2013年Jump to 2009

  Homma, K., Fujisawa, T., Tsuburaya, N., Yamaguchi, N., Kadowaki, H., Takeda, K., Nishitoh, H.,  Matsuzawa, A., Naguro, I., and Ichijo, H.
SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency.
Mol. Cell, 52, 75-86 (2013).

  Puckett M.C.,Goldman, E.H., Cockrell, L.M., Huang, B., Kasinski, A.L., Du, Y., Wang, C.Y., Lin, A., Ichijo, H., Khuri, F. and Fu, H..
Integration of the Apoptosis signal-regulating kinase 1-mediated stress signaling with the Akt/PKB-IκB kinase cascade.
Mol.Cell. Biol., 33, 2252-2259 (2013).

  Yamaguchi, K., Takeda, K., Kadowaki, H., Ueda, I., Namba, Y., Ouchi, Y. Nishitoh, H. and Ichijo, H. Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic ß cell exhaustion.
Biochim. Biophys. Acta, 1830, 3656-3663 (2013).

  Shiizaki, S., Naguro, I. and Ichijo, H.
Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling.
Adv. Biol. Regul., (review article), 53, 135-144 (2013).

  Katome, T., Namekata, K., Guo, X., Semba, K., Kittaka, D., Kawamura, K., Kimura, A., Harada, C., Ichijo, H., Mitamura, Y. and Harada, T.
Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury.
Cell Death Differ., 20, 270-280 (2013).

  Tasaki, T., *Yamada, S., Guo, X., Tanimoto, A., Wang, K-T., Nabeshima, A., Kitada, S., Noguchi H., Kimura, S., Shimajiri, S., Kohno, K., Ichijo, H. and Sasaguri, Y. Apoptosis Signal-regulating Kinase 1 deficiency attenuates vascular injury-induced neointimal hyperplasia by suppressing apoptosis In smooth muscle cells.
Am. J. Pathol., 182, 597-609 (2013).

2012年Jump to 2009

  Naguro, I., Umeda, T., Kobayashi, Y., Maruyama, J., Hattori, K., Shimizu, Y., Kataoka, K., Kim-Mitsuyama, S., Uchida, S., Vandewalle, A., Noguchi, T., Nishitoh, H., Matsuzawa, A., Takeda, K. and Ichijo, H.
ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney.
Nat. Commun., 2012;3:1285 (2012).

  Sekine, Y., Hatanaka, R., Watanabe, T., Sono, N., Iemura, S., Natsume, T., Kuranaga, E., Miura, M., Takeda, K. and Ichijo, H.
The kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.
Mol. Cell, 48, 692-704 (2012).

  Sekine,S., Kanamaru, Y., Koike, M., Nishihara, A., Okada, M., Kinoshita, H., Kamiyama, M., Maruyama, J., Uchiyama, Y., Ishihara, N., Takeda, K. and Ichijo, H.
Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.
J. Biol. Chem., 287, 34635-34645 (2012).

  Fujisawa, T., Homma, K., Yamaguchi, N., Kadowaki, H., Tsuburaya, N., Naguro, I., Matsuzawa, A., Takeda, K., Takahashi, Y., Goto, J., Tsuji, S., Nishitoh, H. and Ichijo, H.
A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants.
Ann. Neurol., 72, 739-749 (2012).

  Hayakawa, Y., Hirata, Y., Sakitani, K., Nakagawa, H., Nakata, W., Kinoshita, H., Takahashi, R.,  Takeda, K., Ichijo, H., Maeda1, S. and Koike, K.
Apoptosis signal-regulating kinase-1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer.
Cancer Sci.,103, 2181-2185 (2012).

  Lin, F.R., Huang, S.Y., Hung, K.H., Su, S.T., Chung, C.H., Matsuzawa, A., Hsiao, M., Ichijo, H. and Lin, K.I.
ASK1 promotes apoptosis of normal and malignant plasma cells.
Blood, 120, 1039-1047 (2012).

  Nako, H., Kataoka, K., Koibuchi, N., Dong, Y.F., Toyama, K., Yamamoto, E., Yasuda, O., Ichijo, H., Ogawa, H. and Mitsuyama, S.H.
Novel mechanism of angiotensin II-induced cardiacinjury in hypertensive rats: the critical role of ASK1.
Hypertens. Res., 35, 194-200 (2012).

  Ishida, Y., Sekine, Y., Oguchi, H., Chihara, T., Miura, M., Ichijo, H. and Takeda, K.
Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster.
PloS ONE, 7: e30265 (2012).

  Lee, K.W., Zhao, X., Im, J.Y., Grosso, H., Jang, W.H., Chan, T.W., Sonsalla, P.K., German, D.C.,  Ichijo, H., Junn, E., and Mouradian, M.M.
Apoptosis Signal-regulating Kinase 1 mediates MPTP toxicity and regulates glial activation.
PloS ONE, 7: e29935 (2012).

  Menu, P., Mayor, A., Zhou, R., Tardivel, A., Ichijo, H., Mori, K. and Tschopp, J.
ER stress activates the NLRP3 inflammasome via an UPR-independent pathway.
Cell Death & Disease, 3:e261 (2012).

  Kamiyama, M., Sato, T., Takeda, K. and Ichijo, H. Roles for the stress-responsive kinase ASK1 and ASK2 in tumorigenesis.
Chemibiomolecular Science: At the Frontier of Chemistry and Biology, (review article), Shibasaki, M., Iino, M. Osada, H.(Eds), Springer Japan KK, 145-153 (2012).

  Hayakawa, R., Hayakawa, T., Takeda, K. and Ichijo, H. Therapeutic targets in the ASK1-dependent stress signalling pathways.
Proc. Jpn. Acad. Ser. B: Phys. Biol. Sci., (review article), 88, 434-453 (2012).

  Kanamaru, Y., Sekine S., Ichijo, H. and Takeda, K.
The Phosphorylation-Dependent Regulation of Mitochondrial Proteins in Stress Responses.
J. Signal Transduct., (review article), 2012, 12 (2012).

