, 7657-7665 (2008).
- Fujino, G., Noguchi, T., Matsuzawa, A., Yamauchi, S., Saitoh, M., Takeda, K. and Ichijo, H.
Thioredoxin and TRAF family proteins regulate ROS-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1.
Mol. Cell. Biol., 27, 8152-8163 (2007).
- Osaka, N., Takahashi, T., Murakami, S., Matsuzawa, A., Noguchi, T.,
Fujiwara, T., Aburatani, H., Moriyama, K., Takeda, K. and Ichijo, H.
ASK1-dependent recruitment and activation of macrophages induce hair growth
in skin wounds.
J. Cell Biol., 176, 903-909 (2007).
- Takeda, K., Shimozono, R., Noguchi, T., Umeda, T., Morimoto, Y., Naguro, I., Tobiume, K., Saitoh, M., Matsuzawa, A. and Ichijo, H.
Apoptosis signal-regulating kinase 2 (ASK2) functions as a MAP3K in a heteromeric
complex with ASK1.
J. Biol. Chem., 282, 7522-7531 (2007).
- Kitagawa, D., Kajiho, H., Negishi, T., Ura, S., Watanabe, T., Wada, T., Ichijo, H., Katada, T. and Nishina, H.
Release of RASSF1C from the nucleus
by Daxx degradation links DNA damage and SAPK/JNK activation.
EMBO J., 25, 3286-3297 (2006).
- Chiang, E., Dang, O., Anderson, K., Matsuzawa, A., Ichijo, H. and
David, M.
Apoptosis- regulating signal kinase 1 is required for reactive
oxygen species-mediated activation of IFN regulatory factor 3 by
lipopolysaccharide.
J. Immunol., 176, 5720-5724 (2006).
- Liu, Q., Wilkins, B.J., Lee, Y.J., Ichijo, H. and Molkentin, J.D.
Direct Interaction and Reciprocal Regulation Between ASK1 and Calcineurin-NFAT Controls Cardiomyocyte Death and Growth.
Mol. Cell. Biol., 26, 3785-3797 (2006).
- Noguchi, T., Takeda, K., Matsuzawa, A., Saegusa, K., Nakano, H., Gohda, J., Inoue, J. and Ichijo, H.
Recruitment of TRAF family proteins to the ASK1 signalosome is essential for oxidative stress-induced cell death.
J. Biol. Chem., 280, 37033-37040 (2005).
- Matsuzawa, A., Saegusa, K., Noguchi, T., Sadamitsu, C., Nishitoh, H., Nagai, S., Koyasu, S., Matsumoto, K., Takeda, K. and Ichijo, H.
ROS-dependent activation of TRAF6-ASK1-p38 pathway is selectively required for TLR-4 mediated innate immunity.
Nat. Immunol., 6, 587-592 (2005).
- Kadowaki, H., Nishitoh, H., Urano, F., Sadamitsu, C., Matsuzawa, A., Takeda, K., Masutani, H., Yodoi, J., Urano, Y., Nagano, T. and Ichijo, H.
Amyloid b induces neuronal cell death through ROS-mediated ASK1 activation.
Cell Death Differ., 12, 19-24 (2005).
- Junn, E., Taniguchi, H., Jeong, B.S., Zhao, X., Ichijo, H. and Mouradian, M.,M.
Interaction of DJ-1 with Daxx inhibits ASK1 activity and cell death.
Proc. Natl. Acad. Sci. USA., 102, 9691-9696 (2005).
- Kaneto, H., Nakatani, Y., Miyatsuka, T., Kawamori, D., Matsuoka, T.A.,
Matsuhisa, M., Kajimoto, Y., Ichijo, H., Yamasaki, Y. and Hori, M.
Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide.
Nat. Med., 10, 1128-1132 (2004).
- Takeda, K., Matsuzawa, A., Nishitoh, H., Tobiume, K., Kishida, S., Ninomiya,T., Tsuji, J., Matsumoto, K., and Ichijo, H.
Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation.
EMBO Rep., 5, 161-166 (2004).
- Yamaguchi, O., Watanabe, T., Nishida, K., Kashiwase, K., Higuchi, Y., Takeda, T., Hikoso, S., Hirotani, S., Asahi, M., Taniike, M., Nakai, A., Tsujimoto, I., Matsumura, Y., Miyazaki, J., Chien, K.R., Matsuzawa, A.,
Sadamitsu, C., Ichijo, H., Baccarini, M., Hori1, M. and Otsu, K.
Cardiac-specific Disruption of c-raf-1 Gene Induces Cardiac Dysfunction and Apoptosis.
