東京大学大学院薬学系研究科 薬化学教室




  • Unexpected Resistance to Base-catalyzed Hydrolysis of Nitrogen Pyramidal Amides Based on the 7-Azabicyclic[2.2.1]heptane Scaffold
    Diego Antonio Ocampo Gutierrez de Velasco, Aoze Su, Luhan Zhai, Satowa Kinoshita, Yuko Otani, Tomohiko Ohwada
    Molecules 2018, 23(9), 2363;
    Open Access
    HTML Version
    PDF Version
    Special Issue: Amide Bond Activation (Guest Editor: Prof. Dr. Michal Szostak, Department of Chemistry, Rutgers University, 73 Warren St, Newark, NJ 07102, United States)
  • Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation
    Masaki Tsuchiya, Yuji Hara, Masaki Okuda, Karin Itoh, Ryotaro Nishioka, Akifumi Shiomi, Kohjiro Nagao, Masayuki Mori, Yasuo Mori, Junichi Ikenouchi, Ryo Suzuki, Motomu Tanaka , Tomohiko Ohwada, Junken Aoki, Motoi Kanagawa, Tatsushi Toda, Yosuke Nagata, Ryoichi Matsuda,Yasunori Takayama, Makoto Tominaga, Masato Umeda
    Nature Communications, volume 9, Article number: 2049 (2018)
    Open access
  • Facile Synthesis of 2,3-Benzodiazepines Using One-pot Two-step Phosphate-Assisted Acylation-Hydrazine Cyclization Reactions
    Akinari Sumita, Jinhee Lee, Yuko Otani, Tomohiko Ohwada1
    Organic & Biomolecular Chemistry, 2018, 16, 4013 - 4020, DOI: 10.1039/C8OB00708J
  • Pharmacokinetic parameters explain the therapeutic activity of antimicrobial agents in a silkworm infection model
    Atmika Paudel, Suresh Panthee, Makoto Urai, Hiroshi Hamamoto, Tomohiko Ohwada & Kazuhisa Sekimizu
    Scientific Reports, volume 8, Article number: 1578 (2018) doi:10.1038/s41598-018-19867-0
  • Latent Bronsted Base Solvent-Assisted Amide Formation from Amines and Acid Chlorides
    Rikuto Otsuka, Kazuo Maruhashi, Tomohiko Ohwada
    Synthesis, 2018, in press, e-First: Publication Date: 20 March 2018 DOI: 10.1055/s-0037-1609342
  • Synthesis, Structure and N-N Bonding Character of 1,1-Disubstituted Indazolium Hexafluorophosphate
    Yingtang Ning; Yuko Otani; Tomohiko Ohwada
    Chemical Communications, 2018, 54, 1881-1884. DOI: 10.1039/C8CC00183A
  • Contrasting C- and O-Atom Reactivities of Neutral Ketone and Enolate Forms of 3-Sulfonyloxyimino-2-Methyl-1-Phenyl-1-Butanones
    Yingtang Ning; Yuko Otani; Tomohiko Ohwada
    Journal of Organic Chemistry, 2018, 83 (1), pp 203–219.
    Publication Date (Web): November 30, 2017 (Article)
    DOI: 10.1021/acs.joc.7b02573


  • Electrophilic activation of aminocarboxylic acid by phosphate ester promotes Friedel-Crafts acylation by overcoming charge-charge repulsion
    Akinari Sumita, Yuko Otani, Tomohiko Ohwada
    Organic & Biomolecular Chemistry, 2017, 15, 9398-9407. DOI: 10.1039/C7OB02158E
  • Elucidation of the E-Amide Preference of N-Acyl Azoles
    Yuka Takahashi, Hirotaka Ikeda, Yuki Kanase, Kosho Makino, Hidetsugu Tabata, Tetsuta Oshitari, Satoshi Inagaki, Yuko Otani, Hideaki Natsugari, Hideyo Takahashi, and Tomohiko Ohwada
    J. Org. Chem., 2017, 82 (21), pp 11370-11382 DOI: 10.1021/acs.joc.7b01759
  • Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6
    Reiya Taniguchi, Asuka Inoue, Misa Sayama, Akiharu Uwamizu, Keitaro Yamashita, Kunio Hirata, Masahito Yoshida, Yoshiki Tanaka, Hideaki E. Kato, Yoshiko Nakada-Nakura, Yuko Otani, Tomohiro Nishizawa, Takayuki Doi, Tomohiko Ohwada, Ryuichiro Ishitani, Junken Aoki, Osamu Nureki
    Nature, 548, 356-360 (17 August 2017). doi:10.1038/nature23448

    細胞生物学:リゾホスファチジン酸受容体LPA 6 によるリガンド認識に関する構造学的考察
  • Probing the Hydrophobic Binding Pocket of G-Protein-Coupled Lysophosphatidylserine Receptor GPR34/LPS1 by Docking-Aided Structure-Activity Analysis
    Misa Sayama, Asuka Inoue, Sho Nakamura, Sejin Jung, Masaya Ikubo, Yuko Otani, Akiharu Uwamizu, Takayuki Kishi, Kumiko Makide, Junken Aoki, Takatsugu Hirokawa, and Tomohiko Ohwada
    J. Med. Chem., 2017, 60 (14), pp 6384-6399. DOI: 10.1021/acs.jmedchem.7b00693
  • Synthesis of Heterocycle-Containing 9,9-Diarylfluorenes Using Superelectrophiles
    Makafui Gasonoo, Akinari Sumita, Kenneth N. Boblak, Kristen Giuffre, Tomohiko Ohwada, and Douglas A Klumpp
    J. Org. Chem., 297,82(12).6044-6053. DOI: 10.1021/acs.joc.7b00311 Publication Date (Web): May 30, 2017
  • Base-Induced Transformation of 2-Acyl-3-alkyl-2H-azirines to Oxazoles: Involvement of Deprotonation-Initiated Pathways
    Yingtang Ning, Yuko Otani and Tomohiko Ohwada
    J. Org. Chem., 2017,82(12).6313-6326. DOI: 10.1021/acs.joc.7b00904 Publication Date (Web): May 23, 2017
  • Phospholipid localization implies microglial morphology and function via Cdc42 in vitro
    Kyohei Tokizane, Hiroyuki Konishi, Kumiko Makide, Hiroki Kawana, Shinichi Nakamuta, Kozo Kaibuchi, Tomohiko Ohwada, Junken Aoki and Hiroshi Kiyama
    GLIA, Volume 65, Issue 5 May 2017, Pages 740-755. DOI: 10.1002/glia.23123
  • Revisiting Secondary Interactions in Neighboring Group Participation, Exemplified by Reactivity Changes of Iminylium Intermediates
    Yingtang Ning, Tomoya Fukuda, Hirotaka Ikeda, Yuko Otani, Masatoshi Kawahata, Kentaro Yamaguchi, Tomohiko Ohwada
    Organic & Biomolecular Chemistry, 2017, 15, 1381 - 1392. DOI: 10.1039/C6OB02719A
  • Use of Charge-Charge Repulsion to Enhance π-electron Delocalization into Anti-aromatic and Aromatic Systems
    Akinari Sumita, Makafui Gasonoo, Kenneth J. Boblak, Tomohiko Ohwada and Douglas Klumpp
    Chemistry - A European Journal, 2017,Volume 23, Issue 11
    February 21, pages 2566-2570. DOI: 10.1002/chem.201606036
  • Chemoselective Generation of Acyl Phosphates, Acylium Ion Equivalent, from Carboxylic Acids With Organophosphate Ester in the Presence of Bronsted Acid
    Akinari Sumita, Yuko Otani, Tomohiko Ohwada
    Chem. Comm., 2017, 53, 1482-1485. DOI: 10.1039/c6cc09618b
  • Molecular Dynamics Study of Nitrogen-Pyramidalized Bicyclic β-Proline Oligomers: Length-Dependent Convergence to Organized Structure
    Yuko Otani*, Satoshi Watanabe, Tomohiko Ohwada, and Akio Kitao*
    J. Phys. Chem. B, 2017, 121 (1), pp 100-109. DOI: 10.1021/acs.jpcb.6b10668
    Publication Date (Web): December 5, 2016
  • Erika S. Chan, 大和田智彦 
    ファルマシア vol 53, No. 4. p372-373 (2017).
  • 廣部雅昭、大和田智彦
    特集 高分子科学のはじまりと未来
    高分子 66巻 4月号 page 163-165 (2017).