  Soga, M., Matsuzawa, A., Ichijo, H.
Oxidative Stress-Induced Diseases via the ASK1 Signaling Pathway.
Int. J. Cell Biol., (review article), 2012, 439587 (2012).

2011年Jump to 2009

  Dosal, R.G., Horan, K.A., Rahbek, S.H., Ichijo, H., Chen, Z.J., Mieyal, J.J., Hartmann, R.,  Paludan, S.R. 
HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6.
PLoS Pathogens, e1002250 (2011).

  Sekine,Y., Takagahara,S., Hatanaka, R., Watanabe, T., Oguchi, H., Noguchi, T., Naguro, I., Kobayashi, K., Tsunoda, M., Funatsu, T., Nomura, H., Toyoda, T., Matsuki, N., Kuranaga, E., Miura, M., Takeda, K. and Ichijo,H.
p38 MAP kinase regulates the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors.
J. Cell Sci., 124, 3006-3016 (2011).

  Nakagawa, H., Hirata, Y., Takeda, K., Hayakawa, Y., Sato, T., Kinoshita, H., Sakamoto, K., Nakata, W., Hikiba, Y., Omata, M., Yoshida, H., Koike, K. Ichijo, H. and Maeda, S.
Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated MAPK.
Hepatology, 54, 185-195 (2011).

  Makena, P.S., Gorantla, V.K., Ghosh, M.C., Bezawada, L., Kandasamy, K., Balazs, L., Luellen, C.L., Thompson, K.E., Parthasarathi, K., Ichijo, H., Waters, C.M. and Sinclair, S.E.
Deletion of apoptosis signal regulating kinase-1 prevents ventilatorinduced lung injury in mice.
Am. J. Respir. Cell Mol. Biol., 46, 461-469 (2011).

  Yamada, S., Ding, Y., Tanimoto, A., Wang, K.Y., Guo, X., Li, Z., Tasaki, T., Nabesima, A., Murata, Y., Shimajiri, S., Kohno, K., Ichijo, H. and Sasaguri, Y.
Apoptosis Signal-Regulating Kinase 1 Deficiency Accelerates Hyperlipidemia-Induced Atheromatous Plaques via Suppression of Macrophage Apoptosis.
Arterioscler. Thromb. Vasc. Biol., 31, 1555-1564 (2011).

  Hayakawa, T., Kato, K., Hayakawa, R., Hisamoto, N., Matsumoto, K., Takeda, K. and Ichijo, H.
Regulation of anoxic death in Caenorhabditis elegans by mammalian apoptosis signal-regulating kinase (ASK) family proteins
Genetics, 187, 785-792 (2011).

  Hayakawa, Y., Hirata, Y., Nakagawa, H., Sakamoto, K., Hikiba, Y., Kinoshita, H., Nakata, W., Takahashi, R., Tateishi, K., Tada, M., Akanuma, M., Yoshida, H., Takeda, K., Ichijo, H., Omata, M., Maeda, S., Koike, K.
Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer.
Proc. Natl. Acad. Sci. USA., 108, 780-785 (2011).

  Okamoto, M., Saito, N., Kojima, H., Okabe, T., Takeda, K., Ichijo, H., Furuya, T. and Nagano, T.
Identification of novel ASK1 inhibitors using virtual screening.
Bioorg. Med. Chem., 19, 486-489 (2011).

  Runchel, C., Matsuzawa, A. and Ichijo, H. MAPKs in mammalian oxidative stress responses.
Antioxid. Redox Signal., (review article), 15, 205-218 (2011).

  Takeda, K., Naguro, I., Nishitoh, H.,Matsuzawa, A. and Ichijo, H.
Apoptosis signaling kinases: from stress response to health outcomes.
Antioxid. Redox Signal., (review article), 15, 719-761 (2011).

2010年Jump to 2012

  Guo, X., Harada, C., Namekata, K., Matsuzawa, A., Camps, M., Ji, H., Swinnen, D., Jorand-Lebrun, C., Muzerelle, M., Vitte, P., Ruckle, T., Kimura, A., Kohyama, K., Matsumoto, Y., Ichijo, H. and Harada, T. 
Regulation of the severity of neuroinflammation and demyelination by TLR-ASK1-p38 pathway.
EMBO Mol. Med., 2, 504-515 (2010).

  Imai, Y., Kanao, T., Sawada, T., Kobayashi, Y., Moriwaki, Y., Ishida, Y., Takeda, K., Ichijo, H., Lu, B. and Takahashi, R.
The Loss of PGAM5 Suppresses the Mitochondrial Degeneration Caused by Inactivation of PINK1 in Drosophila.
PLoS Genet., 6, e1001229 (2010).

  Matsuzawa, A., Takeda, K. and Ichijo, H. ASK1: Molecule Pages,
UCSD-Nature Signaling Gateway, (review article), (2010).

  Kataoka, K., Tokutomi, Y., Yamamoto, E., Nakamura, T., Fukuda, M., Dong, Y.-F., Ichijo, H., Ogawa H. and Kim-Mitsuyama, S.
Apoptosis signal-regulating kinase 1 deficiency eliminates cardiovascular injuries induced by high-salt diet.
J. Hypertens., 29, 76-84 (2010).

   Roy, S., Khanna, S., Azad, A., Schnitt, R., He, G., Weigert, C., Ichijo, H. and Sen, C.K.
Fra-2 mediates oxygen-sensitive induction of transforming growth factor beta in cardiac fibroblasts.
Cardiovasc Res., 87, 647-655 (2010).

   Mnich, S.J., Blanner, P.M., Hu, G., Shaffer, A.F., Happa, F.A., O'Neil, S., Ukairo, O., Weiss, D., Welsh, E., Storer, C., Mbalaviele, G., Ichijo, H., Monahan, J.B., Hardy, M.M. and Eda, H.  
Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis.
Int. Immunopharmacol., 10, 1170-1176 (2010).