J. Clin. Invest., 114, 937-943 (2004).
- Huang, S., Shu, L., Easton, J., Harwood, F. C., Germain, G. S., Ichijo, H. and Houghton, P. J.
Inhibition of Mammalian Target of Rapamycin Activates Apoptosis Signal-Regulating Kinase 1 Signaling by Suppressing Protein Phosphatase 5 Activity.
J. Biol. Chem., 279, 36490-36496 (2004).
- Song, S., Kim, S.Y., Hong, Y.M., Jo, D.G., Lee, J.Y., Shim, S.M., Chung, C.W., Seo, S.J., Yoo, Y.J., Koh, J.Y., Lee, M.C., Yates, A.J., Ichijo, H., Jung, Y.K.
Essential role of E2-25K/Hip-2 in mediating amyloid-beta neurotoxicity.
Mol. Cell, 12, 553-563 (2003).
- Cho, S.-G., Kim, J.W., Lee, Y.H., Hwang, H.S., Kim, M.-S., Ryoo, K., Kim, M.J., Noh K.T., Kim, E.K. Cho, J.-H., Yoon, K.W., Cho, E.-G., Park, H.-S., Chi, S.W.,
Lee, M.-J., Kang, S.S., Ichijo, H. and Choi, E.-J.
Identification of a novel antiapoptotic protein that antagonizes ASK1 and CAD activities.
J. Cell Biol., 163, 71-81 (2003).
- Yamaguchi, O., Higuchi, Y., Hirotani, S., Kashiwase, K., Nakayama, H., Hikoso, S., Takeda, T., Watanabe, T., Asahi, M., Taniike, M., Matsumura, Y., Tsujimoto, I., Hongo, K., Kusakari, Y., Kurihara, S., Nishida, K., Ichijo, H., Hori, M. and Otsu, K.
Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling.
Proc. Natl. Acad. Sci. USA., 100, 15883-15888 (2003).
- Matsukawa, J., Nakayama, K., Nagao, T., Ichijo, H. and Urushidani, T.
Role of ADP-ribosylation factor 6 (ARF6) in gastric acid secretion.
J. Biol. Chem., 278, 36470-36475 (2003).
- Huang, H., Shj, L., Dilling, M.B, Easton, J., Harwood, F.C., Ichijo, H. and Houghton, P.J.
Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/ p21Cip1.
Mol. Cell, 11, 1491-1501 (2003).
- Galvan, V., Logvinova, A., Sperandio, S., Ichijo, H. and Bredesen, D.E.
Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1).
J. Biol. Chem., 278, 13325-13332 (2003).
- Gilot, D., Loyer, P., Corlu, A., Glaise, D., Lagadic-Gossmann, D., Atfi, A., Morel, F., Ichijo, H. and Guguen-Guillouzo, C.
Liver protection from apoptosis requires both blockage of initiator caspase activities and inhibition of ASK1/JNK pathway via glutathione S-transferase regulation.
J. Biol. Chem., 277, 49220-49229 (2002).
- Matsuura, H., Nishitoh, H., Takeda, K., Matsuzawa, A., Amagasa, T., Ito, M., Yoshioka, K. and Ichijo, H.
Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway: a new mode of regulation of the MAP kinase cascade.
J. Biol. Chem., 277, 40703-40709 (2002).
- Inoshita, S., Takeda, K., Hatai, T., Terada, Y., Sano, M., Hata, J., Umezawa, A. and Ichijo, H.
Phosphorylation and Inactivation of Mcl-1 by c-Jun N-terminal Kinase (JNK) in response to oxidative stress.
J. Biol. Chem., 277, 43730-43734 (2002).
- Kuranaga, E., Kanuka, H., Igaki, T., Sawamoto, K., Ichijo, H., Okano, H. and Miura, M.
Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila.
Nat. Cell Biol., 4, 705-710 (2002).
- Nishitoh, H., Matsuzawa, A., Tobiume, K., Saegusa, K., Takeda, K., Inoue, K., Hori, S., Kakizuka, A. and Ichijo, H.
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats.
Genes Dev., 16, 1345-1355 (2002).
- Morita, K., Saitoh, M., Tobiume, K., Matsuura, H., Enomoto, S., Nishitoh, H. and Ichijo, H.
Negative feedback regulation of ASK1 by protein phophatase 5 (PP5) in response to oxidative stress.
EMBO J., 20, 6028-6036 (2001).
- Zou, X., Tsutsui, T., Ray, D., Blomquist, J.F., Ichijo, H., Ucker, D.S. and Kiyokawa, H.
The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1 (ASK1).
Mol. Cell. Biol., 21, 4818-4828 (2001).