  • Identification of lysophosphatidylthreonine with an aromatic fatty acid surrogate as a potent inducer of mast cell degranulation
    Takayuki Kishi, Hiroki Kawana, Misa Sayama, Kumiko Makide, Asuka Inoue, Yuko Otani, Tomohiko Ohwada, Junken Aoki
    Biochemistry and Biophysics Reports, Volume 8, December 2016, Pages 346-351.
    Open Access
  • Nitric oxide-induced oxidative stress impairs pacemaker function of murine interstitial cells of Cajal during inflammation
    N.Kaji, K. Horiguchi, S. Iino, S. Nakayama, T. Ohwada, Y. Otani, Firman, T. Murata, K. M. Sanders, H. Ozaki, M. Hori
    Pharmacol. Res., 2016, 111, 838-848.
  • Identification of lysophosphatidylthreonine with an aromatic fatty acid surrogate as a potent inducer of mast cell degranulation
    Takayuki Kishi, Hiroki Kawana, Misa Sayama, Kumiko Makide, Asuka Inoue, Yuko Otani, Tomohiko Ohwada, Junken Aoki
    Biochemistry and Biophysics Reports Volume 8, December 2016, Pages 346-351
    Open Access
  • Conformational Constraint of the Glycerol Moiety of Lysophosphatidylserine, an Emerging Lysophospholipid Mediator, Affords Compounds with Receptor Subtype Selectivity
    Sejin Jung, Asuka Inoue, Sho Nakamura, Takayuki Kishi, Akiharu Uwamizu, Misa Sayama, Masaya Ikubo, Yuko Otani, Kuniyuki Kano, Kumiko Makide, Junken Aoki, Tomohiko Ohwada
    Journal of Medicinal Chemistry, 2016, 59 (8), pp 3750-3776. DOI: 10.1021/acs.jmedchem.5b01925
  • Hydrogen Bonding to Carbonyl Oxygen of Nitrogen-Pyramidalized Amide-Detection of Pyramidalization Direction Preference by Vibrational Circular Dichroism Spectroscopy.
    Siyuan Wang, Tohru Taniguchi, Kenji Monde, Masatoshi Kawahata, Kentaro Yamaguchi, Yuko Otani, Tomohiko Ohwada
    Chemical Communications, 2016, 52, 4018 - 4021, DOI: 10.1039/C6CC00284F
    Open Access
    Web themed collection of ChemComm on ‘Foldamers’ (ed) by Professors Ivan Huc & Samuel Gellman
  • The synthesis and BK channel-opening activity of N-acylaminoalkyloxime derivatives of dehydroabietic acid.
    Xin-Lan Liu; Hai-Xia Lin; Tomohiko Ohwada; Katsutoshi Ido; Kohei Sawada
    Bioorganic & Medicinal Chemistry Letters, Volume 26, Issue 2, 15 January 2016, Pages 283-287.
  • Tandem Buildup of Complexity of Aromatic Molecules Through Multiple Successive Electrophile Generation in One Pot, Controlled by Varying the Reaction Temperature
    Akinari Sumita, Yuko Otani, and Tomohiko Ohwada
    Organic & Biomolecular Chemistry, 2016, 14, 1680 - 1693.
    Open Access
  • Facile Synthesis of 5- to 7-membered benzolactam compounds via strongly facilitated electrophilic aromatic substitution reaction.
    Hiroaki Kurouchi, Yuko Otani, and Tomohiko Ohwada
    Heterocycle, Vol 93, No. 2, 2016, pp. 705 - 713. DOI: 10.3987/COM-15-S(T)60 Paper | Special issue | The 75th Birthday Anniversary of Prof. Dr. Lutz F. Tietze. Published online: 6th January, 2016


  • Structure-Activity Relationships of Lysophosphatidylserine Analogs as Agonists of G-Protein-Coupled Receptors GPR34, P2Y10, and GPR174
    Masaya Ikubo, Asuka Inoue, Sho Nakamura, Sejin Jung, Misa Sayama, Yuko Otani, Akiharu Uwamizu, Keisuke Suzuki, Takayuki Kishi, Akira Shuto, Jun Ishiguro, Michiyo Okudaira, Kuniyuki Kano, Kumiko Makide, Junken Aoki, and Tomohiko Ohwada
    J. Med. Chem., 2015, 58 (10), pp 4204-4219 DOI: 10.1021/jm5020082
  • Lysophosphatidylserine analogues differentially activate three LysoPS receptors
    Akiharu Uwamizu, Asuka Inoue, Kensuke Suzuki, Michiyo Okudaira, Akira Shuto, Yuji Shinjo, Jun Ishiguro, Kumiko Makide, Masaya Ikubo, Sho Nakamura, Sejin Jung, Misa Sayama, Yuko Otani, Tomohiko Ohwada, and Junken Aoki
    J. Biochem. (2015) 157 (3): 151-160.