  Maruyama, T., Kadowaki, H., Okamoto, N., Nagai, A., Naguro, I., Matsuzawa, A., Shibuya, H., Tanaka, K., Murata, S., Takeda, K., Nishitoh, H. and Ichijo, H.
CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response.
EMBO J., 29, 2501-2514 (2010).

  Katagiri, K., Matsuzawa, A. and Ichijo, H.  
Regulation of Apoptosis Signal-regulating Kinase 1 in redox signaling.
Methods in Enzymology, (review article) 474, 277-288 (2010).

  Shimizu, Y., Naguro, I., Nishitoh, H. and Ichijo, H.
ER stress-induced cell death and inflammatory signaling: a therapeutic insight into intractable diseases.
Endoplasmic Reticulum Stress and Human Disease, (review article), in press.

  Harada, C., Namekata, K., Guo, X., Yoshida, H., Mitamura, Y., Matsumoto, Y., Tanaka, K., Ichijo, H. and Harada, T.
ASK1 deficiency attenuates neural cell death in GLAST deficient mice, a model of normal tension glaucoma.
Cell Death Differ., 17, 1751-1759 (2010).

  Seong, H.A., Jung, H., Ichijo, H. and Ha, H.
Reciprocal negative regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) and apoptosis signal-regulating kinase 1 (ASK1) signaling by direct interaction and phosphorylation.
J. Biol. Chem., 285, 2397-2414 (2010).

  Hayakawa Y, Hirata Y, Nakagawa H, Sakamoto K, Hikiba Y, Otsuka M, Ijichi H, Ikenoue, T., Tateishi, K., Akanuma, M., Ogura, K., Yoshida, H., Ichijo, H., Omata, M. and Maeda, S.
Apoptosis Signal-Regulating Kinase 1 regulates colitis and colitis-associated tumorigenesis via the innate immune responses.
Gastroenterology., 138, 1055-1067 (2010).

  Kumakura, K., Nomura, H., Toyoda, T., Hashikawa, K., Noguchi, T., Takeda, K., Ichijo, H., Tsunoda, M., Funatsu, T., Ikegami, D., Narita, M., Suzuki, T. and Matsuki, N.
Hyperactivity in novel environment with increased dopamine and impaired novelty preference in apoptosis signal-regulating kinase 1 (ASK1)-deficient mice.
Neurosci. Res., 66, 313-320 (2010).

2009年Jump to 2012 2011

  Nagai, H,, Noguchi, T., Homma, K., Katagiri, K., Takeda, K., Matsuzawa, A. and Ichijo, H.
Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death.
Mol. Cell, 36, 805-818 (2009).

  Cekic, C., Casella, C.R., Eaves, C.A., Matsuzawa, A., Ichijo, H. and Mitchell, T.C.
Selective activation of the p38 MAPK pathway by synthetic monophosphoryl lipid A.
J. Biol. Chem., 284, 31982-31991 (2009).

  Takeda, K., Komuro, Y., Hayakawa, T., Oguchi, H., Ishida, Y., Murakami, S., Noguchi, T., Kinoshita, H., Sekine, Y., Iemura, S., Natsume, T., and Ichijo, H.
Mitochondrial Phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1.
Proc. Natl. Acad. Sci. USA., 106, 12301-12305 (2009).

  Kundu, M., Pathak, S.K., Kumawat, K., Basu, S., Chatterjee, G., Pathak, S., Noguchi, T., Takeda, K., Ichijo, H., Thien, C.B., Langdon, W.Y. and Basu, J.
A TNF- and c-Cbl-dependent FLIP(S)-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis.
Nature Immunol., 10, 918-926 (2009).

  Zhou, J., Shao, Z., Kerkela, R., Ichijo, H., Muslin, A., Pombo, C. and Force, T.
Serine 58 of 14-3-3{zeta} is a molecular switch regulating ASK1 and oxidant stress-induced cell death.
Mol. Cell. Biol., 29, 4167-4176 (2009).

  Waak, J., Weber, S. S., Gorner, K., Schall, C., Ichijo, H., Stehle, T. and Kahle, P. J.
Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1.
J. Biol. Chem., 284, 14245-14257 (2009).

  Iriyama, T., Takeda, K., Nakamura, H., Morimoto, Y., Kuroiwa, T., Mizukami, J., Umeda, T., Noguchi, T., Naguro, I., Nishitoh, H., Saegusa, K., Tobiume, K., Homma, T., Shimada, Y., Tsuda, H., Aiko, S., Imoto, I., Inazawa, J., Chida, K., Kamei, Y., Kozuma, S., Taketani, Y., Matsuzawa, A. and Ichijo, H.
ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.
EMBO J., 28, 843-853 (2009).

  Nakamura, T., Kataoka, K., Fukuda, M., Nako, H., Tokutomi, Y., Dong, Y-F. Ichijo, H., Ogawa, H. and Kim-Mitsuyama, S.
Critical role of apoptosis signal-regulating kinase 1 in aldosterone/salt-induced cardiac inflammation and fibrosis.
Hypertension, 54, 544-551 (2009).

  Furuhata, M., Takada, E., Noguchi, T., Ichijo, H. and Mizuguchi, J. 
Apoptosis Signal-Regulating Kinase (ASK)-1 Mediates Apoptosis through activation of JNK1 following Engagement of Membrane Immunoglobulin.
Exp. Cell. Res., 315, 3467-3476 (2009).

  Nagai, A., Kadowaki, H., Maruyama, T., Takeda, K., Nishitoh, H. and Ichijo, H.
USP14 inhibits ER-associated degradation via interaction with IRE1alpha.
Biochem. Biophys. Res. Commun., 379, 995-1000 (2009).

  Nishitoh, H., Kadowaki H.,,Takeda, K. and Ichijo, H.
ER Quality Control, ER Stress-Induced Apoptosis, and Neurodegenerative Diseases.
Protein Misfolding Disorders: A Trip into the ER, (review article) 94-102 (2009).

