Atsushi MATSUZAWA      　　

　　松沢　厚　　マツザワ　アツシ    1966年6月10日　 長野県上田市生まれ

西暦  月　　　　　　　　　　 　　  研究歴

1992  3   東京大学 薬学部薬学科(衛生化学教室) 卒業 1997  3   東京大学 大学院薬学系研究科 博士課程(衛生化学教室) 修了 1997  3   博士(薬学) 取得 1997  4   キッセイ薬品工業株式会社中央研究所 1999  4   東京医科歯科大学 大学院医歯学総合研究科(分子情報伝達学分野)(出向) 2002  7   東京大学 大学院薬学系研究科(細胞情報学教室) 助教 2006  4   米国カリフォルニア大学サンディエゴ校医学部 客員研究員(海外留学) 2008 11   東京大学大学院薬学系研究科(細胞情報学教室) 准教授 （東京大学グローバルCOEプログラム 教務ディレクター） 2013 10　東京大学大学院薬学系研究科(ワンストップ創薬共用ファシリティセンター) 准教授

専門分野：分子生物学、免疫学、生化学

専門領域：MAPキナーゼシグナル伝達機構と分子病態の解明、免疫シグナルの分子生物学的解析、               酸化ストレスと生化学

所属学会：日本分子生物学会、日本生化学会、日本免疫学会、日本薬学会、日本ケミカルバイオロジー学会

資      格:1996年4月 薬剤師国家試験合格

受 賞 歴:長瀬研究振興賞(2012年4月)             BBA General Subjects Top Cired Articles 2006-2011 Award (2011年7月)             第1回 シグナルネットワーク研究会 奨励賞(2009年5月)、             第7回 口腔医科学フロンティア学術集会 奨励賞(2009年3月)、第16回 武見賞 奨励賞(2006年12月)

CURRICULUM VITAE
IDENTICAL INFORMATION
	Name:	ATSUSHI  MATSUZAWA
	Date and place of birth:	10 June, 1966, Ueda, Nagano, Japan
	Position and title:	Associate Professor
	Department / Laboratory:	Graduate School of Pharmaceutical Sciences / Laboratory of Cell Signaling
	Institution:	The University of Tokyo
	Address:	7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan
	Phone:	+81-3-5841-4858
	Fax:	+81-3-5841-4798
	E-mail:	matsushi (at) mol.f.u-tokyo.ac.jp

EDUCATIONAL HISTORY
	Ph.D. Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo: March/1997.
	B.S. Department of Health Chemistry, Faculty of Pharmaceutical Sciences, The University of Tokyo: March/1992.

PROFESSIONAL EXPERIENCE
	November/2008–now:	Associate Professor, Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
	April/2006–October/2008:	Visiting Researcher, Department of Pharmacology, School of Medicine, University of California, San Diego, CA, U.S.A.
	July/2002–October/2008:	Assistant Professor, Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
	April/1999–March/2003:	Lecturer (Part-time) and Researcher, Laboratory of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
	April/1997–July/2002:	Research Biologist, Central Research Laboratories, Kissei Pharmaceutical Co. Ltd., Nagano, Japan.

SPECIAL FIELD OF RESEARCH
	Molecular biology and pathophysiology of MAP kinase signaling.
	Signal transduction of innate immunity.
	Biochemistry of oxidative stress.
MEMBERSHIPS
	The Molecular Biology Society of Japan
	The Japanese Biochemical Society
	The Pharmaceutical Society of Japan
	The Japanese Society of Immunology
	The Japanese Society of Chemical Biology
AWARDS & LICENSE
	Nagase Foundation Award, 2012.
	BBA General Subjects Top Cired Articles 2006-2011 Award, 2011.
	Incitement Award of the Signal Network Society, 2009.
	Incitement Award of the Oral Medical Science Frontier Society, 2009.
	Takemi Award, Prize for encouragement, 2006.
	National Pharmacist Licensure Examination, Passed, 1996.