- Geleziunas, R., Xu, W., Takeda, K., Ichijo, H. and Greene W.C.
HIV-1 nef inhibits ASK1-dependent death signalingproviding a potential mechanism for protecting the infected host cell.
Nature, 410, 834-838 (2001).
- Cho, S.-G., Lee, Y., Park, H.-S., Ryoo, K., Kang, K., Park, J., Eom, S.-J.,
Kim, M., Chang, T.-S., Choi, S.-Y., Shim, J., Kim, Y., Dong, M.-S., Lee, M.-J., Kim, S., Ichijo, H. and Choi, E.-J.
Glutathione s-transferase mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1 (ASK1).
J. Biol. Chem., 276, 12749-12755 (2001).
- Tobiume, K., Matsuzawa, A., Takahashi, T., Nishitoh, H., Morita, K., Takeda, K., Minowa, O., Miyazono, K., Noda, T. and Ichijo, H.
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis.
EMBO reports, 2, 222-228 (2001).
- Sayama, K., Hanakawa, Y., Shirakata, Y., Yamasaki, K., Sawada, Y., Sun, L.,
Yamanishi, K., Ichijo, H. and Hashimoto, K.
Apoptosis signal regulating kinase 1 (ASK1) is an intracellular inducer of keratinocyte differentiation.
J. Biol. Chem., 276, 999-1004 (2001).
- Sawada, Y., Nakamura, K., Doi, K., Takeda, K., Tobiume, K., Saitoh, M., Morita, K., Komuro, I., Kurt De Vos, Sheetz, M. and Ichijo, H.
Rap1 is Involved in Cell Stretching Modulation of p38 but not ERK or JNK MAP Kinase.
J. Cell Sci., 114, 1221-1227 (2001).
- Takeda, K., Hatai, T., Hamazaki, S., Nishitoh, H., Saitoh, M. and Ichijo H.
Apoptosis Signal- regulating Kinase 1 (ASK1) Induces Neuronal Differentiation and Survival of PC12 Cells.
J. Biol. Chem., 275, 9805-9813 (2000).
- Liu, H., Nishitoh, H., Ichijo, H. and Kyriakis, J.M.
Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor- associated factor 2 (TRAF2) requires prior dissociation of the ASK1 inhibitor Thioredoxin.
Mol. Cell. Biol., 20, 2198-2208 (2000).
- Kanamoto, T., Mota, M., Takeda, K., Rubin, L.L., Miyazono, K., Ichijo, H. and Bazenet, C.E.
Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal Kinase pathway and apoptosis in sympathetic neurons.
Mol. Cell. Biol., 20, 196-204 (2000).
- Hatai, T., Matsuzawa, A., Inoshita, S., Mochida, Y., Kuroda, T., Sakamaki, K., Kuida, K., Yonehara, S., Ichijo, H. and Takeda, K.
Execution of ASK1-induced Apoptosis by the Mitochondria-dependent Caspase Activation.
J. Biol. Chem., 275, 26576-26581 (2000).
- Mochida, Y., Takeda, K., Saitoh, M., Nishitoh, H., Amagasa, T., Ninomiya-Tsuji, j., Matsumoto, K. and Ichijo, H.
ASK1 inhibits IL-1-induced NF-kB activity through disruption of TRAF6-TAK1 interaction.
J. Biol. Chem., 275, 32747-32752 (2000).
- Yamamoto, K., Ichijo, H. and Korsmeyer, S.J.
BCL-2 is phosphorylated and inactivated by an ASK1/JNK pathway normally activated at G2/M.
Mol. Cell Biol., 19, 8469-8478 (1999).
- Wang,T.H., Popp,D.M., Wang,H.S., Saitoh, M., Mural, J.G., Henley, D.C., Ichijo, H. and Wimalasena,J.
Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells.
J. Biol. Chem., 274, 8208-8216 (1999).
- Asada, M., Yamada, T., Ichijo, H., Delia, D., Miyazono, K., Fukumuro, K. and Mizutani, S.
Apoptosis inhibitory activity of cytoplasmic p21Cip1/WAF1 in monocytic differentiation.
EMBO J., 18, 1223-1234 (1999).
- Fujii, M., Takeda, K., Imamura, T., Aoki, H., Sampath, T.K., Enomoto, S.,
Kawabata M., Kato, M., Ichijo, H. and Miyazono, K.
Roles of bone morphogenetic protein type I receptors and smad proteins in osteoblast and chondroblast differentiation.
Mol. Biol. Cell, 10, 3801-3813 (1999).