  Homma, K., Katagiri, K., Nishitoh, H. and Ichijo, H.
Targeting ASK1 in ER stress-related Neurodegenerative Diseases.
Expert Opinion on Therapeutic Targets, (review article), 13, 653-664 (2009).

  Hattori, K., Naguro, I., Runchel, C. and Ichijo, H.
The roles of ASK family proteins in stress responses and diseases.
Cell Communication and Signaling, (review article), 7, 9 (2009).

  Galluzzi, L. et al.
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.
Cell Death Differ., (review article), 16, 1093-1107 (2009).

  Hatanaka, R., Sekine, Y., Hayakawa, T., Takeda, K. and Ichijo, H.
Signaling pathways in invertebrate immune and stress response.
Invertebrate Survival Journal, (review article), 6, 32-43 (2009).

  Maruyama, J., Naguro, I., Takeda, K. and Ichijo, H.
Stress-Activated MAP Kinase Cascades in Cellular Senescence.
Curr. Med. Chem., (review article), 16, 1229-1235 (2009).

2008年Jump to 2012 2011 2010

  Nishitoh, H., Kadowaki, H., Nagai, A., Maruyama, T., Yokota, T., Fukutomi, H., Noguchi, T., Matsuzawa, A., Takeda, K. and Ichijo, H.
ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.
Genes. Dev., 22, 1451-1464 (2008).

  Noguchi, T., Ishii, K., Fukutomi, H., Naguro, I., Matsuzawa, A., Takeda, K. and Ichijo, H.
Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAP kinase pathway for extracelluler ATP-induced apoptosis in macrophage.
J. Biol. Chem., 283, 7657-7665 (2008).
  Nakagawa, H., Maeda, S., Hikiba, Y., Ohmae, T., Shibata, W., Yanai, A., Sakamoto, K., Ogura, K., Noguchi, T., Karin, M., Ichijo, H. and Omata, M.
Deletion of Apoptosis Signal-Regulating Kinase 1 Attenuates Acetaminophen-Induced Liver Injury by Inhibiting C-Jun N-Terminal Kinase Activation.
Gastroenterology, 135, 1311-1321 (2008).
  Wu, Y. T., Zhang, S., Kim, Y. S., Tan, H. L., Whiteman, M., Ong, C. N., Liu, Z. G., Ichijo, H. and Shen, H. M.
Signaling pathways from membrane lipid rafts to JNK1 activation in reactive nitrogen species-induced non-apoptotic cell death.
Cell Death Differ., 15, 386-397 (2008).
  Taniike, M., Yamaguchi, O., Tsujimoto, I., Hikoso, S., Takeda, T., Nakai, A., Omiya, S., Mizote, I., Nakano, Y., Higuchi, Y., Matsumura, Y., Nishida, K., Ichijo, H., Hori, M. and Otsu, K.
Apoptosis signal-regulating kinase 1 (ASK1)/p38 signaling pathway negatively regulates physiological hypertrophy.
Circulation, 117, 545-552 (2008).
  Yamamoto, E., Dong, Y.F., Kataoka, K., Yamashita, T., Tokutomi, Y., Matsuba, S., Ichijo, H., Ogawa, H. and Kim-Mitsuyama, S.
Olmesartan Prevents Cardiovascular Injury and Hepatic Steatosis in Obesity and Diabetes, Accompanied by Apoptosis Signal Regulating Kinase-1 Inhibition.
Hypertension, 52, 573-580 (2008).
  Yamauchi, S., Noguchi, T. and Ichijo, H.
Molecular Mechanism of Reactive Oxygen Species-dependent ASK1 Activation in Innate Immunity.
Immune Network, (review article), 8, 1-6 (2008).
  Matsuzawa, A. and Ichijo, H.
Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling.
Biochim. Biophys. Acta., (review article), 1780, 1325-1336 (2008).

  Takeda, K., Noguchi, T., Naguro, I. and Ichijo, H.
Apoptosis Signal-regulating Kinase 1 (ASK1) in stress and immune response.
Annu. Rev. Pharmacol. Toxicol., (review article), 48, 199-225 (2008).