 

●ORIGINAL PUBLICATION Naguro, I., Umeda, T., Kobayashi, Y., Maruyama, J., Hattori, K., Shimizu, Y., Kataoka, K., Kim-Mitsuyama, S., Uchida, S., Vandewalle, A.,　Noguchi, T., Nishitoh, H., Matsuzawa, A., Takeda, K. and Ichijo, H. ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney. Nat. Commun., doi: 10.1038/ncomms2283 (2012). Lin, F.R., Huang, S.Y., Hung, K.H., Su, S.T., Chung, C.H., Matsuzawa, A., Hsiao, M., Ichijo, H. and Lin, K.I. ASK1 promotes apoptosis of normal and malignant plasma cells. Blood, 120, 1039-1047 (2012). Fujisawa, T., Homma, K., Yamaguchi, N., Kadowaki, H., Tsuburaya, N., Naguro, I., Matsuzawa, A., Takeda, K., Takahashi, Y., Goto, J., Tsuji, S., Nishitoh, H. and Ichijo, H. A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants. Ann. Neurol., 72, 739-749 (2012). Guo, X., Harada, C., Namekata, K., Matsuzawa, A., Camps, M., Ji, H., Swinnen, D., Jorand-Lebrun, C., Muzerelle, M., Vitte, P., Ruckle, T., Kimura, A., Kohyama, K., Matsumoto, Y., Ichijo, H. and Harada, T.  Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway. EMBO Molecular Medicine, 2, 504-515 (2010). Maruyama, T., Kadowaki, H., Okamoto, N., Nagai, A., Naguro, I., Matsuzawa, A., Shibuya, H., Tanaka, K., Murata, S., Takeda, K., Nishitoh, H. and Ichijo, H. CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response. EMBO J., 29, 2501-2514 (2010). *Tseng, P. H., *Matsuzawa, A., Zhang, W., Mino, T., Vignali, D. A., Karin, M.  Different modes of TRAF3 ubiquitination selectively activate type I interferon and proinflammatory cytokine expression. Nat. Immunol., 11, 70-75 (2010). * These authors contributed equally to this work. Nagai, H,, Noguchi, T., Homma, K., Katagiri, K., Takeda, K., Matsuzawa, A. and Ichijo, H. Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death. Mol. Cell, 36, 805-818 (2009). Cekic, C., Casella, C.R., Eaves, C.A., Matsuzawa, A., Ichijo, H. and Mitchell, T.C. Selective activation of the p38 MAPK pathway by synthetic monophosphoryl lipid A. J. Biol. Chem., 284, 31982-31991 (2009). Iriyama, T., Takeda, K., Nakamura, H., Morimoto, Y., Kuroiwa, T., Mizukami, J., Umeda, T., Noguchi, T., Naguro, I., Nishitoh, H., Saegusa, K., Tobiume, K., Homma, T., Shimada, Y., Tsuda, H., Aiko, S., Imoto, I., Inazawa, J., Chida, K., Kamei, Y., Kozuma, S., Taketani, Y., Matsuzawa, A. and Ichijo, H. ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. EMBO J., 28, 843-853 (2009). Wang, H., Matsuzawa, A., Brown, S. A., Zhou, J., Guy, C. S., Tseng, P. H., Forbes, K., Nicholson, T. P., Sheppard, P. W., Häcker, H., Karin, M., Vignali, D. A. Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin. Proc. Natl. Acad. Sci. U. S. A., 105, 20197-20202 (2008). *Vallabhapurapu, S.,*Matsuzawa, A., Zhang, W., Tseng, P. H., Keats, J. J., Wang, H., Vignali, D. A., Bergsagel, P. L., Karin M. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kB signaling. Nat. Immunol., 9, 1364-1370 (2008). * These authors contributed equally to this work. †*Matsuzawa, A., *Tseng, P. H., Vallabhapurapu, S., Luo, J. L., Zhang, W., Wang, H., Vignali, D. A., Gallagher, E., Karin, M. Essential Cytoplasmic Translocation of a Cytokine Receptor-Assembled Signaling Complex. Science, 321, 663-668 (2008). † This paper is published as a Research Article. * These authors contributed equally to this work Sakurai, T., He, G., Matsuzawa, A., Yu, G. Y., Maeda, S., Hardiman, G., Karin, M. Hepatocyte necrosis induced by oxidative stress and IL-1a release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell, 14, 156-165 (2008). Nishitoh, H., Kadowaki, H., Nagai, A., Maruyama, T., Yokota, T., Fukutomi, H., Noguchi, T., Matsuzawa, A., Takeda, K., and Ichijo, H. ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1. Genes. Dev., 22, 1451-1464 (2008). Noguchi, T., Ishii, K., Fukutomi, H., Naguro, I., Matsuzawa, A., Takeda, K. and Ichijo, H. Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAP kinase pathway for extracelluler ATP-induced apoptosis in macrophage. J. Biol. Chem., 283, 7657-7665 (2008). Fujino, G., Noguchi, T., Matsuzawa, A., Yamauchi, S., Saitoh, M., Takeda, K. and Ichijo, H. Thioredoxin and TRAF family proteins regulate ROS-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1. Mol. Cell. Biol., 27, 8152-8163 (2007). Osaka, N., Takahashi, T., Murakami, S., Matsuzawa, A., Noguchi, T., Fujiwara, T., Aburatani, H., Moriyama, K., Takeda, K. and Ichijo, H. ASK1-dependent recruitment and activation of macrophages induce hair growth in skin wounds. J. Cell Biol., 176, 903-909 (2007). Takeda, K., Shimozono, R., Noguchi, T., Umeda, T., Morimoto, Y., Naguro, I., Tobiume, K., Saitoh, M., Matsuzawa, A., and Ichijo, H. Apoptosis signal-regulating kinase 2 (ASK2) functions as a MAP3K in a heteromeric complex with ASK1. J. Biol. Chem., 282, 7522-7531 (2007). *Gallagher, E., *Enzler, T., *Matsuzawa, A., Anzelon-Mills, A., Otero, D., Holzer, R., Janssen, E., Gao, M., Karin, M. Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production. Nat. Immunol., 8, 57-63 (2007). * These authors contributed equally to this work. Chiang, E., Dang, O., Anderson, K., Matsuzawa, A., Ichijo, H. and David, M. Apoptosis- regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor 3 by lipopolysaccharide. J. Immunol., 176, 5720-5724 (2006). Harada, C., Nakamura, K., Namekata, K., Okumura, A., Mitamura, Y., Iizuka, Y., Kashiwagi, K., Yoshida, K., Ohno, S., Matsuzawa, A., Tanaka, K., Ichijo, H. and Harada, T. Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo. Am. J. Pathol., 168, 261-269 (2006). *Matsuzawa, A., *Saegusa, K., Noguchi, T., Sadamitsu, C., Nishitoh, H., Nagai, S., Koyasu, S., Matsumoto, K., Takeda, K. and Ichijo, H. ROS-dependent activation of TRAF6-ASK1-p38 pathway is selectively required for TLR-4 mediated innate immunity. Nat. Immunol., 6, 587-592 (2005). * These authors contributed equally to this work. Noguchi, T., Takeda, K., Matsuzawa, A., Saegusa, K., Nakano, H., Gohda, J., Inoue, J. and Ichijo, H. Recruitment of TRAF family proteins to the ASK1 signalosome is essential for oxidative stress-induced cell death. J. Biol. Chem., 280, 37033-37040 (2005). Izumi, Y., Kim-Mitsuyama, S., Yoshiyama, M., Omura, T., Shiota, M., Matsuzawa, A., Yukimura, T., Murohara, T., Takeya, M., Ichijo, H., Yoshikawa, J. and Iwao, H. Important Role of Apoptosis Signal-Regulating Kinase 1 in Ischemia-induced Angiogenesis. Arterioscler. Thromb. Vasc. Biol., 25, 1877-1883 (2005). Kadowaki, H., Nishitoh, H., Urano, F., Sadamitsu, C., Matsuzawa, A., Takeda, K., Masutani, H., Yodoi, J., Urano, Y., Nagano, T., and Ichijo, H. Amyloid ß induces neuronal cell death through ROS-mediated ASK1 activation. Cell Death Differ., 12, 19-24 (2005). Takeda, K., Matsuzawa, A., Nishitoh, H., Tobiume, K., Kishida, S., Ninomiya-Tsuji, J., Matsumoto, K., and Ichijo, H. Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation. EMBO Rep., 5, 161-166 (2004). Yamaguchi, O., Watanabe, T., Nishida, K., Kashiwase, K., Higuchi, Y., Takeda, T., Hikoso, S., Hirotani, S., Asahi, M., Taniike, M., Nakai, A., Tsujimoto, I., Matsumura, Y., Miyazaki, J., Chien, K.R., Matsuzawa, A., Sadamitsu, C., Ichijo, H., Baccarini, M., Hori1, M. and Otsu, K. Cardiac-specific Disruption of c-raf-1 Gene Induces Cardiac Dysfunction and Apoptosis. J. Clin. Invest. 114, 937-943 (2004). Izumiya, Y., Kim, S., Izumi, Y., Yoshida, K., Yoshiyama, M., Matsuzawa, A., Ichijo, H., Iwao, H. Apoptosis Signal-Regulating Kinase 1 Plays a Pivotal Role in Angiotensin II-Induced Cardiac Hypertrophy and Remodeling. Circulation Res. , 93, 874-883 (2003). Izumi, Y., Kim, S., Yoshiyama, M., Izumiya, Y., Yoshida, K., Matsuzawa, A., Koyama, H., Nishizawa, Y., Ichijo, H., Yoshikawa, J. and Iwao, H. Activation of apoptosis signal-regulating kinase 1 in injured artery and its critical role in neointimal hyperplasia. Circulation, 108, 2812-2818 (2003). Hara, K., Honma, T., Matsuzawa, A., Matsuzawa, A., Uchida, M., Koizumi, T., Akahane, S., Kojima, M. Characteristics of the hemostatic action of KFA-1411, an inhibitor of coagulation factor Xa (FXa), in humans and various animals. J. Toxicol. Sci., 28, 25-34 (2003). Jibiki, I., Hashimoto, S., Maruoka, S., Gon, Y., Matsuzawa, A., Nishitoh, H., Ichijo, H., and Horie, T. Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates nitric oxide-induced activator protein-1 activation in human bronchial epithelial cells. Am. J. Respir. Cri. Care Med., 167, 856-861 (2002). Matsuura, H., Nishitoh, H., Takeda, K., Matsuzawa, A., Amagasa, T., Ito, M., Yoshioka, K. and Ichijo, H. Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway: a new mode of regulation of the MAP kinase cascade. J. Biol. Chem., 277, 40703-40709 (2002). Nishitoh, H., Matsuzawa, A., Tobiume, K., Saegusa, K., Takeda, K., Inoue, K., Hori, S., Kakizuka, A. and Ichijo, H. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev., 16, 1345-1355 (2002). *Tobiume, K., *Matsuzawa, A., Takahashi, T., Nishitoh, H., Morita, K., Takeda, K., Minowa, O., Miyazono, K., Noda, T. and Ichijo, H. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep., 2, 222-228 (2001). * These authors contributed equally to this work. Hatai, T., Matsuzawa, A., Inoshita, S., Mochida, Y., Kuroda, T., Sakamaki, K., Kuida, K., Yonehara, S., Ichijo, H., and Takeda, K. Execution of ASK1-induced apoptosis by the mitochondria-dependent caspase activation. J. Biol. Chem., 275, 26576-26581 (2000). Matsuzawa, A., Hattori, K., Aoki, J., Arai, H., Inoue K. Protection against oxidative stress-induced cell death by intracellular platelet-activating factor-acetylhydrolase II. J. Biol. Chem., 272, 32315-32320 (1997). Hattori, K., Adachi, H., Matsuzawa, A., Yamamoto, K., Tsujimoto, M., Aoki, J., Hattori, M., Arai, H., Inoue, K. cDNA cloning and expression of intracellular platelet-activating factor (PAF) acetylhydrolase II. Its homology with plasma PAF acetylhydrolase. J. Biol. Chem., 271, 33032-33038 (1996). Kudo, I., Matsuzawa, A., Imai, K., Murakami, M., Inoue, K. Function of type II phospholipase A2 