  • Deciphering Subtype-Selective Modulations in TRPA1 Biosensor Channels
    Daisuke Kozai, Reiko Sakaguchi, Tomohiko Ohwada and Yasuo Mori*
    Curr. neuropharmacol. 2014, 12,page 1. DOI: 10.2174/1570159X12666141009212356
  • Acid-promoted Chemoselective Introduction of Amide Functionality onto Aromatic Compounds Mediated by Isocyanate Cation Generated from Carbamate.
    Akinari Sumita, Hiroaki Kurouchi, Yuko Otani, Tomohiko Ohwada
    Chemistry - An Asian Journal, 2014, 9 (10), 2995-3004.
  • Robust Trans-Amide Helical Structure of Oligomers of Bicyclic Mimics of beta-Proline: Impact of Positional Switching of Bridgehead Substituent on Amide Cis-Trans Equilibrium
    Siyuan Wang; Yuko Otani; Xin Liu; Masatoshi Kawahata; Kentaro Yamaguchi; Tomohiko Ohwada
    Journal of Organic Chemistry, 2014, 79 (11), pp 5287-5300.
  • Protonation Switching to Least Basic Heteroatom of Carbamate through Cationic Hydrogen Bonding Promotes Formation of Isocyanate Cation
    Hiroaki Kurouchi, Akinari Sumita, Yuko Otani, Tomohiko Ohwada
    Chemistry - A European Journal, 2014, 20, 8682-8690.
  • Trans-nitrosylation directs TRPA1 selectivity in N-nitrosamine activators
    Daisuke Kozai, Yoji Kabasawa, Maximilian Ebert, Shigeki Kiyonaka, Firman, Yuko Otani, Tomohiro Numata, Nobuaki Takahashi, Yasuo Mori, Tomohiko Ohwada
    Molecular Pharmacology, 85, 175-185. doi:10.1124/mol.113.08886


  • Synthesis and BK channel-opening activity of novel N-acylhydrazone derivatives from dehydroabietic acid
    Xia-Shi Lv , Yong-Mei Cui *, He-Yun Wang, Hai-Xia Lin *, Wei-Ya Ni , Tomohiko Ohwada , Katsutoshi Ido , Kohei Sawada 
    Chinese Chemical Letters ,2013, 24,1023-1026 
  • Enantiodivergent Deprotonation-Acylation of α-Amino Nitriles
    Michiko Sasaki, Tomo Takegawa, Kunihiro Sakamoto, Yuri Kotomori, Yuko Otani,・ Tomohiko Ohwada, Masatoshi Kawahata, Kentaro Yamaguchi, and Kei Takeda・
    Angew. Chem. Int. Ed. 2013, 52 (49), 12956-12960.
  • Stereochemical Evidence for Stabilization of a Nitrogen Cation by Neighboring Chlorine or Bromine
    Tomohiko Ohwada, Norihiko Tani , Yuko Sakamaki , Yoji Kabasawa , Yuko Otani , Masatoshi Kawahata , Kentaro Yamaguchi
    Proc. Natl. Acad. Sci. U.S.A., 2013, 110, NO. 11, 4206-4211.
  • Attenuated Desensitization of β-Adrenergic Receptor by Water-Soluble N-Nitrosamines That Induce S-Nitrosylation Without NO Release
    Noriko Makita, Yoji Kabasawa, Yuko Otani, Firman, Junichiro Sato, Makiko Hashimoto, Michio Nakaya, Hiroaki Nishihara, Masaomi Nangaku, Hitoshi Kurose, Tomohiko Ohwada and Taroh Iiri
    Circ Res. 2013, 112, 327-334.
  • Screening quality for Ca2+-activated potassium channel in IonWorks Quattro is greatly improved by using BAPTA-AM and ionomycin
    Katsutoshi Ido, Tomohiko Ohwada, Eriko Yasutomi, Takashi Yoshinaga, Tohru Arai, Mitsuyasu Kato, Kohei Sawada,
    Journal of Pharmacological and Toxicological Methods, 2013, 67, Issue 1, January-February, 16-24.


  • Activation of Electrophilicity of Stable Y-Delocalized Carbamate Cations in Intramolecular Aromatic Substitution Reaction: Evidence for Formation of Diprotonated Carbamates Leading to Generation of Isocyanates
    Hiroaki Kurouchi, Kyoko Kawamoto, Hiromichi Sugimoto, Satoshi Nakamura, Yuko Otani, and Tomohiko Ohwada
    J. Org. Chem., 2012, 77 (20), pp 9313-9328
  • TGFα shedding assay: an accurate and versatile method for detecting GPCR activation
    Asuka Inoue, Jun Ishiguro, Hajime Kitamura, Naoaki Arima, Michiyo Okutani, Akira Shuto, Shigeki Higashiyama, Tomohiko Ohwada, Hiroyuki Arai, Kumiko Makide & Junken Aoki
    Nature Methods, vol 9, No.10, 1021-1029 (2012) doi:10.1038/nmeth.2172
  • Molecular mechanism of pharmacological activation of BK channels
    Guido Gessner, Yong-Mei Cui, Yuko Otani, Tomohiko Ohwada, Malle Soom, Toshinori Hoshi, and Stefan H. Heinemann
    Proceedings of the National Academy of Sciences of the U. S. A. (PNAS) 2012 ;109 (9) 3552-3557
  • econdary Structure of Homo-thiopeptides Based on a Bridged β-Proline Analogue: Preferred Formation of Extended Strand Structures with Trans-Thioamide Bonds
    Yuko Otani, Tetsuharu Hori, Masatoshi Kawahata, Kentaro Yamaguchi and Tomohiko Ohwada
    Special Issue (Symposium in print) on Chemistry of Foldamers
  • GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position
    Hajime Kitamura, Kumiko Makide, Akira Shuto, Masaya Ikubo, Asuka Inoue, Kensuke Suzuki, Yusuke Sato, Sho Nakamura, Yuko Otani, Tomohiko Ohwada, Junken Aoki
    J Biochem (2012) 151 (5): 511-518
    first published online February 16, 2012 doi:10.1093/jb/mvs011
  • Visible-light-triggered Release of Nitric Oxide from N-Pyramidal Nitrosamines
    Fumika Karaki, Yoji Kabasawa, Takahiro Yanagimoto, Nobuhiro Umeda, Firman, Yasuteru Urano, Tetsuo Nagano, Yuko Otani, and Tomohiko Ohwada
    Chemistry - A European Journal
    Volume 18, Issue 4, pages 1127-1141, January 23, 2012
  • Discovery of a Tamoxifen-related compound that suppresses glial L-glutamate transport activity without interaction with estrogen receptors"
    Kaoru Sato , Jun-ichi Kuriwaki, Kanako Takahashi, Yoshihiko Saito, Jun-ichiro Oka, Yuko Otani, Yu Sha, Ken Nakazawa, Yuko Sekino, Tomohiko Ohwada
    ACS Chemical Neuroscience, 2012, 3, 105-113.