2007年Jump to 2012 2011 2010

  Fujino, G., Noguchi, T., Matsuzawa, A., Yamauchi, S., Saitoh, M., Takeda, K. and Ichijo, H.
Thioredoxin and TRAF family proteins regulate ROS-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1.
Mol. Cell. Biol., 27, 8152-8163 (2007).
  Osaka, N., Takahashi, T., Murakami, S., Matsuzawa, A., Noguchi, T., Fujiwara, T., Aburatani, H., Moriyama, K., Takeda, K. and Ichijo, H.
ASK1-dependent recruitment and activation of macrophages induce hair growth in skin wounds.
J. Cell Biol., 176, 903-909 (2007).
Takeda, K., Shimozono, R., Noguchi, T., Umeda, T., Morimoto, Y., Naguro, I., Tobiume, K., Saitoh, M., Matsuzawa, A. and Ichijo, H.
Apoptosis signal-regulating kinase 2 (ASK2) functions as a MAP3K in a heteromeric complex with ASK1.
J. Biol. Chem., 282, 7522-7531 (2007).
Ito, G., Okai, T., Fujino, G., Takeda, K., Ichijo, H., Katada, T. and Iwatsubo, T.
GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial parkinson's disease.
Biochemistry, 46, 1380-1388 (2007).
  Nagai, H., Noguchi, T., Takeda, K.and Ichijo, H.
Pathophysiological Roles of ASK1-MAP Kinase Signaling Pathways.
J. Biochem. Mol. Biol., (review article), 40, 1-6 (2007).
  Murakami, S., Noguchi, T., Takeda, K. and Ichijo, H.
Stress signaling in cancer.
Cancer Sci., (review article), 98, 1521-1527 (2007).
  Fujisawa, T., Takeda, K. and Ichijo, H.
ASK family proteins in stress response and disease.
Mol. Biotechnol., (review article), 37, 13-18 (2007).
  Yan, W., Arai, A., Aoki, M., Ichijo, H. and Miura, O.
ASK1 is activated by arsenic trioxide in leukemic cells through accumulation of reactive oxygen species and may play a egative role in induction of
Biochem. Biophys. Res. Commun., 355, 1038-1044 (2007).
  Kuwamura, H., Tominaga, K., Shiota, M., Ashida, R., Nakao, T., Sasaki, E., Watanabe, T., Fujiwara, Y., Oshitani, N., Higuchi, K., Ichijo, H., Arakawa, T. and Iwao, H.
Growth inhibition of colon cancer cells by transfection of dominant-negative apoptosis signal-regulating kinase-1.
Oncol Rep., 2007 17, 781-786 (2007).
  Saito, J., Toriumi, S., Awano, K., Ichijo, H., Sasaki, K., Kobayashi, T. and Tamura, S.
Regulation of Apoptosis Signal-regulating Kinase 1 by Protein Phosphatase 2Cε.
Biochem. J., 405, 591-596 (2007).
  Kani, S., Nakayama, E., Yoda, A., Onishi, N., Sougawa, N., Hazaka, Y., Umeda, T., Takeda, K., Ichijo, H., Hamada, Y. and Minami, Y.
Chk2 kinase is required for methylglyoxal-induced G2/M cell-cycle checkpoint arrest: implication of cell-cycle checkpoint regulation in diabetic oxidative stress signaling.
Genes Cells, 12, 919-928 (2007).
  Yamashita, T., Yamamoto, E., Kataoka, K., Nakamura, T., Matsuba, S., Tokutomi, Y., Dong, Y-F. Ichijo, H., Ogawa, H. and Kim-Mitsuyama, S.
Apoptosis Signal-regulating Kinase-1 is involved in vascular endothelial and cardiac remodeling caused by nitric oxide deficiency.
Hypertension, 50, 519-524 (2007).
  Galvan, V., Banwait, S., Spilman, P., Gorostiza, O.F., Peel, A., Ataie, M., Crippen, D., Huang, W., Sidhu, G., Ichijo, H. and Bredesen, D.E.
Interaction of ASK1 and the beta-amyloid precursor protein in a stress-signaling complex.
Neurobiol Dis., 28, 65-75 (2007).

Terada, Y., Inoshita, S., Kuwana, H., Kobayashi, T., Okado, T., Ichijo, H. and Sasaki, S.
Important role of apoptosis signal-regulating kinase 1 in ischemic acute kidney injury.
Biochem. Biophys. Res. Commun., 364, 1043-1049 (2007).
  Yamamoto, E., Kataoka, K., Shintaku, H., Yamashita, T., Tokutomi, Y., Dong, Y. F., Matsuba, S., Ichijo, H., Ogawa, H. and Kim-Mitsuyama, S.
Novel mechanism and role of angiotensin II-induced vascular endothelial injury in hypertensive diastolic heart failure.
Arterioscler. Thromb. Vasc. Biol., 27, 2569-2575 (2007).
  Yang, C.-S., Shin, D.-M., Lee, H.-M., Chang, M., Son, J. W., Lee, S. J., Akira, S., El-Benna, J., Ichijo, H. and Jo, E.-K.
ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling.
Cell. Microbiol., 10, 741-754 (2007).

2006年Jump to 2012 2011 2010

  Van Laethem, A., Nys, K., Van Kelst, S., Claerhout, S., Ichijo, H., Vandenheede, J.R., Garmyn, M. and Agostinis, P.
Apoptosis signal regulating kinase-1 connects reactive oxygen species to p38 MAPK-induced mitochondrial apoptosis in UVB-irradiated human keratinocytes.
Free Radic. Biol. Med., 41, 1361-1371 (2006).

  Fujino, G., Noguchi, T., Takeda, K. and Ichijo, H.
Thioredoxin and protein kinases in redox signaling.
Semin. Cancer Biol., (review article), 16, 427-735 (2006).

  Kitagawa, D., Kajiho, H., Negishi, T., Ura, S., Watanabe, T., Wada, T., Ichijo, H., Katada, T. and Nishina, H.
Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation.
EMBO J., 25, 3286-3297 (2006).

  Yokoi, T., Fukuo, K., Yasuda, O., Hotta, M., Miyazaki, J., Takemura, Y., Kawamoto, H., Ichijo, H. and Ogihara, T.
Related articles, links Apoptosis Signal-regulating Kinase 1 mediates cellular senescence induced by high glucose in endothelial cells.
Diabetes, 55, 1660-1665 (2006).

  Chiang, E., Dang, O., Anderson, K., Matsuzawa, A., Ichijo, H. and David, M.
Apoptosis- regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor 3 by lipopolysaccharide.
J. Immunol., 176, 5720-5724 (2006).

  Liu, Q., Wilkins, B.J., Lee, Y.J., Ichijo, H. and Molkentin, J.D.
Direct Interaction and Reciprocal Regulation Between ASK1 and Calcineurin-NFAT Controls Cardiomyocyte Death and Growth.
Mol. Cell. Biol., 26, 3785-3797 (2006).

  Imoto, K., Kukidome, D., Nishikawa, T., Matsuhisa, T., Sonoda, K., Fujisawa, K., Yano, M., Motoshima, H., Taguchi, T., Tsuruzoe, K., Matsumura, T., Ichijo, H. and Araki, E.
Impact of mitochondrial reactive oxygen species and apoptosis signal-regulating kinase 1 on insulin signaling.
Diabetes, 55, 1197-1204 (2006).

  Hayakawa, T., Matsuzawa, A., Noguchi, T., Takeda, K. and Ichijo, H.
The ASK1-MAP kinase pathways in the immune and stress responses.
Microbes Infect., (review article), 8, 1098-1107(2006).