- Nishitoh, H., Saitoh, M., Mochida, Y., Takeda, K., Nakano, H., Rothe, M., Miyazono, K. and Ichijo, H.
ASK1 is essential for JNK/SAPK activation by TRAF2.
Mol. Cell, 2, 389-395 (1998).
- Saitoh, M., Nishitoh, H., Fujii, M., Takeda, K., Tobiume, K., Sawada, Y., Kawabata, M., Miyazono K. and Ichijo, H.
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.
EMBO J., 17, 2596-2606 (1998).
- Chang, HY., Nishitoh, H., Yang, X., Ichijo, H. and Baltimore, D.
Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein daxx.
Science, 281, 1860-1863 (1998).
- Berestetskaya, Y.V., Faure, M.P., Ichijo, H., Tatyana, A. and Yasenetskaya, V.
Regulation of apoptosis by alhpa subunits of G12 and G13 proteins via apoptosis signal-regulating.
J. Biol. Chem., 273, 27816-27823 (1998).
- Takeda, K., Ichijo, H., Fujii, M., Mochida, Y., Saitoh, M., Nishitoh, H., Sampath, T.K. and Miyazono, K.
Identification of a novel bone morphogenetic protein-responsive gene that may function as a noncoding RNA.
J. Biol. Chem., 273, 17079-17085 (1998).
- Wang, T.-H., Wang, H.-S., Ichijo, H., Giannakakou, P., Foster, J.S., Fojo, T. and Wimalasena, J.
Microtuble-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) through both ras and apoptosis signal-regulating kinase (ASK1) pathways.
J. Biol. Chem., 273, 4928-4936 (1998).
- Ichijo, H. Nishida, E., Irie, K., ten Dijke, P., Saitoh, M., Moriguchi, T.,
Takagi, M., Matsumoto, K., Miyazono, K. and Gotoh, Y.
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways.
Science, 275, 90-94 (1997).
- Saitoh, M., Nishitoh, H., Amagasa, T., Miyazono, K., Takagi, M. and Ichijo, H.
Identification of important regions in the cytoplasmic juxtamembrane domain of type I receptor that separate signaling pathways of transforming growth factor-β.
J. Biol. Chem., 271, 2769-2775 (1996).
- Nishitoh, H., Ichijo, H., Kimura, M., Matsumoto, T., Makishima, F., Yamaguchi, A., Yamashita, H., Enomoto, S. and Miyazono, K.
Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5.
J. Biol. Chem., 271, 21345-21352 (1996).
- Okadome, T., Oeda, E., Saitoh, M., Ichijo, H., Moses, H.L. Miyazono, K. and Kawabata, M.
Characterization of the interaction of FKBP12 with the transforming growth factor-β type I receptor in vivo.
J. Biol. Chem., 271, 21687-21690 (1996).
- ten Dijke, P., Yamashita, H., Sampath, K., Reddi, H., Riddle, D., Ichijo, H., Heldin, C.-H., Miyazono, K.
Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.
J. Biol. Chem., 269, 16985-16988 (1994).
- ten Dijke, P., Yamashita, H., Ichijo, H., Franzen, P., Laiho, M., Miyazono, K. and Heldin, C.-H.
Characterization of type I receptors for transforming growth factor-β and activin.
Science, 264, 101-104 (1994).
- Yamashita, H., Ichijo, H., Grimsby, S., Moren, A., ten Dijke, P. and Miyazono, K.
Endoglin forms a heteromeric complex with the signalling receptors for transforming growth factor-β.
J. Biol. Chem., 269, 1995-2001 (1994).
- Franzen, P., ten Dijke, P., Ichijo, H., Yamashita, H., Schulz, P., Heldin, C.-H. and Miyazono, K.
Cloning of a TGF-β type I receptor that forms a heteromeric complex with the TGF-β type II receptor.
Cell, 75, 681-692 (1993).
- Ichijo, H., Hellman, U., Wernstedt, C., Gonez, L.-J., Claesson-Welsh, L., Heldin, C.-H. and Miyazono, K.
Molecular cloning and characterization of ficolin, a multimeric protein with fibrinogen- and collagen-like domains.
J. Biol. Chem., 268, 14505-14513 (1993).
- Ichijo, H., Ronnstrand, L., Miyagawa, K., Ohashi, H., Heldin, C.-H. and Miyazono, K.
Purification of transforming growth factor-β1 binding proteins from porcine uterus membranes.
J. Biol. Chem., 266, 22459-22464 (1991).
- Ichijo, H., Momose, F., and Miyazono, K.
Biological effects and binding properties of transforming growth factor-β on human oral squamous cell carcinoma cells.
Exp. Cell Res., 187, 263-269 (1990).
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