  • 7-Azabicyclo[2.2.1]heptane as a Structural Motif to Block Mutagenicity of Nitrosamines
    Tomohiko Ohwada, Satoko Ishikawa, Yusuke Mine, Keiko Inami, Takahiro Yanagimoto, Fumika Karaki, Yoji Kabasawa, Yuko Otani, Masataka Mochizuki
    Bioorganic & Medicinal Chemistry, 2011, 19, 2726-2741. DOI: 10.1016/j.bmc.2011.02.049


  • Dynamic NMR: スペクトルの線形解析によるチオアミド結合の回転障壁の算出 
  • Design, Synthesis and Characterization of BK Channel Openers Based on Oximation of Abietane Diterpene Derivatives
    Yong-Mei Cui, Eriko Yasutomi, Yuko Otani, Katsutoshi Ido, Takashi Yoshinaga, Kohei Sawada, and Tomohiko Ohwada
    Bioorganic & Medicinal Chemistry, 2010 18, 8642-8659. doi:10.1016/j.bmc.2010.09.072. 
  • Water-stable Helical Structure of Tertiary Amides of Bicyclic β-Amino Acid Bearing 7-Azabicyclo[2.2.1]heptane. Full Control of Amide Cis-Trans Equilibrium by Bridgehead Substitution
    Masahiro Hosoya; Yuko Otani; Masatoshi Kawahata; Kentaro Yamaguchi; Tomohiko Ohwada
    Journal of the American Chemical Society, 2010, 132, 42, 14780-14789. DOI: 10.1021/ja1017877
  • Cyclization of Arylacetoacetates to Indene and Dihydronaphthalene Derivatives in Strong Acid. Evidenece for Involvement of Further Protonation of O,O-Diprotonated beta-Ketoester, Leading to Enhancement of Cyclization
    Hiroaki Kurouchi, Hiromichi Sugimoto, Yuko Otani, Tomohiko Ohwada
    J. Am. Chem. Soc., 2010, 132, 807-815.


  • Phenylation Reaction of alpha-Acylnitromethanes To Give 1,2-Diketone Monooximes: Involvement of Carbon Electrophile at the Position alpha to the Nitro Group.
    Mikihiro Takamoto, Hiroaki Kurouchi, Yuko Otani, Tomohiko Ohwada
    Synthesis, 2009, 24, 4129-4136.
  • Synthesis and Evaluation of Lysophosphatidylserine Analogs as Inducers of Mast Cell Degranulation. Potent Activities of Lysophosphatidyl- threonine and Its 2-Deoxy Derivative
    Masazumi Iwashita, Kumiko Makide, Taro Nonomura, Yoshimasa Misumi, Yuko Otani, Mayuko Ishida, Ryo Taguchi, Masafumi Tsujimoto, Junken Aoki, Hiroyuki Arai, Tomohiko Ohwada
    J. Med. Chem., October 8, 2009, Volume 52, Issue 19, pp 5837-5863.
  • Theoretical study on the excited states of heteroarene chromophores: Comparison of calculated and experimental values
    Toshiyuki Tsuji, Maki Onoda, Yuko Otani, Tomohiko Ohwada, Takahito Nakajima, Kimihiko Hirao
    Chemical Physics Letters, 2009, 473 (1-3), 29 April 2009, 196-200


  • Novel Oxime and Oxime Ether Derivatives of 12,14-Dichlorodehydroabietic Acid: Design, Synthesis and BK Channel-Opening Activity
    Yong-Mei Cui, Eriko Yasutomi, Yuko Otani, Takashi Yoshinaga, Katsutoshi Ido, Kohei Sawada, Masatoshi Kawahata; Kentaro Yamaguchi Tomohiko Ohwada,
    Bioorganic & Medicinal Chemistry Letters, 2008, 18 (24) 6386-6389.
  • Nonplanar Structures of Thioamides Derived from 7-Azabicyclo[2.2.1]heptane. Electronically Tunable Planarity of Thioamides
    Hori, Tetsuharu; Otani, Yuko; Kawahata, Masatoshi; Yamaguchi, Kentaro; Ohwada, Tomohiko
    J. Org. Chem, 2008,73, 22, 9102-9108.
  • Novel BK channel openers containing dehydroabietic acid skeleton: Structure?activity relationship for peripheral substituents on ring C
    Yong-Mei Cui, Eriko Yasutomi, Yuko Otani, Takashi Yoshinaga, Katsutoshi Ido, Kohei Sawada, Tomohiko Ohwada,
    Bioorganic & Medicinal Chemistry Letters, 2008, 18, 5201-5205.
  • Design, synthesis and characterization of podocarpate derivatives as openers of BK channels.
    Yong-Mei Cui, Eriko Yasutomi, Yuko Otani, Takashi Yoshinaga, Katsutoshi Ido,Kohei Sawada, Tomohiko Ohwada,
    Bioorganic & Medicinal Chemistry Letters, 2008, 18, 5197-5200.
  • Effects of Tamoxifen on L-Glutamate Transporters of Astrocytes
    Sato, Kaoru; Saito, Yoshihiko; Oka, Jun-ichiro, Ohwada, Tomohio; Nakazawa, Kenichi,
    J. of Pharmacolo. Sci., 2008, 107, 226-230..
  • Superacid-catalyzed Intramolecular Cyclization Reaction of Arylcyanopropionate:Geminal Substitution Effect on Superelectrophilicity
    Nakamura, Satoshi; Sugimoto, Hiromichi; Ohwada, Tomohiko
    Journal of Organic Chemistry, 2008,73(11), 4219-4224
  • Temperature-Dependent Fluorescence Lifetime of a Fluorescent Polymeric Thermometer, Poly(N-isopropylacrylamide), Labeled by Polarity and Hydrogen Bonding Sensitive 4-Sulfamoyl-7-aminobenzofurazan
    Gota, C.; Uchiyama, S.; Yoshihara, T.; Tobita, S.; Ohwada, T.
    J. Phys. Chem. B.; (Article); 2008; 112(10); 2829-2836


  • Retro-Diels-Alder Reaction of 4H-1,2-Benzoxazines to Generate o-Quinone Methides: Involvement of Highly Polarized Transition States
    Hiromichi Sugimoto, Satoshi Nakamura, and Tomohiko Ohwada
    Journal of Organic Chemistry, 2007, 72(26); 10088-10095.
  • Fluorogenic Ion Sensing System Working in Water, Based on Stimulus-Responsive Copolymers Incorporating a Polarity-Sensitive Fluorophore
    Maki Onoda, Seiichi Uchiyama, Tomohiko Ohwada
    Macromolecules, 2007, 40(26); 9651-9657. 
  • Anchoring Cationic Amphiphiles for Nucleotide Delivery Significance of DNA Release from Cationic Liposomes for Transfection
    Naohide Hirashima, Kazuhiro Minatani, Yoshifumi Hattori, Tomohiko Ohwada, and Mamoru Nakanishia,
    Biol. Pharm. Bull., 2007,30,1117-1122.
  • Transnitrosation of Thiols from Aliphatic N-Nitrosamines: S-Nitrosation and Indirect Generation of Nitric Oxide
    Takahiro Yanagimoto, Takeshi Toyota, Norio Matsuki, Yumi Makino, Seiichi Uchiyama, Tomohiko Ohwada
    Journal of the American Chemical Society 2007, 129,736-737.
  • Formation of 4H-1,2-Benzoxazines by Intramolecular Cyclization of Nitroalkanes. Scope of Aromatic Oxygen-functionalization Reaction Involving a Nitro Oxygen Atom, and Mechanistic Insights
    Satoshi Nakamura, Hiromichi Sugimoto, Tomohiko Ohwada
    Journal of the American Chemical Society 2007, 129, 1724-1732.
  • Generation and Application of o-Benzoquinone Methides Bearing Various Substituents on the Benzene Ring.
    Hiromichi Sugimoto, Satoshi Nakamura, Tomohiko Ohwada
    Advanced Synthesis & Catalysis 2007, 349, 669-679.
  • Accurate fluorescent polymeric thermometers containing an ionic component
    Chie Gota, Seiichi Uchiyama, Tomohiko Ohwada
    The Analyst, 2007, (2),121-126. 