  Takeda, K., Noguchi, T. and Ichijo, H.
ASK1 signalosome: a signaling complex essential for cellular stress responses.
J. Oral Biosci, (review article), 48, 7-11 (2006).

  Sekine, Y., Takeda, K. and Ichijo, H.
The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases.
Curr. Mol. Med., (review article), 6, 87-97 (2006).

  Lee, KH., Nishimura, S., Matsunaga, S., Fusetani, N., Ichijo, H., Horinouchi, S. and Yoshida, M.
Induction of a ribotoxic stress response that stimulates stress-activated protein kinases by 13- deoxytedanolide, an antitumor marine macrolide.
Biosci. Biotechnol. Biochem., 70, 161-171 (2006).

  Harada, C., Nakamura, K., Namekata, K., Okumura, A., Mitamura, Y., Iizuka, Y., Kashiwagi, K., Yoshida, K., Ohno, S., Matsuzawa, A., Tanaka, K., Ichijo, H. and Harada, T.
Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo.
Am. J. Pathol., 168, 261-269 (2006).

  Mizumura, K., Takeda, K., Hashimoto, S., Horie, T. and Ichijo, H.
Identification of Op18/ stathmin as a potential target of ASK1-p38 MAP kinase cascade.
J. Cell. Physiol., 206, 363-370 (2006).

2005年Jump to 2012 2011 2010

  Noguchi, T., Takeda, K., Matsuzawa, A., Saegusa, K., Nakano, H., Gohda, J., Inoue, J. and Ichijo, H.
Recruitment of TRAF family proteins to the ASK1 signalosome is essential for oxidative stress-induced cell death.
J. Biol. Chem., 280, 37033-37040 (2005).

  Matsuzawa, A., Saegusa, K., Noguchi, T., Sadamitsu, C., Nishitoh, H., Nagai, S., Koyasu, S., Matsumoto, K., Takeda, K. and Ichijo, H.
ROS-dependent activation of TRAF6-ASK1-p38 pathway is selectively required for TLR-4 mediated innate immunity.
Nature Immunol., 6, 587-592 (2005).

Junn, E., Taniguchi, H., Jeong, B.S., Zhao, X., Ichijo, H. and Mouradian, M.,M.
Interaction of DJ-1 with Daxx inhibits ASK1 activity and cell death.
Proc. Natl. Acad. Sci. USA., 102, 9691-9696 (2005).

  Watanabe, T., Otsu, K., Takeda, T., Yamaguchi, O., Hikoso, S., Kashiwase, K., Higuchi, Y., Taniike, M., Nakai, A., Matsumura, Y., Nishida, K., Ichijo, H. and Hori, M.
Apoptosis signal-regulating kinase 1 is involved not only in apoptosis but also in non-apoptotic cardiomyocyte death.
Biochem. Biophys. Res. Commun., 333, 562-567 (2005).

  Izumi, Y., Kim-Mitsuyama, S., Yoshiyama, M., Omura, T., Shiota, M., Matsuzawa, A., Yukimura, T., Murohara, T., Takeya, M., Ichijo, H., Yoshikawa, J. and Iwao, H.
Important Role of Apoptosis Signal-Regulating Kinase 1 in Ischemia-induced Angiogenesis.
Arterioscler. Thromb. Vasc. Biol., 25, 1877-1883 (2005).

  Kumasawa, F., Hashimoto, S., Onose, A., Jibiki, I. , Mizumura, K., Matsumoto, M., Maruoka, S., Gon, Y., Kobayashi, T., Takahashi, N., Ichijo, H. and Horie, T.
Apoptosis signal- regulating kinase 1 in leukotriene D(4)-induced activator protein-1 in airway smooth muscle cells.
Eur. J. Pharmacol., 517, 11-16 (2005).

  Kadowaki, H., Nishitoh, H., Urano, F., Sadamitsu, C., Matsuzawa, A., Takeda, K., Masutani, H., Yodoi, J., Urano, Y., Nagano, T. and Ichijo, H.
Amyloid b induces neuronal cell death through ROS-mediated ASK1 activation.
Cell Death Differ., 12, 19-24 (2005).

  Dersch, K., Ichijo, H., Bhakdi, S. and Husmann, M.
Fatty acids liberated from low density lipoprotein trigger endothelial apoptosis via mitogen activated protein kinases.
Cell Death Differ., 12, 1107-1114 (2005).

  Sayama, K., Komatsuzawa, H., Yamasaki, K., Shirakata, Y., Hanakawa, Y., Ouhara, K., Tokumaru, S., Dai, X., Tohyama, M., ten Dijke, P., Sugai, M., Ichijo, H. and Hashimoto, K.
New mechanisms of skin innate immunity: ASK1-mediated keratinocyte differentiation regulates the expression of b-defensins, LL37, and TLR2.
Eur. J. Immunol., 35, 1886-1895 (2005).

  Bijangi-Vishehsaraei, K., Saadatzadeh, M.R., Werne, A., McKenzie, K.A., Kapur, R., Ichijo,H. and Haneline, L.S.
Enhanced TNF-α induced apoptosis in fanconi anemia type C deficient cells is dependent on Apoptosis Signal-regulating Kinase 1.
Blood, 106, 4124-4130 (2005).

  Omura, T., Yoshiyama, M., Matsumoto, R., Kusuyama, T., Enomoto, S., Nishiya, D., Izumi, Y., Kim, S., Ichijo, H., Motojima, M., Akioka, K., Iwao, H., Takeuchi, K. and Yoshikawa, J.
Role of c-Jun NH2-terminal kinase in G-protein-coupled receptor agonist-induced cardiac plasminogen activator inhibitor-1 expression.
J. Mol. Cell Cardiol., 38, 583-592 (2005).

  Matsuzawa, A. and Ichijo, H.
Stress-responsive protein kinases in redox-regulated apoptosis signaling.
Antioxid. Redox Signal, (review article), 7, 472-481 (2005).