in dopamine secretion by rat neuronal PC12 cells. J. Lipid Mediat. Cell Signal., 14, 25-31 (1996). Matsuzawa, A., Murakami, M., Atsumi, G., Imai, K., Prados, P., Inoue, K., Kudo, I. Release of secretory phospholipase A2 from rat neuronal cells and its possible function in the regulation of catecholamine secretion. Biochem. J., 318, 701-709 (1996). Murakami, M., Kudo, I., Umeda, M., Matsuzawa, A., Takeda, M., Komada, M., Fujimori. Y., Takahashi, K., Inoue, K. Detection of three distinct phospholipases A2 in cultured mast cells. J. Biochem., 111, 175-181 (1992). ●REVIEW ARTICLES Soga, M., Matsuzawa, A., Ichijo, H. Oxidative Stress-Induced Diseases via the ASK1 Signaling Pathway. Int. J. Cell Biol., (review article),2012, 439587 (2012). Runchel, C., Matsuzawa, A. and Ichijo, H.　 MAPKs in mammalian oxidative stress responses. Antioxid. Redox Signal. (review article), 15, 205-218 (2011). Takeda, K., Naguro, I., Nishitoh, H., Matsuzawa, A. and Ichijo, H. Apoptosis signaling kinases: from stress response to health outcomes. Antioxid. Redox Signal. (review article), 15, 719-761 (2011). Matsuzawa, A., Takeda, K. and Ichijo, H. ASK1: Molecule Pages, UCSD-Nature Signaling Gateway, (review article) (2010) (doi:10.1038/mp.a002816.01). Katagiri, K., Matsuzawa, A. and Ichijo, H. Regulation of Apoptosis Signal-regulating Kinase 1 in redox signaling. Methods in Enzymology, (review article) 474, 277-288, 2010. Matsuzawa, A. and Ichijo, H. Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling. Biochim. Biophys. Acta., (review article), 1780, 1325-1336 (2008). Hayakawa, T., Matsuzawa, A., Noguchi, T., Takeda, K. and Ichijo, H. The ASK1-MAP kinase pathways in the immune and stress responses. Microbes Infect., (review article), 8, 1098-1107(2006). Matsuzawa, A. and Ichijo, H. Stress-responsive protein kinases in redox-regulated apoptosis signaling. Antioxid. Redox Signal, (review article), 7, 472-481 (2005). Matsukawa, J., Matsuzawa, A., Takeda, K. and Ichijo, H. Functions of MAP Kinase cascades: The ASK1-MAP Kinase cascades in mammalian stress response. J. Biochem. (review article), 136, 261-265 (2004). Takeda, K., Matsuzawa, A., Nishitoh, H. and Ichijo, H. Roles of MAPKKK ASK1 in Stress-Induced Cell Death. Cell Struct Funct. (review article), 28, 23-29 (2003). Matsuzawa, A., Nishitoh, H., Tobiume, K., Takeda, K. and Ichijo, H. Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice. Antioxid. Redox Signal, 4, 415-425 (2002). Matsuzawa, A. and Ichijo, H. Molecular Mechanisms of the Decision between Life and Death: Regulation of Apoptosis by Apoptosis Signal-Regulating Kinase 1. J. Biochem., 130, 1-8 (2001).   ●BOOK CHAPTER Matsuzawa, A., Nishitoh, H., Takeda, K. and Ichijo, H. MAP Kinases in Redox Signaling in "Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles" ed. by Forman HJ., Fukuto, J. and Torres, M., Kluwer Academic (review article), 223-236 (2003).   ●PROCEEDING Osaka, N., Matsuzawa, A., Takahashi, K., Moriyama, K., Aburatani, H., Takeda, K., Ichijo, H. “Physiological roles of stress-activated protein kinases in skin” in “Interface Oral Health Science - Proceedings of the International Symposium for Interface Oral Health, held in Sendai, Japan, between 2 and 3 February 2005” ed. by Watanabe, M., Takahashi, N., Takada, H. International Congress Series, 1284, 305-309 (2005).