  • Environment-sensitive Fluorophore Emitting in Protic Environments
    Seiichi Uchiyama, Kazuyuki Takehira, Toshitada Yoshihara, Seiji Tobita, and Tomohiko Ohwada
    Organic Letters, 2006, 8, 5869-5872..
  • Mechanisms of BK channel activation by a novel BK channel opener, 12, 14-dichlorodehydroabietic acid
    Kazuho Sakamoto, Taro Nonomura, Susumu Ohya, Katsuhiko Muraki,
    Tomohiko Ohwada and Yuji Imaizumi
    J. Pharmacol. Exper. Ther. 2006, 316, 144-153,
  • Oligomers of beta-Amino Acid Bearing Nonplanar Amides form Ordered Structures
    Yuko Otani, Shiroh Futaki, Tatsuto Kiwada, Yukio Sugiura, Atsuya Muranaka, Nagao Kobayashi, Masanobu Uchiyama, Kentrao Yamaguchi and Tomohiko Ohwada
    Tetrahedron, 2006, 62. 11635-11644.
  • Design, Synthesis and BK Channel-Opening Activity of Hexahydrodibenzazepinones Derivatives
    Toshihiko Tashima, Yoshimi Toriumi, Yumi Mochizuki, Taro Nonomura, Satoru Nagaoka, Katsuo Furukawa, Hiromichi Tsuru, Satomi Adachi-Akahane, and Tomohiko Ohwada 
    Bioorg. Med. Chem. 2006, 14, 8014-8031.


  • Theoretical Revisit of Regioselectivities of Diels-Alder Reactions. Quantitative Evaluation of Multicentered Reactivity Based on Reactive Hybrid Orbitals
    Hajime Hirao , and Tomohiko Ohwada
    J. Phys. Chem., A, 2005, 109, 816-824.
  • Generation of Orbitals that Control Molecular Reactivity: Projected Reactive Orbital Approach
    Haijime Hirao, Tomohiko Ohwada
    J. Phys. Chem., A, 2005, 109, 7642-7647.
  • Cp2TiCl2-Catalyzed Regio- and Chemoselective One-Step Synthesis of gamma-Substituted Allylsilanes from Terminal Alkenes Using Dianion-Type Zincate (SiSiNOL-Zn-ate)
    Nakamura, S.; Uchiyama, M.; Ohwada, T.;
    J. Am. Chem. Soc, 2005; 127, 13116-13117.
  • Compounds Structurally Related to Tamoxifen as Openers of Large-Conductance Calcium-Activated K+ Channel
    Sha Yu, Toshihiko Tashima, Yumi, Mochizuki, Yoshimi Toriumi, Satomi Adachi-Akahane, Taro Nonomura, Maosheng Cheng, Tomohiko Ohwada
    Chem. Pharm. Bull., 2005, 53, 1372-1373.
  • 理論計算への取り組み
    T. Ohwada,
    Farumashia. 2005, 41, 737-739.
  • Large-conductance Ca2+-activated K+ channel beta1 subunit in cardiac mitochondria and cardioprotective effects of BK channel openers
    Ohya, S Sakamoto, K Kuwata, Y Muraki, K Ohwada, T Imaizumi, Y
    Yakugaku Zasshi (Journal of the Pharmaceutical Society of Japan), 2005, 125 (2), 149-150.
  • 12,14-Dichrolodehydroabietic acid, a novel opener of mitochondrial large conductance Ca2+-activated K+ channels
    Sakamoto, K Ohya, S Muraki, K Ohwada, T Imaizumi, Y
    Biophysical Journal, 2005, 88(1), 441A-442A.


  • alpha,alpha-Disubstituted Amino Acids Bearing a Large Hydrocarbon Ring. Peptide Self-Assembly through Novel Hydrophobic Recognition
    Tomohiko Ohwada, Daisuke Kojima, Tatsuto Kiwada, Shiroh Futaki, Yukio Sugiura, Kentaro Yamaguchi, Yoshinori Nishi, Yuji Kobayashi.
    Chemistry-A European Journal 2004, 10, 617-626.
  • A New Chemoselective Anionic Polymerization Method in Aqueous Media: Design and Application of Bulky Zincate Possessing Little Basicity
    Minoru Kobayashi, Yotaro Matsumoto, Masanobu Uchiyama, and Tomohiko Ohwada
    Macromolecules, 2004, 37,4339-4341..
  • Development of A New Catalytic Electron Transfer System Mediated by Transition Metal Ate Complexes: Applicability and Tunability of Electron-releasing Potential for Organic Transformations
    Masanobu Uchiyama, Yotaro Matsumoto, Shinji Nakamura, Tomohiko Ohwada, Natsuno Yamashita, Atsushi Matsumiya, Takao Sakamoto
    J. Am. Chem. Soc., 2004,126, 8755-8759.
  • Rationale for the Acidity of Meldrum's Acid. Consistent Relation of C-H Acidities to the Properties of Localized Reactive Orbital
    Satoshi Nakamura, Hajime Hirao, Tomohiko Ohwada
    J. Org. Chem., 2004, 69, 4309-4316.
  • Regio- and Chemoselective Direct Generation of Functionalized Aromatic Aluminium Compounds Using Aluminium Ate Base
    Uchiyama, M.; Naka, H.; Matsumoto, Y.; Ohwada, T.
    Journal American Chemical Society, 2004, 126,10526-10527.
  • Theoretical Analysis of Lewis Basicity Based on Local Electron-Donating Ability. Origin of Basic Strength of Cyclic Amines Tomohiko Ohwada, Hajime Hirao, Atsushi Ogawa
    J. Org. Chem., 2004, 69, 7486-7494.
  • Mechanism and Ligand-Transfer Selectivity of 1,2-Addition of Organozincate Complexes to Aldehyde
    Uchiyama, M.; Nakamura, S.; Ohwada, T.; Nakamura, M.; Nakamura, E.
    J. Am. Chem. Soc. 2004, 126, 10897-10903.
  • Chemoselective Silylzincation of Functionalized Terminal Alkynes Using Dianion-Type Zincate (SiBNOL-Zn-ate): Regiocontrolled Synthesis of Vinylsilanes
    Nakamura, S.; Uchiyama, M.; Ohwada, T.
    J. Am. Chem. Soc. 2004, 126, 11146-11147.
  • Optimization of the internal calibrant for exact mass measurements by FAB-MS
    Hara, R Sakabe, C Ohwada, T Yamaguchi, K
    Bunseki Kagaku, 2004, 53(6), 623-627.