2004年Jump to 2012 2011 2010

  Matsukawa, J., Matsuzawa, A., Takeda, K. and Ichijo, H.
Functions of MAP Kinase cascades: The ASK1-MAP Kinase cascades in mammalian stress response.
J. Biochem. (review article), 136, 261-265 (2004).

  Kaneto, H., Nakatani, Y., Miyatsuka, T., Kawamori, D., Matsuoka, T.A., Matsuhisa, M., Kajimoto, Y., Ichijo, H., Yamasaki, Y. and Hori, M.
Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide.
Nature Med., 10, 1128-1132 (2004).

  Takeda, K., Matsuzawa, A., Nishitoh, H., Tobiume, K., Kishida, S., Ninomiya,T., Tsuji, J., Matsumoto, K., and Ichijo, H.
Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation.
EMBO Rep., 5, 161-166 (2004).

  Naguro, I., Adachi-Akahane, S. and Ichijo, H.
Calcium signaling via voltage-dependent L-type Ca2+ channels.
Signal Transduction (review article), 4, 195-205 (2004).

  Kadowaki, H., Nishitoh, H. and Ichijo, H.
Survival and apoptosis signals in ER stress: the role of protein kinases.
J. Chem. Neuroanat. (review article), 28, 93-100 (2004).

  Yamaguchi, O., Watanabe, T., Nishida, K., Kashiwase, K., Higuchi, Y., Takeda, T., Hikoso, S., Hirotani, S., Asahi, M., Taniike, M., Nakai, A., Tsujimoto, I., Matsumura, Y., Miyazaki, J., Chien, K.R., Matsuzawa, A.,
Sadamitsu, C., Ichijo, H., Baccarini, M., Hori1, M. and Otsu, K.
Cardiac-specific Disruption of c-raf-1 Gene Induces Cardiac Dysfunction and Apoptosis.
J. Clin. Invest., 114, 937-943 (2004).

  Huang, S., Shu, L., Easton, J., Harwood, F. C., Germain, G. S., Ichijo, H. andHoughton, P. J.
Inhibition of Mammalian Target of Rapamycin Activates Apoptosis Signal-Regulating Kinase 1 Signaling by Suppressing Protein Phosphatase 5 Activity.
J. Biol. Chem., 279, 36490-36496 (2004).

  Omura, T., Yoshiyama, M., Kim, S., Matsumoto, R., Nakamura, Y., Izumi, Y., Ichijo, H., Sudo, T., Akioka, K., Iwao, H., Takeuchi, K. and Yoshikawa, J.
Involvement of Apoptosis Signal-Regulating Kinase-1 on Angiotensin II-Induced Monocyte Chemoattractant Protein-1 Expression.
Arterioscler Thromb Vasc Biol., 24, 1-6 (2004).

  Subramanian RR, Zhang H, Wang H, Ichijo H, Miyashita T, Fu H.
Interaction of apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins.
Exp Cell Res., 294, 581-91 (2004).

2003年Jump to 2012 2011 2010

  Song, S., Kim, S.Y., Hong, Y.M., Jo, D.G., Lee, J.Y., Shim, S.M., Chung, C.W., Seo, S.J., Yoo, Y.J., Koh, J.Y., Lee, M.C., Yates, A.J., Ichijo, H. and Jung, Y.K.
Essential role of E2-25K/Hip-2 in mediating amyloid-beta neurotoxicity.
Mol. Cell, 12, 553-563 (2003).

  Izumiya, Y., Kim, S., Izumi, Y., Yoshida, K., Yoshiyama, M., Matsuzawa, A., Ichijo, H. and Iwao, H.
Apoptosis Signal-Regulating Kinase 1 Plays a Pivotal Role in Angiotensin II-Induced Cardiac Hypertrophy and Remodeling.
Circulation Res., 93, 874-883 (2003).

  Cho, S.-G., Kim, J.W., Lee, Y.H., Hwang, H.S., Kim, M.-S., Ryoo, K., Kim, M.J., Noh K.T., Kim, E.K. Cho, J.-H., Yoon, K.W., Cho, E.-G., Park, H.-S., Chi, S.W., Lee, M.-J., Kang, S.S., Ichijo, H. , and Choi, E.-J.
Identification of a novel antiapoptotic protein that antagonizes ASK1 and CAD activities.
J. Cell Biol., 163, 71-81 (2003).

  Izumi, Y., Kim, S., Yoshiyama, M., Izumiya, Y., Yoshida, K., Matsuzawa, A., Koyama, H., Nishizawa, Y., Ichijo, H., Yoshikawa, J. and Iwao, H.
Activation of apoptosis signal-regulating kinase 1 in injured artery and its critical role in neointimal hyperplasia.
Circulation, 108, 2812-2818 (2003).

  Hashimoto, Y., Niikura, T., Chiba, T., Tsukamoto, E., Kadowaki, H., Nishitoh, H., Yamaguchi, Y., Ishizaka, M., Yamada, M., Nawa, M., Terashita, K., Aiso, S., Ichijo, H. and Nishimoto, I.
The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained ASK1/JNK mediated neurotoxic signal via dimerization.
J. Pharmacol. Exp. Ther., 306, 889-902 (2003).

  Maruoka, S., Hashimoto, S., Gon, Y., Nishitoh, H., Takeshita, I., Asai, Y., Mizumura, K., Shimizu, K., Ichijo, H. and Horie, T.
ASK1 regulates influenza virus infection-induced apoptotic cell death.
Biochem. Biophys. Res. Commun., 307, 870-876 (2003).

  Takeda, K., Matsuzawa, A., Nishitoh, H. and Ichijo, H.
Roles of MAPKKK ASK1 in Stress-Induced Cell Death.
Cell Struct Funct. (review article), 28, 23-29 (2003).

  Oberst, A., Baehrecke, E., Mehmet, H., Ichijo, H. and Gupta, S.
A place to die for: apoptosis in cancer and infection, Capri 2002.
Cell Death Differ., 10, 393-395 (2003).