  • Structural Design and Synthesis of Nitric Oxide Donors Amied to Controlled Release
    Ohwada, T.; Uchiyama, M.
    Journal of Synthetic Organic Chemistry, Japan, 2003, 61, 45-57.
  • Theoretical Study of Reactivities in Electrophilic Aromatic Substitution Reactions :Reactive Hybrid Orbital Analysis
    Hirao, H. ; Ohwada, T.
    J. Phys. Chem., A, 2003, 107, 2875-2881.
  • 4H-1,2-Benzoxazines with Electron-withdrawing Substituents on the Benzene Ring. Synthesis and Application as Potent Intermediates for Oxygen-Functionalized Aromatic Compounds
    Nakamura, S., Uchiyama, M.; Ohwada, T.
    J. Am. Chem. Soc., 2003, 125, 5282-5283.
  • Stereoselectivity of Superacid-Catalyzed Pictet-Spengler Cyclization Reactions
    Nakamura, S., Tanaka, M. Taniguchi, T.,Uchiyama, M.; Ohwada, T.
    Organic Letters., 2003, 5, 2087-2090.
  • An Evaluation of Amide Group Planarity in 7-Azabicyclo[2.2.1]heptane Amides. Low Amide Bond Rotation Barrier in Solution.
    Yuko Otani, Osamu Nagae, Yuji Naruse, Satoshi Inagaki,Masashi Ohno, Kentaro Yamaguchi, Gaku Yamamoto, Masanobu Uchiyama, and Tomohiko Ohwada
    J. Am. Chem. Soc., 2003, 125, 15191-15199.
  • Dehydroabietic Acid Derivatives as a Novel Scaffold for Large-Conductance Calcium-Activated K+ Channel Openers.
    Tomohiko Ohwada, Taro Nonomura, Keisuke Maki, Kazuho Sakamoto, Susumu Ohya, Katsuhiko Muraki, Yuji Imaizum
    Bioorganic Medicinal Chemistry Letters, 2003, 13, 3971-3974.


  • Mutagenicity of aristolochic acid in the lambda/lacZ transgenic mouse (MutaMouse).
    Kohara, Arihiro; Suzuki, Takayoshi; Honma, Masamitsu; Ohwada, Tomohiko; Hayashi, Makoto.
    Mutation Research, 2002, 515(1-2), 63-72.
  • Dinitropyrenes induce gene mutations in multiple organs of the lambda/lacZ transgenic mouse (Muta Mouse).
    Kohara, Arihiro; Suzuki, Takayoshi; Honma, Masamitsu; Oomori, Takashi; Ohwada, Tomohiko; Hayashi, Makoto.
    Mutation Research, 2002, 515(1-2), 73-83.
  • Generation of Functionalized Asymmetric Benzynes Using TMP-Zincates. Effects of Ligands on Selectivity and Reactivity of Zincates.
    Uchiyama, M.; Miyoshi, T.; Kajihara, Y.; Sakamoto, T.; Otani, Y.; Ohwada, T.; Kondo, Y.
    J. Am. Chem. Soc., 2002, 124, 8514-8515.
  • Molecular basis of pimaran compounds as novel activators of large conductance Ca2+ activated K+ channel alpha-subunit
    Imaizumi, Y.; Sakamoto, K.; Yamada, A.; Hotta, A.; Ohya, S.; Muraki, K.; Uchiyama, M. ; Ohwada, T.
    Molecular Pharmacology, 2002, 62, 836-846.


  • Mutation spectrum of o-aminoazotoluene in the cII gene of lambda/lacZ transgenic mice (Muta(TM)Mouse).
    Kohara, A., Suzuki, T., Honma, M., Hirano, N. , Ohsawa, K. , Ohwada,T. Hayashi, M.
    Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2001, 491, 211-220
  • Space-filling Effects in Membrane Disruption by Cationic Amphiphiles
    Fujiwara, T.;Hirashima, H. ;Hasegawa, S. ; Nakanishi, M.; Ohwada, T.,
    Biooranic Medicinal Chemistry , 2001, 9, 1013-1024.
  • 窒素ピラミッドアミドおよび関連化合物の構造特性
    薬学雑誌, 2001, 121, 65-77
  • Regioselective Superacid-Catalyzed Electrocyclization of Diphenylmethyl Cations. Fluorenes, Phenanthrol and Benzofuran Cyclizations.
    Yoshida N.; Ohwada, T.
    Synthesis, 2001, 1487-1494.
  • Stereoselction of Sterically Unbiased Diels-Alder Dienes with Spiro Conjugation.
    Igarashi, H.; Sakamoto, S,; Yamaguchi, K.; Ohwada, T.
    Tetrahedron Letters, 2001, 42, 5257-5260.
  • Usefulness and Limitation of DiBAC4(3), a Voltage-sensitive Fluoresent Dye, for the measurement of membrane Potentials regulated by recombinant large conductance Ca2+-Activated K+ Channels in HEK293 Cells.
    Yamada, Aki; Gaja, Norikazu, Ohya Sususmu, Muraki Katsuhiko; Narita Hiroshi, Tomohiko Ohwada, Imaizumi Yuji
    Jpn. J. Pharmacol., 2001, 86, 342-350.
  • Anchoring and Bola Cationic Amphiphiles for Nucleotide Delivery. Effects of Orientation and Extension of Hydrophobic Regions
    Tomonobu Yoshimura, Seiji Hasegawa, Naohide Hirashima, Mamoru Nakanishi, ; Tomohiko Ohwada
    Bioorganic & Medicinal Chemisty Letters, 2001, 11, 2897-2901.
  • Structural Features of Aliphatic N-Nitrosamines of 7-Azabicyclo[2.2.1]heptanes That Facilitate N-NO Bond Cleavage
    Tomohiko Ohwada,Motoko Miura, Haruko Tanaka, Shigeru Sakamoto, Kentaro Yamaguchi, Hirotaka Ikeda, and Satoshi Inagaki
    J. Am. Chem. Soc., 2001, 123, 10164-10172.


  • Influenec of Structure on N-NO bond cleavage of aliphatic N-nitrosamines.
    Miura, M.; Sakamoto, S.; Yamaguchi, K.; Ohwada, T.,
    Tetrahedron Letters, 2000, 41, 3637-3641.
  • Gene Transfection activities of amphiphilic Steroid-polyamine Conjugates
    Fujiwara, T.; Hasegawa, S.; Hirashima, H.; Nakanishi, M.; Ohwada, T.,
    Biochim. Biophys. Acta, 2000, 1468, 396-402.


  • The Prototype Pictet-Spengler Reactions Catalyzed by Superacids. Involvement of Dicationic Superelectrophiles
    Yokoyama,A.; Ohwada, T.; Shudo, K.
    J. Org. Chem., 1999, 64, 611-617.
  • Orbital-Controlled Stereoselections in Sterically Unbiased Cyclic Systems
    Ohwada, T.
    Chemical Reviews , 1999, 99, 1337-1375.
  • Electrons-in-a-Box model for conjugation in linear carbanions
    Tomohiko Ohwada, Hirotaka Kagawa,and Hiroshi Ichikawa
    Int. J. Quan. Chem., 1998, 68, 65-72.
  • Protonation Enthalpies in Fluorosulfonic Acid Using Ab Initio Self-Consistent Reaction Field Theory
    Harris,N.: Ohwada, T.; Lammertsma, K.
    Journal of Computational Chemistry, 1998, 19, 250-257.
  • Superacid-catalyzed Electrocyclization of Diphenylmethyl Cations to Fluorenes. Kinetic and Theoretical Revisit Supporting the Involvement of Ethylene Dications
    Ohwada, T;Suzuki, T.; Shudo, K.
    Journal of the American Chemical Society, 1998, 120, 4629-4637.
  • Facial Selectivities of Benzofluorenes Bearing a Carbonyl, an Olefin, or a Diene Group in Spiro Geometry. ? Spiro Substituent Effects
    Tsuji, M.; Ohwada, T.; Shudo, K.
    Tetrahedron Letters, 1998, 39, 403-406
  • On the Planarity of Amide Nitrogen. Intrinsic Pyramidal Nitrogen of N-Acyl-7-Azabicyclo[2.2.1]heptanes
    Ohwada, T.; Achiwa, T.; Okamoto, I.; Shudo, K.; Yamaguchi, K.
    Tetrahedron Letters, 1998, 39, 865-868.
  • Intrinsic Pyramidal Nitrogen of N-Sufonylamides
    Ohwada, T.; Okamoto, I.; Shudo, K.; Yamaguchi, K.
    Tetrahedron Letters, 1998, 39, 7877-7880.
  • Nitration of Quinoline 1-Oxide: Mechanism of Regioselectivity
    Yokoyama, A.; Ohwada, T.; Saito, S.; Shudo, K.
    Chemical and Pharmaceutical Bulletin., 1997, 45, 279-283.
  • pi-Conjugation in Y-Shaped Configuration. Does a Special Stability Exist?
    Ohwada, T.; Kagawa, H.; Ichikawa, H.
    Bulletin of the Chemical Society of Japan, 1997, 70, 2411-2415.
  • Superacid-catalyzed Electrocyclization of 1-Phenyl-2-propene-1-ones to 1-Indanones. Kinetic and Theoretical Studies of Electrocyclization of Oxonium Carbenium Dications
    Suzuki, T.: Ohwada, T.; Shudo, K.
    Journal of the American Chemical Society, 1997, 119, 6774-6780.
  • Non-Steric Facial Selectivity in Nucleophilic 1,4-Conjugate Addition
    Okamoto, I.; Ohwada, T.; Shudo, K.
    Tetrahedron Letters, 1997, 38, 425-428.
  • A Cyclopropyl Group Shows Reverse Facial Selectivity Depending on the Bicyclic Ring System
    Tsuji, M.; Ohwada, T.; Shudo, K.
    Tetrahedron Letters, 1997, 38, 6693-6698.
  • Superacid-Catalyzed Reaction of Substituted Benzaldehydes with Benzene
    Saito, S.; Ohwada, T.; Shudo, K.
    Journal of Organic Chemistry, 1996, 61, 8089-8093.
  • Structures and Reactivities of Ethylene Dication Electrophiles
    Ohwada, T,; Yamazaki, T.; Suzuki, T.; Saito, S.; Shudo, K.
    Journal of the American Chemical Society, 1996, 118, 6220-6224.
  • Three-Center, Two-Electron Systems. Origin of the Tilting of Their Substituents.
    Lammertsma, K.; Ohwada, T.
    Journal of the American Chemical Society, 1996, 118, 7247-7254.
  • Unsymmetrization of the Olefin Group of Bicyclo[2.2.2]octenes. ??? Coupling.
    Ohwada. T.; Uchiyama, M.; Tuji, M.; Okamoto, I.; Shudo, K.
    Chemical and Pharmaceutical Bulletin, 1996, 44, 296-306.
  • A Remote Substituent Can Determine Magnitude of Facial Selectivity in
    Benzobicyclo[2.2.2]octatrienesOhwada, T.; Tsuji, M.; Okamoto, I.; Shudo, K.
    Tetrahedron Letters, 1996, 37, 2609-2612.
  • Orbital Unsymmetrization Affects Facial Selectivities of Diels-Alder Dienophiles
    Okamoto, I.; Ohwada, T.; Shudo, K.
    Journal of Organic Chemistry ,1996, 61, 3155-3166.
  • Friedel-Crafts-Type Reaction of Benzaldehyde with Benzene. Diprotonated Benzaldehyde as the Reactive Intermediate
    Saito, S.; Ohwada, T.; Shudo, K.
    Journal of the American Chemical Society, 1995, 117, 11081-11084.
  • Acid-catalyzed Reactions of 1,2-Dicarbonylethanes with Benzene. Ethylene Dication Electrophiles.
    Yamazaki, T.; Saito, S.; Ohwada, T, Shudo, K.
    Tetrahedron Letters, 1995, 36, 5749-5752.
  • Involvement of Dicationic Species as the Reactive Intermediates in Gattermann, Houben-Hoesch, and Friedel-Crafts Reactions of Nonactivated Benzenes
    Sato, Y.; Yato, M.: Ohwada, T.; Saito, S.; Shudo,K.
    Journal of the American Chemical Society, 1995, 117, 3037-3043.
  • Friedel-Crafts-Type Cyclodehydration of 1,3-Diphenyl-1-propanones. Kinetic Evidence for the Involvement of Dication
    Satio, S.; Sato, Y.; Ohwada, T.; Shudo, K.
    Journal of the American Chemical Society, 1994, 116, 2312-2317.
  • Distortion of Olefin and Carbonyl pi-orbitals in Dibenzobicyclo[2.2.2]octatrienes and Dibenzobicyclo[2.2.2]octadienones. Unsymmetrization of pi Lobes Arising from sigma-pi Orbital Interactions.
    Ohwada, T.; Okamoto, I.; Haga, N.; Shudo, K.
    Journal of Organic Chemistry ,1994, 59, 3975-3984.
  • Dihedral angle-dependent Orbital Distortions Arising from Vicinal Bonds in Norbornane and 2-Norbornanone.Ohwada, T.
    Tetrahedron, 1993, 49, 7649-7656.
  • Orbital Distortion Arising from Remote Substituents. Nitration,Reduction, and Epoxidation of Fluorenes Bearing a Carbonyl or an Olefin Group in Spiro Geometry
    Ohwada, T.
    Journal of the American Chemical Society, 1992, 114, 8818-8827.
  • Orbital Distortion Arising in Dibenzobicyclo[2.2.2]octatrienes. Biased Epoxidation and Dihydroxylation of the Olefin Moiety.
    Haga, N.; Ohwada, T.; Okamoto, I.; Shudo, K.
    Chemical and Pharmaceutical Bulletin, 1992, 40, 3349-3351.
  • The Hammett Acidity Function H0 of Trifluoromethanesulfonic Acid-Trifluoroacetic Acid and Related Acid Systems. A Versatile Nonaqueous Acid System
    Saito, S. Saito, S.;Ohwada, T.;Shudo, K.
    Chemical and Pharmaceutical Bulletin, 1991, 39, 2718-2720.
  • Friedel-Crafts-Type Reactions Involving Di- and Tricationic Species. Onium-Allyl Dications and O,O-Diprotonated aci-Nitro Species Bearing a Protonated Carbonyl Group
    Ohwada, T.; Yamagata, N.; Shudo, K.
    Journal of the American Chemical Society, 1991, 113, 1364-1373.
  • Orbital Distortion Arising from Remote Substituents. Nitration and Reduction of Spiro[cyclopenta-1,9'-fluorene]-2-ones
    Ohwada,T. and Shudo, K.
    Chemical and Pharmaceutical Bulletin, 1991, 39, 2176-2178.
  • Requirements for Houben-Hoesch and Gattermann Reactions. Involvement of Diprotonated Cyanides in the Reactions with Benzene
    Yato, M.; Ohwada, T.; Shudo, K.
    Journal of the American Chemical Society, 1991, 113, 691-692.
  • Direct Observation of an Intermediate in the Oxygen Atom Rearrangement of 2-Cyclopropylnitrobenzene in a Strong Acid
    Ohwada, T.; Kasuga, M.: Shudo, K.
    Journal of Organic Chemistry, 1990, 55, 2717-2719.
  • 4H-1,2-Benzoxazines as Novel Precursors of o-Benzoquinone Methide
    Yato, M.; Ohwada, T.; Shudo, K.
    Journal of the American Chemical Society, 1990, 112, 5341-5342.
  • Reactions of O,O-Diprotonated Nitro Olefins with Benzenes. Formations of Phenylacetones, 4H-1,2-Benzoxazines and Biarylacetone Oximes
    Ohwada, T.; Okabe, K.; Ohta, T.; Shudo, K.
    Tetrahedron, 1990, 46, 7539-7555.