  Matsuzawa, A., Nishitoh, H., Takeda, K. and Ichijo, H.
MAP Kinases in Redox Signaling in
"Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles" ed. by Forman HJ., Fukuto, J. and Torres, M., Kluwer Academic (review article), 223-236 (2003).

  Machino, T., Hashimoto, S., Maruoka, S., Gon, Y., Hayashi, S., Nishitoh, H., Ichijo, H. and Horie, T.
Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates hydrogen peroxide -induced apoptosis in human pulmonary vascular endothelial cells.
Crit. Care Med., 31, 2776-2781 (2003).

  Huang, H., Shj, L., Dilling, M.B, Easton, J., Harwood, F.C., Ichijo, H. and Houghton, P.J.
Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/ p21Cip1.
Mol. Cell, 11, 1491-1501 (2003).

  Galvan, V., Logvinova, A., Sperandio, S., Ichijo, H. and Bredesen, D.E.
Type 1 insulin-like growth factor receptor (IGF-IR) signaling inhibits apoptosis signal-regulating kinase 1 (ASK1).
J. Biol. Chem., 278, 13325-13332 (2003).

  Yamagishi, S., Yamada, M., Koshimizu, H., Takai, S., Hatanaka, H., Takeda, K., Ichijo, H., Shimoke, K. and Ikeuchi, T.
Apoptosis-Signal Regulating Kinase-1 Is Involved in the Low Potassium-Induced Activation of p38 Mitogen-Activated Protein Kinase and c-Jun in Cultured Cerebellar Granule Neurons
J. Biochem., 133, 719-724 (2003).

  Yamaguchi, O., Higuchi, Y., Hirotani, S., Kashiwase, K., Nakayama, H., Hikoso, S., Takeda, T., Watanabe, T., Asahi, M., Taniike, M., Matsumura, Y., Tsujimoto, I., Hongo, K., Kusakari, Y., Kurihara, S., Nishida, K., Ichijo, H., Hori, M. and Otsu, K.
Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling.
Proc. Natl. Acad. Sci. USA., 100, 15883-15888 (2003).

  Takamatsu, H., Nagao, T., Ichijo, H. and Adachi-Akahane, S.
L-type Ca2+ channels serve as a sensor of the SR Ca2+ for tuning the efficacy of Ca2+-induced Ca2+ release in rat ventricular myocytes.
J. Physiol., 552, 415-424 (2003).

  Matsukawa, J., Nakayama, K., Nagao, T., Ichijo, H. and Urushidani, T.
Role of ADP-ribosylation factor 6 (ARF6) in gastric acid secretion.
J. Biol. Chem., 278, 36470-36475 (2003).

  Tashiro,K., Nagao, T., Kurose, H., Ichijo, H. and Urushidani, T.
Role of Rho in Rabbit Parietal Cell.
J. Cell. Physiol., 197, 409-417 (2003).

  Yamaguchi, S., Zhorov, B.S., Yoshioka, K., Nagao, T., Ichijo, H., and Adachi-Akahane, S.
Key roles of Phe1112 and Ser1115 in the pore-forming IIIS5-S6 linker of L-type Ca2+ channel a1C subunit (CaV1.2) in binding of dihydropyridines and action of Ca2+ channel agonists.
Mol. Phamracol., 64, 235-248 (2003).

2002年Jump to 2012 2011 2010

Saeki, K., Kobayashi, N., Inazawa, Y., Zhang, H., Nishitoh, H., Ichijo, H., Saeki, K., Isemura, M. and Yuo, A.
Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway from those of chemically induced and receptor-mediated apoptosis.
Biochem. J., 368, 705-720 (2002).

  Jibiki, I., Hashimoto, S., Maruoka, S., Gon, Y., Matsuzawa, A., Nishitoh, H., Ichijo, H., and Horie, T.
Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates nitric oxide-induced activator protein-1 activation in human bronchial epithelial cells.
Am. J. Respir. Cri. Care Med., 167, 856-861 (2002).

  Gilot, D., Loyer, P., Corlu, A., Glaise, D., Lagadic-Gossmann, D., Atfi, A., Morel, F., Ichijo, H. and Guguen-Guillouzo, C.
Liver protection from apoptosis requires both blockage of initiator caspase activities and inhibition of ASK1/JNK pathway via glutathione S-transferase regulation.
J. Biol. Chem., 277, 49220-49229 (2002).

  Matsuura, H., Nishitoh, H., Takeda, K., Matsuzawa, A., Amagasa, T., Ito, M., Yoshioka, K. and Ichijo, H.
Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway: a new mode of regulation of the MAP kinase cascade.
J. Biol. Chem., 277, 40703-40709 (2002).

Inoshita, S., Takeda, K., Hatai, T., Terada, Y., Sano, M., Hata, J., Umezawa, A. and Ichijo, H.
Phosphorylation and Inactivation of Mcl-1 by c-Jun N-terminal Kinase (JNK) in response to oxidative stress.
J. Biol. Chem., 277, 43730-43734 (2002).

Takeda, K. and Ichijo, H.
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
Genes Cells (review article), 7, 1099-1111 (2002).

  Kuranaga, E., Kanuka, H., Igaki, T., Sawamoto, K., Ichijo, H., Okano, H. and Miura, M.
Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila.
Nature Cell Biol., 4, 705-710 (2002).

  Nishitoh, H., Matsuzawa, A., Tobiume, K., Saegusa, K., Takeda, K., Inoue, K., Hori, S., Kakizuka, A. and Ichijo, H.
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats.
Genes Dev., 16, 1345-1355 (2002).

  Matsuzawa, A., Nishitoh, H., Tobiume, K., Takeda, K. and Ichijo, H.
Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.
Antioxid. Redox Signal, 4, 415-425 (2002).

  Tobiume, K., Saitoh, M. and Ichijo, H.
Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer.
J. Cell. Physiol., 191, 1091-1099 (2002).

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