  • Novel Electrophilic Species Equivalent to alpha-Keto Cations. Reactions of O,O-Diprotonated Nitro Olefins with Benzenes Yield Arylmethyl Ketones
    Okabe, K.; Ohwada, T.; Ohta, T.; Shudo, K.
    Journal of Organic Chemistry, 1989, 54, 733-734.
  • Substituted Ethylene Dications. Structures of Phenylmethyl Cations Substituted with an Electron-Withdrawing Group on the Cation Center
    Ohwada, T.; Shudo, K.
    Journal of the American Chemical Society, 1989, 111, 34-40.
  • Ethylene Dications Substituted with Electron-Donating Groups
    Ohwada, T.; Shudo, K.
    Journal of Organic Chemistry, 1989, 54, 5227-5237.
  • Reaction of Diphenylmethyl Cations in a Strong Acid. Participation of Carbodications with Positive Charge Substantially Delocalized over the Aromatic Rings
    Ohwada, T.; Shudo, K.
    Journal of the American Chemical Society, 1988, 110, 1862-1870.
  • Nitroethylene Yields N,N-Dihydroxyiminum-Methylium Dication in Trifluoromethanesulfonic Acid.
    Dications Stabilized by Y Delocalization
    Ohwada, T.; Itai, A.; Ohta, T.; Shudo, K.
    Journal of the American Chemical Society, 1987, 109, 7036-7041.
  • Reaction of beta-Nitrostyrenes with Benzene Catalyzed by Trifluoromethanesulfonic Acid. Formation and Reaction of N,N-Dihydroxyiminum-Benzyl Dications.
    Ohwada, T.; Ohta, T.; Shudo, K.
    Tetrahedron, 1987, 43, 297-305.
  • Acid-catalyzed Reactions of N-Phenylhydroxylamines-Introduction of Carbon Groups on the Benzene Nucleus.
    Hizatate, S.; Ohwada, T.; Shudo, K.,
    J. Phrmaceutical Sciences, 1987, 76(11), 233-233.
  • Protonation of Nitro Groups. Diprotonation of beta-Nitrostyrenes in
    Trifluoromethanesulfonic Acid.
    Ohwada, T.; Ohta, T.; Shudo, K.
    Journal of the American Chemical Society, 1986, 108, 3029-3032.


  • Tomohiko Ohwada (book chapter), Topics in Current Chemistry, Orbitals in Chemistry, 2009, August 1, Satoshi Inagaki (ed), Springler,
  • 大和田智彦(監訳,分担),マクマリー 有機化学-生体反応へのアプローチー(東京化学同人)(John McMurry著),監訳:柴﨑正勝,岩澤伸治,大和田智彦,増野匡彦,2009
  • 化学者のための電気生理学入門③,イオンチャネルが細胞を興奮させる,
    大和田智彦,渡辺 恵,
    現代化学(東京化学同人),2007,12月号, 43-46.
  • 化学者のための電気生理学入門②,イオンチャネルと化合物の相互作用を調べる,
    大和田智彦,渡辺 恵,
    現代化学(東京化学同人),2007,11月号, 32-35.
  • 化学者のための電気生理学入門①,イオンチャネル -はじめの一歩-
    大和田智彦,渡辺 恵,
    現代化学(東京化学同人),2007,10月号, 36-49.
  • 人名反応に学ぶ有機合成戦略
    大和田智彦(分担) L. Kurti, B. Czako 著 監訳 富岡清  
  • 知っておきたい有機反応100
    大和田智彦(編集委員,分担) 日本薬学会編  
    (東京化学同人200) 5 
  • トップ・ドラッグ
    大和田智彦,夏苅英昭 訳(J.サウンダース著) 
  • 量子有機化学(朝倉書店) 藤本博 編 2001,共著 3章 大和田智彦 有機分子の構造-量子化学計算に基づく概念構築の試み
  • chapter 16 “Electrophilic species that can react with benzene are dicationic”
    Shudo, K.; Ohwada, T. (book chapter)
    Stable Carbocation Chemistry, 1997, Prakash, K. S.; Schleyer, P. v. R. (ed), 525-548, John Wiley & Sons, Inc.
  • "Reactive Carbon Electrophiles in Friedel-Crafts Reactions"
    Ohwada, T.
    Reviews on Heteroatom Chemistry, 1995, 12, 179-209.